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ENGN Overview

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Intellectia

Loading chart...

High
1.750
Open
1.710
VWAP
1.57
Vol
17.39M
Mkt Cap
592.86M
Low
1.450
Amount
27.24M
EV/EBITDA(TTM)
--
Total Shares
66.99M
EV
-150.54M
EV/OCF(TTM)
--
P/S(TTM)
--
enGene Therapeutics Inc., formerly enGene Holdings Inc., is a clinical-stage biotechnology company mainstreaming gene therapy through the delivery of therapeutics to mucosal tissues and other organs. The Company’s lead program is detalimogene voraplasmid, (detalimogene) for patients with non-muscle invasive bladder cancer (NMIBC), a disease with a high clinical burden. Detalimogene is being evaluated in the ongoing multi-cohort LEGEND Phase II trial, which includes a pivotal cohort studying detalimogene in Bacillus Calmette-Guerin (BCG)-unresponsive patients with carcinoma in situ (CIS). Detalimogene is being developed through its proprietary Dually Derivatized Oligochitosan (DDX) platform, which enables penetration of mucosal tissues and delivery of a range of sizes and types of cargo, including Deoxyribonucleic acid (DNA) and various forms of Ribonucleic acid (RNA).
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Events Timeline

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News

Globenewswire
7.0
05-07Globenewswire
Investigation into enGene Therapeutics Investor Claims
  • Clinical Trial Results Disclosure: On May 7, 2026, enGene announced that in its LEGEND trial using detalimogene voraplasmid for high-risk bladder cancer patients, the complete response rate was 54% at any time and 43% at six months, but the 12-month duration of response was only 25%, indicating efficacy below expectations and potentially impacting investor confidence.
  • Investor Loss Investigation: Following a sharp decline in enGene's stock price due to unfavorable results, Johnson Fistel is investigating whether the company violated federal securities laws, which may lead to claims for investor losses, reflecting concerns over corporate governance and transparency.
  • Poor Patient Assessment Results: Among 32 patients assessed recently, the complete response rate dropped to 39% at any time and 32% at six months, significantly lower than previously reported results, which could undermine investor confidence in the company's future prospects.
  • Law Firm Involvement: Johnson Fistel is a nationally recognized shareholder rights law firm focused on representing investors in securities class actions, ranked among the Top 10 Plaintiff Law Firms in 2024, demonstrating its strength in advocating for investor rights.
Yahoo Finance
2.0
05-07Yahoo Finance
enGene Reports Interim Results from NMIBC Clinical Trial
  • Efficacy Data Update: In the ongoing LEGEND Phase 2 trial, 54% of the 125 high-risk non-muscle invasive bladder cancer patients achieved a complete response (CR) at any time, with a 43% CR rate at six months, indicating the therapy's effectiveness and potential market prospects.
  • Low Progression Rate: The trial reported a low progression rate to muscle-invasive or higher disease at only 3.2%, suggesting that patients remain eligible for other bladder-sparing therapies, enhancing the treatment's appeal.
  • Good Safety Profile: 55% of patients experienced treatment-related adverse events (TRAEs), predominantly mild (Grade 1 and 2), with only 2.4% of patients experiencing treatment interruptions or discontinuations, demonstrating the therapy's favorable tolerability.
  • FDA Engagement Plans: enGene plans to further engage with the FDA in preparation for a potential Biologics License Application (BLA) and will provide updates in the second half of 2026, reflecting the company's confidence and strategic positioning for future market opportunities.
PRnewswire
8.5
03-19PRnewswire
Global Oncology Market Set for Rapid Growth
  • Market Size Forecast: The global oncology market is projected to reach $279.98 billion in 2026 and grow to $748.17 billion by 2035, indicating a structural shift from single-agent treatments to combination therapies and next-generation cell therapies.
  • Immuno-Oncology Expansion: The immuno-oncology segment is expected to expand from $65.22 billion in 2025 to $170.19 billion by 2032, as approvals of combination therapies convert previously resistant tumors into viable treatment targets, driving market demand.
  • Oncolytics Biotech New Data: Oncolytics Biotech will present new data at the 2026 American Association for Cancer Research Annual Meeting, indicating that its lead drug pelareorep can make tumors more susceptible to immunotherapy, particularly showing positive results in breast and gastrointestinal cancer trials.
  • Clinical Trial Progress: Oncolytics' REO 033 trial demonstrated a total survival of 27 months in second-line RAS-mutant, microsatellite-stable metastatic colorectal cancer patients, with the FDA granting Fast Track Designation, which is expected to enhance the company's position in high-value markets.
Newsfilter
7.5
03-19Newsfilter
Global Oncology Market Expected to Reach $748.17 Billion
  • Market Growth Potential: The global oncology market is valued at $279.98 billion in 2026 and is projected to reach $748.17 billion by 2035, indicating a strong trend towards a shift from single-agent treatments to combination platforms and next-generation cell therapies, potentially creating significant market opportunities for related companies.
  • Immuno-Oncology Expansion: The immuno-oncology segment is expected to grow from $65.22 billion in 2025 to $170.19 billion by 2032, as the approval of combination therapies transforms previously resistant tumors into viable treatment targets, driving rapid industry growth.
  • Oncolytics Biotech New Data: Oncolytics Biotech is set to present new mechanistic and translational data at the 2026 American Association for Cancer Research Annual Meeting, indicating that its lead drug pelareorep can enhance tumor sensitivity to immunotherapy, potentially providing crucial scientific support for the company in a competitive market.
  • Clinical Trial Progress: Oncolytics' REO 033 trial for KRAS-mutant metastatic colorectal cancer shows an overall survival of 27 months and a 33% objective response rate, with the FDA granting Fast Track Designation, which is expected to create significant market opportunities for the company.
moomoo
4.0
03-11moomoo
ENGENE HOLDINGS INC.: OPPENHEIMER LOWERS TARGET PRICE FROM $33 TO $30
  • Company Overview: Engene Holdings Inc. is a company involved in various business activities, including investments and holdings.

  • Target Price Adjustment: Oppenheimer has reduced the target price for Engene Holdings from $33 to $30.

seekingalpha
9.5
03-09seekingalpha
enGene Holdings Q1 Financial Highlights
  • Earnings Performance: enGene Holdings reported a Q1 GAAP EPS of $0.44, indicating stable profitability despite competitive market pressures.
  • Cash Position: As of January 31, 2026, the company held $312.5 million in cash, cash equivalents, and marketable securities, providing ample funding for future investments and operations.
  • Operating Expense Increase: Operating expenses for Q1 2026 totaled $31.2 million, a 17.3% increase from $26.6 million in 2025, reflecting ongoing investments in R&D and market expansion.
  • Positive Market Reaction: enGene Holdings saw a 14% surge in stock price on Friday, indicating investor optimism regarding the company's future prospects, particularly with major catalysts on the horizon.
Wall Street analysts forecast ENGN stock price to rise
8 Analyst Rating
Wall Street analysts forecast ENGN stock price to rise
7 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
10.00
Averages
23.88
High
33.00
Current: 0.000
sliders
Low
10.00
Averages
23.88
High
33.00
Oppenheimer
Oppenheimer
Outperform
to
Perform
downgrade
AI Analysis
2026-05-08
New
Reason
Oppenheimer
Oppenheimer
Price Target
AI Analysis
2026-05-08
New
downgrade
Outperform
to
Perform
Reason
Oppenheimer downgraded enGene to Perform from Outperform. The firm views updated interim data from the pivotal LEGEND cohort in BCG-unresponsive NMIBC as disappointing, and while the approval door may remain open, Oppenheimer is less optimistic on detalimogene's ability to compete in this evolving marketplace. The firm believes that enGene is now a "show-me" story for which investor enthusiasm will be limited for the foreseeable future. Oppenheimer expects an update on BLA submission plans in the second half of 2026 following the company's further engagement with FDA.
Leerink
Outperform
to
Market Perform
downgrade
$2
2026-05-08
New
Reason
Leerink
Price Target
$2
2026-05-08
New
downgrade
Outperform
to
Market Perform
Reason
Leerink downgraded enGene to Market Perform from Outperform with a $2 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ENGN
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Valuation Metrics

The current forward P/E ratio for enGene Therapeutics Inc (ENGN.O) is 0.00, compared to its 5-year average forward P/E of -3.05. For a more detailed relative valuation and DCF analysis to assess enGene Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.05
Current PE
0.00
Overvalued PE
-0.13
Undervalued PE
-5.97

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.07
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
1.25
Undervalued EV/EBITDA
-5.40

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
2.18
Current PS
4.38
Overvalued PS
8.83
Undervalued PS
-4.46

Financials

AI Analysis
Annual
Quarterly

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Whales Holding ENGN

V
VR Management, LLC
Holding
ENGN
+18.39%
3M Return
P
Perceptive Advisors LLC
Holding
ENGN
+16.35%
3M Return
A
Artal Group S.A.
Holding
ENGN
+14.33%
3M Return
V
Vestal Point Capital, LP
Holding
ENGN
+9.90%
3M Return
F
Fonds de solidarité FTQ
Holding
ENGN
+1.48%
3M Return
C
Cormorant Asset Management, LP
Holding
ENGN
-0.47%
3M Return

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Frequently Asked Questions

What is enGene Therapeutics Inc (ENGN) stock price today?

The current price of ENGN is 1.5 USD — it has decreased -12.79

What is enGene Therapeutics Inc (ENGN)'s business?

enGene Therapeutics Inc., formerly enGene Holdings Inc., is a clinical-stage biotechnology company mainstreaming gene therapy through the delivery of therapeutics to mucosal tissues and other organs. The Company’s lead program is detalimogene voraplasmid, (detalimogene) for patients with non-muscle invasive bladder cancer (NMIBC), a disease with a high clinical burden. Detalimogene is being evaluated in the ongoing multi-cohort LEGEND Phase II trial, which includes a pivotal cohort studying detalimogene in Bacillus Calmette-Guerin (BCG)-unresponsive patients with carcinoma in situ (CIS). Detalimogene is being developed through its proprietary Dually Derivatized Oligochitosan (DDX) platform, which enables penetration of mucosal tissues and delivery of a range of sizes and types of cargo, including Deoxyribonucleic acid (DNA) and various forms of Ribonucleic acid (RNA).

What is the price predicton of ENGN Stock?

Wall Street analysts forecast ENGN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ENGN is23.88 USD with a low forecast of 10.00 USD and a high forecast of 33.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is enGene Therapeutics Inc (ENGN)'s revenue for the last quarter?

enGene Therapeutics Inc revenue for the last quarter amounts to -31.18M USD, increased 17.18

What is enGene Therapeutics Inc (ENGN)'s earnings per share (EPS) for the last quarter?

enGene Therapeutics Inc. EPS for the last quarter amounts to -29056000.00 USD, increased 11.78

How many employees does enGene Therapeutics Inc (ENGN). have?

enGene Therapeutics Inc (ENGN) has 45 emplpoyees as of May 10 2026.

What is enGene Therapeutics Inc (ENGN) market cap?

Today ENGN has the market capitalization of 592.86M USD.