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CNTA Overview

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$
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ET
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ET
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Intellectia

Loading chart...

High
27.670
Open
27.177
VWAP
27.32
Vol
378.83K
Mkt Cap
4.12B
Low
26.920
Amount
10.35M
EV/EBITDA(TTM)
--
Total Shares
146.08M
EV
3.98B
EV/OCF(TTM)
--
P/S(TTM)
--
Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.
Show More

Events Timeline

(ET)
2025-12-11
10:10:00
Centessa Shares Down 8.4% to $27.08
select
2025-12-11
07:10:00
Centessa Pharmaceuticals Appoints Mario Accardi as CEO
select
2025-12-01 (ET)
2025-12-01
08:40:00
B. Riley Raises Centessa Price Target to $42, Maintains Buy Rating
select

News

Fool
6.5
02-26Fool
Investment Comparison: Centessa vs. Vertex Pharmaceuticals
  • Centessa's Drug Potential: Centessa Pharmaceuticals is developing ORX750 for narcolepsy type 1, type 2, and idiopathic hypersomnia, which could become a foundational therapy due to its broad applicability and novel mechanism; however, it has yet to demonstrate efficacy in late-stage studies, posing significant risks.
  • Market Performance Comparison: Centessa's shares have significantly outperformed broader equities over the past year, with a current market cap of $3.6 billion, yet as a smaller biotech without any products on the market and ongoing losses, it carries high investment risks.
  • Vertex's Stability: Vertex Pharmaceuticals has successfully revolutionized the standard of care for cystic fibrosis, generating consistent revenue and profits with a market cap of $123 billion, making it a safer investment option compared to Centessa.
  • Future Development Prospects: Vertex is advancing several late-stage pipeline candidates, including zimislecel for type 1 diabetes, which is expected to seek regulatory approval this year; successful outcomes could further solidify its market position and attract investors with average risk tolerance.
Fool
5.0
02-23Fool
Commodore Capital Reduces Stake in Centessa Pharmaceuticals
  • Stake Reduction Details: According to a February 17, 2026 SEC filing, Commodore Capital sold 1,850,000 shares of Centessa Pharmaceuticals in Q4, with an estimated transaction value of approximately $46.86 million, indicating a cautious outlook on the company's future prospects.
  • Position Value Decline: This sale resulted in a $44.10 million decrease in Commodore's quarter-end position value in Centessa, reflecting not only the sale activity but also the impact of price movements, suggesting a potential waning confidence in the stock.
  • Ownership Ratio Adjustment: Following the reduction, Commodore's stake in Centessa dropped to 1.66%, indicating a significant shift in its investment strategy that may influence future investment decisions and portfolio management.
  • Market Performance Analysis: Despite Centessa's stock price rising 53.4% over the past year, Commodore's divestment suggests a capital redeployment strategy, prompting investors to monitor the company's strategic transformation under new CEO leadership and its implications for future performance.
Fool
8.5
02-19Fool
Braidwell Acquires Significant Stake in Centessa Pharmaceuticals
  • Stake Acquisition: On February 17, 2026, Braidwell disclosed the acquisition of 2,188,320 shares of Centessa Pharmaceuticals for approximately $54.73 million, indicating confidence in the company, although this stake represents only 1.75% of its reportable assets.
  • Stock Performance: As of February 17, 2026, Centessa's stock price stood at $24.94, reflecting a 53.4% increase over the past year, significantly outperforming the S&P 500 by 34.19 percentage points, indicating positive market expectations for its clinical pipeline.
  • Company Overview: Centessa focuses on developing clinical-stage drug candidates, including Lixivaptan for polycystic kidney disease and SerpinPC for hemophilia, aiming to create value through successful drug approvals and commercialization, addressing the needs of patients with rare and autoimmune diseases.
  • Strategic Shift: The appointment of Mario Accardi as CEO underscores a sharpened focus on OX2R agonists, suggesting potential expansion into neuropsychiatric indications, despite the inherent volatility in clinical-stage neuroscience.
Fool
5.0
02-02Fool
Tanager Wealth Management Fully Exits Centessa Pharmaceuticals Stake
  • Complete Exit: Tanager Wealth Management disclosed in a January 26 SEC filing that it sold its entire stake in Centessa Pharmaceuticals, totaling 598,044 shares in the fourth quarter, with an estimated transaction value of $14.50 million, indicating a complete liquidation of its investment in the company.
  • Asset Management Shift: This exit means that Centessa now represents 0% of Tanager's reportable 13F AUM, down from 1.5% in the previous quarter, reflecting a significant reduction in confidence towards the stock.
  • Improving Fundamentals: Despite Tanager's exit, Centessa's fundamentals are improving, as evidenced by its latest earnings report showing $349 million in cash and investments, along with a $250 million investment received in November, indicating a strengthening financial position.
  • Market Performance Comparison: Centessa's stock price has risen approximately 56.7% over the past year, significantly outperforming the S&P 500's roughly 14% gain during the same period, highlighting its potential and market recognition in the biotechnology sector.
NASDAQ.COM
6.5
02-02NASDAQ.COM
Tanager Wealth Management Exits Entire CNTA Position
  • Position Change: Tanager Wealth Management completely exited its position in Centessa Pharmaceuticals (CNTA) in Q4, selling 598,044 shares, resulting in a $14.50 million decrease in position value, reflecting both stock price movement and the sale itself.
  • Asset Management Ratio Decline: This exit reduced CNTA's representation in Tanager Wealth Management's reported AUM from 1.5% to 0%, highlighting the fund's risk management strategy regarding individual biotech stocks.
  • Market Performance Comparison: As of January 26, CNTA shares were priced at $25.73, up approximately 56.7% over the past year, significantly outperforming the S&P 500's roughly 14% gain during the same period, indicating market confidence in its fundamentals.
  • Improving Company Fundamentals: Centessa Pharmaceuticals reported $349 million in cash and investments in its latest earnings release, along with $250 million from investors in November, showcasing its robust development in the clinical-stage biotech sector.
Globenewswire
9.0
01-14Globenewswire
Centessa Pharmaceuticals Presents New OX2R Agonist Data, Enhancing Mood in Depression Models
  • New Data Presentation: Centessa Pharmaceuticals showcased preclinical data on OX2R agonists at the ACNP annual meeting, demonstrating significant improvements in behavioral despair and wakefulness in depression animal models, indicating potential for rapid mood enhancement.
  • Clear Strategic Direction: CEO Mario Alberto Accardi, PhD, emphasized the company's commitment to exploring new therapeutic options through its multi-asset OX2R agonist pipeline, addressing mood symptoms and excessive daytime sleepiness, showcasing foresight in the neuroscience field.
  • Clinical Trial Progress: The OX2R agonist ORX750 is currently undergoing Phase 2 CRYSTAL-1 study aimed at treating sleep-wake disorders, including narcolepsy, indicating Centessa's potential expansion into high unmet clinical needs.
  • Solid Scientific Foundation: The presented research supports the scientific basis for OX2R agonists as novel treatment modalities, potentially offering new therapeutic options for various neuropsychiatric disorders, further solidifying Centessa's leadership in this domain.
Wall Street analysts forecast CNTA stock price to rise
13 Analyst Rating
Wall Street analysts forecast CNTA stock price to rise
13 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
27.00
Averages
38.75
High
62.00
Current: 0.000
sliders
Low
27.00
Averages
38.75
High
62.00
Wolfe Research
NULL -> Outperform
initiated
$40
AI Analysis
2026-02-23
Reason
Wolfe Research
Price Target
$40
AI Analysis
2026-02-23
initiated
NULL -> Outperform
Reason
Wolfe Research initiated coverage of Centessa with an Outperform rating and $40 price target, citing the firm's "high-conviction" in lead asset ORX750.
Truist
Buy
upgrade
$33 -> $38
2026-01-29
Reason
Truist
Price Target
$33 -> $38
2026-01-29
upgrade
Buy
Reason
Truist raised the firm's price target on Centessa to $38 from $33 and keeps a Buy rating on the shares. The firm is adjusting its model after re-examining the existing evidence across the orexin-2 receptor agonist class, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for CNTA
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Valuation Metrics

The current forward P/E ratio for Centessa Pharmaceuticals PLC (CNTA.O) is -14.61, compared to its 5-year average forward P/E of -6.24. For a more detailed relative valuation and DCF analysis to assess Centessa Pharmaceuticals PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.24
Current PE
-14.61
Overvalued PE
-2.38
Undervalued PE
-10.10

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.64
Current EV/EBITDA
-12.64
Overvalued EV/EBITDA
-0.48
Undervalued EV/EBITDA
-8.81

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
256.19
Current PS
4511.78
Overvalued PS
1307.59
Undervalued PS
-795.20

Financials

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Whales Holding CNTA

A
Artal Group S.A.
Holding
CNTA
+7.65%
3M Return
E
EcoR1 Capital, LLC
Holding
CNTA
+7.52%
3M Return
C
Commodore Capital LP
Holding
CNTA
+6.92%
3M Return
S
Sofinnova Investment, Inc.
Holding
CNTA
+4.38%
3M Return
P
Perceptive Advisors LLC
Holding
CNTA
+3.66%
3M Return
T
TCG Crossover Management, LLC
Holding
CNTA
+2.13%
3M Return

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Frequently Asked Questions

What is Centessa Pharmaceuticals PLC (CNTA) stock price today?

The current price of CNTA is 27.36 USD — it has decreased -3.05

What is Centessa Pharmaceuticals PLC (CNTA)'s business?

Centessa Pharmaceuticals plc is a clinical-stage pharmaceutical company. The Company is developing a new class of potential therapies within its orexin receptor 2 (OX2R) agonist program for the treatment of excessive daytime sleepiness (EDS), impaired attention, cognitive deficits, fatigue and other symptoms across neurological, neurodegenerative and neuropsychiatric disorders. It also has an early-stage immuno-oncology program focused on its LockBody technology platform. Its OX2R agonist pipeline includes ORX750, its advanced OX2R agonist development candidate, and ORX142, ORX489 and OX2R agonists in preclinical development. Its ORX750, an investigational, orally administered, highly potent and selective OX2R agonist, is in a Phase IIa study of participants with narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH). ORX142 is the second OX2R agonist development candidate being advanced for the treatment of neurological and neurodegenerative disorders and other symptoms.

What is the price predicton of CNTA Stock?

Wall Street analysts forecast CNTA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CNTA is38.75 USD with a low forecast of 27.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Centessa Pharmaceuticals PLC (CNTA)'s revenue for the last quarter?

Centessa Pharmaceuticals PLC revenue for the last quarter amounts to 0.00 USD, decreased

What is Centessa Pharmaceuticals PLC (CNTA)'s earnings per share (EPS) for the last quarter?

Centessa Pharmaceuticals PLC. EPS for the last quarter amounts to -0.41 USD, increased 10.81

How many employees does Centessa Pharmaceuticals PLC (CNTA). have?

Centessa Pharmaceuticals PLC (CNTA) has 77 emplpoyees as of March 12 2026.

What is Centessa Pharmaceuticals PLC (CNTA) market cap?

Today CNTA has the market capitalization of 4.12B USD.