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CLDX Overview

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ET
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Intellectia

Loading chart...

High
29.720
Open
29.380
VWAP
28.89
Vol
733.70K
Mkt Cap
1.90B
Low
28.400
Amount
21.19M
EV/EBITDA(TTM)
--
Total Shares
66.57M
EV
1.45B
EV/OCF(TTM)
--
P/S(TTM)
1.27K
Celldex Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is focused on exploring the science of mast cell biology and the development of transformative therapeutics for patients. Its pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly affect critical pathways to improve the lives of patients with severe inflammatory, allergic, autoimmune and other devastating diseases. Its drug candidates include monoclonal and bispecific antibodies designed to address mast cell mediated diseases. Its Barzolvolimab (CDX-0159) is a monoclonal antibody that specifically binds the KIT receptor and potently inhibits its activity, which is being studied across multiple mast cell driven diseases, including Chronic Urticarias, Prurigo Nodularis, Atopic Dermatitis and Eosinophilic Esophagitis. The Company’s bispecific platform includes CDX- 622. The CDX- 622 is a bispecific candidate for inflammatory diseases.
Show More

Events Timeline

(ET)
2026-03-01
11:40:00
Celldex Presents New Data on Cold Urticaria
select
2026-02-25 (ET)
2026-02-25
16:21:00
Celldex Reports Q4 Revenue of $121,000, Below Consensus
select
2026-02-25
07:20:00
Celldex Completes Enrollment in Phase 3 Trials for Chronic Spontaneous Urticaria
select
2025-12-09 (ET)
2025-12-09
08:10:00
Celldex Initiates Global Phase 3 Trial for Barzolvolimab
select
2025-11-10 (ET)
2025-11-10
16:02:51
Celldex Announces Q3 Earnings Per Share of $1.01, Exceeding Consensus Estimate of 89 Cents
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News

NASDAQ.COM
9.0
03-02NASDAQ.COM
Celldex's Barzolvolimab Shows Strong Efficacy in Skin Conditions
  • Efficacy Consistency: Celldex Therapeutics' Barzolvolimab demonstrates that retreatment yields the same profound efficacy in patients with Cold Urticaria and Symptomatic Dermographism, indicating its potential to transform treatment strategies for chronic skin conditions.
  • Clinical Trial Results: In a Phase 2 open-label extension study, patients who experienced symptom recurrence regained high levels of disease control upon retreatment, with complete response rates consistent with first-time treatment, underscoring the drug's sustained effectiveness.
  • Good Safety Profile: Barzolvolimab was well tolerated, with a safety profile in line with earlier studies, supporting its application in real-world treatment scenarios, particularly for patients requiring intermittent therapy.
  • Global Research Initiative: Celldex is currently conducting a global Phase 3 program, EMBARQ, to further evaluate Barzolvolimab's efficacy in Cold Urticaria and Symptomatic Dermographism, signaling potential market expansion in the future.
Newsfilter
9.0
03-01Newsfilter
Celldex Presents Positive Data on Barzolvolimab for ColdU and SD Treatment
  • Clinical Trial Results: Celldex presented positive data at the 2026 AAAAI Annual Meeting, indicating that re-treatment with barzolvolimab led to a complete response in 62% of ColdU patients and 60% of SD patients at Week 20, highlighting the drug's potential in chronic urticaria treatment.
  • Retreatment Mechanism: Barzolvolimab, a humanized monoclonal antibody, targets mast cells with a unique mechanism, enabling rapid improvement in urticaria control upon symptom recurrence, reinforcing its position as a best-in-class treatment option for chronic urticaria patients.
  • Study Participation: In the main study, 193 patients received barzolvolimab or placebo, with 121 entering the Open Label Extension (OLE), demonstrating that patients retreated entered the OLE faster than those initially treated, further validating its clinical applicability and flexibility.
  • Safety and Tolerability: Barzolvolimab re-treatment exhibited good tolerability with a safety profile consistent with prior studies, indicating its feasibility in real-world applications and potentially offering new treatment options for chronic urticaria patients.
Newsfilter
9.0
02-27Newsfilter
Celldex Reports Positive Data on Barzolvolimab Efficacy
  • Clinical Trial Results: Celldex presented positive data on barzolvolimab at the 2026 AAAAI Annual Meeting, showing that 71% of patients achieved complete symptom relief after 52 weeks of treatment, indicating significant efficacy and potential disease-modifying effects.
  • Improvement in Quality of Life: Among patients treated for 52 weeks, 83% reported no impact of the disease on their quality of life, and 74% of those with baseline angioedema were free of it post-treatment, highlighting barzolvolimab's substantial effect on enhancing patient quality of life.
  • Global Clinical Trial Progress: Celldex has completed enrollment in its global Phase 3 program for CSU, involving 1,939 patients, making it the largest study conducted in antihistamine-refractory CSU, showcasing the company's leadership in this field.
  • Therapeutic Outlook: Barzolvolimab's unique mechanism targets mast cells, positioning it as a potential first-in-class treatment for CSU, ColdU, and symptomatic dermographism, signaling a major breakthrough in the treatment of allergic diseases.
stocktwits
9.0
02-26stocktwits
Celldex Completes Enrollment for Barzolvolimab Trial Ahead of Schedule
  • Enrollment Completion: Celldex announced the completion of enrollment for its large-scale Chronic Spontaneous Urticaria (CSU) clinical trial six months ahead of schedule, with 1,939 patients enrolled, highlighting the significant unmet need in this area, with data expected in Q4 2026.
  • Regulatory Submission Plans: The company plans to submit an application for barzolvolimab approval to the U.S. FDA in 2027 based on clinical trial data, aiming to establish its efficacy and safety in CSU patients, which could facilitate market entry.
  • Positive Market Sentiment: On Stocktwits, retail sentiment around CLDX stock remains in the 'bullish' territory, with users optimistic about the drug's annual sales potential, projecting the company's market capitalization to rise to $25 billion, indicating strong investor confidence in the drug's prospects.
  • Analyst Ratings Optimistic: According to Koyfin data, the average price target for CLDX is $53.36, representing a potential upside of about 73% from current trading levels, with 13 out of 16 analysts rating it 'Buy' or higher, reflecting a positive outlook for the stock.
seekingalpha
9.5
02-25seekingalpha
Celldex Q4 Earnings Miss Expectations
  • Disappointing Earnings: Celldex reported a Q4 GAAP EPS of -$1.22, missing expectations by $0.20, indicating ongoing challenges in profitability that may affect investor confidence.
  • Significant Revenue Decline: The company generated only $0.12M in revenue for Q4, a staggering 89.8% year-over-year drop, falling short of the anticipated $1.34M, reflecting a notable weakness in product sales that could increase future cash flow pressures.
  • Decreased Cash Reserves: As of December 31, 2025, Celldex's cash, cash equivalents, and marketable securities totaled $518.6M, down from $583.2M as of September 30, 2025, highlighting challenges in cash management that may impact its R&D and operational capabilities.
  • Clinical Trial Progress: Despite the poor financial performance, Celldex has completed enrollments in late-stage trials for its lead asset, potentially paving the way for future product launches, although short-term financial pressures remain.
Yahoo Finance
8.5
02-25Yahoo Finance
Celldex Completes Enrollment in Chronic Spontaneous Urticaria Studies Ahead of Schedule
  • Rapid Research Progress: Celldex completed enrollment in its global chronic spontaneous urticaria (CSU) registration studies six months ahead of schedule, enrolling 1,939 patients, which reflects strong interest in barzolvolimab, with topline data expected in Q4 2026 to support a planned BLA submission in 2027.
  • New Drug Development Outlook: The company is actively accruing patients in its Phase 3 studies for cold urticaria and symptomatic dermographism (EMBARQ-ColdU and -SD), where barzolvolimab has demonstrated clinical benefits in a large randomized controlled trial, further solidifying its leadership in immunology.
  • Financial Position Analysis: As of December 31, 2025, Celldex reported cash and cash equivalents of $518.6 million, down from $583.2 million as of September 30, 2025, primarily due to increased operating expenses in the fourth quarter, indicating the company's commitment to accelerating clinical trials.
  • Future Prospects: Celldex anticipates multiple important data readouts in 2026, including topline data from CSU and other indications, marking the company's ongoing efforts to drive innovative treatment solutions that could transform the treatment landscape and enhance its competitive position in the market.
Wall Street analysts forecast CLDX stock price to rise
10 Analyst Rating
Wall Street analysts forecast CLDX stock price to rise
9 Buy
0 Hold
1 Sell
Strong Buy
Current: 0.000
sliders
Low
24.00
Averages
55.00
High
90.00
Current: 0.000
sliders
Low
24.00
Averages
55.00
High
90.00
Goldman Sachs
Richard Law
Neutral
maintain
$30 -> $34
AI Analysis
2026-03-02
Reason
Goldman Sachs
Richard Law
Price Target
$30 -> $34
AI Analysis
2026-03-02
maintain
Neutral
Reason
Goldman Sachs analyst Richard Law raised the firm's price target on Celldex to $34 from $30 and keeps a Neutral rating on the shares. Celldex is entering a catalyst-rich period with completed enrollments across multiple Phase 3 and Phase 2 programs, key topline data readouts beginning in mid-2026, and additional Phase 1 updates expected in 2026, alongside new Phase 3 and asthma studies initiated in late 2025 and early 2026, the analyst tells investors in a research note.
Stifel
Alex Thompson
Buy
maintain
$58 -> $68
2026-02-26
Reason
Stifel
Alex Thompson
Price Target
$58 -> $68
2026-02-26
maintain
Buy
Reason
Stifel analyst Alex Thompson raised the firm's price target on Celldex to $68 from $58 and keeps a Buy rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for CLDX
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Valuation Metrics

The current forward P/E ratio for Celldex Therapeutics Inc (CLDX.O) is -6.13, compared to its 5-year average forward P/E of -13.24. For a more detailed relative valuation and DCF analysis to assess Celldex Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-13.24
Current PE
-6.13
Overvalued PE
-6.92
Undervalued PE
-19.56

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.51
Current EV/EBITDA
-4.54
Overvalued EV/EBITDA
1.19
Undervalued EV/EBITDA
-6.21

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
589.90
Current PS
500.11
Overvalued PS
858.54
Undervalued PS
321.26

Financials

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Whales Holding CLDX

C
Commodore Capital LP
Holding
CLDX
+6.76%
3M Return
V
Vestal Point Capital, LP
Holding
CLDX
+5.32%
3M Return
K
Kynam Capital Management, LP
Holding
CLDX
+1.03%
3M Return
B
Braidwell LP
Holding
CLDX
-1.29%
3M Return
E
Eversept Partners, L.P.
Holding
CLDX
-4.62%
3M Return
B
Bellevue Asset Management AG
Holding
CLDX
-5.90%
3M Return

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Frequently Asked Questions

What is Celldex Therapeutics Inc (CLDX) stock price today?

The current price of CLDX is 28.54 USD — it has decreased -3.71

What is Celldex Therapeutics Inc (CLDX)'s business?

Celldex Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is focused on exploring the science of mast cell biology and the development of transformative therapeutics for patients. Its pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly affect critical pathways to improve the lives of patients with severe inflammatory, allergic, autoimmune and other devastating diseases. Its drug candidates include monoclonal and bispecific antibodies designed to address mast cell mediated diseases. Its Barzolvolimab (CDX-0159) is a monoclonal antibody that specifically binds the KIT receptor and potently inhibits its activity, which is being studied across multiple mast cell driven diseases, including Chronic Urticarias, Prurigo Nodularis, Atopic Dermatitis and Eosinophilic Esophagitis. The Company’s bispecific platform includes CDX- 622. The CDX- 622 is a bispecific candidate for inflammatory diseases.

What is the price predicton of CLDX Stock?

Wall Street analysts forecast CLDX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CLDX is55.00 USD with a low forecast of 24.00 USD and a high forecast of 90.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Celldex Therapeutics Inc (CLDX)'s revenue for the last quarter?

Celldex Therapeutics Inc revenue for the last quarter amounts to 121.00K USD, decreased -89.70

What is Celldex Therapeutics Inc (CLDX)'s earnings per share (EPS) for the last quarter?

Celldex Therapeutics Inc. EPS for the last quarter amounts to -1.22 USD, increased 71.83

How many employees does Celldex Therapeutics Inc (CLDX). have?

Celldex Therapeutics Inc (CLDX) has 198 emplpoyees as of March 19 2026.

What is Celldex Therapeutics Inc (CLDX) market cap?

Today CLDX has the market capitalization of 1.90B USD.