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TNYA Overview

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ET
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ET
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Intellectia

Loading chart...

High
0.820
Open
0.627
VWAP
0.75
Vol
31.84M
Mkt Cap
125.88M
Low
0.601
Amount
23.78M
EV/EBITDA(TTM)
--
Total Shares
216.51M
EV
67.96M
EV/OCF(TTM)
--
P/S(TTM)
--
Tenaya Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering, developing, and delivering curative therapies that address the underlying drivers of heart disease. Its pipeline includes TN-201, TN-401, and TN-301. TN-201 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy designed to deliver a working MYBPC3 gene to heart muscle cells via a single intravenous infusion, increasing MyBP-C protein levels to address the underlying cause of MYBPC3-associated HCM with the aim of halting or even reversing disease after a single dose. Its MyPEAK-1 Phase I b/2 clinical trial is an ongoing, multi-center, open-label, dose-escalating study designed to assess the safety, tolerability and clinical efficacy of a one-time intravenous infusion of TN-201 gene replacement therapy. TN-401 is its AAV9-based gene therapy being developed for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) due to disease-causing variants in the PKP2 gene.
Show More

Events Timeline

(ET)
2026-03-05
08:40:00
Tenaya Therapeutics Partners with Alnylam to Develop Cardiovascular Disease Treatments
select
2026-01-09 (ET)
2026-01-09
08:40:00
Tenaya Therapeutics Updates Clinical Development Plans, Outlines 2026 Priorities
select
2025-12-11 (ET)
2025-12-11
16:20:00
Leerink Partners and Piper Sandler Act as Joint Bookrunning Managers for Proposed Offering
select
2025-12-11
16:20:00
Tenaya Therapeutics Reports Interim Data from TN-401 Clinical Trial
select
2025-12-11
16:10:00
Tenaya Therapeutics Lifts Clinical Hold on TN-201 Trial
select

News

Yahoo Finance
4.5
19:04 PMYahoo Finance
Health Care Stocks Decline, NYSE Health Care Index Drops 2.3%
  • Overall Decline in Health Care Stocks: On Thursday afternoon, health care stocks broadly fell, with the NYSE Health Care Index dropping 2.3%, reflecting market concerns about the sector's outlook, which could impact investor confidence and lead to capital outflows.
  • Diminished Market Sentiment: The downward trend in the health care sector may be linked to overall economic uncertainty, as investors grow increasingly wary of potential policy changes and regulatory pressures, thereby affecting stock performance.
  • Investor Reactions: In light of the decline in health care stocks, investors may reassess their portfolios, seeking more defensive asset allocations to mitigate potential market volatility and risks.
  • Uncertain Industry Outlook: The short-term performance of the health care sector may be influenced by multiple factors, including policy changes and fluctuations in market demand, prompting investors to closely monitor developments to adjust their investment strategies.
Benzinga
2.0
19:03 PMBenzinga
Tenaya Therapeutics Partners with Alnylam for Genetic Research
  • Collaboration Agreement: Tenaya Therapeutics has entered into a research collaboration with Alnylam Pharmaceuticals focused on identifying genetic targets for cardiovascular diseases, with Tenaya set to validate up to 15 gene targets and potentially receive $10 million upfront and up to $1.13 billion in milestone payments, significantly enhancing its research capabilities.
  • Technical Advantages: Tenaya employs human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for high-throughput genetic target identification, alongside engineered heart tissue and preclinical in vivo models for validation, having generated over 150 genetic targets that contribute to the development of clinical-stage candidates.
  • Clinical Trial Progress: In December 2025, Tenaya shared interim data from the RIDGE-1 Phase 1b/2 trial of TN-401 gene therapy for rare inherited heart disease, reporting safety, biopsy, and arrhythmia results from three patients, indicating the therapy's potential in treating such conditions.
  • Market Performance Analysis: Despite a 31.20% increase to 76 cents, Tenaya's stock remains 29.1% and 23.6% below its 100-day and 200-day simple moving averages, indicating a bearish trend in the medium to long term, with analysts generally rating it as a
seekingalpha
7.5
14:11 PMseekingalpha
Tenaya Therapeutics Partners with Alnylam for Up to $1.1B Cardiovascular Drug Collaboration
  • Collaboration Agreement: Tenaya Therapeutics has signed a research collaboration with Alnylam Pharmaceuticals worth up to $1.1 billion, aimed at discovering 15 genetic targets associated with cardiovascular diseases, showcasing the company's strong potential in the biotech sector.
  • Upfront Payment and Milestone Rewards: Under the terms, Tenaya will receive up to $10 million as an upfront payment and is eligible for an additional $1.13 billion based on development and commercial milestones, significantly enhancing the company's liquidity and supporting its R&D activities.
  • Strategic Importance: CEO Faraz Ali emphasized that this multi-target collaboration underscores Tenaya's commitment to rigorous science and leverages its proprietary capabilities to drive the discovery and development of cardiovascular candidates, further solidifying its position in the biopharmaceutical industry.
  • Positive Market Reaction: Following the announcement of the collaboration, Tenaya's stock rose approximately 10% in premarket trading, reflecting investor optimism regarding the potential of this partnership, which may enhance the company's market recognition and future growth prospects.
NASDAQ.COM
7.5
14:04 PMNASDAQ.COM
Tenaya and Alnylam Enter Research Collaboration Agreement
  • Collaboration Agreement: Tenaya Therapeutics has signed a research collaboration agreement with Alnylam Pharmaceuticals to discover potential human genetic targets for cardiovascular disease, marking a strategic partnership in gene therapy.
  • Funding Support: Tenaya will receive up to $10 million in upfront payments along with reimbursement for related costs, ensuring sufficient funding for its research activities during the two-year validation period.
  • Potential Earnings: Should all genetic targets lead to approved therapeutics, Tenaya could be eligible for up to $1.13 billion in development and commercial milestone payments, significantly enhancing its financial position and market competitiveness.
  • Stock Price Reaction: In pre-market trading on Nasdaq, Tenaya's shares rose by 11.8% to $0.6499, reflecting positive market expectations and increased investor confidence regarding the collaboration.
Newsfilter
7.5
13:42 PMNewsfilter
Tenaya and Alnylam Forge Collaboration for Genetic Heart Disease Targets
  • Collaboration Overview: Tenaya Therapeutics has entered into a research collaboration agreement with Alnylam Pharmaceuticals to identify and validate up to 15 gene targets for cardiovascular diseases, showcasing a powerful alliance in the field of gene therapy.
  • Financial Support: Tenaya will receive up to $10 million in upfront payments, along with reimbursement for related costs during the two-year validation period, and could earn up to $1.13 billion in milestone payments if all targets lead to successful therapeutics, significantly enhancing its liquidity.
  • Technological Edge: Leveraging human induced pluripotent stem cell-derived cardiomyocytes and high-throughput screening technologies, Tenaya has generated over 150 genetic targets, which will accelerate the development of new therapies and enhance its competitive position in cardiovascular disease treatment.
  • Strategic Implications: This collaboration not only demonstrates Tenaya's innovative capabilities in heart disease treatment but also has the potential to meet the growing market demand through the development of transformational therapies, further solidifying its leadership in the biotechnology sector.
Globenewswire
3.5
01-09Globenewswire
Tenaya Therapeutics Plans 2026 Data Release for Heart Disease Gene Therapies
  • Clinical Progress: Tenaya Therapeutics plans to release key clinical data for TN-201 and TN-401 in the first half of 2026, which is expected to provide new treatment hope for heart disease patients and further solidify the company's leadership in gene therapy.
  • Funding Support: The company successfully raised $60 million in Q4 2025, ensuring sufficient operational funding through mid-2027, thereby enhancing its financial stability in gene therapy development.
  • Regulatory Alignment: Tenaya aims to pursue regulatory alignment for pivotal studies of TN-201 and TN-401 in 2026, intending to accelerate the product launch process to meet the urgent market demand for innovative therapies.
  • Safety Data: Both TN-201 and TN-401 demonstrated good tolerability in clinical trials with no dose-limiting toxicities observed, indicating their potential in treating genetic heart diseases and possibly laying a foundation for the company's future market performance.
Wall Street analysts forecast TNYA stock price to rise
8 Analyst Rating
Wall Street analysts forecast TNYA stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
2.00
Averages
9.14
High
40.00
Current: 0.000
sliders
Low
2.00
Averages
9.14
High
40.00
Morgan Stanley
Overweight
downgrade
$5 -> $2
AI Analysis
2026-01-08
Reason
Morgan Stanley
Price Target
$5 -> $2
AI Analysis
2026-01-08
downgrade
Overweight
Reason
Morgan Stanley lowered the firm's price target on Tenaya Therapeutics to $2 from $5 and keeps an Overweight rating on the shares. The firm sees a continuation of U.S. small-to-mid cap biotech's outperformance in 2026 as commercial names transition from "capital consumers to producers" and Large Cap Biopharma faces a looming patent cliff, the analyst tells investors in an outlook note for the group.
Canaccord
Buy
downgrade
$6 -> $4
2025-12-18
Reason
Canaccord
Price Target
$6 -> $4
2025-12-18
downgrade
Buy
Reason
Canaccord lowered the firm's price target on Tenaya Therapeutics to $4 from $6 and keeps a Buy rating on the shares. The firm two key updates from the company; the lifting of the clinical hold on the MyPEAK-1 trial of TN-201 by the FDA and the first look at interim data from the RIDGE-1 Ph1B clinical trial of TN-401 for PKP2-associated ARVC.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for TNYA
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Valuation Metrics

The current forward P/E ratio for Tenaya Therapeutics Inc (TNYA.O) is -1.42, compared to its 5-year average forward P/E of -2.67. For a more detailed relative valuation and DCF analysis to assess Tenaya Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.67
Current PE
-1.42
Overvalued PE
-0.37
Undervalued PE
-4.96

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.92
Current EV/EBITDA
-0.80
Overvalued EV/EBITDA
1.54
Undervalued EV/EBITDA
-5.39

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
62.39
Current PS
0.00
Overvalued PS
200.07
Undervalued PS
-75.29

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Whales Holding TNYA

C
Casdin Capital, LLC
Holding
TNYA
-13.63%
3M Return

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Frequently Asked Questions

What is Tenaya Therapeutics Inc (TNYA) stock price today?

The current price of TNYA is 0.8193 USD — it has increased 40.94

What is Tenaya Therapeutics Inc (TNYA)'s business?

Tenaya Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering, developing, and delivering curative therapies that address the underlying drivers of heart disease. Its pipeline includes TN-201, TN-401, and TN-301. TN-201 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy designed to deliver a working MYBPC3 gene to heart muscle cells via a single intravenous infusion, increasing MyBP-C protein levels to address the underlying cause of MYBPC3-associated HCM with the aim of halting or even reversing disease after a single dose. Its MyPEAK-1 Phase I b/2 clinical trial is an ongoing, multi-center, open-label, dose-escalating study designed to assess the safety, tolerability and clinical efficacy of a one-time intravenous infusion of TN-201 gene replacement therapy. TN-401 is its AAV9-based gene therapy being developed for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) due to disease-causing variants in the PKP2 gene.

What is the price predicton of TNYA Stock?

Wall Street analysts forecast TNYA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TNYA is9.14 USD with a low forecast of 2.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Tenaya Therapeutics Inc (TNYA)'s revenue for the last quarter?

Tenaya Therapeutics Inc revenue for the last quarter amounts to -20.94M USD, decreased -21.62

What is Tenaya Therapeutics Inc (TNYA)'s earnings per share (EPS) for the last quarter?

Tenaya Therapeutics Inc. EPS for the last quarter amounts to -15625000.00 USD, decreased -21.95

How many employees does Tenaya Therapeutics Inc (TNYA). have?

Tenaya Therapeutics Inc (TNYA) has 97 emplpoyees as of March 05 2026.

What is Tenaya Therapeutics Inc (TNYA) market cap?

Today TNYA has the market capitalization of 125.88M USD.