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ATYR Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
0.899
Open
0.850
VWAP
0.88
Vol
962.99K
Mkt Cap
83.34M
Low
0.841
Amount
845.96K
EV/EBITDA(TTM)
--
Total Shares
98.05M
EV
5.35M
EV/OCF(TTM)
--
P/S(TTM)
415.86
aTyr Pharma, Inc. is a clinical-stage biotechnology company. The Company is leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. Its lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease (ILD), a group of immune-mediated disorders that can cause inflammation and fibrosis, or scarring, of the lungs. Efzofitimod is a tRNA synthetase-derived therapy that selectively modulates activated myeloid cells through neuropilin-2 (NRP2) to resolve aberrant inflammation without immune suppression and potentially prevent the progression of fibrosis. ATYR0101 is a fusion protein derived from a domain of aspartyl-tRNA synthetase (DARS). ATYR0750 is a fusion protein derived from the domain of alanyl-tRNA synthetase (AARS). ATYR0750 is a novel ligand to fibroblast growth factor receptor 4 (FGFR4).
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Events Timeline

(ET)
2026-02-03
08:10:00
aTyr Pharma to Discuss efzofitimod with FDA
select
2025-11-06 (ET)
2025-11-06
16:23:14
aTyr Pharma Announces Q3 Earnings Per Share of 26 Cents, Exceeding Consensus Estimate of 18 Cents
select
2025-09-30 (ET)
2025-09-30
06:16:31
aTyr Pharma announces positive clinical outcomes for efzofitimod in various diseases
select

News

seekingalpha
9.5
03-06seekingalpha
aTyr Pharma Q4 Earnings Beat Expectations
  • Earnings Report: aTyr Pharma reported a Q4 GAAP EPS of -$0.14, beating market expectations by $0.02, indicating improvements in financial management that may bolster investor confidence.
  • Cash Reserves: As of 2025, the company holds $80.9 million in cash, cash equivalents, restricted cash, and investments, ensuring sufficient funding for future R&D and operations, supporting its long-term strategic goals.
  • FDA Meeting Plans: aTyr Pharma is set to meet with the FDA in April to discuss its lead asset, a move that could pave the way for future product approvals and enhance market recognition of its R&D capabilities.
  • Market Attention: Seeking Alpha's Quant Rating on aTyr Pharma reflects market interest in its financial performance, potentially attracting more investors to the company's growth prospects.
NASDAQ.COM
9.5
03-06NASDAQ.COM
aTYR Pharma Reports Reduced Q4 Loss
  • Financial Performance Improvement: aTYR Pharma reported a fourth-quarter loss of $13.96 million, or $0.14 per share, which is an improvement from last year's loss of $14.97 million, or $0.18 per share, indicating a positive trend in financial health.
  • Year-over-Year Comparison: Although still in the red, the narrowing of losses suggests that the company may have made progress in cost control and operational efficiency, which could enhance investor confidence in future profitability.
  • Market Reaction Expectations: With the reduction in losses, the market may adopt a more optimistic outlook on aTYR Pharma's future performance, particularly in the competitive biopharmaceutical sector, where financial improvements could attract more investor interest.
  • Strategic Adjustment Necessity: Despite the reduced losses, the company must continue to optimize its business strategy to achieve profitability, especially in terms of investments in R&D and marketing to ensure long-term sustainable growth.
seekingalpha
9.0
02-03seekingalpha
aTyr Pharma Sets Timeline for FDA Meeting
  • FDA Meeting Scheduled: aTyr Pharma has announced a Type C meeting with the FDA in mid-April 2026 to discuss the results of its EFZO-FIT study for the lung disease candidate efzofitimod, marking a significant step in advancing the drug's development.
  • Impact of Clinical Trial Failure: In September, aTyr's efzofitimod failed in a Phase 3 trial for pulmonary sarcoidosis, leading to a drop in the company's stock price and raising concerns about its research and development capabilities in the market.
  • Market Reaction: Following the announcement of the FDA meeting timeline, aTyr's shares fell approximately 8% on Tuesday, reflecting investor uncertainty about the company's future, particularly after the clinical trial failure.
  • Patient Impact: Pulmonary sarcoidosis affects around 200,000 Americans, and if aTyr can successfully advance efzofitimod, it would provide a new treatment option for this patient population, carrying significant social and economic implications.
Newsfilter
9.0
02-03Newsfilter
aTyr Pharma Schedules FDA Meeting for efzofitimod Review
  • FDA Meeting Scheduled: aTyr Pharma has received FDA approval for a meeting in mid-April 2026 to discuss the results of its Phase 3 EFZO-FIT™ study for efzofitimod, which is expected to provide guidance for future development pathways.
  • Clinical Trial Results: Although the EFZO-FIT™ study did not meet its primary endpoint, clinical benefits were observed for efzofitimod across multiple efficacy parameters in 268 patients, particularly with improvements in the KSQ-Lung score and Fatigue Assessment Scale, achieving p=0.0479 and p=0.0226, respectively.
  • Safety and Tolerability: Efzofitimod demonstrated good maintenance of lung function and a safety profile consistent with prior trials, indicating its potential application in treating pulmonary sarcoidosis.
  • Market Demand and Growth Potential: With increasing demand for safe and effective treatments for lung diseases, efzofitimod, as a novel biologic immunomodulator, may open new market opportunities in the interstitial lung disease space, addressing urgent patient needs.
PRnewswire
7.0
2025-12-15PRnewswire
aTyr Pharma Faces Shareholder Lawsuit Investigation Over Phase 3 Trial Disclosures
  • Lawsuit Investigation Launched: Johnson Fistel, PLLP is investigating potential derivative claims on behalf of aTyr Pharma, Inc. concerning fiduciary breaches related to disclosures from November 7, 2024, to September 12, 2025, which could impact the company's reputation and shareholder interests.
  • Clinical Trial Results Impact: Following negative results from the Phase 3 EFZO-FIT clinical trial, aTyr's stock price dropped significantly, indicating management failures in clinical disclosure controls that may expose the company to litigation risks.
  • Shareholder Rights Protection: Shareholders who have continuously held aTyr shares during the investigation period may have standing to pursue derivative claims on behalf of the company, aiming to protect their investment interests and seek compensation.
  • Legal Firm Background: Johnson Fistel, PLLP is a nationally recognized shareholder rights law firm specializing in securities fraud and investor rights, providing legal support to help investors recover losses, highlighting its expertise in safeguarding shareholder interests.
Globenewswire
7.0
2025-12-11Globenewswire
aTyr Pharma Faces Shareholder Derivative Claims Investigation Over Phase 3 Trial Disclosures
  • Investigation Launched: Johnson Fistel, PLLP is investigating potential derivative claims on behalf of aTyr Pharma, Inc. concerning fiduciary breaches related to disclosures from November 7, 2024, to September 12, 2025, which may expose shareholders to significant losses.
  • Clinical Trial Controversy: Allegations suggest that aTyr made false or misleading statements regarding the design and expectations of the Phase 3 EFZO-FIT trial, leading to a substantial drop in stock price following negative trial results, indicating management failures in clinical disclosure oversight.
  • Shareholder Rights Protection: Current shareholders who held aTyr shares continuously before November 7, 2024, may have standing to pursue derivative claims, aiming to protect shareholder interests and seek potential compensation for losses incurred.
  • Reputational Risk Heightened: The board's failure to oversee disclosures adequately could lead to broader legal repercussions, undermining investor confidence and negatively impacting the company's future financing capabilities.
Wall Street analysts forecast ATYR stock price to rise
2 Analyst Rating
Wall Street analysts forecast ATYR stock price to rise
0 Buy
2 Hold
0 Sell
Hold
Current: 0.000
sliders
Low
1.00
Averages
1.00
High
1.00
Current: 0.000
sliders
Low
1.00
Averages
1.00
High
1.00
Leerink
Faisal Khurshid
Outperform
maintain
$NULL
AI Analysis
2025-09-15
Reason
Leerink
Faisal Khurshid
Price Target
$NULL
AI Analysis
2025-09-15
maintain
Outperform
Reason
Leerink analyst Faisal Khurshid keeps an Outperform rating on aTyr Pharma after the company said the Phase 3 EFZO-FIT trial of efzofitimod in pulmonary sarcoidosis failed to meet its primary endpoint of steroid reduction. While aTyr plans to engage with the FDA on a potential path forward, Leerink's expectations are low given the primary endpoint miss and unclear relevance of KSQ-Lung score improvements alone, the analyst tells investors in a research note. Going into the readout, the firm expected a primary endpoint miss would see 80%-90% share downside. aTyr Pharma shares are down 82%, or $4.97, to $1.07 in early trading.
Cantor Fitzgerald
Overweight -> Neutral
downgrade
2025-09-15
Reason
Cantor Fitzgerald
Price Target
2025-09-15
downgrade
Overweight -> Neutral
Reason
Cantor Fitzgerald downgraded aTyr Pharma to Neutral from Overweight after the company announced that the Phase 3 pulmonary sarcoidosis trial for efzofitimod missed the primary endpoint of change in mean steroid dose from baseline at week 48. aTyr plans to engage with the FDA to determine the path forward, but the firm doesn't have much confidence in the path forward for efzo in pulmonary sarcoidosis, the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ATYR
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Valuation Metrics

The current forward P/E ratio for aTyr Pharma Inc (ATYR.O) is -1.33, compared to its 5-year average forward P/E of -2.81. For a more detailed relative valuation and DCF analysis to assess aTyr Pharma Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.81
Current PE
-1.33
Overvalued PE
-1.13
Undervalued PE
-4.49

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.41
Current EV/EBITDA
0.05
Overvalued EV/EBITDA
0.58
Undervalued EV/EBITDA
-3.39

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
495.88
Current PS
68.15
Overvalued PS
1518.05
Undervalued PS
-526.30

Financials

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Frequently Asked Questions

What is aTyr Pharma Inc (ATYR) stock price today?

The current price of ATYR is 0.8945 USD — it has increased 5.18

What is aTyr Pharma Inc (ATYR)'s business?

aTyr Pharma, Inc. is a clinical-stage biotechnology company. The Company is leveraging evolutionary intelligence to translate tRNA synthetase biology into new therapies for fibrosis and inflammation. Its lead therapeutic candidate is efzofitimod, a first-in-class biologic immunomodulator in clinical development for the treatment of interstitial lung disease (ILD), a group of immune-mediated disorders that can cause inflammation and fibrosis, or scarring, of the lungs. Efzofitimod is a tRNA synthetase-derived therapy that selectively modulates activated myeloid cells through neuropilin-2 (NRP2) to resolve aberrant inflammation without immune suppression and potentially prevent the progression of fibrosis. ATYR0101 is a fusion protein derived from a domain of aspartyl-tRNA synthetase (DARS). ATYR0750 is a fusion protein derived from the domain of alanyl-tRNA synthetase (AARS). ATYR0750 is a novel ligand to fibroblast growth factor receptor 4 (FGFR4).

What is the price predicton of ATYR Stock?

Wall Street analysts forecast ATYR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ATYR is1.00 USD with a low forecast of 1.00 USD and a high forecast of 1.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is aTyr Pharma Inc (ATYR)'s revenue for the last quarter?

aTyr Pharma Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is aTyr Pharma Inc (ATYR)'s earnings per share (EPS) for the last quarter?

aTyr Pharma Inc. EPS for the last quarter amounts to -0.14 USD, decreased -22.22

How many employees does aTyr Pharma Inc (ATYR). have?

aTyr Pharma Inc (ATYR) has 56 emplpoyees as of March 16 2026.

What is aTyr Pharma Inc (ATYR) market cap?

Today ATYR has the market capitalization of 83.34M USD.