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AKTX Overview

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Intellectia

Loading chart...

High
6.580
Open
6.540
VWAP
6.32
Vol
4.28K
Mkt Cap
7.15M
Low
6.130
Amount
27.06K
EV/EBITDA(TTM)
--
Total Shares
1.14M
EV
2.71M
EV/OCF(TTM)
--
P/S(TTM)
--
Akari Therapeutics, Plc is a biotechnology company developing precision bifunctional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its ADC discovery platform, it generates bifunctional ADC candidates and optimizes them based on the desired application to target a range of cancers. Its lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells, and with a proprietary linker, delivers its novel PH1 payload directly into the tumor. PH1 is a novel bifunctional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Its pipeline includes AKTX-101 and AKTX-102, a discovery-stage ADC that pairs PH1 with an undisclosed target antibody. It is pursuing research on two additional novel payloads, such as PH5 and PH6. It also has an ADC Platform for oncology and PHP-303 program for genetic disease, liver disease and inflammation.
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Events Timeline

(ET)
2026-04-27
09:30:00
Akari Therapeutics Secures Australian Patent for Core Technology
select
2026-04-20 (ET)
2026-04-20
08:50:00
Akari Therapeutics Presents Positive Preclinical Data for AKTX-101
select
2026-04-06 (ET)
2026-04-06
09:10:00
Akari Therapeutics Partners with WuXi XDC to Accelerate PH1 Development
select
2026-02-26 (ET)
2026-02-26
09:20:00
Akari Therapeutics Appoints Prafulla Gokhale to Scientific Advisory Board
select
2026-02-23 (ET)
2026-02-23
09:00:00
Akari Therapeutics Appoints Dr. Olga Anczukow to Scientific Advisory Board
select

News

Newsfilter
8.5
04-27Newsfilter
Akari Secures Australian Patent, Strengthening ADC Platform
  • Patent Coverage Expansion: Akari has secured an Australian patent (Application No. 2024201765) covering its core Thailanstatin analogs, further protecting its antibody-drug conjugate (ADC) platform and enhancing its intellectual property across global markets, supporting the advancement of AKTX-101 and its ADC pipeline.
  • Innovative Drug Development: The patent includes broad composition-of-matter claims for cytotoxic ADC therapeutics, utilizing state-of-the-art ADC linkers to target various proteins on cancer cells, thereby enhancing therapeutic efficacy and driving new drug development.
  • Significant Market Potential: Akari's AKTX-101 is currently undergoing IND-enabling studies, with a first-in-human clinical trial expected to commence in late 2026 to early 2027, aiming to penetrate the TROP2-targeted therapy market projected to reach approximately $12 billion by 2033.
  • Strategic Implications: This patent approval not only solidifies Akari's intellectual property in payload chemistry, ADC architecture, and therapeutic applications but also supports the company's strategy to establish a durable and differentiated platform for next-generation ADC development, advancing cancer treatment progress.
NASDAQ.COM
9.0
04-21NASDAQ.COM
Akari Therapeutics Presents Positive Preclinical Data for AKTX-101
  • Positive Preclinical Data: Akari Therapeutics presented promising preclinical data for AKTX-101 at the 2026 AACR annual meeting, indicating significant anti-tumor effects across various cancer indications, potentially offering new hope in cancer treatment.
  • Unique Mechanism of Action: By targeting TROP2 and incorporating Topoisomerase 1 inhibitors, AKTX-101 exhibits a unique cytotoxic and immune-activating mechanism, demonstrating enhanced durability in anti-tumor efficacy, particularly against resistant cancer cells.
  • Strong Potency: In non-small cell lung cancer cell lines, AKTX-101 showed sub-nanomolar potency, significantly outperforming existing TROP2 ADCs, highlighting its potential in treating bladder, lung, and breast cancers.
  • Future Development Plans: The company anticipates submitting an investigational new drug application in Q4 2026 and plans to initiate a Phase 1 trial by early 2027, with projections indicating the TROP2 ADC market could reach $12 billion by 2033, allowing for expansion into various solid tumors.
Newsfilter
8.5
04-20Newsfilter
Akari Therapeutics Showcases Potent Efficacy of AKTX-101
  • Preclinical Data Breakthrough: Akari Therapeutics presented positive preclinical data for its TROP2-targeting ADC, AKTX-101, at the 2026 AACR Annual Meeting, demonstrating superior efficacy compared to existing Topoisomerase I inhibitor payloads across bladder, lung, and breast cancer models, indicating its potential in anti-tumor therapy.
  • Resistance Overcoming Potential: The unique RNA splicing modulator payload of AKTX-101 shows promise in overcoming resistance to Topoisomerase I inhibitors, exhibiting potent cancer cell killing at lower concentrations, thereby offering patients more durable anti-tumor effects.
  • Broad Market Prospects: With the TROP2 ADC market projected to reach approximately $12 billion by 2033, AKTX-101's innovative payload is expected to further drive market growth, particularly across various tumor types including bladder, lung, and breast cancers.
  • Clinical Trial Plans: Akari plans to submit an IND application in Q4 2026 and initiate Phase 1 clinical trials for AKTX-101 in Q1 2027, demonstrating the company's commitment and capability in rapidly advancing clinical development.
NASDAQ.COM
7.5
04-07NASDAQ.COM
Akari Therapeutics Partners with WuXi XDC to Advance PH1 Payload Development
  • Strategic Partnership: Akari Therapeutics has formed a strategic partnership with WuXi XDC to accelerate the development of its proprietary PH1 payload, which is expected to support Akari's IND filing by late 2026 and advance its lead program AKTX-101, initially targeting metastatic urothelial cancer.
  • Innovative Drug Platform: The PH1 payload represents a differentiated ADC approach designed to disrupt RNA splicing in cancer cells, offering direct cytotoxicity while activating both innate and adaptive immune responses, and has shown superior tumor regression and complete remissions compared to traditional ADCs, highlighting its potential as a next-generation therapy.
  • Clinical Trial Plans: A Phase 1 clinical trial for AKTX-101 is anticipated to begin in late 2026 or early 2027, subject to regulatory clearance, which will lay the groundwork for Akari's further expansion in oncology treatment.
  • Market Dynamics: Akari implemented a 1-for-40 reverse stock split on March 30, 2026; despite closing at $3.54 on Monday, down 20.81%, the stock rebounded to $3.60 in overnight trading, reflecting a 1.69% increase.
seekingalpha
7.5
04-06seekingalpha
Akari Partners with WuXi to Accelerate Cancer Drug Development
  • Partnership to Accelerate Development: Akari Therapeutics has partnered with WuXi Biologics' subsidiary WuXi XDC to leverage their expertise in antibody-drug conjugate (ADC) manufacturing, aiming to accelerate the development of its new cancer drug component, PH1, which is expected to significantly shorten the R&D timeline.
  • Clinical Trial Plans: This collaboration supports Akari's lead program, AKTX-101, which is anticipated to enter Phase 1 trials by late 2026 or early 2027, pending approval, bringing its next-generation cancer therapies closer to market.
  • Stock Price Impact: Following this announcement, Akari Therapeutics' stock fell by 21.65% to $3.50 in intraday trading, reflecting market concerns over its R&D progress, which may affect investor confidence.
  • Market Outlook Analysis: By partnering with WuXi, Akari not only enhances the development efficiency of its ADC pipeline but also positions itself more favorably in the competitive cancer treatment market, potentially strengthening its long-term growth prospects.
seekingalpha
8.5
03-17seekingalpha
Akari Therapeutics Adjusts ADS Ratio to Meet Nasdaq Requirements
  • ADS Ratio Change: Akari Therapeutics is changing its American Depositary Shares (ADS) ratio from 1:2,000 to 1:80,000 effective March 31, 2026, aimed at meeting Nasdaq's minimum bid price requirements to ensure continued listing.
  • Shareholder Exchange Mechanism: Under the revised structure, shareholders will exchange 40 existing ADS for 1 new ADS, which is expected to elevate the per-share price, enhance investor confidence, and attract more institutional investors.
  • Ordinary Shares Unchanged: Despite the change in ADS ratio, the company's underlying ordinary shares remain unchanged, indicating that the company's fundamentals are not directly impacted, which may preserve investor perceptions of long-term value.
  • Positive Market Reaction: Following the announcement of the adjustment, Akari Therapeutics' shares rose by 4.2% in after-hours trading, reflecting a positive market response to this strategic adjustment and potentially signaling investor optimism about the company's future prospects.
Wall Street analysts forecast AKTX stock price to rise
3 Analyst Rating
Wall Street analysts forecast AKTX stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
1.00
Averages
3.33
High
7.00
Current: 0.000
sliders
Low
1.00
Averages
3.33
High
7.00
Maxim
Maxim
Buy -> Hold
downgrade
AI Analysis
2026-04-09
Reason
Maxim
Maxim
Price Target
AI Analysis
2026-04-09
downgrade
Buy -> Hold
Reason
Maxim downgraded Akari Therapeutics to Hold from Buy without a price target. The selloff post the partnership with WuXi XDC is due in part due to Akari's additional capital needs and continued pressure following the ratio change that took effect on March 31, the analyst tells investors in a research note. With the shares near an all-time low and a market capitalization below $5M, Maxim believes the company's risks are elevated in an already challenging financing environment. It cites funding risk for the downgrade.
Maxim
Jason McCarthy
Buy
to
Hold
downgrade
2026-04-08
Reason
Maxim
Jason McCarthy
Price Target
2026-04-08
downgrade
Buy
to
Hold
Reason
Maxim analyst Jason McCarthy downgraded Akari Therapeutics to Hold from Buy.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AKTX
Unlock Now

Valuation Metrics

The current forward P/E ratio for Akari Therapeutics PLC (AKTX.O) is 0.00, compared to its 5-year average forward P/E of 92.55. For a more detailed relative valuation and DCF analysis to assess Akari Therapeutics PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
92.55
Current PE
0.00
Overvalued PE
328.17
Undervalued PE
-143.06

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.32
Current PS
0.00
Overvalued PS
2.03
Undervalued PS
-1.39

Financials

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Frequently Asked Questions

What is Akari Therapeutics PLC (AKTX) stock price today?

The current price of AKTX is 6.25 USD — it has decreased -5.02

What is Akari Therapeutics PLC (AKTX)'s business?

Akari Therapeutics, Plc is a biotechnology company developing precision bifunctional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its ADC discovery platform, it generates bifunctional ADC candidates and optimizes them based on the desired application to target a range of cancers. Its lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells, and with a proprietary linker, delivers its novel PH1 payload directly into the tumor. PH1 is a novel bifunctional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Its pipeline includes AKTX-101 and AKTX-102, a discovery-stage ADC that pairs PH1 with an undisclosed target antibody. It is pursuing research on two additional novel payloads, such as PH5 and PH6. It also has an ADC Platform for oncology and PHP-303 program for genetic disease, liver disease and inflammation.

What is the price predicton of AKTX Stock?

Wall Street analysts forecast AKTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AKTX is3.33 USD with a low forecast of 1.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Akari Therapeutics PLC (AKTX)'s revenue for the last quarter?

Akari Therapeutics PLC revenue for the last quarter amounts to -3.23M USD, decreased -24.87

What is Akari Therapeutics PLC (AKTX)'s earnings per share (EPS) for the last quarter?

Akari Therapeutics PLC. EPS for the last quarter amounts to USD, decreased -100.00

How many employees does Akari Therapeutics PLC (AKTX). have?

Akari Therapeutics PLC (AKTX) has 5 emplpoyees as of May 11 2026.

What is Akari Therapeutics PLC (AKTX) market cap?

Today AKTX has the market capitalization of 7.15M USD.