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AKTX Overview

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Intellectia

Loading chart...

High
6.289
Open
4.570
VWAP
5.59
Vol
734.25K
Mkt Cap
6.80M
Low
4.535
Amount
4.10M
EV/EBITDA(TTM)
--
Total Shares
1.14M
EV
2.35M
EV/OCF(TTM)
--
P/S(TTM)
--
Akari Therapeutics, Plc is a biotechnology company developing precision bifunctional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its ADC discovery platform, it generates bifunctional ADC candidates and optimizes them based on the desired application to target a range of cancers. Its lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells, and with a proprietary linker, delivers its novel PH1 payload directly into the tumor. PH1 is a novel bifunctional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Its pipeline includes AKTX-101 and AKTX-102, a discovery-stage ADC that pairs PH1 with an undisclosed target antibody. It is pursuing research on two additional novel payloads, such as PH5 and PH6. It also has an ADC Platform for oncology and PHP-303 program for genetic disease, liver disease and inflammation.
Show More

Events Timeline

(ET)
2026-04-20
08:50:00
Akari Therapeutics Presents Positive Preclinical Data for AKTX-101
select
2026-04-06 (ET)
2026-04-06
09:10:00
Akari Therapeutics Partners with WuXi XDC to Accelerate PH1 Development
select
2026-02-26 (ET)
2026-02-26
09:20:00
Akari Therapeutics Appoints Prafulla Gokhale to Scientific Advisory Board
select
2026-02-23 (ET)
2026-02-23
09:00:00
Akari Therapeutics Appoints Dr. Olga Anczukow to Scientific Advisory Board
select
2026-01-26 (ET)
2026-01-26
08:50:00
Akari Therapeutics Files Patent Application for AKTX-102
select

News

Newsfilter
8.5
04-20Newsfilter
PinnedAkari Therapeutics Showcases Potent Efficacy of AKTX-101
  • Preclinical Data Breakthrough: Akari Therapeutics presented positive preclinical data for its TROP2-targeting ADC, AKTX-101, at the 2026 AACR Annual Meeting, demonstrating superior efficacy compared to existing Topoisomerase I inhibitor payloads across bladder, lung, and breast cancer models, indicating its potential in anti-tumor therapy.
  • Resistance Overcoming Potential: The unique RNA splicing modulator payload of AKTX-101 shows promise in overcoming resistance to Topoisomerase I inhibitors, exhibiting potent cancer cell killing at lower concentrations, thereby offering patients more durable anti-tumor effects.
  • Broad Market Prospects: With the TROP2 ADC market projected to reach approximately $12 billion by 2033, AKTX-101's innovative payload is expected to further drive market growth, particularly across various tumor types including bladder, lung, and breast cancers.
  • Clinical Trial Plans: Akari plans to submit an IND application in Q4 2026 and initiate Phase 1 clinical trials for AKTX-101 in Q1 2027, demonstrating the company's commitment and capability in rapidly advancing clinical development.
NASDAQ.COM
7.5
04-07NASDAQ.COM
Akari Therapeutics Partners with WuXi XDC to Advance PH1 Payload Development
  • Strategic Partnership: Akari Therapeutics has formed a strategic partnership with WuXi XDC to accelerate the development of its proprietary PH1 payload, which is expected to support Akari's IND filing by late 2026 and advance its lead program AKTX-101, initially targeting metastatic urothelial cancer.
  • Innovative Drug Platform: The PH1 payload represents a differentiated ADC approach designed to disrupt RNA splicing in cancer cells, offering direct cytotoxicity while activating both innate and adaptive immune responses, and has shown superior tumor regression and complete remissions compared to traditional ADCs, highlighting its potential as a next-generation therapy.
  • Clinical Trial Plans: A Phase 1 clinical trial for AKTX-101 is anticipated to begin in late 2026 or early 2027, subject to regulatory clearance, which will lay the groundwork for Akari's further expansion in oncology treatment.
  • Market Dynamics: Akari implemented a 1-for-40 reverse stock split on March 30, 2026; despite closing at $3.54 on Monday, down 20.81%, the stock rebounded to $3.60 in overnight trading, reflecting a 1.69% increase.
seekingalpha
7.5
04-06seekingalpha
Akari Partners with WuXi to Accelerate Cancer Drug Development
  • Partnership to Accelerate Development: Akari Therapeutics has partnered with WuXi Biologics' subsidiary WuXi XDC to leverage their expertise in antibody-drug conjugate (ADC) manufacturing, aiming to accelerate the development of its new cancer drug component, PH1, which is expected to significantly shorten the R&D timeline.
  • Clinical Trial Plans: This collaboration supports Akari's lead program, AKTX-101, which is anticipated to enter Phase 1 trials by late 2026 or early 2027, pending approval, bringing its next-generation cancer therapies closer to market.
  • Stock Price Impact: Following this announcement, Akari Therapeutics' stock fell by 21.65% to $3.50 in intraday trading, reflecting market concerns over its R&D progress, which may affect investor confidence.
  • Market Outlook Analysis: By partnering with WuXi, Akari not only enhances the development efficiency of its ADC pipeline but also positions itself more favorably in the competitive cancer treatment market, potentially strengthening its long-term growth prospects.
seekingalpha
8.5
03-17seekingalpha
Akari Therapeutics Adjusts ADS Ratio to Meet Nasdaq Requirements
  • ADS Ratio Change: Akari Therapeutics is changing its American Depositary Shares (ADS) ratio from 1:2,000 to 1:80,000 effective March 31, 2026, aimed at meeting Nasdaq's minimum bid price requirements to ensure continued listing.
  • Shareholder Exchange Mechanism: Under the revised structure, shareholders will exchange 40 existing ADS for 1 new ADS, which is expected to elevate the per-share price, enhance investor confidence, and attract more institutional investors.
  • Ordinary Shares Unchanged: Despite the change in ADS ratio, the company's underlying ordinary shares remain unchanged, indicating that the company's fundamentals are not directly impacted, which may preserve investor perceptions of long-term value.
  • Positive Market Reaction: Following the announcement of the adjustment, Akari Therapeutics' shares rose by 4.2% in after-hours trading, reflecting a positive market response to this strategic adjustment and potentially signaling investor optimism about the company's future prospects.
Newsfilter
5.0
02-26Newsfilter
Akari Therapeutics Appoints New Scientific Advisor to Advance AKTX-101
  • New Scientific Advisor: Akari Therapeutics has appointed Dr. Prafulla Gokhale to its Scientific Advisory Board, leveraging his extensive experience in experimental therapeutics and translational oncology to enhance the development of AKTX-101, which is expected to improve the likelihood of successful product advancement.
  • Clinical Trial Advancement: Dr. Gokhale's expertise comes at a pivotal time as AKTX-101 progresses toward clinical trials, and his insights will help ensure the drug enters the clinic with a focused, data-driven high-impact program to optimize therapeutic outcomes.
  • Unique Drug Mechanism: The novel PH1 payload of AKTX-101 targets RNA splicing, offering a different mechanism compared to traditional antibody-drug conjugates, potentially disrupting tumor survival pathways while enhancing immune system engagement.
  • Future Outlook: Akari aims to initiate its First-In-Human trial for AKTX-101 by late 2026 to early 2027, and Dr. Gokhale's involvement is expected to accelerate this process, bolstering the company's competitiveness in oncology drug development.
Newsfilter
8.5
02-18Newsfilter
Akari Therapeutics to Present at Biocom Global Partnering Conference
  • Presentation Schedule: Akari Therapeutics' CEO Abizer Gaslightwala will present at the Biocom Global Partnering & Investor Conference on February 25, 2026, at 11:00 AM PST in San Diego, CA, showcasing the company's advancements in antibody-drug conjugates (ADCs), which is expected to attract investor interest and enhance the company's visibility.
  • Innovative Drug Development: The company's lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells and utilizes a unique PH1 payload designed to modulate RNA splicing, inducing cancer cell death, with significant anti-tumor activity demonstrated in preclinical animal models, potentially offering new hope in cancer treatment.
  • Clinical Trial Plans: Akari has initiated IND enabling studies for AKTX-101, aiming to start its First-In-Human trial by late 2026 or early 2027, marking a significant milestone in the company's oncology drug development and potentially laying the groundwork for future market introduction.
  • Multiple Target Potential: AKTX-101 has shown prolonged survival potential when used in combination with checkpoint inhibitors and demonstrates strong activity against cancer cells with key oncogenic drivers, providing a broad application prospect across various cancer types.
Wall Street analysts forecast AKTX stock price to rise
3 Analyst Rating
Wall Street analysts forecast AKTX stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
1.00
Averages
3.33
High
7.00
Current: 0.000
sliders
Low
1.00
Averages
3.33
High
7.00
Maxim
Maxim
Buy -> Hold
downgrade
AI Analysis
2026-04-09
Reason
Maxim
Maxim
Price Target
AI Analysis
2026-04-09
downgrade
Buy -> Hold
Reason
Maxim downgraded Akari Therapeutics to Hold from Buy without a price target. The selloff post the partnership with WuXi XDC is due in part due to Akari's additional capital needs and continued pressure following the ratio change that took effect on March 31, the analyst tells investors in a research note. With the shares near an all-time low and a market capitalization below $5M, Maxim believes the company's risks are elevated in an already challenging financing environment. It cites funding risk for the downgrade.
Maxim
Jason McCarthy
Buy
to
Hold
downgrade
2026-04-08
Reason
Maxim
Jason McCarthy
Price Target
2026-04-08
downgrade
Buy
to
Hold
Reason
Maxim analyst Jason McCarthy downgraded Akari Therapeutics to Hold from Buy.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AKTX
Unlock Now

Valuation Metrics

The current forward P/E ratio for Akari Therapeutics PLC (AKTX.O) is 0.00, compared to its 5-year average forward P/E of 102.28. For a more detailed relative valuation and DCF analysis to assess Akari Therapeutics PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
102.28
Current PE
0.00
Overvalued PE
351.78
Undervalued PE
-147.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.32
Current PS
0.00
Overvalued PS
2.02
Undervalued PS
-1.39

Financials

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Frequently Asked Questions

What is Akari Therapeutics PLC (AKTX) stock price today?

The current price of AKTX is 5.94 USD — it has increased 2.41

What is Akari Therapeutics PLC (AKTX)'s business?

Akari Therapeutics, Plc is a biotechnology company developing precision bifunctional antibody drug conjugates (ADC) for the treatment of cancer. Utilizing its ADC discovery platform, it generates bifunctional ADC candidates and optimizes them based on the desired application to target a range of cancers. Its lead candidate, AKTX-101, targets the TROP2 receptor on cancer cells, and with a proprietary linker, delivers its novel PH1 payload directly into the tumor. PH1 is a novel bifunctional payload that is designed to disrupt RNA splicing within cancer cells, inducing tumor-specific cell death while generating immunostimulatory effects and minimizing off-target toxicity. Its pipeline includes AKTX-101 and AKTX-102, a discovery-stage ADC that pairs PH1 with an undisclosed target antibody. It is pursuing research on two additional novel payloads, such as PH5 and PH6. It also has an ADC Platform for oncology and PHP-303 program for genetic disease, liver disease and inflammation.

What is the price predicton of AKTX Stock?

Wall Street analysts forecast AKTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AKTX is3.33 USD with a low forecast of 1.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Akari Therapeutics PLC (AKTX)'s revenue for the last quarter?

Akari Therapeutics PLC revenue for the last quarter amounts to -3.23M USD, decreased -24.87

What is Akari Therapeutics PLC (AKTX)'s earnings per share (EPS) for the last quarter?

Akari Therapeutics PLC. EPS for the last quarter amounts to USD, decreased -100.00

How many employees does Akari Therapeutics PLC (AKTX). have?

Akari Therapeutics PLC (AKTX) has 5 emplpoyees as of April 21 2026.

What is Akari Therapeutics PLC (AKTX) market cap?

Today AKTX has the market capitalization of 6.80M USD.