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GUTS Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
0.439
Open
0.426
VWAP
0.43
Vol
554.59K
Mkt Cap
67.74M
Low
0.425
Amount
239.88K
EV/EBITDA(TTM)
--
Total Shares
158.65M
EV
20.86M
EV/OCF(TTM)
--
P/S(TTM)
7.51K
Fractyl Health, Inc. is a metabolic therapeutics company. The Company is focused on developing new approaches to the treatment of metabolic diseases, including obesity and type 2 diabetes (T2D). The Company’s lead product candidate, Revita, is designed to remodel the duodenal lining via hydrothermal ablation (i.e. duodenal mucosal resurfacing) to reverse damage to intestinal nutrient sensing and signaling mechanisms caused by chronic high-fat and high-sugar diets that are a root cause of metabolic disease. The Revita clinical program is focused on patients living with obesity who want to maintain their weight loss after GLP-1 drug discontinuation. The Company’s Rejuva platform focuses on developing adeno-associated virus (AAV)-based, locally delivered gene therapies for the treatment of obesity and T2D. The Rejuva platform leverages advanced delivery systems and proprietary screening methods to identify and develop metabolically active gene therapy candidates targeting the pancreas.
Show More

Events Timeline

(ET)
2026-02-26
07:30:00
Fractyl Health Completes Participant Randomization in REMAIN-1 Study
select
2026-02-02 (ET)
2026-02-02
11:50:00
Fractyl Health Sees 420.59% Surge in Search Activity
select
2026-01-29 (ET)
2026-01-29
07:20:00
Fractyl Health Reports Positive Six-Month Results for Revita
select
2026-01-06 (ET)
2026-01-06
07:10:00
Fractyl Health Appoints Lara Smith Weber as CFO
select

News

PRnewswire
8.5
03-27PRnewswire
Avaí Bio Initiates α-Klotho Cell Production Phase
  • Market Growth Potential: The global cell therapy manufacturing market is projected to exceed $7 billion in 2026 and reach $14 billion by 2035, indicating strong growth momentum that drives strategic positioning for companies like Avaí Bio.
  • Regulatory Flexibility Enhancement: The FDA's easing of manufacturing requirements for cell and gene therapies accelerates the approval timeline for life-saving products, creating a historic shift that provides companies with scalable bioproduction infrastructure and enhances market competitiveness.
  • Cell Bank Development: Avaí Bio, in partnership with Austrianova, has begun manufacturing a Master Cell Bank (MCB) for α-Klotho protein, establishing a stable production foundation that ensures product quality and consistency for future cell therapies.
  • Clinical Trial Outlook: The production of α-Klotho cells will directly support Austrianova's Cell-in-a-Box® platform, aiming to provide patients with durable anti-aging treatments, marking a significant advancement for the company in addressing aging-related diseases.
Newsfilter
8.5
03-27Newsfilter
Global Cell Therapy Market Reaches Inflection Point with $7 Billion Projection
  • Market Growth: The global cell therapy manufacturing market is projected to exceed $7 billion in 2026 and reach $14 billion by 2035, indicating robust growth potential that drives demand for cell and gene therapies.
  • FDA Regulatory Impact: The FDA's easing of manufacturing requirements accelerates the approval timeline for life-saving products, creating sustainable value for therapy developers like Avaí Bio, marking a historic shift in the industry.
  • Strategic Production Capacity: As biologics production capacity becomes a coveted strategic asset, Avaí Bio and Austrianova have commenced manufacturing a Master Cell Bank of α-Klotho protein, ensuring high quality and consistency for future production.
  • Innovative Technology Application: Avaí Bio's cell therapy products will be developed using the Cell-in-a-Box® encapsulation platform, aiming to provide durable anti-aging treatments for patients, signifying the company's successful pivot into biotechnology.
Yahoo Finance
9.5
03-25Yahoo Finance
Fractyl Health Q4 2025 Earnings Report Analysis
  • Financial Overview: Fractyl Health Inc reported a net loss of $43.7 million for Q4 2025, significantly up from $25 million in Q4 2024, indicating pressure on cost control that may impact future funding capabilities.
  • R&D and Operating Expenses: Research and development expenses were $16.5 million, down from $20.3 million in Q4 2024, reflecting a cautious approach to R&D investment, while SG&A expenses rose to $6.8 million, increasing operational burdens.
  • Cash Flow and Funding Outlook: As of December 31, 2025, the company had approximately $81.5 million in cash and cash equivalents, expected to fund operations into early 2027, providing some financial flexibility despite economic pressures.
  • FDA Feedback and Market Opportunity: Fractyl Health received favorable feedback from the FDA regarding the Revita device, indicating potential Class II device classification, which, combined with a growing market demand, could provide strong support for the company's future commercialization efforts.
seekingalpha
9.5
03-24seekingalpha
Fractyl Health Q4 2025 Earnings Call Insights
  • Revita Platform Progress: CEO Harith Rajagopalan emphasized the Revita platform's significance for weight maintenance post-GLP-1 discontinuation, with favorable FDA feedback on the filing strategy laying a solid foundation for future growth.
  • Clinical Trial Data: The company has enrolled over 300 participants in the REMAIN-1 study, with a retention rate exceeding 95%, demonstrating strong execution in clinical trials and confidence in upcoming data releases.
  • Improved Financial Position: CFO Lara Weber reported R&D expenses of $16.5 million for Q4 2025, down from $20.3 million in Q4 2024, indicating progress in cost control measures.
  • Future Outlook: Management expects to deliver 6-month primary endpoint data from the REMAIN-1 study in early Q4 2026 and plans to submit a De Novo application later that year, reflecting confidence in future growth prospects.
seekingalpha
9.5
03-24seekingalpha
Fractyl Health Reports Increased Q4 Losses Amid Market Challenges
  • Increased Net Loss: For the fourth quarter ended December 31, 2025, Fractyl Health reported a net loss of $43.7 million, significantly up from $25.0 million in the same period of 2024, indicating ongoing challenges in the market environment.
  • Adjusted EBITDA Improvement: The adjusted EBITDA for Q4 2025 was negative $21.2 million, an improvement from negative $22.1 million in Q4 2024, primarily due to a reduction in operating expenses, showcasing the company's efforts in cost control.
  • Strong Cash Position: As of December 31, 2025, Fractyl had approximately $81.5 million in cash and cash equivalents, and with an additional $4.1 million from warrant exercises in January 2026, the company believes it can fund operations into early 2027, enhancing market confidence in its operational sustainability.
  • Low Market Expectations: Fractyl Health faces low market expectations regarding its future growth potential; however, analysts suggest that upcoming catalysts in 2026 may present trading opportunities, reflecting a potential reassessment of the company's value by the market.
Businesswire
7.0
01-30Businesswire
DJS Law Group Investigates Claims for Fractyl Health Investors
  • Investigation Background: DJS Law Group is investigating Fractyl Health (NASDAQ: GUTS) for potential violations of securities laws, particularly whether the company issued misleading statements or failed to disclose material information to investors, indicating possible compliance risks.
  • FDA Feedback Request: On January 29, 2026, Fractyl Health requested FDA feedback on potentially reclassifying Revita under the De Novo pathway instead of seeking Premarket Approval (PMA), which has drawn significant market attention.
  • Stock Price Plunge: Following this news, shares of Fractyl Health fell by 67.48% in intraday trading on the same day, reflecting investor concerns about the company's future prospects and a sharp decline in market confidence.
  • Commitment to Legal Services: DJS Law Group focuses on enhancing investor returns through balanced counseling and aggressive advocacy, dedicated to providing high-value litigation services for clients, particularly in securities class actions and corporate governance litigation.
Wall Street analysts forecast GUTS stock price to rise
4 Analyst Rating
Wall Street analysts forecast GUTS stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
2.00
Averages
5.00
High
8.00
Current: 0.000
sliders
Low
2.00
Averages
5.00
High
8.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$8
AI Analysis
2026-03-17
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$8
AI Analysis
2026-03-17
maintain
Buy
Reason
AH.C. Wainwright says Fractyl Health's January announcement of the six-month randomized data from the REMAIN-1 midpoint cohort evaluating Revita duodenal mucosal resurfacing maintenance after GLP-1 drug discontinuation triggered a 65% selloff in the shares. Investors focused on "critical friction points, including lack of statistical significance and weight-regain kinetics," the analyst tells investors in a research note. H.C. Wainwright, however, interpreted the results as consistent with the overall Revita trajectory observed in the pilot REVEAL-1 open-label extension cohort and earlier REMAIN-1 midpoint readouts. The firm has positive expectations for the REMAIN-1 pivotal readout anticipated in Q4. The readout could position Revita as a one-time procedural backbone for patients who discontinue GLP-1 therapy, Wainwright contends. It tells investors to "take a breath," saying Revita's data warrant a closer look. The firm has a Buy rating on Fractyl with an $8 price target.
BofA
Buy
downgrade
$5 -> $2
2026-01-30
Reason
BofA
Price Target
$5 -> $2
2026-01-30
downgrade
Buy
Reason
BofA lowered the firm's price target on Fractyl Health to $2 from $5 and keeps a Buy rating on the shares after the company provided new, six-month randomized controlled data of its Revita procedure in weight maintenance post-discontinuation of a GLP1 therapy. The "data were not perfect," but the firm thinks the pivotal results should benefit from a much larger sample size and optimization of trial execution, says the analyst, who lowered the firm's sales forecast pending clarity on the profile strength based on additional data.
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Valuation Metrics

The current forward P/E ratio for Fractyl Health Inc (GUTS.O) is -3.31, compared to its 5-year average forward P/E of -1.93. For a more detailed relative valuation and DCF analysis to assess Fractyl Health Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.93
Current PE
-3.31
Overvalued PE
-0.62
Undervalued PE
-3.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.24
Current EV/EBITDA
-3.07
Overvalued EV/EBITDA
0.18
Undervalued EV/EBITDA
-4.66

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
4900.68
Current PS
0.00
Overvalued PS
10155.91
Undervalued PS
-354.55

Financials

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Whales Holding GUTS

N
Nantahala Capital Management, LLC
Holding
GUTS
-15.93%
3M Return

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Frequently Asked Questions

What is Fractyl Health Inc (GUTS) stock price today?

The current price of GUTS is 0.43265 USD — it has increased 1.41

What is Fractyl Health Inc (GUTS)'s business?

Fractyl Health, Inc. is a metabolic therapeutics company. The Company is focused on developing new approaches to the treatment of metabolic diseases, including obesity and type 2 diabetes (T2D). The Company’s lead product candidate, Revita, is designed to remodel the duodenal lining via hydrothermal ablation (i.e. duodenal mucosal resurfacing) to reverse damage to intestinal nutrient sensing and signaling mechanisms caused by chronic high-fat and high-sugar diets that are a root cause of metabolic disease. The Revita clinical program is focused on patients living with obesity who want to maintain their weight loss after GLP-1 drug discontinuation. The Company’s Rejuva platform focuses on developing adeno-associated virus (AAV)-based, locally delivered gene therapies for the treatment of obesity and T2D. The Rejuva platform leverages advanced delivery systems and proprietary screening methods to identify and develop metabolically active gene therapy candidates targeting the pancreas.

What is the price predicton of GUTS Stock?

Wall Street analysts forecast GUTS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GUTS is5.00 USD with a low forecast of 2.00 USD and a high forecast of 8.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Fractyl Health Inc (GUTS)'s revenue for the last quarter?

Fractyl Health Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Fractyl Health Inc (GUTS)'s earnings per share (EPS) for the last quarter?

Fractyl Health Inc. EPS for the last quarter amounts to -0.71 USD, increased 47.92

How many employees does Fractyl Health Inc (GUTS). have?

Fractyl Health Inc (GUTS) has 107 emplpoyees as of March 31 2026.

What is Fractyl Health Inc (GUTS) market cap?

Today GUTS has the market capitalization of 67.74M USD.