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GPCR Overview

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0.000(0.000%)Aft-market
ET
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0.000
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ET
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Intellectia

Loading chart...

High
50.550
Open
50.500
VWAP
49.53
Vol
37.36K
Mkt Cap
3.60B
Low
48.880
Amount
1.85M
EV/EBITDA(TTM)
--
Total Shares
70.84M
EV
2.15B
EV/OCF(TTM)
--
P/S(TTM)
--
Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.
Show More

Events Timeline

(ET)
2026-04-14
16:20:00
Structure Therapeutics Appoints Matthew Lang as COO and General Counsel
select
2026-03-16 (ET)
2026-03-16
11:10:00
Structure Therapeutics' GLP-1 Pill Averages Over 16% Weight Loss
select
link
2026-03-16
07:20:00
Structure Therapeutics Announces Aleniglipron Clinical Data
select
2026-01-30 (ET)
2026-01-30
12:00:00
Major Averages Broadly Lower as Tech Stocks Decline
select
2026-01-30
10:50:00
Structure Therapeutics Emerges as Next M&A Target for Big Pharma
select
link

News

seekingalpha
5.0
04-14seekingalpha
Structure Therapeutics Appoints New COO
  • Executive Appointment: Structure Therapeutics has appointed Matthew Lang as Chief Operating Officer, bringing over 15 years of executive leadership experience in global biopharmaceutical organizations, which is expected to positively impact the company's strategic development.
  • Legal and Compliance Expertise: While serving as Chief Legal Officer at Metsera, Lang successfully guided the company through an acquisition valued at up to $10 billion, showcasing his deep expertise in legal and compliance matters that will aid Structure Therapeutics in risk management.
  • Business Development Background: Prior to joining Structure Therapeutics, Lang held the position of Chief Business and Legal Officer at Lyell Immunopharma, and his extensive business development experience will support the company in expanding its operations in a competitive market.
  • Market Reaction: Following the announcement of Lang's appointment, Structure Therapeutics' stock rose 1.76% in after-hours trading to $54.27, reflecting market optimism regarding the new COO's potential contributions.
Barron's
5.0
04-07Barron's
The 'Diabesity' Market Is Poised for Rapid Growth: Key Catalysts for Lilly and Novo Stocks.
  • Weight-loss Drugs in Focus: The spotlight is on weight-loss drugs, particularly GLP-1 medications like Wegovy and Zepbound, as they gain popularity.

  • Market Competition: Eli Lilly and Novo Nordisk are key players in the emerging "diabesity" market, indicating a competitive landscape ahead.

NASDAQ.COM
6.5
04-03NASDAQ.COM
SPDR S&P China ETF Analysts See 34.69% Upside
  • ETF Target Price Analysis: The SPDR S&P China ETF (GXC) has an implied analyst target price of $124.19 per unit, with a current trading price of $92.21, indicating a 34.69% upside potential that reflects market optimism about the ETF's future performance.
  • Stock Potential Unveiled: Legend Biotech Corp (LEGN) trades at $19.14, while analysts set a target price of $60.63, suggesting a remarkable 216.78% upside, highlighting the company's strong growth potential in the biotech sector.
  • Structure Therapeutics Outlook: Structure Therapeutics Inc (GPCR) is priced at $53.48, with an analyst target of $109.00, indicating a potential increase of 103.81%, showcasing market expectations for its innovative drug development.
  • Market Confidence in VNET: VNET Group Inc (VNET) currently trades at $8.19, with an analyst target price of $16.34, reflecting a 99.55% upside, which indicates investor confidence in its future performance.
CNBC
5.0
04-02CNBC
Wegovy Pill Shows Superior Weight Loss Over Foundayo
  • Weight Loss Efficacy: The Wegovy pill demonstrated significantly greater mean weight loss of 16.6% compared to Eli Lilly's Foundayo, which showed only 12.4%, indicating Wegovy's competitive edge in the weight-loss drug market.
  • Patient Preference Insights: An analysis by Novo revealed that 84% of patients preferred the drug profile of Wegovy, highlighting strong patient recognition of its lifestyle compatibility, which provides robust support for Novo's market promotion efforts.
  • Market Competition Dynamics: The launch of the Wegovy pill is seen as the beginning of a new era in weight-loss medications; however, analysts note that the rapid increase in prescriptions may slow down as Foundayo approaches its market entry, potentially impacting Wegovy's market share.
  • Side Effect Comparison: Recent studies indicate that Wegovy outperforms Foundayo in terms of discontinuation rates, with the latter associated with about 14 times higher odds of stopping treatment due to side effects, providing Wegovy with a crucial differentiation advantage in the increasingly competitive anti-obesity drug market.
stocktwits
9.0
03-30stocktwits
Viking and Structure Intensify Competition in Obesity Drug Development
  • Clinical Trial Progress: Viking announced the enrollment of approximately 1,000 patients with obesity or overweight type 2 diabetes in the late-stage trial of VK2735, with a primary endpoint assessing weight change after 78 weeks, which could significantly enhance its market competitiveness if successful.
  • Significant Drug Efficacy: In a mid-stage trial, VK2735 achieved a mean weight loss of 14.7% in 13 weeks, establishing a solid foundation for its subsequent clinical development and potentially attracting more investor interest.
  • Market Potential: According to Koyfin, GPCR stock has a 12-month target of $109, implying a 147.95% upside, while VKTX's target is $92.72, representing a 209.80% upside, indicating strong prospects for both companies in the obesity drug market.
  • Investor Sentiment Shift: While VKTX stock has risen 24% this year, GPCR has surged 154%, reflecting differing market perceptions, with VKTX sentiment remaining neutral and GPCR appearing more bearish.
Fool
8.5
03-22Fool
B Group Initiates Position in Structure Therapeutics
  • New Position Disclosure: B Group disclosed a new position in Structure Therapeutics by acquiring 90,000 shares in Q4 2025, amounting to $6.26 million, reflecting confidence in the company's drug development potential, particularly in chronic disease treatments.
  • Asset Allocation Impact: This new stake represents 4.62% of B Group's reportable U.S. equity assets, indicating a strategic focus on the biopharmaceutical sector that may attract further investor interest in its future performance.
  • Strong Market Performance: As of last Friday, Structure Therapeutics shares were priced at $48.59, marking a staggering 132% increase over the past year, significantly outperforming the S&P 500's 15% rise, showcasing strong market demand for its products and investor confidence.
  • R&D Challenges and Opportunities: Despite posting a net loss of $141 million for 2025 and increased R&D spending, the lead drug candidate's mid-stage trial showed over 16% weight loss, indicating competitive strength in the obesity and metabolic disease market, with future clinical execution being crucial.
Wall Street analysts forecast GPCR stock price to rise
15 Analyst Rating
Wall Street analysts forecast GPCR stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$114 -> $100
AI Analysis
2026-03-16
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$114 -> $100
AI Analysis
2026-03-16
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Structure Therapeutics to $100 from $114 and keeps a Buy rating on the shares. While the company reported "breakthrough" 44-week data for aleniglipron that the firm thinks "redefines what's achievable with oral GLP-1 therapies," the firm revisited its penetration assumptions given the emerging nausea and vomiting profile of aleniglipron, despite what it calls "a competitive discontinuation rate."
H.C. Wainwright
Buy
maintain
$90 -> $114
2026-03-02
Reason
H.C. Wainwright
Price Target
$90 -> $114
2026-03-02
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Structure Therapeutics to $114 from $90 and keeps a Buy rating on the shares. The firm believes the 44-week ACCESS II data, expected in Q1, could be the most significant near-term catalyst for "crystallizing" Structure's takeover interest.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GPCR
Unlock Now

Valuation Metrics

The current forward P/E ratio for Structure Therapeutics Inc (GPCR.O) is 0.00, compared to its 5-year average forward P/E of -34.31. For a more detailed relative valuation and DCF analysis to assess Structure Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-34.31
Current PE
0.00
Overvalued PE
-20.41
Undervalued PE
-48.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.95
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-8.09

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
9370.42
Current PS
83389.15
Overvalued PS
39337.02
Undervalued PS
-20596.17

Financials

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Whales Holding GPCR

A
Artal Group S.A.
Holding
GPCR
+19.34%
3M Return
A
Avoro Capital Advisors LLC
Holding
GPCR
+14.87%
3M Return
E
EcoR1 Capital, LLC
Holding
GPCR
+12.59%
3M Return
T
TCG Crossover Management, LLC
Holding
GPCR
+12.38%
3M Return
L
Logos Global Management, L.P.
Holding
GPCR
+11.12%
3M Return
P
Pacific Heights Asset Management, LLC
Holding
GPCR
+10.35%
3M Return

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Frequently Asked Questions

What is Structure Therapeutics Inc (GPCR) stock price today?

The current price of GPCR is 49.17 USD — it has decreased -3.11

What is Structure Therapeutics Inc (GPCR)'s business?

Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.

What is the price predicton of GPCR Stock?

Wall Street analysts forecast GPCR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GPCR is106.50 USD with a low forecast of 65.00 USD and a high forecast of 140.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Structure Therapeutics Inc (GPCR)'s revenue for the last quarter?

Structure Therapeutics Inc revenue for the last quarter amounts to 13.74M USD, decreased -129.20

What is Structure Therapeutics Inc (GPCR)'s earnings per share (EPS) for the last quarter?

Structure Therapeutics Inc. EPS for the last quarter amounts to -65912000.00 USD, increased 80.66

How many employees does Structure Therapeutics Inc (GPCR). have?

Structure Therapeutics Inc (GPCR) has 220 emplpoyees as of April 20 2026.

What is Structure Therapeutics Inc (GPCR) market cap?

Today GPCR has the market capitalization of 3.60B USD.