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GPCR Overview

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ET
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Intellectia

Loading chart...

High
45.800
Open
45.660
VWAP
44.15
Vol
1.01M
Mkt Cap
3.11B
Low
42.720
Amount
44.43M
EV/EBITDA(TTM)
--
Total Shares
70.84M
EV
1.81B
EV/OCF(TTM)
--
P/S(TTM)
--
Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.
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Events Timeline

(ET)
2026-03-16
11:10:00
Structure Therapeutics' GLP-1 Pill Averages Over 16% Weight Loss
select
link
2026-03-16
07:20:00
Structure Therapeutics Announces Aleniglipron Clinical Data
select
2026-01-30 (ET)
2026-01-30
12:00:00
Major Averages Broadly Lower as Tech Stocks Decline
select
2026-01-30
10:50:00
Structure Therapeutics Emerges as Next M&A Target for Big Pharma
select
link

News

stocktwits
9.0
03-30stocktwits
Viking and Structure Intensify Competition in Obesity Drug Development
  • Clinical Trial Progress: Viking announced the enrollment of approximately 1,000 patients with obesity or overweight type 2 diabetes in the late-stage trial of VK2735, with a primary endpoint assessing weight change after 78 weeks, which could significantly enhance its market competitiveness if successful.
  • Significant Drug Efficacy: In a mid-stage trial, VK2735 achieved a mean weight loss of 14.7% in 13 weeks, establishing a solid foundation for its subsequent clinical development and potentially attracting more investor interest.
  • Market Potential: According to Koyfin, GPCR stock has a 12-month target of $109, implying a 147.95% upside, while VKTX's target is $92.72, representing a 209.80% upside, indicating strong prospects for both companies in the obesity drug market.
  • Investor Sentiment Shift: While VKTX stock has risen 24% this year, GPCR has surged 154%, reflecting differing market perceptions, with VKTX sentiment remaining neutral and GPCR appearing more bearish.
Fool
8.5
03-22Fool
B Group Initiates Position in Structure Therapeutics
  • New Position Disclosure: B Group disclosed a new position in Structure Therapeutics by acquiring 90,000 shares in Q4 2025, amounting to $6.26 million, reflecting confidence in the company's drug development potential, particularly in chronic disease treatments.
  • Asset Allocation Impact: This new stake represents 4.62% of B Group's reportable U.S. equity assets, indicating a strategic focus on the biopharmaceutical sector that may attract further investor interest in its future performance.
  • Strong Market Performance: As of last Friday, Structure Therapeutics shares were priced at $48.59, marking a staggering 132% increase over the past year, significantly outperforming the S&P 500's 15% rise, showcasing strong market demand for its products and investor confidence.
  • R&D Challenges and Opportunities: Despite posting a net loss of $141 million for 2025 and increased R&D spending, the lead drug candidate's mid-stage trial showed over 16% weight loss, indicating competitive strength in the obesity and metabolic disease market, with future clinical execution being crucial.
NASDAQ.COM
8.5
03-22NASDAQ.COM
B Group Acquires Shares in Structure Therapeutics
  • New Investment Disclosure: On February 17, 2026, B Group disclosed to the SEC that it acquired 90,000 shares of Structure Therapeutics in the fourth quarter, indicating a continued interest in the biotechnology sector.
  • Value Growth: As of December 31, 2025, B Group's stake in Structure Therapeutics was valued at $6.26 million, representing 4.62% of its 13F assets, which, while not in the top five holdings, still reflects confidence in the company.
  • Market Potential Analysis: Structure Therapeutics focuses on developing innovative oral small molecule drugs for chronic diseases, with its lead candidate GSBR-1290 achieving over 16% weight loss in mid-stage trials, showcasing its competitiveness in the obesity and metabolic disease market.
  • Financial Condition Consideration: Despite posting a net loss of approximately $141 million last year and a 28% drop in stock price this year, Structure Therapeutics' long-term growth potential hinges on clinical execution, necessitating investor attention on its R&D progress.
CNBC
9.0
03-19CNBC
Novo Nordisk's High-Dose Wegovy Approved by FDA
  • High-Dose Approval: The FDA has approved Novo Nordisk's high-dose Wegovy at 7.2 mg, set to launch in April, aiming to regain market share against Eli Lilly's Zepbound.
  • Clinical Trial Results: In a phase three trial, high-dose Wegovy led to an average weight loss of 20.7% over 72 weeks, significantly outperforming the standard dose's 15%, enhancing its competitive edge.
  • Increased Patient Options: The new dosage provides more options for patients who struggle to meet weight loss targets, as noted by Novo Nordisk's U.S. medical head, potentially improving treatment satisfaction and outcomes.
  • Policy Support: This approval marks the first GLP-1 treatment under the FDA's new national priority voucher plan, aimed at expediting drug review times, highlighting Novo Nordisk's strategic positioning in the industry.
seekingalpha
8.5
03-16seekingalpha
Structure Therapeutics Reports Promising Phase 2 Data for Obesity Drug
  • Clinical Trial Results: Structure Therapeutics reported significant weight loss of 16.3% and 16% at 180 mg and 240 mg doses respectively in the ACCESS II study, highlighting the potential of aleniglipron in obesity treatment and opening new market opportunities for the company.
  • Sustained Weight Loss: In the open-label extension study, aleniglipron achieved a continued weight loss of 16.2% at the 120 mg dose over 56 weeks without a weight loss plateau, indicating long-term efficacy and enhancing its competitive edge in the market.
  • Future Development Plans: The company anticipates moving into phase 3 clinical trials in the second half of the year, paving the way for potential product launch, which could attract more investor interest and boost stock performance.
  • Positive Market Reaction: Following the release of promising clinical data, Structure Therapeutics' stock rose approximately 8% in Monday trading, reflecting market optimism regarding the prospects of its obesity treatment drug and potentially strengthening the company's position in the biopharmaceutical sector.
Fool
6.5
02-27Fool
Casdin Capital Reduces Stake in Structure Therapeutics
  • Stake Reduction Transaction: According to a February 17, 2026 SEC filing, Casdin Capital sold 380,000 shares of Structure Therapeutics in Q4, an estimated $15.52 million trade that reflects a cautious outlook on the company's future performance.
  • Change in Holdings Proportion: Following this sale, Structure Therapeutics accounted for only 5.08% of Casdin's 13F assets, indicating a reallocation of the investment portfolio that may impact the company's future liquidity.
  • Market Performance Analysis: As of February 17, 2026, GPCR shares were priced at $71.41, reflecting a 214.3% increase over the past year, significantly outperforming the S&P 500 by 180.87 percentage points, indicating strong market confidence in its potential products.
  • Financial Overview: Despite ending 2025 with $1.4 billion in cash and investments sufficient to fund operations through 2028, the company reported a net loss of $141.2 million, highlighting the financial strain from high R&D expenditures during its clinical stage.
Wall Street analysts forecast GPCR stock price to rise
15 Analyst Rating
Wall Street analysts forecast GPCR stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$114 -> $100
AI Analysis
2026-03-16
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$114 -> $100
AI Analysis
2026-03-16
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Structure Therapeutics to $100 from $114 and keeps a Buy rating on the shares. While the company reported "breakthrough" 44-week data for aleniglipron that the firm thinks "redefines what's achievable with oral GLP-1 therapies," the firm revisited its penetration assumptions given the emerging nausea and vomiting profile of aleniglipron, despite what it calls "a competitive discontinuation rate."
H.C. Wainwright
Buy
maintain
$90 -> $114
2026-03-02
Reason
H.C. Wainwright
Price Target
$90 -> $114
2026-03-02
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Structure Therapeutics to $114 from $90 and keeps a Buy rating on the shares. The firm believes the 44-week ACCESS II data, expected in Q1, could be the most significant near-term catalyst for "crystallizing" Structure's takeover interest.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GPCR
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Valuation Metrics

The current forward P/E ratio for Structure Therapeutics Inc (GPCR.O) is -43.34, compared to its 5-year average forward P/E of -34.32. For a more detailed relative valuation and DCF analysis to assess Structure Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-34.32
Current PE
-43.34
Overvalued PE
-20.42
Undervalued PE
-48.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.96
Current EV/EBITDA
-11.92
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-8.11

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
4.95
Current PS
0.00
Overvalued PS
14.95
Undervalued PS
-5.06

Financials

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Whales Holding GPCR

D
Driehaus Capital Management LLC
Holding
GPCR
+2.90%
3M Return
A
Artal Group S.A.
Holding
GPCR
+1.99%
3M Return
P
Pacific Heights Asset Management, LLC
Holding
GPCR
+1.45%
3M Return
E
EcoR1 Capital, LLC
Holding
GPCR
-1.35%
3M Return
T
TCG Crossover Management, LLC
Holding
GPCR
-2.27%
3M Return
B
BVF Partners L.P.
Holding
GPCR
-2.32%
3M Return

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Frequently Asked Questions

What is Structure Therapeutics Inc (GPCR) stock price today?

The current price of GPCR is 43.94 USD — it has decreased -4.31

What is Structure Therapeutics Inc (GPCR)'s business?

Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.

What is the price predicton of GPCR Stock?

Wall Street analysts forecast GPCR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GPCR is106.50 USD with a low forecast of 65.00 USD and a high forecast of 140.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Structure Therapeutics Inc (GPCR)'s revenue for the last quarter?

Structure Therapeutics Inc revenue for the last quarter amounts to 13.74M USD, decreased -129.20

What is Structure Therapeutics Inc (GPCR)'s earnings per share (EPS) for the last quarter?

Structure Therapeutics Inc. EPS for the last quarter amounts to -65912000.00 USD, increased 80.66

How many employees does Structure Therapeutics Inc (GPCR). have?

Structure Therapeutics Inc (GPCR) has 220 emplpoyees as of March 31 2026.

What is Structure Therapeutics Inc (GPCR) market cap?

Today GPCR has the market capitalization of 3.11B USD.