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GPCR Overview

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ET
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ET
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Intellectia

Loading chart...

High
60.610
Open
56.950
VWAP
58.59
Vol
932.86K
Mkt Cap
4.12B
Low
56.950
Amount
54.66M
EV/EBITDA(TTM)
--
Total Shares
70.84M
EV
2.56B
EV/OCF(TTM)
--
P/S(TTM)
--
Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.
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Events Timeline

(ET)
2026-01-30
12:00:00
Major Averages Broadly Lower as Tech Stocks Decline
select
2026-01-30
10:50:00
Structure Therapeutics Emerges as Next M&A Target for Big Pharma
select
link
2026-01-14 (ET)
2026-01-14
13:10:00
Novo Nordisk CEO Signals M&A Interest, Viking Therapeutics Up Nearly 11%
select
2026-01-14
12:50:00
Novo Nordisk Seeks Acquisitions to Boost Obesity Portfolio
select
link
2026-01-13 (ET)
2026-01-13
12:10:00
Structure Therapeutics Stock Rises 14.1% to $79.15
select

News

Fool
6.5
02-27Fool
Casdin Capital Reduces Stake in Structure Therapeutics
  • Stake Reduction Transaction: According to a February 17, 2026 SEC filing, Casdin Capital sold 380,000 shares of Structure Therapeutics in Q4, an estimated $15.52 million trade that reflects a cautious outlook on the company's future performance.
  • Change in Holdings Proportion: Following this sale, Structure Therapeutics accounted for only 5.08% of Casdin's 13F assets, indicating a reallocation of the investment portfolio that may impact the company's future liquidity.
  • Market Performance Analysis: As of February 17, 2026, GPCR shares were priced at $71.41, reflecting a 214.3% increase over the past year, significantly outperforming the S&P 500 by 180.87 percentage points, indicating strong market confidence in its potential products.
  • Financial Overview: Despite ending 2025 with $1.4 billion in cash and investments sufficient to fund operations through 2028, the company reported a net loss of $141.2 million, highlighting the financial strain from high R&D expenditures during its clinical stage.
seekingalpha
9.5
02-26seekingalpha
Structure Therapeutics Reports Q4 Net Income of $33 Million
  • Net Income Reversal: In Q4 2025, Structure Therapeutics reported a net income of $33 million, a significant turnaround from a net loss of $36.5 million in Q4 2024, indicating the company's potential for market recovery.
  • Increased Share-Based Compensation: Despite the rise in net income, non-cash share-based compensation expenses increased from $5.8 million to $8.1 million, reflecting ongoing investments in talent attraction and retention, which may impact future profitability.
  • Annual Net Loss Overview: The total net loss for 2025 was $141.2 million, up from $122.5 million in 2024, indicating that the company still faces challenges in expansion and R&D, necessitating close monitoring of its long-term financial health.
  • Strong Cash Reserves: As of December 31, 2025, the company had $1.4 billion in cash and short-term investments, expected to fund operations and key clinical milestones through the end of 2028, demonstrating solid financial stability and future growth potential.
Fool
6.5
02-25Fool
BVF Increases Stake in Structure Therapeutics with $11.2 Million Purchase
  • Stake Increase: Hedge fund BVF disclosed on February 17, 2026, that it increased its position in Structure Therapeutics by 275,105 shares, with an estimated transaction value of $11.2 million, indicating strong confidence in the company's future prospects.
  • Value Growth: BVF's quarter-end position in Structure Therapeutics reached $242 million, up $152.3 million from the previous filing, reflecting positive changes in the company's stock price and trading activity.
  • Strong Market Performance: As of February 17, 2026, Structure Therapeutics shares were priced at $71.41, representing a 214.3% increase over the past year, significantly outperforming the S&P 500, indicating market recognition of its product potential.
  • Strategic Focus: Structure Therapeutics specializes in developing oral therapeutics for chronic diseases, particularly GSBR-1290 for type-2 diabetes and obesity, showcasing its differentiated competitive advantage in the biopharmaceutical sector.
CNBC
8.5
02-23CNBC
Eli Lilly's Dominance in Obesity Drug Market Reinforced
  • Clinical Trial Comparison: Eli Lilly's Zepbound demonstrated superior efficacy in a head-to-head trial, with participants losing an average of 25.5% of their body weight compared to Novo Nordisk's CagriSema at 23%, reinforcing Lilly's leadership in obesity drug effectiveness and solidifying its market position.
  • New Device Launch: Lilly introduced a new Zepbound injection device in the U.S. that provides a month's supply, enhancing patient convenience; while the immediate financial impact may be limited, it showcases Lilly's supply chain advantages and commitment to patient care.
  • Significant Market Reaction: Following disappointing trial results, Novo Nordisk's shares fell over 15%, while Lilly's stock rose more than 4%, reflecting investor confidence in Lilly's growth potential and widening the gap between the two companies in the market.
  • Future Development Potential: Lilly is advancing multiple next-generation obesity treatments, including retatrutide and eloralintide, targeting appetite-related hormones, with analysts noting that Lilly's competitive edge is expanding, positioning the company for further market leadership in the obesity drug sector.
Fool
6.5
02-17Fool
Rock Springs Capital Reduces Stake in Structure Therapeutics
  • Share Reduction Details: On February 17, 2026, Rock Springs Capital Management LP disclosed a sale of 202,918 shares of Structure Therapeutics, valued at approximately $8.29 million, indicating a cautious outlook on the company's future performance.
  • Impact on Holdings: Following this reduction, Structure Therapeutics now constitutes 2.67% of Rock Springs' portfolio, falling outside the top five holdings, which suggests a shift in investor preference towards larger, more diversified biotech firms.
  • Market Performance Analysis: As of February 13, 2026, Structure Therapeutics shares were priced at $70.07, reflecting a remarkable 187.5% increase over the past year, significantly outperforming the S&P 500 index by 175.73 percentage points, highlighting its strong position in the biotech sector.
  • Investor Strategy Insights: In the context of strong biotech stock performance, the reduction is viewed as risk management rather than a loss of conviction, emphasizing the need for discipline among investors to navigate potential future volatility.
Fool
5.0
02-05Fool
Structure Therapeutics' GLP-1 Drug Shows Promising Potential
  • Intensifying Market Competition: Novo Nordisk and Eli Lilly currently lead the GLP-1 drug market, but as more pharmaceutical companies enter this space, the market share is expected to expand further, representing a significant growth opportunity in healthcare.
  • Clinical Trial Progress: Structure Therapeutics' GLP-1 weight loss pill, aleniglipron, has entered phase 3 trials, with recent data showing a placebo-adjusted weight loss of 15.3% at the highest dosage, demonstrating effectiveness comparable to other top weight loss drugs on the market.
  • Safety Advantages: Unlike other GLP-1 drugmakers that typically require trials lasting over 60 weeks, Structure has achieved comparable weight loss results at an earlier stage, and with no liver injuries or significant side effects reported, the treatment appears to be safe.
  • Investment Risks and Opportunities: While Structure Therapeutics has a market cap of $6.5 billion and its stock has tripled in the past year, investors should be cautious of its elevated valuation, as any negative outcomes from the phase 3 trials could lead to a steep sell-off.
Wall Street analysts forecast GPCR stock price to rise
15 Analyst Rating
Wall Street analysts forecast GPCR stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
H.C. Wainwright
Buy
maintain
$90 -> $114
AI Analysis
2026-03-02
Reason
H.C. Wainwright
Price Target
$90 -> $114
AI Analysis
2026-03-02
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Structure Therapeutics to $114 from $90 and keeps a Buy rating on the shares. The firm believes the 44-week ACCESS II data, expected in Q1, could be the most significant near-term catalyst for "crystallizing" Structure's takeover interest.
Citizens
Jonathan Wolleben
Outperform
downgrade
$120 -> $113
2026-02-27
Reason
Citizens
Jonathan Wolleben
Price Target
$120 -> $113
2026-02-27
downgrade
Outperform
Reason
Citizens analyst Jonathan Wolleben lowered the firm's price target on Structure Therapeutics to $113 from $120 and keeps an Outperform rating on the shares. Structure Therapeutics is entering a catalyst-rich year highlighted by multiple aleniglipron updates, including upcoming 44-week ACCESS II data and an end-of-Phase 2 FDA meeting to finalize Phase 3 design, following Phase 2b results showing 11%-15% placebo-adjusted weight loss at 36 weeks with improved tolerability at a 2.5 mg starting dose, the analyst tells investors in a research note. With strong early uptake of oral GLP-1s reinforcing demand for effective oral therapies, Structure appears well-positioned in obesity with a potential best-in-class oral candidate and an expanding metabolic pipeline, the firm says.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GPCR
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Valuation Metrics

The current forward P/E ratio for Structure Therapeutics Inc (GPCR.O) is -43.34, compared to its 5-year average forward P/E of -34.32. For a more detailed relative valuation and DCF analysis to assess Structure Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-34.32
Current PE
-43.34
Overvalued PE
-20.42
Undervalued PE
-48.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.96
Current EV/EBITDA
-11.92
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-8.11

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
4.95
Current PS
0.00
Overvalued PS
14.95
Undervalued PS
-5.06

Financials

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Whales Holding GPCR

P
Pacific Heights Asset Management, LLC
Holding
GPCR
+9.97%
3M Return
D
Driehaus Capital Management LLC
Holding
GPCR
+8.18%
3M Return
E
EcoR1 Capital, LLC
Holding
GPCR
+7.87%
3M Return
A
Artal Group S.A.
Holding
GPCR
+7.70%
3M Return
B
BVF Partners L.P.
Holding
GPCR
+6.57%
3M Return
T
TCG Crossover Management, LLC
Holding
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+1.37%
3M Return

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Frequently Asked Questions

What is Structure Therapeutics Inc (GPCR) stock price today?

The current price of GPCR is 58.22 USD — it has increased 3.04

What is Structure Therapeutics Inc (GPCR)'s business?

Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.

What is the price predicton of GPCR Stock?

Wall Street analysts forecast GPCR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GPCR is106.50 USD with a low forecast of 65.00 USD and a high forecast of 140.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Structure Therapeutics Inc (GPCR)'s revenue for the last quarter?

Structure Therapeutics Inc revenue for the last quarter amounts to 13.74M USD, decreased -129.20

What is Structure Therapeutics Inc (GPCR)'s earnings per share (EPS) for the last quarter?

Structure Therapeutics Inc. EPS for the last quarter amounts to -65912000.00 USD, increased 80.66

How many employees does Structure Therapeutics Inc (GPCR). have?

Structure Therapeutics Inc (GPCR) has 220 emplpoyees as of March 11 2026.

What is Structure Therapeutics Inc (GPCR) market cap?

Today GPCR has the market capitalization of 4.12B USD.