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GPCR Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

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High
41.182
Open
41.182
VWAP
39.86
Vol
507.10K
Mkt Cap
2.80B
Low
39.060
Amount
20.21M
EV/EBITDA(TTM)
--
Total Shares
71.07M
EV
1.40B
EV/OCF(TTM)
--
P/S(TTM)
--
Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.
Show More

Events Timeline

(ET)
2026-04-14
16:20:00
Structure Therapeutics Appoints Matthew Lang as COO and General Counsel
select
2026-03-16 (ET)
2026-03-16
11:10:00
Structure Therapeutics' GLP-1 Pill Averages Over 16% Weight Loss
select
link
2026-03-16
07:20:00
Structure Therapeutics Announces Aleniglipron Clinical Data
select
2026-01-30 (ET)
2026-01-30
12:00:00
Major Averages Broadly Lower as Tech Stocks Decline
select
2026-01-30
10:50:00
Structure Therapeutics Emerges as Next M&A Target for Big Pharma
select
link

News

stocktwits
6.0
05-28stocktwits
Truist Initiates Coverage on VKTX with Buy Rating and $83 Price Target
  • Analyst Rating Boost: Truist has initiated coverage on Viking Therapeutics (VKTX) with a ‘Buy’ rating and an $83 price target, indicating a potential upside of 162% from current levels, reflecting strong market confidence in its growth prospects.
  • Weight Loss Market Dynamics: Eli Lilly (LLY) saw its stock price climb nearly 25% over the past month, making it the strongest performer among major obesity drug stocks, highlighting investor recognition of its sustained demand for GLP-1 therapies and market leadership.
  • Viking's Competitive Edge: Truist emphasized that Viking's VK2735 drug achieved a 14.7% weight loss in just 13 weeks, with patients continuing to lose weight, showcasing its differentiated competitive advantage in the obesity drug market that could attract more patients.
  • Lilly's Market Expansion: Lilly recently announced deals worth up to $3.8 billion with three vaccine developers, further expanding its footprint in infectious diseases and long-term healthcare infrastructure, indicating growth potential beyond its obesity drug portfolio.
Fool
6.5
05-24Fool
Deep Track Capital Increases Stake in Structure Therapeutics
  • Stake Increase: Deep Track Capital disclosed an acquisition of 168,066 shares of Structure Therapeutics in Q1 2026, with an estimated transaction value of $11.50 million, indicating confidence in the company's growth potential.
  • Ownership Proportion: Following this purchase, Deep Track's stake in Structure rose to 3.37%, representing a significant position within its $6.12 billion reportable U.S. equity holdings, highlighting the fund's commitment to the company.
  • Market Performance: As of last Friday, Structure Therapeutics' shares were priced at $39.19, reflecting a 60% increase over the past year, significantly outperforming the S&P 500's 28% rise, suggesting strong market optimism regarding its future.
  • R&D Progress: The company reported a Phase 2 trial for its oral GLP-1 candidate aleniglipron showing up to 16.3% weight loss, with plans to initiate Phase 3 studies in Q3 2026, which could solidify its competitive position in the obesity market if successful.
NASDAQ.COM
6.5
05-24NASDAQ.COM
Deep Track Capital Increases Stake in Structure Therapeutics
  • Stake Increase: Deep Track Capital acquired an additional 168,066 shares of Structure Therapeutics in Q1 2026, with an estimated transaction value of $11.50 million, indicating confidence in the company's future value creation potential.
  • Decline in Position Value: Despite the increase, the quarter-end position value decreased by $79.69 million, reflecting the dual impact of trading activity and stock price fluctuations, highlighting market concerns about the stock's volatility.
  • Clinical Advancements: Structure Therapeutics' oral GLP-1 candidate aleniglipron demonstrated a weight loss of up to 16.3% in Phase 2 trials, potentially comparable to injectable therapies, enhancing its competitiveness in the obesity market.
  • Strong Financial Position: The company ended the quarter with approximately $1.5 billion in cash and short-term investments, sufficient to support operations through the end of 2028, showcasing a robust financial foundation for R&D and market expansion.
Fool
6.5
05-20Fool
Monashee Reduces Stake in Structure Therapeutics Amid Competitive Landscape
  • Stake Reduction Details: Monashee Investment Management reduced its holdings in Structure Therapeutics by 175,000 shares in Q1 2026, with an estimated transaction value of $11.98 million, resulting in a $13.24 million decrease in its GPCR position, indicating a cautious outlook on the company's future potential.
  • Holding Proportion Analysis: Post-reduction, Monashee's remaining stake accounts for 1.8% of its 13F reportable assets, suggesting a diminished confidence in the company despite its strong performance in clinical testing.
  • Market Competition Landscape: The GLP-1 weight loss drug market is highly competitive, and while Structure's oral therapies show promising results in trials, numerous pharmaceutical companies are developing similar products, increasing future uncertainty.
  • Investor Strategy Recommendation: Given Monashee's reduction, investors may prefer ETFs that encompass the GLP-1 sector, such as the Roundhill GLP-1 & Weight Loss ETF, to diversify risk and capture market opportunities.
Fool
5.0
05-17Fool
HighVista Strategies Sells Shares of Structure Therapeutics
  • Share Reduction Transaction: HighVista Strategies sold 69,092 shares of Structure Therapeutics in Q1 2026, with an estimated transaction value of $4.73 million, indicating a potential shift in confidence regarding the company.
  • Decline in Position Value: This sale resulted in a $7.45 million decrease in HighVista's position value in Structure Therapeutics, highlighting the impact of market price fluctuations on its investment portfolio.
  • Strong Company Performance: As of May 14, 2026, Structure Therapeutics' shares were priced at $39.84, reflecting a 60% increase over the past year, significantly outperforming the S&P 500's 25% gain, indicating strong market recognition of its future potential.
  • Positive Clinical Progress: Structure Therapeutics reported promising Phase 2 data for its oral obesity candidate aleniglipron, showing up to 16.3% placebo-adjusted weight loss at 44 weeks, underscoring its competitive edge in the GLP-1 therapy market.
Fool
6.5
05-10Fool
ACT Capital Management Fully Exits Structure Therapeutics Stake
  • Complete Exit: ACT Capital Management sold all 38,500 shares of Structure Therapeutics in Q1 2026, with an estimated trade value of $2.63 million, indicating a full exit that reflects a cautious stance amid biotech market volatility.
  • Net Position Change: The transaction resulted in a $2.68 million decrease in ACT's net position, suggesting that after a significant price increase, management opted to lock in profits at a high point to mitigate potential market risks.
  • Strong Company Performance: As of May 7, 2026, Structure Therapeutics shares were priced at $39.15, up 47% over the past year, outperforming the S&P 500 by 17 percentage points, highlighting its robust growth potential in chronic disease treatment.
  • Strong Financial Position: Structure ended the quarter with approximately $1.5 billion in cash and short-term investments, which is expected to fund operations through the end of 2028, enhancing its competitive edge in future product development and commercialization.
Wall Street analysts forecast GPCR stock price to rise
15 Analyst Rating
Wall Street analysts forecast GPCR stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Canaccord
NULL
to
Buy
initiated
$101
AI Analysis
2026-04-27
Reason
Canaccord
Price Target
$101
AI Analysis
2026-04-27
initiated
NULL
to
Buy
Reason
Canaccord initiated coverage of Structure Therapeutics with a Buy rating and $101 price target. The stock in premarket trading is up 3% to $46.90. The firm says Structure is the only company in the obesity drug development space that has a pipeline of all orally administered drugs. Structure's lead, aleniglipron, has demonstrated a "robust effect" on weight loss coupled with a more benign side effect profile than approved GLP-1 therapies, the analyst tells investors in a research note. Canaccord adds that aleniglipron is one of two "backbone strategies" Structure is pursuing to address both monotherapy and combination approaches to weight loss. It believes the company offers "optionality along with potential best-in-class efficacy."
Canaccord
Buy
initiated
$101
2026-04-27
Reason
Canaccord
Price Target
$101
2026-04-27
initiated
Buy
Reason
Canaccord initiated coverage of Structure Therapeutics with a Buy rating and $101 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GPCR
Unlock Now

Valuation Metrics

The current forward P/E ratio for Structure Therapeutics Inc (GPCR.O) is 0.00, compared to its 5-year average forward P/E of -34.31. For a more detailed relative valuation and DCF analysis to assess Structure Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-34.31
Current PE
0.00
Overvalued PE
-20.41
Undervalued PE
-48.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.95
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-8.09

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
11329.35
Current PS
68516.03
Overvalued PS
42628.43
Undervalued PS
-19969.73

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Whales Holding GPCR

T
TCG Crossover Management, LLC
Holding
GPCR
+16.06%
3M Return
A
Avoro Capital Advisors LLC
Holding
GPCR
+15.03%
3M Return
D
Driehaus Capital Management LLC
Holding
GPCR
+14.26%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
GPCR
+11.81%
3M Return
A
Artal Group S.A.
Holding
GPCR
+11.24%
3M Return
D
Deerfield Management Company, L.P.
Holding
GPCR
+9.36%
3M Return

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Frequently Asked Questions

What is Structure Therapeutics Inc (GPCR) stock price today?

The current price of GPCR is 39.34 USD — it has decreased -2.07

What is Structure Therapeutics Inc (GPCR)'s business?

Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.

What is the price predicton of GPCR Stock?

Wall Street analysts forecast GPCR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GPCR is106.50 USD with a low forecast of 65.00 USD and a high forecast of 140.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Structure Therapeutics Inc (GPCR)'s revenue for the last quarter?

Structure Therapeutics Inc revenue for the last quarter amounts to -89.38M USD, increased 58.72

What is Structure Therapeutics Inc (GPCR)'s earnings per share (EPS) for the last quarter?

Structure Therapeutics Inc. EPS for the last quarter amounts to 14052000.00 USD, decreased -126.74

How many employees does Structure Therapeutics Inc (GPCR). have?

Structure Therapeutics Inc (GPCR) has 220 emplpoyees as of May 30 2026.

What is Structure Therapeutics Inc (GPCR) market cap?

Today GPCR has the market capitalization of 2.80B USD.