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GPCR Overview

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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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ET
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Intellectia

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High
39.925
Open
38.160
VWAP
38.91
Vol
803.11K
Mkt Cap
2.78B
Low
37.690
Amount
31.25M
EV/EBITDA(TTM)
--
Total Shares
71.07M
EV
1.32B
EV/OCF(TTM)
--
P/S(TTM)
--
Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.
Show More

Events Timeline

(ET)
2026-04-14
16:20:00
Structure Therapeutics Appoints Matthew Lang as COO and General Counsel
select
2026-03-16 (ET)
2026-03-16
11:10:00
Structure Therapeutics' GLP-1 Pill Averages Over 16% Weight Loss
select
link
2026-03-16
07:20:00
Structure Therapeutics Announces Aleniglipron Clinical Data
select
2026-01-30 (ET)
2026-01-30
12:00:00
Major Averages Broadly Lower as Tech Stocks Decline
select
2026-01-30
10:50:00
Structure Therapeutics Emerges as Next M&A Target for Big Pharma
select
link

News

Fool
6.5
12:06 PMFool
ACT Capital Management Fully Exits Structure Therapeutics Stake
  • Complete Exit: ACT Capital Management sold all 38,500 shares of Structure Therapeutics in Q1 2026, with an estimated trade value of $2.63 million, indicating a full exit that reflects a cautious stance amid biotech market volatility.
  • Net Position Change: The transaction resulted in a $2.68 million decrease in ACT's net position, suggesting that after a significant price increase, management opted to lock in profits at a high point to mitigate potential market risks.
  • Strong Company Performance: As of May 7, 2026, Structure Therapeutics shares were priced at $39.15, up 47% over the past year, outperforming the S&P 500 by 17 percentage points, highlighting its robust growth potential in chronic disease treatment.
  • Strong Financial Position: Structure ended the quarter with approximately $1.5 billion in cash and short-term investments, which is expected to fund operations through the end of 2028, enhancing its competitive edge in future product development and commercialization.
stocktwits
6.0
04-28stocktwits
Analyst Reiterates Strong Buy Rating for VKTX Ahead of Earnings
  • Strong Buy Rating: Raymond James reiterated a 'Strong Buy' rating on Viking Therapeutics (VKTX) with a $118 price target, implying a substantial 258% upside, reflecting analysts' strong confidence in the company's future performance.
  • Financial Expectations: Consensus estimates anticipate VKTX will report a GAAP loss per share of $1.03, widening from last year's $0.4 loss, with projected EBITDA losses nearing $129.5 million, indicating ongoing financial pressures as the company remains in the clinical stage.
  • Clinical Trial Progress: Investor focus remains on the ongoing Phase 3 Vanquish obesity treatment program, with enrollment for the second phase completed in March and results from a maintenance-dose study expected in Q3, highlighting strong demand for new treatment options.
  • Intensifying Market Competition: As emerging biotech firms and large pharma companies expand their obesity drug pipelines, competition is intensifying, with Viking facing challenges from companies like Structure Therapeutics and Altimmune, while Eli Lilly's new drug Foundayo shows slower initial prescription data.
stocktwits
9.5
04-22stocktwits
Viking Therapeutics Q1 Earnings Preview Highlights Losses and Market Potential
  • Earnings Loss Forecast: Koyfin estimates a Q1 GAAP loss per share of $1.03 for Viking Therapeutics, widening from a $0.4 loss a year earlier, indicating ongoing losses during the clinical development phase with zero expected revenue as commercial sales have not yet commenced.
  • Clinical Trial Progress: Investor focus remains on the Vanquish program, which completed enrollment for Vanquish-2 in March, evaluating a 78-week weight reduction treatment, reflecting strong demand for additional obesity treatment options as noted by CEO Brian Lian regarding rapid enrollment.
  • Intensifying Market Competition: The obesity drug market is becoming increasingly competitive, with Viking's main rival Structure Therapeutics reporting over 16% weight loss from its oral GLP-1 candidate over ten months, while Amazon has launched an integrated GLP-1 treatment platform, intensifying competition in the sector.
  • Analyst Optimism: Despite the anticipated losses, Koyfin projects a 174% upside for VKTX stock with a 12-month price target of $92.72, as coverage from 19 analysts mostly reflects a 'Strong Buy' consensus, indicating market confidence in its obesity drug development.
seekingalpha
5.0
04-14seekingalpha
Structure Therapeutics Appoints New COO
  • Executive Appointment: Structure Therapeutics has appointed Matthew Lang as Chief Operating Officer, bringing over 15 years of executive leadership experience in global biopharmaceutical organizations, which is expected to positively impact the company's strategic development.
  • Legal and Compliance Expertise: While serving as Chief Legal Officer at Metsera, Lang successfully guided the company through an acquisition valued at up to $10 billion, showcasing his deep expertise in legal and compliance matters that will aid Structure Therapeutics in risk management.
  • Business Development Background: Prior to joining Structure Therapeutics, Lang held the position of Chief Business and Legal Officer at Lyell Immunopharma, and his extensive business development experience will support the company in expanding its operations in a competitive market.
  • Market Reaction: Following the announcement of Lang's appointment, Structure Therapeutics' stock rose 1.76% in after-hours trading to $54.27, reflecting market optimism regarding the new COO's potential contributions.
Barron's
5.0
04-07Barron's
The 'Diabesity' Market Is Poised for Rapid Growth: Key Catalysts for Lilly and Novo Stocks.
  • Weight-loss Drugs in Focus: The spotlight is on weight-loss drugs, particularly GLP-1 medications like Wegovy and Zepbound, as they gain popularity.

  • Market Competition: Eli Lilly and Novo Nordisk are key players in the emerging "diabesity" market, indicating a competitive landscape ahead.

NASDAQ.COM
6.5
04-03NASDAQ.COM
SPDR S&P China ETF Analysts See 34.69% Upside
  • ETF Target Price Analysis: The SPDR S&P China ETF (GXC) has an implied analyst target price of $124.19 per unit, with a current trading price of $92.21, indicating a 34.69% upside potential that reflects market optimism about the ETF's future performance.
  • Stock Potential Unveiled: Legend Biotech Corp (LEGN) trades at $19.14, while analysts set a target price of $60.63, suggesting a remarkable 216.78% upside, highlighting the company's strong growth potential in the biotech sector.
  • Structure Therapeutics Outlook: Structure Therapeutics Inc (GPCR) is priced at $53.48, with an analyst target of $109.00, indicating a potential increase of 103.81%, showcasing market expectations for its innovative drug development.
  • Market Confidence in VNET: VNET Group Inc (VNET) currently trades at $8.19, with an analyst target price of $16.34, reflecting a 99.55% upside, which indicates investor confidence in its future performance.
Wall Street analysts forecast GPCR stock price to rise
15 Analyst Rating
Wall Street analysts forecast GPCR stock price to rise
15 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Current: 0.000
sliders
Low
65.00
Averages
106.50
High
140.00
Canaccord
NULL
to
Buy
initiated
$101
AI Analysis
2026-04-27
Reason
Canaccord
Price Target
$101
AI Analysis
2026-04-27
initiated
NULL
to
Buy
Reason
Canaccord initiated coverage of Structure Therapeutics with a Buy rating and $101 price target. The stock in premarket trading is up 3% to $46.90. The firm says Structure is the only company in the obesity drug development space that has a pipeline of all orally administered drugs. Structure's lead, aleniglipron, has demonstrated a "robust effect" on weight loss coupled with a more benign side effect profile than approved GLP-1 therapies, the analyst tells investors in a research note. Canaccord adds that aleniglipron is one of two "backbone strategies" Structure is pursuing to address both monotherapy and combination approaches to weight loss. It believes the company offers "optionality along with potential best-in-class efficacy."
Canaccord
Buy
initiated
$101
2026-04-27
Reason
Canaccord
Price Target
$101
2026-04-27
initiated
Buy
Reason
Canaccord initiated coverage of Structure Therapeutics with a Buy rating and $101 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for GPCR
Unlock Now

Valuation Metrics

The current forward P/E ratio for Structure Therapeutics Inc (GPCR.O) is 0.00, compared to its 5-year average forward P/E of -34.31. For a more detailed relative valuation and DCF analysis to assess Structure Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-34.31
Current PE
0.00
Overvalued PE
-20.41
Undervalued PE
-48.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.95
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-8.09

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
10382.54
Current PS
66773.14
Overvalued PS
41150.04
Undervalued PS
-20384.95

Financials

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Whales Holding GPCR

D
Driehaus Capital Management LLC
Holding
GPCR
+14.61%
3M Return
A
Avoro Capital Advisors LLC
Holding
GPCR
+14.33%
3M Return
A
Artal Group S.A.
Holding
GPCR
+14.33%
3M Return
E
EcoR1 Capital, LLC
Holding
GPCR
+13.84%
3M Return
T
TCG Crossover Management, LLC
Holding
GPCR
+10.13%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
GPCR
+9.03%
3M Return

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Frequently Asked Questions

What is Structure Therapeutics Inc (GPCR) stock price today?

The current price of GPCR is 39.1 USD — it has decreased -0.13

What is Structure Therapeutics Inc (GPCR)'s business?

Structure Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Its programs include Aleniglipron (GSBR-1290), ACCG-2671, GIP and GCG Receptor Oral Small Molecule Obesity Programs, ANPA-0073, and LTSE-2578. Its Aleniglipron is an oral and biased small molecule agonist of GLP-1R, a validated GPCR drug target for obesity. ACCG-2671 is an oral small molecule amylin receptor agonist for obesity. ANPA-0073 is a biased agonist targeting the apelin (APJ) receptor agonist. Its LTSE-2578, an Oral Small Molecule LPA1R Antagonist for IPF. It is developing an antagonist that targets lysophosphatidic acid 1 receptor (LPA1R), a GPCR implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of IPF. It is developing oral incretins for potential combination therapy with GLP-1R or amylin candidates.

What is the price predicton of GPCR Stock?

Wall Street analysts forecast GPCR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GPCR is106.50 USD with a low forecast of 65.00 USD and a high forecast of 140.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Structure Therapeutics Inc (GPCR)'s revenue for the last quarter?

Structure Therapeutics Inc revenue for the last quarter amounts to -89.38M USD, increased 58.72

What is Structure Therapeutics Inc (GPCR)'s earnings per share (EPS) for the last quarter?

Structure Therapeutics Inc. EPS for the last quarter amounts to 14052000.00 USD, decreased -126.74

How many employees does Structure Therapeutics Inc (GPCR). have?

Structure Therapeutics Inc (GPCR) has 220 emplpoyees as of May 10 2026.

What is Structure Therapeutics Inc (GPCR) market cap?

Today GPCR has the market capitalization of 2.78B USD.