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AXSM Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
188.845
Open
188.190
VWAP
184.41
Vol
717.38K
Mkt Cap
9.65B
Low
181.425
Amount
132.29M
EV/EBITDA(TTM)
--
Total Shares
51.15M
EV
9.52B
EV/OCF(TTM)
--
P/S(TTM)
14.70
Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia.
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Events Timeline

(ET)
2026-04-01
07:30:00
Axsome Acquires Exclusive Global Rights to Takeda's TAK-063
select
2026-02-24 (ET)
2026-02-24
07:40:00
Axsome Therapeutics Begins CLARITY Phase 3 Trial
select

News

NASDAQ.COM
8.5
04-08NASDAQ.COM
Axsome Therapeutics' Future Outlook Remains Uncertain
  • Strong IPO Performance: Since its IPO in 2015, Axsome Therapeutics has achieved a compound annual growth rate of 33.32%, meaning a $50,000 investment would now be worth nearly $1 million, highlighting its robust market performance and investment appeal.
  • Product Line Driving Growth: Its key product, Auvelity, saw a 66% year-over-year revenue increase in 2025, reaching $638.5 million, and is expected to expand into Alzheimer's agitation treatment, addressing the needs of over five million patients in the U.S.
  • Robust Pipeline: Axsome Therapeutics has several phase 3 assets that could target over 150 million patients, with peak sales projections exceeding $16 billion for its current lineup, indicating significant future growth potential.
  • Risks and Challenges: Despite strong performance, the company's long-term outlook remains uncertain, as it must navigate regulatory hurdles and market competition to ensure future clinical and commercial progress, necessitating cautious consideration from investors.
Fool
8.5
04-08Fool
Analysis of Axsome Therapeutics' Future Growth Potential
  • Significant Investment Returns: Since its IPO in 2015, Axsome Therapeutics has achieved a compound annual growth rate of 33.32%, meaning a $50,000 investment would now be worth nearly $1 million, highlighting its strong market performance and investment appeal.
  • Key Product Driving Growth: In 2025, Axsome's Auvelity drug saw a 66% year-over-year revenue increase to $638.5 million, with potential label expansion for agitation treatment in Alzheimer's disease, significantly broadening its market potential among over five million patients in the U.S.
  • Robust Product Pipeline: Axsome boasts multiple phase 3 assets, predicting peak sales of over $16 billion for its current lineup, targeting more than 150 million patients, indicating a promising growth trajectory ahead.
  • Risks and Challenges Ahead: Despite strong performance, Axsome has faced regulatory setbacks in the past, and future risks include potential market share erosion from newer drugs, necessitating careful evaluation of its long-term outlook by investors.
NASDAQ.COM
8.5
04-01NASDAQ.COM
Axsome Acquires Global Rights to TAK-063 from Takeda
  • Asset Purchase Agreement: Axsome Therapeutics has signed an asset purchase agreement with Takeda Pharmaceutical to acquire exclusive global rights to TAK-063 (balipodect), further expanding its leading CNS portfolio and demonstrating strategic positioning in neuropsychiatric treatment.
  • Clinical Trial Plans: Axsome intends to initiate Phase 3 trial-enabling activities for schizophrenia in 2026, indicating strong confidence in the development of balipodect and aiming to improve treatment outcomes for patients through this novel mechanism.
  • Clinical Trial Results: Balipodect has shown positive results in a 164-patient proof-of-concept Phase 2 trial for schizophrenia and has demonstrated a favorable safety and tolerability profile in clinical studies involving over 360 individuals, enhancing its market potential.
  • Financial Arrangement: Under the agreement, Axsome obtains worldwide commercial, development, and manufacturing rights to balipodect, while Takeda receives an upfront payment and is eligible for additional payments related to development, regulatory, and commercial milestones, as well as royalties on potential global net sales, ensuring mutual benefit.
NASDAQ.COM
9.0
03-30NASDAQ.COM
FDA Accelerates Biosimilar Drug Development and Approves New Treatments
  • Accelerated Biosimilar Development: On March 9, 2026, the FDA recommended streamlining unnecessary clinical pharmacokinetic studies when scientifically justified, aiming to expedite biosimilar drug development and improve medicine affordability, thereby enhancing market competitiveness.
  • Alternative to Animal Testing: The FDA released draft guidance on March 18, 2026, to assist drug developers in validating new approach methodologies as alternatives to animal testing, reflecting its commitment to scientific rigor and humane practices, which could reshape drug development standards.
  • New Therapy Approval: On March 10, 2026, the FDA approved Wellcovorin as the first treatment for cerebral folate deficiency, a rare neurological condition, marking a significant advancement in neuroscience and potentially offering new hope for patients.
  • Gene Therapy Innovation: The FDA approved Rocket Pharma's Kresladi on March 26, 2026, as the first gene therapy for Severe Leukocyte Adhesion Deficiency Type I, showcasing the potential of gene therapy in treating rare diseases and possibly driving stock price increases for related biotech companies.
Fool
8.5
03-25Fool
Summit Therapeutics Faces FDA Review Risk for Ivonescimab
  • Regulatory Application Progress: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, survival data from Western countries has not shown statistical significance, potentially jeopardizing its marketing authorization.
  • Market Valuation Changes: Currently, Summit's market cap stands at $12 billion, approximately 48% higher than Axsome and 17% higher than Madrigal, but if the FDA declines ivonescimab, the stock could face a drop of over 20%.
  • Competitor Dynamics: Axsome Therapeutics and Madrigal Pharmaceuticals reported revenue growth of 65.5% and 432% in 2025, respectively, indicating strong market potential that could see them surpass Summit in the near future.
  • Investor Risk Assessment: While Summit has long-term potential in oncology, its short-term outlook is uncertain, prompting investors to carefully evaluate risks, especially in light of possible negative clinical trial outcomes.
NASDAQ.COM
8.5
03-25NASDAQ.COM
Summit Therapeutics Faces FDA Approval Risk for Ivonescimab
  • FDA Approval Crucial: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, the drug has not shown statistically significant overall survival in Western countries, and a rejection could lead to a significant drop in stock price.
  • Intensifying Market Competition: Axsome Therapeutics and Madrigal Pharmaceuticals have market caps of $8.1 billion and $10.2 billion respectively, with both companies poised to potentially surpass Summit by 2026, highlighting the fierce competition in the biotech sector.
  • Axsome's Growth Momentum: Axsome Therapeutics reported a 65.5% revenue increase in 2025, reaching $638.5 million, and is awaiting FDA approval for its Alzheimer's drug AXS-05, which could significantly expand its market reach.
  • Madrigal's Sales Surge: Madrigal Pharmaceuticals achieved $958.4 million in sales from its Rezdiffra drug in 2025, a 432% increase from 2024, indicating strong growth potential in the metabolic dysfunction space, with expectations for continued excellent financial performance.
Wall Street analysts forecast AXSM stock price to rise
15 Analyst Rating
Wall Street analysts forecast AXSM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
UBS
Buy
maintain
$251 -> $259
AI Analysis
2026-04-10
Reason
UBS
Price Target
$251 -> $259
AI Analysis
2026-04-10
maintain
Buy
Reason
UBS raised the firm's price target on Axsome Therapeutics to $259 from $251 and keeps a Buy rating on the shares ahead of the April 30 FDA action date for Auvelity's Alzheimer's disease agitation filing. UBS has "high conviction" in Auvelity's approvability and believes the new indication could add $2bn in incremental sales. The firm believes the decision could come earlier than April 30 and expects a "clean label."
Guggenheim
Buy
maintain
$220 -> $245
2026-03-25
Reason
Guggenheim
Price Target
$220 -> $245
2026-03-25
maintain
Buy
Reason
Guggenheim raised the firm's price target on Axsome Therapeutics to $245 from $220 and keeps a Buy rating on the shares. The firm increased its view of the probability of approval in Alzheimer's Disease Agitation to 85% from 75% ahead of the upcoming April 30 PDUFA date for Axsome's AXS-05, or Auvelity, the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AXSM
Unlock Now

Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics Inc (AXSM.O) is 333.33, compared to its 5-year average forward P/E of -2.01. For a more detailed relative valuation and DCF analysis to assess Axsome Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.01
Current PE
333.33
Overvalued PE
85.98
Undervalued PE
-89.99

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-19.39
Current EV/EBITDA
-34.72
Overvalued EV/EBITDA
64.11
Undervalued EV/EBITDA
-102.88

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
1339.98
Current PS
6.25
Overvalued PS
7472.42
Undervalued PS
-4792.47

Financials

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Whales Holding AXSM

E
Edgestream Partners, L.P.
Holding
AXSM
+101.33%
3M Return
A
Algert Global LLC
Holding
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+13.28%
3M Return
P
Perceptive Advisors LLC
Holding
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+12.71%
3M Return
V
Vestal Point Capital, LP
Holding
AXSM
+12.47%
3M Return
N
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.
Holding
AXSM
+8.79%
3M Return
I
IFP Advisors, LLC
Holding
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+7.50%
3M Return

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Frequently Asked Questions

What is Axsome Therapeutics Inc (AXSM) stock price today?

The current price of AXSM is 182.97 USD — it has decreased -3.03

What is Axsome Therapeutics Inc (AXSM)'s business?

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia.

What is the price predicton of AXSM Stock?

Wall Street analysts forecast AXSM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AXSM is209.54 USD with a low forecast of 153.00 USD and a high forecast of 260.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Axsome Therapeutics Inc (AXSM)'s revenue for the last quarter?

Axsome Therapeutics Inc revenue for the last quarter amounts to 196.00M USD, increased 65.03

What is Axsome Therapeutics Inc (AXSM)'s earnings per share (EPS) for the last quarter?

Axsome Therapeutics Inc. EPS for the last quarter amounts to -0.56 USD, decreased -63.64

How many employees does Axsome Therapeutics Inc (AXSM). have?

Axsome Therapeutics Inc (AXSM) has 925 emplpoyees as of April 21 2026.

What is Axsome Therapeutics Inc (AXSM) market cap?

Today AXSM has the market capitalization of 9.65B USD.