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AXSM Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
165.160
Open
164.990
VWAP
161.09
Vol
656.79K
Mkt Cap
8.16B
Low
158.600
Amount
105.80M
EV/EBITDA(TTM)
--
Total Shares
51.15M
EV
8.38B
EV/OCF(TTM)
--
P/S(TTM)
12.96
Axsome Therapeutics, Inc. is a biopharmaceutical company. The Company is focused on the development and commercialization of medicines for people living with central nervous system (CNS) conditions. The Company's commercial products include Auvelity, Sunosi and Symbravo. It is also advancing a diversified, late-stage pipeline of product candidates for serious neurological and psychiatric conditions, which include AXS-05, AXS-12, AXS-14 and AXS-17. Auvelity (dextromethorphan-bupropion) is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder (MDD). Sunosi (solriamfetol) is an oral medication indicated for the treatment of excessive daytime sleepiness (EDS), in patients with narcolepsy or obstructive sleep apnea. Symbravo (meloxicam and rizatriptan, 20 mg/10mg tablets) is an oral, single-dose medicine approved for the acute treatment of migraine with or without aura in adults.
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Events Timeline

(ET)
2026-02-24
07:40:00
Axsome Therapeutics Begins CLARITY Phase 3 Trial
select
2026-02-23 (ET)
2026-02-23
12:00:00
Major Averages Drop Over 1% Due to Tariff Policy
select
2026-02-23
07:10:00
Axsome Believes Current Cash Sufficient to Fund Operations to Profitability
select

News

Fool
2.0
03-10Fool
Undervalued Investment Opportunities: Axsome and Madrigal
  • Axsome's Growth Potential: Axsome Therapeutics' stock has more than doubled over the past five years, primarily due to clinical and commercial progress with its leading candidate Auvelity, with new approvals and label expansions expected to significantly enhance financial performance and potentially lead to profitability in the next five years.
  • Significant Revenue Increase: In 2025, Axsome's revenue surged by 66% to $638.5 million, while its net loss per share improved to $3.68 from $5.99 in 2024, indicating strong performance in large, underserved markets.
  • Madrigal's FDA Approval: Madrigal Pharmaceuticals received FDA approval for Rezdiffra in 2024, the first drug indicated for metabolic dysfunction-associated steatohepatitis, generating $958.4 million in revenue last year, highlighting robust market demand.
  • Huge Market Demand: Madrigal targets 315,000 patients, having treated about 36,250 so far, indicating significant market potential in the MASH area, with prospects for sustained financial growth and competitive returns in the future.
NASDAQ.COM
9.5
03-10NASDAQ.COM
Axsome and Madrigal's Market Potential
  • Axsome's Growth Potential: Axsome Therapeutics' stock has more than doubled over the past five years, primarily due to clinical and commercial progress with its leading candidate Auvelity, which is expected to significantly improve financial performance through new approvals and label expansions over the next five years.
  • Significant Revenue Increase: In 2025, Axsome's revenue surged by 66% to $638.5 million, and although the net loss per share was $3.68, it showed improvement compared to the $5.99 loss per share reported in 2024, indicating potential for profitability.
  • Madrigal's Market Breakthrough: Madrigal Pharmaceuticals received FDA approval for Rezdiffra in 2024, the first drug indicated for metabolic dysfunction-associated steatohepatitis, generating $958.4 million in revenue last year solely from this product, highlighting strong market demand.
  • Unmet Medical Needs: Madrigal has treated approximately 36,250 patients, targeting 315,000, indicating a significant unmet need in the metabolic dysfunction-associated steatohepatitis space, which is likely to drive continued financial growth.
Fool
5.0
03-09Fool
Axsome Therapeutics CEO Sells Shares Amid Expiring Options
  • Insider Share Sale: Axsome Therapeutics CEO Herriot Tabuteau exercised and sold 32,410 common shares on February 2, 2026, totaling $6 million, reducing his direct holdings by 81.76% to just 7,229 shares, which may indicate a waning confidence in the company's future prospects.
  • Transaction Context: The sale was prompted by the exercise of options nearing expiration, with all shares sold immediately in the open market, indicating that Tabuteau did not engage in any new direct or indirect share grants or purchases, reflecting a cautious stance towards the market.
  • Company Financials: With a market capitalization of $8.37 billion and a 66% year-over-year growth in net product revenue for 2025, Axsome Therapeutics demonstrates strong performance in the CNS drug market, despite a net income loss of $183.2 million, attracting growth-oriented investors.
  • FDA Review Progress: The FDA has granted Priority Review for AXS-05 targeting Alzheimer's disease agitation, with a decision expected by April 30, 2026, marking a pivotal moment that could significantly impact the company's future revenue and profitability outlook.
PRnewswire
8.5
02-26PRnewswire
Helus Pharma's Psychedelic Drug Achieves Phase 3 Success
  • Clinical Trial Breakthrough: Helus Pharma's SPL026 demonstrated significant efficacy in a randomized controlled trial for treatment-resistant depression, with a MADRS score difference of -7.35 (p=0.023) among 34 participants, providing clinical proof-of-concept that could shift regulatory and investor perspectives on psychedelic applications in psychiatry.
  • Production Quota Increase: The DEA raised the 2026 psilocybin production quota by 67%, creating larger market opportunities for companies like Helus Pharma and accelerating their research and development efforts in psychedelic therapies.
  • Strong Financial Backing: As of December 31, 2025, Helus Pharma reported $195.1 million in cash, ensuring continued advancement of its multi-asset clinical pipeline, particularly for key assets like HLP003 and HLP004.
  • Optimistic Future Outlook: HLP003 has shown a 100% response rate and 71% remission rate in two pivotal Phase 3 studies, with topline data expected in Q4 2026, further solidifying Helus Pharma's market position in depression treatment.
Newsfilter
8.5
02-26Newsfilter
Helus Pharma Achieves Breakthrough in Depression Treatment
  • Clinical Trial Success: Helus Pharma's SPL026 achieved significant results in a Phase 2 trial for treatment-resistant depression, with a mean MADRS difference of -7.35 (p=0.023) among 34 participants receiving a 21.5 mg dose, indicating strong efficacy and market potential for the drug.
  • FDA Breakthrough Therapy: Helus's HLP003 has received FDA Breakthrough Therapy designation and is undergoing two pivotal Phase 3 trials, with early data showing 100% response rates and 71% remission at 12 months, potentially offering new treatment options for depression and solidifying the company's position in the psychiatric drug market.
  • Strong Financial Backing: As of December 31, 2025, Helus Pharma reported $195.1 million in cash reserves, providing robust financial support for the continued advancement of its multi-asset clinical pipeline, ensuring the company can maintain its competitive edge in a rapidly evolving market.
  • Significant Market Potential: The World Health Organization estimates that depression and anxiety cost the global economy over $1 trillion annually in lost productivity, positioning Helus Pharma's innovative drugs to meet this substantial market demand and drive future growth and investment appeal.
moomoo
6.0
02-24moomoo
UBS Increases Target Price for AXSOME THERAPEUTICS INC to $251, Up from $248
  • Company Overview: Athera Therapeutics has raised its target price to $251 from $248.
  • Market Impact: This adjustment reflects a positive outlook on the company's performance and potential growth.
Wall Street analysts forecast AXSM stock price to rise
15 Analyst Rating
Wall Street analysts forecast AXSM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
Morgan Stanley
Equal Weight
maintain
$204 -> $207
AI Analysis
2026-02-24
Reason
Morgan Stanley
Price Target
$204 -> $207
AI Analysis
2026-02-24
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Axsome Therapeutics to $207 from $204 and keeps an Equal Weight rating on the shares. After the company reported Q4 revenues in-line with the company's January pre-announcement, the next area of focus is the AXS-05 PDUFA data on April 30 as well as continued pipeline expansion, the analyst tells investors.
UBS
Buy
maintain
$248 -> $251
2026-02-24
Reason
UBS
Price Target
$248 -> $251
2026-02-24
maintain
Buy
Reason
UBS raised the firm's price target on Axsome Therapeutics to $251 from $248 and keeps a Buy rating on the shares. Axsome is seeing significant operating leverage due to the "attractive" ADA launch, despite the meaningful salesforce expansion, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AXSM
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Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics Inc (AXSM.O) is -122.77, compared to its 5-year average forward P/E of -23.47. For a more detailed relative valuation and DCF analysis to assess Axsome Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-23.47
Current PE
-122.77
Overvalued PE
-2.61
Undervalued PE
-44.33

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-18.87
Current EV/EBITDA
230.47
Overvalued EV/EBITDA
66.49
Undervalued EV/EBITDA
-104.23

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
1391.56
Current PS
10.38
Overvalued PS
7633.78
Undervalued PS
-4850.65

Financials

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Whales Holding AXSM

A
Algert Global LLC
Holding
AXSM
+19.02%
3M Return
N
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.
Holding
AXSM
+6.66%
3M Return
V
Vestal Point Capital, LP
Holding
AXSM
+6.42%
3M Return
S
Sofinnova Investment, Inc.
Holding
AXSM
+4.38%
3M Return
B
BVF Partners L.P.
Holding
AXSM
+4.20%
3M Return
P
Perceptive Advisors LLC
Holding
AXSM
+3.66%
3M Return

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Frequently Asked Questions

What is Axsome Therapeutics Inc (AXSM) stock price today?

The current price of AXSM is 159.5 USD — it has decreased -4.11

What is Axsome Therapeutics Inc (AXSM)'s business?

Axsome Therapeutics, Inc. is a biopharmaceutical company. The Company is focused on the development and commercialization of medicines for people living with central nervous system (CNS) conditions. The Company's commercial products include Auvelity, Sunosi and Symbravo. It is also advancing a diversified, late-stage pipeline of product candidates for serious neurological and psychiatric conditions, which include AXS-05, AXS-12, AXS-14 and AXS-17. Auvelity (dextromethorphan-bupropion) is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder (MDD). Sunosi (solriamfetol) is an oral medication indicated for the treatment of excessive daytime sleepiness (EDS), in patients with narcolepsy or obstructive sleep apnea. Symbravo (meloxicam and rizatriptan, 20 mg/10mg tablets) is an oral, single-dose medicine approved for the acute treatment of migraine with or without aura in adults.

What is the price predicton of AXSM Stock?

Wall Street analysts forecast AXSM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AXSM is209.54 USD with a low forecast of 153.00 USD and a high forecast of 260.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Axsome Therapeutics Inc (AXSM)'s revenue for the last quarter?

Axsome Therapeutics Inc revenue for the last quarter amounts to 196.00M USD, increased 65.03

What is Axsome Therapeutics Inc (AXSM)'s earnings per share (EPS) for the last quarter?

Axsome Therapeutics Inc. EPS for the last quarter amounts to -0.56 USD, decreased -63.64

How many employees does Axsome Therapeutics Inc (AXSM). have?

Axsome Therapeutics Inc (AXSM) has 925 emplpoyees as of March 12 2026.

What is Axsome Therapeutics Inc (AXSM) market cap?

Today AXSM has the market capitalization of 8.16B USD.