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AXSM Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
171.600
Open
160.200
VWAP
166.85
Vol
677.10K
Mkt Cap
8.65B
Low
159.920
Amount
112.97M
EV/EBITDA(TTM)
--
Total Shares
51.15M
EV
8.08B
EV/OCF(TTM)
--
P/S(TTM)
12.50
Axsome Therapeutics, Inc. is a biopharmaceutical company. The Company is focused on the development and commercialization of medicines for people living with central nervous system (CNS) conditions. The Company's commercial products include Auvelity, Sunosi and Symbravo. It is also advancing a diversified, late-stage pipeline of product candidates for serious neurological and psychiatric conditions, which include AXS-05, AXS-12, AXS-14 and AXS-17. Auvelity (dextromethorphan-bupropion) is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder (MDD). Sunosi (solriamfetol) is an oral medication indicated for the treatment of excessive daytime sleepiness (EDS), in patients with narcolepsy or obstructive sleep apnea. Symbravo (meloxicam and rizatriptan, 20 mg/10mg tablets) is an oral, single-dose medicine approved for the acute treatment of migraine with or without aura in adults.
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Events Timeline

(ET)
2026-02-24
07:40:00
Axsome Therapeutics Begins CLARITY Phase 3 Trial
select
2026-02-23 (ET)
2026-02-23
12:00:00
Major Averages Drop Over 1% Due to Tariff Policy
select

News

NASDAQ.COM
9.0
03-30NASDAQ.COM
FDA Accelerates Biosimilar Drug Development and Approves New Treatments
  • Accelerated Biosimilar Development: On March 9, 2026, the FDA recommended streamlining unnecessary clinical pharmacokinetic studies when scientifically justified, aiming to expedite biosimilar drug development and improve medicine affordability, thereby enhancing market competitiveness.
  • Alternative to Animal Testing: The FDA released draft guidance on March 18, 2026, to assist drug developers in validating new approach methodologies as alternatives to animal testing, reflecting its commitment to scientific rigor and humane practices, which could reshape drug development standards.
  • New Therapy Approval: On March 10, 2026, the FDA approved Wellcovorin as the first treatment for cerebral folate deficiency, a rare neurological condition, marking a significant advancement in neuroscience and potentially offering new hope for patients.
  • Gene Therapy Innovation: The FDA approved Rocket Pharma's Kresladi on March 26, 2026, as the first gene therapy for Severe Leukocyte Adhesion Deficiency Type I, showcasing the potential of gene therapy in treating rare diseases and possibly driving stock price increases for related biotech companies.
Fool
8.5
03-25Fool
Summit Therapeutics Faces FDA Review Risk for Ivonescimab
  • Regulatory Application Progress: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, survival data from Western countries has not shown statistical significance, potentially jeopardizing its marketing authorization.
  • Market Valuation Changes: Currently, Summit's market cap stands at $12 billion, approximately 48% higher than Axsome and 17% higher than Madrigal, but if the FDA declines ivonescimab, the stock could face a drop of over 20%.
  • Competitor Dynamics: Axsome Therapeutics and Madrigal Pharmaceuticals reported revenue growth of 65.5% and 432% in 2025, respectively, indicating strong market potential that could see them surpass Summit in the near future.
  • Investor Risk Assessment: While Summit has long-term potential in oncology, its short-term outlook is uncertain, prompting investors to carefully evaluate risks, especially in light of possible negative clinical trial outcomes.
NASDAQ.COM
8.5
03-25NASDAQ.COM
Summit Therapeutics Faces FDA Approval Risk for Ivonescimab
  • FDA Approval Crucial: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, the drug has not shown statistically significant overall survival in Western countries, and a rejection could lead to a significant drop in stock price.
  • Intensifying Market Competition: Axsome Therapeutics and Madrigal Pharmaceuticals have market caps of $8.1 billion and $10.2 billion respectively, with both companies poised to potentially surpass Summit by 2026, highlighting the fierce competition in the biotech sector.
  • Axsome's Growth Momentum: Axsome Therapeutics reported a 65.5% revenue increase in 2025, reaching $638.5 million, and is awaiting FDA approval for its Alzheimer's drug AXS-05, which could significantly expand its market reach.
  • Madrigal's Sales Surge: Madrigal Pharmaceuticals achieved $958.4 million in sales from its Rezdiffra drug in 2025, a 432% increase from 2024, indicating strong growth potential in the metabolic dysfunction space, with expectations for continued excellent financial performance.
Fool
8.5
03-18Fool
Superstring Capital Acquires Position in Axsome Therapeutics
  • New Investment Disclosure: Superstring Capital Management disclosed a new position in Axsome Therapeutics, acquiring 37,433 shares worth $6.84 million in Q4 2025, indicating strong confidence in the company's prospects.
  • Asset Allocation Shift: This acquisition represents nearly 4% of Superstring's 13F assets, highlighting Axsome's increasing significance in the portfolio and potentially influencing future investment strategies.
  • Strong Company Performance: Axsome Therapeutics boasts a market capitalization of $8.1 billion, with a 27% stock price increase over the past year, significantly outperforming the S&P 500's 19% gain, showcasing its competitive edge in the biopharmaceutical sector.
  • Diverse Product Pipeline: Axsome's portfolio includes commercial therapies for depression, migraine, and sleep disorders, which are expected to drive revenue growth, reduce financing risks, and enhance investment appeal.
Globenewswire
7.0
03-12Globenewswire
Investigation into Atkore and Others by Johnson Fistel
  • Shareholder Investigation: Johnson Fistel, PLLP is investigating whether executives at Atkore Inc. and others breached their fiduciary duties, allowing shareholders who held shares continuously since specific dates to seek corporate governance reforms.
  • Antitrust Allegations: Atkore is accused in a lawsuit of colluding with other PVC pipe manufacturers to engage in price-fixing, which artificially inflated prices and led to a significant decline in pricing once exposed, severely impacting the company's operations.
  • Lack of Transparency at Axsome: Axsome Therapeutics faces allegations of failing to disclose critical chemistry and manufacturing issues during the preparation of its New Drug Application, potentially jeopardizing its market prospects and investor confidence.
  • CTO's Financial Misrepresentation: CTO Realty Growth is accused of misleading investors about the sustainability of its dividends and using deceptive practices to inflate its financial performance, undermining investor trust in the company's future prospects.
Fool
2.0
03-10Fool
Undervalued Investment Opportunities: Axsome and Madrigal
  • Axsome's Growth Potential: Axsome Therapeutics' stock has more than doubled over the past five years, primarily due to clinical and commercial progress with its leading candidate Auvelity, with new approvals and label expansions expected to significantly enhance financial performance and potentially lead to profitability in the next five years.
  • Significant Revenue Increase: In 2025, Axsome's revenue surged by 66% to $638.5 million, while its net loss per share improved to $3.68 from $5.99 in 2024, indicating strong performance in large, underserved markets.
  • Madrigal's FDA Approval: Madrigal Pharmaceuticals received FDA approval for Rezdiffra in 2024, the first drug indicated for metabolic dysfunction-associated steatohepatitis, generating $958.4 million in revenue last year, highlighting robust market demand.
  • Huge Market Demand: Madrigal targets 315,000 patients, having treated about 36,250 so far, indicating significant market potential in the MASH area, with prospects for sustained financial growth and competitive returns in the future.
Wall Street analysts forecast AXSM stock price to rise
15 Analyst Rating
Wall Street analysts forecast AXSM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
Current: 0.000
sliders
Low
153.00
Averages
209.54
High
260.00
Guggenheim
Buy
maintain
$220 -> $245
AI Analysis
2026-03-25
Reason
Guggenheim
Price Target
$220 -> $245
AI Analysis
2026-03-25
maintain
Buy
Reason
Guggenheim raised the firm's price target on Axsome Therapeutics to $245 from $220 and keeps a Buy rating on the shares. The firm increased its view of the probability of approval in Alzheimer's Disease Agitation to 85% from 75% ahead of the upcoming April 30 PDUFA date for Axsome's AXS-05, or Auvelity, the analyst tells investors.
Morgan Stanley
Equal Weight
maintain
$204 -> $207
2026-02-24
Reason
Morgan Stanley
Price Target
$204 -> $207
2026-02-24
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Axsome Therapeutics to $207 from $204 and keeps an Equal Weight rating on the shares. After the company reported Q4 revenues in-line with the company's January pre-announcement, the next area of focus is the AXS-05 PDUFA data on April 30 as well as continued pipeline expansion, the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AXSM
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Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics Inc (AXSM.O) is 333.33, compared to its 5-year average forward P/E of -5.29. For a more detailed relative valuation and DCF analysis to assess Axsome Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.29
Current PE
333.33
Overvalued PE
78.34
Undervalued PE
-88.93

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-19.18
Current EV/EBITDA
-19.58
Overvalued EV/EBITDA
64.35
Undervalued EV/EBITDA
-102.70

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
1341.89
Current PS
5.31
Overvalued PS
7476.48
Undervalued PS
-4792.70

Financials

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Whales Holding AXSM

A
Algert Global LLC
Holding
AXSM
+15.18%
3M Return
P
Perceptive Advisors LLC
Holding
AXSM
+8.68%
3M Return
B
BVF Partners L.P.
Holding
AXSM
+6.59%
3M Return
V
Vestal Point Capital, LP
Holding
AXSM
+6.42%
3M Return
S
Sofinnova Investment, Inc.
Holding
AXSM
+4.93%
3M Return
N
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.
Holding
AXSM
+2.07%
3M Return

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Frequently Asked Questions

What is Axsome Therapeutics Inc (AXSM) stock price today?

The current price of AXSM is 169.02 USD — it has increased 5.31

What is Axsome Therapeutics Inc (AXSM)'s business?

Axsome Therapeutics, Inc. is a biopharmaceutical company. The Company is focused on the development and commercialization of medicines for people living with central nervous system (CNS) conditions. The Company's commercial products include Auvelity, Sunosi and Symbravo. It is also advancing a diversified, late-stage pipeline of product candidates for serious neurological and psychiatric conditions, which include AXS-05, AXS-12, AXS-14 and AXS-17. Auvelity (dextromethorphan-bupropion) is an oral, N-methyl-D-aspartate (NMDA) receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder (MDD). Sunosi (solriamfetol) is an oral medication indicated for the treatment of excessive daytime sleepiness (EDS), in patients with narcolepsy or obstructive sleep apnea. Symbravo (meloxicam and rizatriptan, 20 mg/10mg tablets) is an oral, single-dose medicine approved for the acute treatment of migraine with or without aura in adults.

What is the price predicton of AXSM Stock?

Wall Street analysts forecast AXSM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AXSM is209.54 USD with a low forecast of 153.00 USD and a high forecast of 260.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Axsome Therapeutics Inc (AXSM)'s revenue for the last quarter?

Axsome Therapeutics Inc revenue for the last quarter amounts to 196.00M USD, increased 65.03

What is Axsome Therapeutics Inc (AXSM)'s earnings per share (EPS) for the last quarter?

Axsome Therapeutics Inc. EPS for the last quarter amounts to -0.56 USD, decreased -63.64

How many employees does Axsome Therapeutics Inc (AXSM). have?

Axsome Therapeutics Inc (AXSM) has 925 emplpoyees as of April 01 2026.

What is Axsome Therapeutics Inc (AXSM) market cap?

Today AXSM has the market capitalization of 8.65B USD.