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AXSM Should I Buy

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Intellectia

Should You Buy Axsome Therapeutics Inc (AXSM) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Buy
Latest Price
182.970
1 Day change
-3.03%
52 Week Range
191.500
Analysis Updated At
2026/04/17
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Axsome Therapeutics Inc (AXSM) is a good buy for a beginner investor with a long-term strategy and $50,000-$100,000 available for investment. The stock has strong positive catalysts, bullish technical indicators, favorable analyst ratings with increasing price targets, and a high conviction for FDA approval of a key drug. Although the financials show a net income loss, the revenue growth and gross margin improvement indicate strong operational progress.

Technical Analysis

The technical indicators for AXSM are bullish. The MACD is above 0 and positively contracting, indicating continued upward momentum. The RSI is at 82.18, signaling overbought conditions, but this is typical for a strong uptrend. Moving averages are bullish (SMA_5 > SMA_20 > SMA_200), and the stock is trading near resistance levels (R1: 183.27, R2: 187.961), suggesting potential for further upside.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
3
Buy
9

Positive Catalysts

  • High conviction from analysts for FDA approval of AXS-05 for Alzheimer's Disease Agitation by April 30, with potential for $2 billion in incremental sales.

  • Multiple analysts have raised price targets recently, with UBS at $259, Guggenheim at $245, and others showing strong confidence in the company's growth prospects.

  • Revenue grew by 65.03% YoY in Q4 2025, and gross margin improved to 92.89%.

Neutral/Negative Catalysts

  • Net income dropped by 61.88% YoY, and EPS declined by 63.64%, reflecting ongoing losses.

  • The stock is overbought (RSI: 82.18), which could lead to short-term pullbacks.

  • No significant insider or hedge fund trading trends, and no recent congress trading data.

Financial Performance

In Q4 2025, Axsome Therapeutics reported a 65.03% YoY revenue increase to $195.99M, highlighting strong growth. However, net income dropped to -$28.56M (-61.88% YoY), and EPS fell to -0.56 (-63.64% YoY). Gross margin improved to 92.89%, up 3.45% YoY, indicating operational efficiency despite the losses.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts are overwhelmingly positive on AXSM, with multiple firms raising price targets recently. UBS has the highest target at $259, citing high conviction in FDA approval for AXS-05. Guggenheim, RBC Capital, and others also raised targets, emphasizing strong product performance, pipeline growth, and operating leverage. The consensus is a strong Buy.

Wall Street analysts forecast AXSM stock price to rise
15 Analyst Rating
Wall Street analysts forecast AXSM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 188.690
sliders
Low
153
Averages
209.54
High
260
Current: 188.690
sliders
Low
153
Averages
209.54
High
260
UBS
Buy
maintain
$251 -> $259
AI Analysis
2026-04-10
Reason
UBS
Price Target
$251 -> $259
AI Analysis
2026-04-10
maintain
Buy
Reason
UBS raised the firm's price target on Axsome Therapeutics to $259 from $251 and keeps a Buy rating on the shares ahead of the April 30 FDA action date for Auvelity's Alzheimer's disease agitation filing. UBS has "high conviction" in Auvelity's approvability and believes the new indication could add $2bn in incremental sales. The firm believes the decision could come earlier than April 30 and expects a "clean label."
Guggenheim
Buy
maintain
$220 -> $245
2026-03-25
Reason
Guggenheim
Price Target
$220 -> $245
2026-03-25
maintain
Buy
Reason
Guggenheim raised the firm's price target on Axsome Therapeutics to $245 from $220 and keeps a Buy rating on the shares. The firm increased its view of the probability of approval in Alzheimer's Disease Agitation to 85% from 75% ahead of the upcoming April 30 PDUFA date for Axsome's AXS-05, or Auvelity, the analyst tells investors.
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