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VRTX Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
444.010
Open
444.010
VWAP
440.29
Vol
789.46K
Mkt Cap
111.71B
Low
437.670
Amount
347.59M
EV/EBITDA(TTM)
21.48
Total Shares
254.36M
EV
105.21B
EV/OCF(TTM)
28.97
P/S(TTM)
9.44
Vertex Pharmaceuticals Incorporated is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases, with a focus on specialty markets. It has seven approved medicines: five that treat the underlying cause of cystic fibrosis (CF), one that treats severe sickle cell disease (SCD) and transfusion dependent beta thalassemia (TDT), and one that treats moderate-to-severe acute pain. Its pipeline includes clinical-stage programs in CF, SCD, beta thalassemia, acute and peripheral neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy and other autoimmune renal diseases and cytopenias, type 1 diabetes, myotonic dystrophy type 1, and autosomal dominant polycystic kidney disease. Its marketed medicines are TRIKAFTA/KAFTRIO (elexacaftor/tezacaftor/ivacaftor and ivacaftor), SYMDEKO/SYMKEVI (elexacaftor/tezacaftor/ivacaftor and ivacaftor), ORKAMBI (lumacaftor/ivacaftor), and KALYDECO (ivacaftor).
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Events Timeline

(ET)
2026-04-07
08:10:00
Halozyme Enters Global Exclusive Collaboration with Vertex Pharmaceuticals
select
2026-04-01 (ET)
2026-04-01
07:40:00
Vertex Pharmaceuticals' Alyftrek Approved for Expanded Use by FDA
select

News

NASDAQ.COM
7.5
04-19NASDAQ.COM
Vertex and Mirum Pharmaceuticals Market Dynamics
  • Vertex Financial Growth: Vertex Pharmaceuticals reported a record annual revenue of $12 billion in 2025, marking a 9% increase primarily driven by its dominance in cystic fibrosis (CF) therapies, with projected sales for 2026 expected to reach between $12.95 billion and $13.1 billion, solidifying its market leadership.
  • Mirum Profitability Outlook: Mirum Pharmaceuticals achieved revenue of $521.3 million in 2025, a 54% increase, with Livmarli contributing $360 million, and forecasts for 2026 sales between $630 million and $650 million, indicating strong growth potential in the rare liver disease market.
  • New Drug Development Progress: Mirum is conducting four potential registrational trials with key data expected over the next 18 months, and positive results could significantly expand its market reach, particularly in treating chronic hepatitis delta virus (HDV).
  • Acquisition Strategy: Mirum completed its $820 million acquisition of Bluejay Therapeutics in January 2023 to enhance its pipeline with breakthrough therapies, which could generate over $750 million in annual revenue if successful, further strengthening its competitive position in the market.
Fool
8.5
04-19Fool
Vertex and Mirum: Biotech Investment Opportunities
  • Mirum Revenue Growth: Mirum has successfully commercialized Livmarli, achieving $521.3 million in revenue for 2025, a 54% increase, with Livmarli contributing $360 million, up 69%, indicating strong demand in the rare liver disease market, and forecasts sales of $630 million to $650 million in 2026, further solidifying its market position.
  • Pipeline Potential: Mirum expects four potential registrational readouts over the next 18 months, particularly studies targeting chronic hepatitis delta virus; positive results could significantly expand its market coverage and enhance overall company valuation.
  • Strategic Significance of Bluejay Acquisition: Mirum's $820 million acquisition of Bluejay Therapeutics adds brelovitug, which holds Breakthrough Therapy status, targeting HDV with no current approved therapies, potentially generating over $750 million in annual revenue and enhancing market competitiveness.
  • Vertex Market Dominance: Vertex received FDA approval to expand the label for Trikafta and Alyftrek, covering 95% of U.S. cystic fibrosis patients, with 2025 revenue reaching $12 billion and expected growth to $12.95 billion to $13.1 billion in 2026, reinforcing its leadership in the biotech sector.
Yahoo Finance
6.0
04-18Yahoo Finance
Vertex Pharmaceuticals Target Price Raised to $612 by Morgan Stanley
  • Target Price Increase: Morgan Stanley raised Vertex Pharmaceuticals' price target from $596 to $612 while maintaining an Overweight rating, reflecting updates in its biopharma models and indicating strong performance ahead of the upcoming Q1 earnings report.
  • Analyst Expectations: RBC Capital Markets analyst increased VRTX's price target from $541 to $543, keeping an Outperform rating, noting that seasonal pressures in Q1 may be exacerbated by weather disruptions, although increased M&A activity could help balance these pressures.
  • Product Line Diversification: Vertex Pharmaceuticals focuses on developing medicines for serious diseases, with seven approved drugs including five for cystic fibrosis, showcasing the company's strong competitive edge and innovation in specialty markets.
  • Market Outlook Analysis: While acknowledging VRTX's investment potential, analysts suggest that certain AI stocks present greater upside potential and lower downside risk, encouraging investors to consider more attractive short-term investment opportunities.
CNBC
6.5
04-18CNBC
Vertex Pharmaceuticals Stock Performance Strong
  • Investment Recommendation: Jim Cramer highlighted Vertex Pharmaceuticals' strong stock performance, suggesting that buying early was a good decision, reflecting market confidence in its future growth and potentially attracting more investor interest.
  • Industry Challenges: Oddity Tech's performance fell short of expectations, with Cramer admitting he underestimated the industry's complexities, indicating that market confidence in the company may be waning, prompting investors to carefully assess its future potential.
  • Risk Assessment: ImmunityBio faces uncertainty, with Cramer emphasizing the need to observe how it resolves current issues, which could impact its stock price trajectory, necessitating vigilance from investors to navigate potential risks.
  • Buying Opportunity: Copart is viewed as undervalued, with Cramer suggesting it represents a good buying opportunity, likely attracting investors looking for undervalued stocks and enhancing market interest in the company.
Fool
7.5
04-16Fool
Vertex Pharmaceuticals Faces Challenges in Cystic Fibrosis Market Dominance
  • Market Dominance: Over the past decade, Vertex Pharmaceuticals has delivered market-beating returns primarily due to its monopoly in the cystic fibrosis drug market, which provides stable revenue but also exposes the company to threats from new entrants.
  • Competitive Drug Development: Krystal Biotech's KB407 gene therapy has shown promising results in phase 1 studies, targeting all cystic fibrosis patients, while Vertex's drugs only address specific mutations, potentially leading to a loss of market share for Vertex.
  • Diversification Strategy: To counter potential competition, Vertex has actively diversified its product lineup over the past three years, launching new drugs like Casgevy for sickle cell disease and Journavx for acute pain, with expectations for more approvals in the coming years.
  • Strong Financial Performance: Despite facing competitive risks, Vertex is expected to continue delivering strong financial results, with its core products protected by patents until the late 2030s, making its stock still attractive for investors.
NASDAQ.COM
7.5
04-16NASDAQ.COM
Vertex Pharmaceuticals Faces Competitive Threats
  • Market Competition Risk: Vertex Pharmaceuticals faces significant threats as companies like Krystal Biotech develop new cystic fibrosis drugs, particularly KB407, which has the potential to treat all CF patients and could lead to Vertex losing market share for 95% of U.S. patients.
  • Core Business Security: Despite the competitive landscape, Vertex's core franchise appears secure for the foreseeable future, primarily due to its monopoly in the cystic fibrosis drug market, with key products protected by patents until the late 2030s.
  • Product Diversification Strategy: Vertex is actively pursuing diversification of its product lineup, having launched new drugs like Casgevy and Journavx over the past three years, and is expected to gain additional approvals in the coming years, enhancing its competitive edge.
  • R&D Progress: Vertex recently reported strong phase 3 results for povetacicept, an investigational drug for IgA nephropathy, and plans to announce more phase 3 results by year-end, potentially leading to regulatory approvals for treatments targeting APOL1-mediated kidney disease, further solidifying its market position.
Wall Street analysts forecast VRTX stock price to rise
22 Analyst Rating
Wall Street analysts forecast VRTX stock price to rise
17 Buy
5 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
414.00
Averages
515.88
High
604.00
Current: 0.000
sliders
Low
414.00
Averages
515.88
High
604.00
Morgan Stanley
NULL
to
Overweight
maintain
$596 -> $612
AI Analysis
2026-04-10
Reason
Morgan Stanley
Price Target
$596 -> $612
AI Analysis
2026-04-10
maintain
NULL
to
Overweight
Reason
Morgan Stanley raised the firm's price target on Vertex Pharmaceuticals to $612 from $596 and keeps an Overweight rating on the shares. The firm adjusted models among its biopharma coverage for IQVIA trends as well as intra-quarter updates ahead of Q1 earnings reporting from the group.
RBC Capital
Brian Abrahams
Outperform
maintain
$541 -> $543
2026-04-07
Reason
RBC Capital
Brian Abrahams
Price Target
$541 -> $543
2026-04-07
maintain
Outperform
Reason
RBC Capital analyst Brian Abrahams raised the firm's price target on Vertex Pharmaceuticals to $543 from $541 and keeps an Outperform rating on the shares as part of the firm's broader research note previewing Q1 results in Biotech. Seasonal headwinds around gross/net, reimbursement resets, and fewer selling days may be exacerbated in Q1 by weather impact, particularly for launching and in-clinic products, but the robust return of M&A, coupled with clarity on limited tariff/Most Favored Nation drug pricing impacts, could help offset both this and broader macro volatility while keeping sector perceptions favorable, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for VRTX
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Valuation Metrics

The current forward P/E ratio for Vertex Pharmaceuticals Inc (VRTX.O) is 23.15, compared to its 5-year average forward P/E of 186.73. For a more detailed relative valuation and DCF analysis to assess Vertex Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
186.73
Current PE
23.15
Overvalued PE
780.53
Undervalued PE
-407.08

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
22.98
Current EV/EBITDA
18.88
Overvalued EV/EBITDA
46.96
Undervalued EV/EBITDA
-0.99

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
8.67
Current PS
7.84
Overvalued PS
10.12
Undervalued PS
7.22

Financials

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G
Global X Japan Co. Ltd.
Holding
VRTX
+154.55%
3M Return
O
ODDO BHF Asset Management SAS
Holding
VRTX
+73.62%
3M Return
A
Architas Multi-Manager Europe Ltd.
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VRTX
+53.95%
3M Return
V
Victory Capital Management Inc.
Holding
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+50.32%
3M Return
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Janus Henderson Group plc
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Los Angeles Capital Management LLC
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Frequently Asked Questions

What is Vertex Pharmaceuticals Inc (VRTX) stock price today?

The current price of VRTX is 439.18 USD — it has decreased -0.46

What is Vertex Pharmaceuticals Inc (VRTX)'s business?

Vertex Pharmaceuticals Incorporated is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases, with a focus on specialty markets. It has seven approved medicines: five that treat the underlying cause of cystic fibrosis (CF), one that treats severe sickle cell disease (SCD) and transfusion dependent beta thalassemia (TDT), and one that treats moderate-to-severe acute pain. Its pipeline includes clinical-stage programs in CF, SCD, beta thalassemia, acute and peripheral neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy and other autoimmune renal diseases and cytopenias, type 1 diabetes, myotonic dystrophy type 1, and autosomal dominant polycystic kidney disease. Its marketed medicines are TRIKAFTA/KAFTRIO (elexacaftor/tezacaftor/ivacaftor and ivacaftor), SYMDEKO/SYMKEVI (elexacaftor/tezacaftor/ivacaftor and ivacaftor), ORKAMBI (lumacaftor/ivacaftor), and KALYDECO (ivacaftor).

What is the price predicton of VRTX Stock?

Wall Street analysts forecast VRTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VRTX is515.88 USD with a low forecast of 414.00 USD and a high forecast of 604.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Vertex Pharmaceuticals Inc (VRTX)'s revenue for the last quarter?

Vertex Pharmaceuticals Inc revenue for the last quarter amounts to 3.19B USD, increased 9.55

What is Vertex Pharmaceuticals Inc (VRTX)'s earnings per share (EPS) for the last quarter?

Vertex Pharmaceuticals Inc. EPS for the last quarter amounts to 4.65 USD, increased 30.99

How many employees does Vertex Pharmaceuticals Inc (VRTX). have?

Vertex Pharmaceuticals Inc (VRTX) has 6400 emplpoyees as of April 21 2026.

What is Vertex Pharmaceuticals Inc (VRTX) market cap?

Today VRTX has the market capitalization of 111.71B USD.