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  3. VRTX
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VRTX

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    Overview
    Forecast
    Valuation
    Earnings
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Market Estimates

Earnings Estimates
Earnings Estimates
Revenue
YoY Chg
EPS
YoYChg
FY2025Q4
FY2026Q1
FY2026Q2
3.18B
+9.35%
5.172
+29.94%
3.14B
+13.42%
4.889
+20.41%
3.20B
+8.01%
5.000
+10.62%
Estimates Revision
The market is revising Downward the revenue expectations for Vertex Pharmaceuticals Incorporated (VRTX) for FY2025, with the revenue forecasts being adjusted by -0.05% over the past three months. During the same period, the stock price has changed by 15.22%.
Revenue Estimates for FY2025
Revise Downward
down Image
-0.05%
In Past 3 Month
EPS Estimates for FY2025
Revise Upward
up Image
+2.5%
In Past 3 Month
Stock Price
Go Up
up Image
+15.22%
In Past 3 Month
Wall Street analysts forecast VRTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VRTX is 482.53 USD with a low forecast of 401.00 USD and a high forecast of 575.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
22 Analyst Rating
Wall Street analysts forecast VRTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VRTX is 482.53 USD with a low forecast of 401.00 USD and a high forecast of 575.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
14 Buy
8 Hold
0 Sell
Moderate Buy
Current: 457.360
sliders
Low
401.00
Averages
482.53
High
575.00
Current: 457.360
sliders
Low
401.00
Averages
482.53
High
575.00
Morgan Stanley
Terence Flynn
Equal Weight -> Overweight
upgrade
$438 -> $516
2025-12-03
New
Reason
Morgan Stanley
Terence Flynn
Price Target
$438 -> $516
2025-12-03
New
upgrade
Equal Weight -> Overweight
Reason
Morgan Stanley analyst Terence Flynn upgraded Vertex Pharmaceuticals to Overweight from Equal Weight with a price target of $516, up from $438. The firm is taking a more positive stance on the company's kidney franchise pipeline, including Pove and Inaxaplin. If the drugs are successful in Phase 3, with key data coming in 2026, they will accelerate Vertex's earnings and revenue growth and drive diversification away from cystic fibrosis, the analyst tells investors in a research note.
Scotiabank
NULL -> Outperform
initiated
$495
2025-11-12
Reason
Scotiabank
Price Target
$495
2025-11-12
initiated
NULL -> Outperform
Reason
Scotiabank initiated coverage of Vertex Pharmaceuticals with an Outperform rating and $495 price target.
UBS
Buy
downgrade
$553 -> $546
2025-11-07
Reason
UBS
Price Target
$553 -> $546
2025-11-07
downgrade
Buy
Reason
UBS lowered the firm's price target on Vertex Pharmaceuticals to $546 from $553 and keeps a Buy rating on the shares.
Stifel
Hold
downgrade
$455 -> $445
2025-11-04
Reason
Stifel
Price Target
$455 -> $445
2025-11-04
downgrade
Hold
Reason
Stifel lowered the firm's price target on Vertex Pharmaceuticals to $445 from $455 and keeps a Hold rating on the shares. The commercial business appears to have a more narrow variance on a quarter-to-quarter basis, making Vertex "less of a beat-and-raise story and more one that may be dependent on pipeline for significant upside," the analyst tells investors in a post-earnings note.
RBC Capital
Sector Perform
downgrade
$423 -> $415
2025-11-04
Reason
RBC Capital
Price Target
$423 -> $415
2025-11-04
downgrade
Sector Perform
Reason
RBC Capital lowered the firm's price target on Vertex Pharmaceuticals to $415 from $423 and keeps a Sector Perform rating on the shares. Compared to Q2, the company registered a more uneventful quarter, the analyst tells investors in a research note. Vertex's cystic fibrosis, CF, franchise remains healthy, though slow launches elsewhere and increased spend underscore intrinsic limitations to operating leverage growth as the company diversifies, the analyst tells investors in a research note.
Barclays
Gena Wang
Equal Weight
maintain
$408 -> $414
2025-11-04
Reason
Barclays
Gena Wang
Price Target
$408 -> $414
2025-11-04
maintain
Equal Weight
Reason
Barclays analyst Gena Wang raised the firm's price target on Vertex Pharmaceuticals to $414 from $408 and keeps an Equal Weight rating on the shares. The company reported a slight beat in Q3 with a slight raise to the lower end of its revenue guidance, the analyst tells investors in a research note.
See All Ratings

Valuation Metrics

The current forward P/E ratio for Vertex Pharmaceuticals Inc (VRTX.O) is 22.86, compared to its 5-year average forward P/E of 186.45. For a more detailed relative valuation and DCF analysis to assess Vertex Pharmaceuticals Inc 's fair value, click here.
  • Forward PE
  • Forward EV/EBITDA
  • Forward PS

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
186.45
Current PE
22.86
Overvalued PE
780.33
Undervalued PE
-407.44

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
22.42
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
46.57
Undervalued EV/EBITDA
-1.72

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
8.64
Current PS
0.00
Overvalued PS
10.10
Undervalued PS
7.17
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Financials

Annual
Quarterly
N/A
Total Revenue
N/A
Operating Profit
N/A
Net Income after Tax
N/A
EPS - Diluted
N/A
Free Cash Flow
N/A
Gross Profit Margin - %
N/A
FCF Margin - %
N/A
Net Margin - %
N/A
ROIC

Trading Trends

  • Insider
  • Hedge Fund
  • Congress Trading
Insider
Insiders areSelling! The selling amount has increased 31294.44% over the last month.
Sold
Bought
Hedge Fund
Hedge Funds areSelling! The selling amount has increased 149.17% over the last quarter.
Sold
Bought
Congress Trading
Congress are Neutral. There are no significant trading trends over the last month.
Sold
Bought
Insider
Insiders areSelling! The selling amount has increased 31294.44% over the last month.
Sold
Bought
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VRTX News & Events

Events Timeline

(ET)
2025-12-03
16:20:00
Major US Indices Close Higher as Markets Price in Fed Rate Cut This Month
select
2025-12-03
12:30:00
Dow Jones and S&P 500 Rise as Markets Price in Fed Rate Cut This Month
select
2025-11-09 (ET)
2025-11-09
12:11:13
Vertex Pharmaceuticals reveals new findings from RUBY-3 study on povetacicept
select
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News

[object Object]
Preview
6.5
02:15 AMYahoo Finance
Analysts Believe Vertex Pharmaceuticals' Narrative is Changing Due to New Pipeline Developments and Valuation Discussions

  • Fair Value and Analyst Ratings: Vertex Pharmaceuticals' fair value estimate has increased slightly to approximately $485 per share, with various analysts providing mixed ratings; Scotiabank and Citi are bullish, while RBC Capital and Barclays express caution.

  • Pipeline Developments: The company reported promising data for its kidney disease treatments and refined its 2025 revenue guidance to $11.9B to $12.0B, driven by continued growth in cystic fibrosis and new product launches.

  • Shareholder Returns: Vertex has been actively returning capital to shareholders, completing significant share repurchase programs totaling over $3.5 billion.

  • Future Outlook: Analysts are closely monitoring Vertex's evolving narrative, including its kidney pipeline and potential challenges from competition and regulatory hurdles, as they assess long-term revenue growth and valuation.

[object Object]
Preview
2.0
12-04NASDAQ.COM
SPDR MSCI USA StrategicFactors ETF Sees Significant Withdrawal of Funds

  • QUS Share Price Analysis: QUS's share price is currently at $173.76, with a 52-week low of $137.58 and a high of $174.10, indicating a stable position near its high point.

  • Understanding ETFs: Exchange-traded funds (ETFs) function like stocks, where investors buy and sell "units" that can be created or destroyed based on demand, impacting the underlying assets.

  • Monitoring ETF Flows: Weekly monitoring of shares outstanding helps identify ETFs with significant inflows (new units created) or outflows (units destroyed), which can affect the individual components of the ETFs.

  • Disclaimer on Views: The opinions expressed in the article are those of the author and do not necessarily represent the views of Nasdaq, Inc.

[object Object]
Preview
3.0
12-04NASDAQ.COM
Key Stock Updates for Procter & Gamble, Lam Research, and Texas Instruments

  • Zacks Research Daily Highlights: Today's report features research on 16 major stocks, including Procter & Gamble, Lam Research, and Texas Instruments, along with two micro-cap stocks, SandRidge Energy and Crown Crafts, showcasing unique insights into smaller companies.

  • Procter & Gamble Performance: Despite a 14.5% decline in shares over the past year, P&G's strong portfolio and cost-saving measures are expected to support modest sales growth and significant shareholder returns, although challenges like commodity costs and macroeconomic issues persist.

  • Lam Research Growth Prospects: Lam Research has outperformed its industry with a 101% increase in shares, driven by advancements in 3D DRAM and etch technologies, although concerns about global spending on mature nodes and trade tensions remain.

  • Texas Instruments and Micro-Cap Stocks: Texas Instruments faces challenges from a slow industrial recovery but benefits from strong data center demand, while micro-cap stocks SandRidge Energy and Crown Crafts show contrasting performances, with SandRidge thriving on oil production and Crown Crafts struggling with margin pressures.

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FAQ

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What is Vertex Pharmaceuticals Inc (VRTX) stock price today?

The current price of VRTX is 457.36 USD — it has decreased -1.25 % in the last trading day.

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What is Vertex Pharmaceuticals Inc (VRTX)'s business?

Vertex Pharmaceuticals Incorporated is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases, with a focus on specialty markets. It has seven approved medicines: five that treat the underlying cause of cystic fibrosis (CF), one that treats severe sickle cell disease (SCD) and transfusion dependent beta thalassemia (TDT), and one that treats moderate-to-severe acute pain. Its pipeline includes clinical-stage programs in CF, SCD, beta thalassemia, acute and peripheral neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy and other autoimmune renal diseases and cytopenias, type 1 diabetes, myotonic dystrophy type 1, and autosomal dominant polycystic kidney disease. Its marketed medicines are TRIKAFTA/KAFTRIO (elexacaftor/tezacaftor/ivacaftor and ivacaftor), SYMDEKO/SYMKEVI (elexacaftor/tezacaftor/ivacaftor and ivacaftor), ORKAMBI (lumacaftor/ivacaftor), and KALYDECO (ivacaftor).

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What is the price predicton of VRTX Stock?

Wall Street analysts forecast VRTX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VRTX is 482.53 USD with a low forecast of 401.00 USD and a high forecast of 575.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

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What is Vertex Pharmaceuticals Inc (VRTX)'s revenue for the last quarter?

Vertex Pharmaceuticals Inc revenue for the last quarter amounts to 3.08B USD, increased 10.99 % YoY.

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What is Vertex Pharmaceuticals Inc (VRTX)'s earnings per share (EPS) for the last quarter?

Vertex Pharmaceuticals Inc. EPS for the last quarter amounts to 4.20 USD, increased 4.74 % YoY.

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What changes have occurred in the market's expectations for Vertex Pharmaceuticals Inc (VRTX)'s fundamentals?

The market is revising Downward the revenue expectations for Vertex Pharmaceuticals Incorporated (VRTX) for FY2025, with the revenue forecasts being adjusted by -0.05% over the past three months. During the same period, the stock price has changed by 15.22%.
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How many employees does Vertex Pharmaceuticals Inc (VRTX). have?

Vertex Pharmaceuticals Inc (VRTX) has 6100 emplpoyees as of December 05 2025.

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What is Vertex Pharmaceuticals Inc (VRTX) market cap?

Today VRTX has the market capitalization of 116.04B USD.

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