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AMLX Overview

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ET
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Intellectia

Loading chart...

High
15.460
Open
15.200
VWAP
14.90
Vol
1.89M
Mkt Cap
1.64B
Low
14.510
Amount
28.20M
EV/EBITDA(TTM)
--
Total Shares
111.19M
EV
1.36B
EV/OCF(TTM)
--
P/S(TTM)
--
Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company. The Company is focused on four investigational therapies across several diseases. Its lead investigational asset is avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist. Avexitide has been evaluated as a treatment for Post-Bariatric Hypoglycemia (PBH) and congenital HI, two indications characterized by hyperinsulinemic hypoglycemia. In addition to avexitide, it is advancing AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol in Wolfram syndrome, AMX0114 in amyotrophic lateral sclerosis (ALS), and AMX0318 in PBH and other rare diseases. AMX0035 is designed to mitigate neurodegeneration by targeting endoplasmic reticulum stress and mitochondrial dysfunction, two cellular processes central to neuronal cell death and neurodegeneration. AMX0114 is an investigational antisense oligonucleotide and AMX0318 is a novel GLP-1 receptor antagonist.
Show More

Events Timeline

(ET)
2026-05-07
07:10:00
Amylyx Completes LUCIDITY Trial Enrollment, Anticipates Q3 Data Release
select
2026-05-07
07:10:00
Amylyx Cash and Short-term Investments Drop to $279.8 Million
select
2026-03-24 (ET)
2026-03-24
07:10:00
Amylyx Pharmaceuticals Completes Randomization of Last Participant in Phase 3 Avexitide Trial
select
2026-03-03 (ET)
2026-03-03
08:10:00
Amylyx Files Automatic Mixed Securities Shelf
select
2026-03-03
07:40:00
Amylyx Focuses on Phase 3 Avexitide Trial in 2026
select

News

seekingalpha
9.5
05-07seekingalpha
Amylyx Pharmaceuticals Q1 2026 Earnings Call Insights
  • Clinical Trial Progress: In Q1 2026, Amylyx Pharmaceuticals randomized and dosed the last participant in the Phase III LUCIDITY trial, marking a significant milestone with top-line data expected next quarter, which will lay the groundwork for future drug commercialization.
  • Accelerated Commercial Readiness: The company is actively advancing its NDA preparations, having begun drafting relevant sections, and plans to launch avexitide in 2027, reflecting a strong commitment to market demand and positive revenue outlook.
  • Market Education Initiative: Amylyx plans to launch a disease state education campaign for PBH this summer to enhance market awareness, while strengthening marketing and commercial operations through key hires, which is expected to help the company secure a competitive position in the market.
  • Strong Financial Position: As of the end of Q4, the company reported $279.8 million in cash and marketable securities, sufficient to fund operations into 2028, despite operating expenses of $43.8 million, indicating ongoing investment in clinical development to drive avexitide's commercialization.
Newsfilter
9.5
04-30Newsfilter
Amylyx Pharmaceuticals to Report Q1 2026 Financial Results on May 7
  • Earnings Report Schedule: Amylyx Pharmaceuticals is set to release its Q1 2026 financial results on May 7, 2026, reflecting the company's ongoing commitment to transparency and investor communication.
  • Management Conference Call: The senior management team will host a conference call at 8:00 a.m. ET to discuss the financial results and other company updates, which is expected to attract significant attention from investors and analysts.
  • Participation Details: Investors can join the call by dialing +1 (888) 880-3330 for U.S. and Canada or +1 (646) 357-8766 for international participants, ensuring they call at least 10 minutes prior to the start time for smooth access.
  • Webcast and Replay: The call will be available via live audio webcast under the “Events and Presentations” section of the company’s website, with a replay accessible for 90 days post-event, enhancing investor access to information.
PRnewswire
7.0
04-10PRnewswire
Halper Sadeh LLC Investigates Amylyx Management for Fiduciary Breaches
  • Shareholder Rights Protection: Halper Sadeh LLC encourages shareholders of Amylyx Pharmaceuticals to contact the firm to discuss their rights and options, emphasizing the importance of timely action to protect shareholder interests.
  • Legal Fee Arrangement: The firm commits to handling cases on a contingent fee basis, meaning shareholders will not incur any out-of-pocket legal fees or expenses, thereby lowering the barrier for shareholder participation.
  • Corporate Governance Reforms: Long-term shareholders of Amylyx stock may have the opportunity to seek corporate governance reforms, fund returns, or court-approved financial incentive awards, aimed at enhancing transparency and accountability, ultimately increasing shareholder value.
  • Global Investor Representation: Halper Sadeh LLC represents investors worldwide, focusing on combating securities fraud and corporate misconduct, with attorneys playing a crucial role in implementing corporate reforms and recovering funds for defrauded investors, showcasing their expertise in protecting investor rights.
Newsfilter
2.0
03-24Newsfilter
Amylyx Completes Last Participant Enrollment in LUCIDITY Trial for Avexitide
  • Trial Enrollment Completion: Amylyx announced that the last participant has been randomized and dosed in the LUCIDITY trial, which enrolled a total of 78 participants, marking a significant milestone with topline data expected in Q3 2026, and a potential commercial launch of avexitide anticipated in 2027 if approved.
  • Clinical Trial Design: The LUCIDITY trial is a 16-week, multicenter, randomized, double-blind, placebo-controlled study aimed at evaluating the efficacy of avexitide in reducing Level 2 and Level 3 hypoglycemic events in adults post-Roux-en-Y gastric bypass surgery, aligning with FDA-agreed primary outcomes.
  • Early Data Support: Previous Phase 1 and Phase 2 trials demonstrated statistically significant reductions in hypoglycemic events with avexitide, indicating its potential to improve patient quality of life and address the urgent need for effective treatments in post-bariatric hypoglycemia.
  • Urgent Market Need: Post-bariatric hypoglycemia (PBH) affects approximately 8% of patients who undergo weight-loss surgery, highlighting a significant unmet medical need; the development of avexitide could not only fill this gap but also alleviate the healthcare burden associated with this chronic condition.
Yahoo Finance
8.5
03-11Yahoo Finance
Amylyx Pharmaceuticals Updates on Avexitide LUCIDITY Trial Progress
  • Trial Progress: Amylyx Pharmaceuticals' LUCIDITY trial is nearly fully enrolled and expects to release top-line results for avexitide in Q3; this 16-week randomized, placebo-controlled study aims to evaluate the drug's efficacy in treating post-bariatric hypoglycemia, highlighting the company's potential in an area lacking approved therapies.
  • Drug Mechanism and Market Need: Avexitide, as a first-in-class GLP-1 receptor antagonist, targets approximately 160,000 U.S. patients suffering from post-bariatric hypoglycemia, with prior trials demonstrating significant reductions in hypoglycemic events and supporting its FDA Breakthrough Therapy designation, underscoring its market relevance.
  • Efficacy and Data Support: In a Phase II trial, avexitide achieved a 64% reduction in hypoglycemic events at the highest tested dose, with a p-value of 0.003, showcasing its clinical effectiveness and bolstering investor confidence in the drug's potential.
  • Future Development Plans: Amylyx is also pursuing a long-acting GLP-1 receptor antagonist, AMX0318, and has reported positive signals in its Wolfram syndrome program, indicating the company's strategic commitment to expanding its product pipeline and addressing unmet medical needs.
Yahoo Finance
8.5
03-04Yahoo Finance
Amylyx Pharmaceuticals: 2026 Could Be Transformative Ahead of Avexitide Phase 3 Readout
  • Clinical Trial Progress: Amylyx Pharmaceuticals announced at TD Cowen's 46th Annual Healthcare Conference that the LUCIDITY Phase 3 trial for avexitide was initiated in 2025, with enrollment expected to complete by March 2026; positive results could support a New Drug Application in 2027, highlighting the company's potential in treating post-bariatric hypoglycemia.
  • Market Demand Analysis: Approximately 160,000 people in the U.S. currently suffer from post-bariatric hypoglycemia, with an incidence rate of about 8%, supported by over 2 million bariatric surgeries performed in the past decade, indicating a significant unmet medical need that could lay the groundwork for avexitide's market introduction.
  • Efficacy Data Support: Previous clinical studies demonstrated that avexitide achieved a 52% and 66% reduction in level 2 and level 3 hypoglycemic events, respectively, showcasing its potential to improve patient quality of life and reinforcing its status as a breakthrough therapy.
  • Future Development Plans: The company aims for avexitide commercialization in 2027 and is actively preparing the NDA submission materials, reflecting confidence in future market opportunities and responsiveness to patient needs, which is expected to positively impact the company's financial performance.
Wall Street analysts forecast AMLX stock price to rise
6 Analyst Rating
Wall Street analysts forecast AMLX stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
15.00
Averages
21.67
High
28.00
Current: 0.000
sliders
Low
15.00
Averages
21.67
High
28.00
Mizuho
Graig Suvannavejh
Outperform
maintain
$19 -> $21
AI Analysis
2026-04-28
Reason
Mizuho
Graig Suvannavejh
Price Target
$19 -> $21
AI Analysis
2026-04-28
maintain
Outperform
Reason
Mizuho analyst Graig Suvannavejh raised the firm's price target on Amylyx to $21 from $19 and keeps an Outperform rating on the shares ahead of the Q1 report. The firm reduced Amylyx's spending assumptions to reflect the company's current pipeline and timelines. It remains bullish on Amylyx's lead asset, avexitide and sees a favorable risk/reward at current share levels.
Guggenheim
Seamus Fernandez
Buy
maintain
$25 -> $30
2026-03-19
Reason
Guggenheim
Seamus Fernandez
Price Target
$25 -> $30
2026-03-19
maintain
Buy
Reason
Guggenheim analyst Seamus Fernandez raised the firm's price target on Amylyx to $30 from $25 and keeps a Buy rating on the shares based on "high confidence" in a positive LUCIDITY readout with topline data confirmed to be coming in Q3. Data from LUCIDITY could establish avexitide as the first-ever FDA approved treatment for 150,000-plus postbariatric hypoglycemia patients in the U.S., the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AMLX
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Valuation Metrics

The current forward P/E ratio for Amylyx Pharmaceuticals Inc (AMLX.O) is 2.77, compared to its 5-year average forward P/E of 0.98. For a more detailed relative valuation and DCF analysis to assess Amylyx Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
0.98
Current PE
2.77
Overvalued PE
13.88
Undervalued PE
-11.92

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
1.52
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
13.61
Undervalued EV/EBITDA
-10.56

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
1026.97
Current PS
41.99
Overvalued PS
4764.62
Undervalued PS
-2710.68

Financials

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Perceptive Advisors LLC
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3M Return
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Nantahala Capital Management, LLC
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3M Return
T
TCG Crossover Management, LLC
Holding
AMLX
+10.13%
3M Return
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Logos Global Management, L.P.
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Sofinnova Investment, Inc.
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Cormorant Asset Management, LP
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Frequently Asked Questions

What is Amylyx Pharmaceuticals Inc (AMLX) stock price today?

The current price of AMLX is 14.73 USD — it has decreased -3.09

What is Amylyx Pharmaceuticals Inc (AMLX)'s business?

Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company. The Company is focused on four investigational therapies across several diseases. Its lead investigational asset is avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist. Avexitide has been evaluated as a treatment for Post-Bariatric Hypoglycemia (PBH) and congenital HI, two indications characterized by hyperinsulinemic hypoglycemia. In addition to avexitide, it is advancing AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol in Wolfram syndrome, AMX0114 in amyotrophic lateral sclerosis (ALS), and AMX0318 in PBH and other rare diseases. AMX0035 is designed to mitigate neurodegeneration by targeting endoplasmic reticulum stress and mitochondrial dysfunction, two cellular processes central to neuronal cell death and neurodegeneration. AMX0114 is an investigational antisense oligonucleotide and AMX0318 is a novel GLP-1 receptor antagonist.

What is the price predicton of AMLX Stock?

Wall Street analysts forecast AMLX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AMLX is21.67 USD with a low forecast of 15.00 USD and a high forecast of 28.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Amylyx Pharmaceuticals Inc (AMLX)'s revenue for the last quarter?

Amylyx Pharmaceuticals Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Amylyx Pharmaceuticals Inc (AMLX)'s earnings per share (EPS) for the last quarter?

Amylyx Pharmaceuticals Inc. EPS for the last quarter amounts to -0.37 USD, decreased -11.90

How many employees does Amylyx Pharmaceuticals Inc (AMLX). have?

Amylyx Pharmaceuticals Inc (AMLX) has 136 emplpoyees as of May 11 2026.

What is Amylyx Pharmaceuticals Inc (AMLX) market cap?

Today AMLX has the market capitalization of 1.64B USD.