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AMLX Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
15.185
Open
14.310
VWAP
14.71
Vol
789.24K
Mkt Cap
1.66B
Low
13.960
Amount
11.61M
EV/EBITDA(TTM)
--
Total Shares
110.54M
EV
1.34B
EV/OCF(TTM)
--
P/S(TTM)
--
Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company. The Company is focused on three investigational therapies across several neurodegenerative and endocrine diseases. Its lead investigational asset is avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist. Avexitide has been evaluated as a treatment for Post-Bariatric Hypoglycemia (PBH) and congenital HI, two indications characterized by hyperinsulinemic hypoglycemia. In addition to avexitide, it is advancing AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol in Wolfram syndrome and progressive supranuclear palsy (PSP), and AMX0114 in amyotrophic lateral sclerosis (ALS). AMX0035 is designed to mitigate neurodegeneration by targeting endoplasmic reticulum stress and mitochondrial dysfunction, two cellular processes central to neuronal cell death and neurodegeneration. AMX0114 is an investigational antisense oligonucleotide.
Show More

Events Timeline

(ET)
2026-03-03
08:10:00
Amylyx Files Automatic Mixed Securities Shelf
select
2026-03-03
07:40:00
Amylyx Focuses on Phase 3 Avexitide Trial in 2026
select
2026-01-08 (ET)
2026-01-08
07:20:00
Amylyx Selects AMX0318 as Development Candidate for PBH
select

News

Yahoo Finance
8.5
02:04 AMYahoo Finance
PinnedAmylyx Pharmaceuticals Updates on Avexitide LUCIDITY Trial Progress
  • Trial Progress: Amylyx Pharmaceuticals' LUCIDITY trial is nearly fully enrolled and expects to release top-line results for avexitide in Q3; this 16-week randomized, placebo-controlled study aims to evaluate the drug's efficacy in treating post-bariatric hypoglycemia, highlighting the company's potential in an area lacking approved therapies.
  • Drug Mechanism and Market Need: Avexitide, as a first-in-class GLP-1 receptor antagonist, targets approximately 160,000 U.S. patients suffering from post-bariatric hypoglycemia, with prior trials demonstrating significant reductions in hypoglycemic events and supporting its FDA Breakthrough Therapy designation, underscoring its market relevance.
  • Efficacy and Data Support: In a Phase II trial, avexitide achieved a 64% reduction in hypoglycemic events at the highest tested dose, with a p-value of 0.003, showcasing its clinical effectiveness and bolstering investor confidence in the drug's potential.
  • Future Development Plans: Amylyx is also pursuing a long-acting GLP-1 receptor antagonist, AMX0318, and has reported positive signals in its Wolfram syndrome program, indicating the company's strategic commitment to expanding its product pipeline and addressing unmet medical needs.
Yahoo Finance
8.5
03-04Yahoo Finance
Amylyx Pharmaceuticals: 2026 Could Be Transformative Ahead of Avexitide Phase 3 Readout
  • Clinical Trial Progress: Amylyx Pharmaceuticals announced at TD Cowen's 46th Annual Healthcare Conference that the LUCIDITY Phase 3 trial for avexitide was initiated in 2025, with enrollment expected to complete by March 2026; positive results could support a New Drug Application in 2027, highlighting the company's potential in treating post-bariatric hypoglycemia.
  • Market Demand Analysis: Approximately 160,000 people in the U.S. currently suffer from post-bariatric hypoglycemia, with an incidence rate of about 8%, supported by over 2 million bariatric surgeries performed in the past decade, indicating a significant unmet medical need that could lay the groundwork for avexitide's market introduction.
  • Efficacy Data Support: Previous clinical studies demonstrated that avexitide achieved a 52% and 66% reduction in level 2 and level 3 hypoglycemic events, respectively, showcasing its potential to improve patient quality of life and reinforcing its status as a breakthrough therapy.
  • Future Development Plans: The company aims for avexitide commercialization in 2027 and is actively preparing the NDA submission materials, reflecting confidence in future market opportunities and responsiveness to patient needs, which is expected to positively impact the company's financial performance.
seekingalpha
9.5
03-03seekingalpha
Amylyx Pharmaceuticals Q4 2025 Earnings Call Insights
  • Pipeline Advancement: Amylyx Pharmaceuticals made significant strides in 2025 by initiating the pivotal Phase III LUCIDITY trial for avexitide targeting post-bariatric hypoglycemia and nominating AMX0318 as a development candidate, indicating a strategic focus on rare diseases.
  • Strong Financial Position: As of Q4 2025, the company reported $317 million in cash and marketable securities, down from $344 million in Q3, yet still ensuring a cash runway into 2028 to support future R&D and commercialization efforts.
  • Optimized R&D Spending: The R&D expenses for Q4 were $21.2 million, primarily reflecting increased investment in avexitide clinical development while showing a decrease compared to the same period in 2024, demonstrating effective resource allocation.
  • Clear Market Opportunity: Management highlighted that approximately 160,000 people in the U.S. suffer from post-bariatric hypoglycemia, with urgent market demand; preparations for the potential commercialization of avexitide are underway, targeting a 2027 launch to strengthen the company's market position.
NASDAQ.COM
2.0
03-03NASDAQ.COM
Amylyx (AMLX) Q4 2025 Earnings Call Transcript
seekingalpha
9.5
03-03seekingalpha
Amylyx Pharmaceuticals Q4 2025 Earnings Beat Expectations
  • Earnings Beat: Amylyx Pharmaceuticals reported a Q4 2025 GAAP EPS of -$0.30, exceeding expectations by $0.04, indicating an improvement in financial performance despite ongoing losses.
  • Cash Position: As of December 31, 2025, the company held $317.0 million in cash, cash equivalents, and short-term investments, down from $344.0 million on September 30, 2025, reflecting its cash utilization in operations.
  • Cash Runway Outlook: Based on current operating plans, Amylyx expects its cash runway to extend into 2028, providing financial stability for long-term growth and demonstrating management's confidence in future operations.
  • Increased Market Attention: With the company's presentation at the Citi Annual Global Healthcare Conference, Amylyx is gaining increased market attention, potentially paving the way for future financing and partnership opportunities.
Benzinga
6.5
03-03Benzinga
Wall Street Analysts Adjust Ratings
  • Analyst Rating Updates: Top Wall Street analysts have adjusted their ratings on several companies, including upgrades, downgrades, and initiations, reflecting the latest market perspectives and expectations for these firms.
  • Market Dynamics Overview: While specific company names are not mentioned, changes in analyst ratings typically influence investor decisions, potentially leading to price fluctuations in the related stocks.
  • Investor Considerations: For those considering buying AMLX stock, analysts' opinions will serve as a crucial reference point, potentially impacting their investment strategies and market confidence.
  • Source of Information: This information is provided by Benzinga, highlighting the significance of analyst ratings in investment decisions, although specific rating details are not disclosed.
Wall Street analysts forecast AMLX stock price to rise
6 Analyst Rating
Wall Street analysts forecast AMLX stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
15.00
Averages
21.67
High
28.00
Current: 0.000
sliders
Low
15.00
Averages
21.67
High
28.00
H.C. Wainwright
Andrew Fein
Buy
maintain
$28 -> $34
AI Analysis
2026-03-04
Reason
H.C. Wainwright
Andrew Fein
Price Target
$28 -> $34
AI Analysis
2026-03-04
maintain
Buy
Reason
H.C. Wainwright analyst Andrew Fein raised the firm's price target on Amylyx to $34 from $28 and keeps a Buy rating on the shares. Following recent engagement with institutional investors and key opinion leaders on the Phase 3 LUCIDITY trial, the firm reported all the KOLs it spoke to were "very enthusiastic" and commented on the severe unmet need for a disease modifying drug. Given its confidence in the avexitide program, the firm revisited its view of the odds of success and refined its probability-weighted success estimate to 65%from 35%, the analyst noted.
Stifel
NULL -> Buy
initiated
$21
2026-03-02
Reason
Stifel
Price Target
$21
2026-03-02
initiated
NULL -> Buy
Reason
Stifel initiated coverage of Amylyx with a Buy rating and $21 price target. The firm thinks avexitide's Phase 3 study likely works, pinning 75% odds of success on that outcome, and that post-bariatric hypoglycemia has the potential to be "a large orphan opportunity," the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AMLX
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Valuation Metrics

The current forward P/E ratio for Amylyx Pharmaceuticals Inc (AMLX.O) is -8.87, compared to its 5-year average forward P/E of 0.79. For a more detailed relative valuation and DCF analysis to assess Amylyx Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
0.79
Current PE
-8.87
Overvalued PE
14.23
Undervalued PE
-12.65

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
1.51
Current EV/EBITDA
-8.15
Overvalued EV/EBITDA
13.60
Undervalued EV/EBITDA
-10.57

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
1125.49
Current PS
12059.03
Overvalued PS
5026.85
Undervalued PS
-2775.87

Financials

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C
Commodore Capital LP
Holding
AMLX
+6.85%
3M Return
P
Perceptive Advisors LLC
Holding
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+6.14%
3M Return
S
Sofinnova Investment, Inc.
Holding
AMLX
+5.81%
3M Return
T
TCG Crossover Management, LLC
Holding
AMLX
+1.37%
3M Return
C
Cormorant Asset Management, LP
Holding
AMLX
+0.42%
3M Return
L
Logos Global Management, L.P.
Holding
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-0.20%
3M Return

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Frequently Asked Questions

What is Amylyx Pharmaceuticals Inc (AMLX) stock price today?

The current price of AMLX is 14.98 USD — it has increased 4.68

What is Amylyx Pharmaceuticals Inc (AMLX)'s business?

Amylyx Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company. The Company is focused on three investigational therapies across several neurodegenerative and endocrine diseases. Its lead investigational asset is avexitide, an investigational, first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist. Avexitide has been evaluated as a treatment for Post-Bariatric Hypoglycemia (PBH) and congenital HI, two indications characterized by hyperinsulinemic hypoglycemia. In addition to avexitide, it is advancing AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol in Wolfram syndrome and progressive supranuclear palsy (PSP), and AMX0114 in amyotrophic lateral sclerosis (ALS). AMX0035 is designed to mitigate neurodegeneration by targeting endoplasmic reticulum stress and mitochondrial dysfunction, two cellular processes central to neuronal cell death and neurodegeneration. AMX0114 is an investigational antisense oligonucleotide.

What is the price predicton of AMLX Stock?

Wall Street analysts forecast AMLX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AMLX is21.67 USD with a low forecast of 15.00 USD and a high forecast of 28.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Amylyx Pharmaceuticals Inc (AMLX)'s revenue for the last quarter?

Amylyx Pharmaceuticals Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Amylyx Pharmaceuticals Inc (AMLX)'s earnings per share (EPS) for the last quarter?

Amylyx Pharmaceuticals Inc. EPS for the last quarter amounts to -0.30 USD, decreased -45.45

How many employees does Amylyx Pharmaceuticals Inc (AMLX). have?

Amylyx Pharmaceuticals Inc (AMLX) has 136 emplpoyees as of March 11 2026.

What is Amylyx Pharmaceuticals Inc (AMLX) market cap?

Today AMLX has the market capitalization of 1.66B USD.