RedHill Biopharma's Opaganib Reduces CLL Cells by 50% in Combination with Venetoclax
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 15 2025
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Source: Newsfilter
- Efficacy Breakthrough: RedHill Biopharma's study reveals that combining Opaganib with Venetoclax reduces Chronic Lymphocytic Leukemia (CLL) cell counts by 50%, providing new treatment hope for patients resistant to Venetoclax.
- Mechanism Exploration: Research indicates that SPHK2 is overexpressed in venetoclax-resistant cancer cells, and inhibiting SPHK2 may not only reduce T-cell-induced resistance but also resensitize previously resistant cells, thereby improving treatment outcomes for patients.
- Clinical Prospects: Opaganib has demonstrated a favorable safety and tolerability profile in over 470 clinical trials, and is currently undergoing preliminary clinical trials in combination with Darolutamide, further validating its potential applications across various cancers.
- Market Potential: As a mainstay therapy for CLL, Venetoclax achieved sales of approximately $2.5 billion in 2024, and the combination therapy with Opaganib is expected to enhance its market competitiveness, addressing the urgent demand for new treatment options.
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Analyst Views on RDHL
About RDHL
RedHill Biopharma Ltd is an Israel-based specialty biopharmaceutical company primarily focused on gastrointestinal and infectious diseases. RedHill promotes the gastrointestinal drugs such as, Talicia for the treatment of Helicobacter pylori (H. pylori) infection, and Aemcolo, for the treatment of travelers’ diarrhea. RedHill’s clinical late-stage development programs include: :info: RHB-204, for pulmonary nontuberculous mycobacteria (NTM) disease; opaganib (ABC294640), host-directed, SPHK2 inhibitor targeting multiple indications, RHB-107 (upamostat), an oral, host-directed serine protease inhibitor with potential for pandemic preparedness, is in late-stage development for treatment of non-hospitalized symptomatic COVID-19, and is targeting multiple other cancer and inflammatory gastrointestinal diseases; RHB-104 for Crohn's disease; and RHB-102 for chemotherapy and radiotherapy induced nausea and vomiting.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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