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TYRA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

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High
38.860
Open
36.000
VWAP
37.63
Vol
596.37K
Mkt Cap
2.05B
Low
36.000
Amount
22.44M
EV/EBITDA(TTM)
--
Total Shares
53.87M
EV
1.72B
EV/OCF(TTM)
--
P/S(TTM)
--
Tyra Biosciences, Inc. is a clinical-stage biotechnology company focused on developing precision medicines that target large opportunities in FGFR biology. Its in-house precision medicine platform, SNAP, enables precise drug design through iterative molecular SNAPshots that help predict genetic alterations to cause acquired resistance to existing therapies. It has a differentiated pipeline with three product candidates in clinical development in targeted oncology and genetically defined conditions. Its lead precision medicine stemming from SNAP, TYRA-300, is a potential selective FGFR3 inhibitor that is designed to avoid the toxicities associated with inhibition of FGFR1, FGFR2 and FGFR4, while being agnostic for the FGFR3 gatekeeper mutations. It is also developing TYRA-200, an oral, investigational, FGFR1/2/3 inhibitor, in the SURF201 study for metastatic intrahepatic cholangiocarcinoma, and TYRA-430, an oral, investigational FGFR4/3-biased inhibitor for FGF19+/FGFR4-driven cancers.
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Events Timeline

(ET)
2026-03-02
16:30:00
TYRA CEO Emphasizes FGFR3 Importance, Plans $256M Investment
select
2026-02-27 (ET)
2026-02-27
15:50:00
Lenz Therapeutics Short Interest Rises to 44%
select

News

Fool
8.5
03-20Fool
Boone Capital Acquires New Stake in Tyra Biosciences
  • New Investment Disclosure: On February 17, 2026, Boone Capital Management disclosed its position in Tyra Biosciences, acquiring 398,482 shares worth $10.48 million, reflecting confidence in the company's growth potential.
  • Asset Management Proportion: The newly acquired shares represent 3.3% of Boone Capital's 13F reportable AUM as of December 31, 2025, indicating the firm's significant focus on Tyra within its investment portfolio.
  • Stock Performance: As of last Friday, Tyra's shares were priced at $38.67, having surged 253% over the past year, significantly outperforming the S&P 500's 16% increase during the same period, showcasing strong market optimism.
  • Financial Status Analysis: Despite a net loss nearing $120 million over the past year, Tyra maintains approximately $256 million in cash and investments, sufficient to fund operations into 2027, highlighting its ongoing development potential in the biotech sector.
NASDAQ.COM
8.5
03-20NASDAQ.COM
Boone Capital Acquires 398,482 Shares of Tyra Biosciences
  • New Investment Disclosure: Boone Capital disclosed the acquisition of 398,482 shares of Tyra Biosciences in Q4 2026, totaling $10.48 million, indicating a strategic interest in the biotech sector despite this position not being among the fund's top five holdings.
  • Financial Condition Analysis: Tyra Biosciences focuses on precision therapies for cancer and rare diseases, and while the company reported a net loss of approximately $120 million for the year, its $256 million in cash and investments is sufficient to fund operations into 2027, showcasing financial stability.
  • Clinical Strategy Focus: Tyra is narrowing its focus around a defined clinical strategy with three Phase 2 programs targeting FGFR3 biology, demonstrating discipline and foresight in the biotech field despite facing significant losses.
  • Market Performance Review: Since the end of last quarter, Tyra's shares have climbed about 47%, suggesting Boone Capital's investment may have already paid off, although the analyst team did not include Tyra in their current list of top investment stocks.
seekingalpha
9.5
03-02seekingalpha
Tyra Biosciences Q4 Earnings Report Analysis
  • Disappointing Earnings: Tyra Biosciences reported a Q4 GAAP EPS of -$0.57, missing expectations by $0.04, indicating ongoing challenges in profitability that could undermine investor confidence.
  • Net Loss Reported: The company recorded a net loss of $33.8 million, reflecting high costs in R&D and operations, which may lead to increased future financing needs and impact shareholder returns.
  • Cash Position: As of the end of the reporting period, Tyra Biosciences held $256 million in cash, cash equivalents, and marketable securities, providing a solid liquidity position, yet ongoing losses may restrict future investment and expansion capabilities.
  • Market Reaction Outlook: Given the earnings miss, investors may adopt a cautious stance towards Tyra Biosciences' future performance, potentially leading to stock price volatility and a decline in market confidence.
PRnewswire
8.5
03-02PRnewswire
Tyra Biosciences Launches 'Dabogratinib 3x3' Strategy for Blockbuster Indications
  • New Strategy Launch: Tyra Biosciences has unveiled its 'dabogratinib 3x3' strategy, aiming to conduct three late-stage clinical studies in low-grade upper tract urothelial carcinoma (LG-UTUC), intermediate-risk non-muscle invasive bladder cancer (IR NMIBC), and achondroplasia (ACH), demonstrating the company's strategic focus in precision medicine.
  • Clinical Data Progress: Interim Phase 2 data readouts for SURF302 are expected by the end of 1H 2026, with BEACH301 scheduled for 2H 2026, indicating Tyra's proactive advancement in clinical trials that may lay the groundwork for future regulatory submissions.
  • Strong Financial Position: As of Q4 2025, Tyra reported cash, cash equivalents, and marketable securities totaling $256 million, providing a runway through at least 2027, showcasing its financial resilience in supporting R&D and market expansion.
  • Significant Market Potential: By focusing on selective FGFR3 inhibition, Tyra aims to address high unmet medical needs while creating substantial long-term value, underscoring its strategic importance and competitive edge in the biotechnology sector.
PRnewswire
8.5
02-23PRnewswire
Tyra Biosciences to Present New Research at ASCO GU Conference
  • Research Presentation: Tyra Biosciences announced that two abstracts have been accepted for the 2026 ASCO GU Cancer Symposium, showcasing its latest advancements in FGFR biology, which is expected to enhance the company's reputation in precision medicine.
  • Clinical Trial Progress: One study involves ctDNA monitoring of FGFR3-altered metastatic urothelial cancer patients treated with dabogratinib (formerly TYRA-300), demonstrating the company's innovative capabilities in cancer treatment.
  • Multicenter Study: The other study is a Phase 2 multicenter, open-label trial evaluating the efficacy and safety of dabogratinib in participants with FGFR3-altered low-grade, intermediate-risk non-muscle invasive bladder cancer, further solidifying TYRA's clinical standing in oncology.
  • Future Development Potential: TYRA's oral dabogratinib, a potential first-in-class selective FGFR3 inhibitor, is undergoing multiple Phase 2 clinical studies, indicating the company's broad application prospects in FGFR-targeted therapies.
Newsfilter
8.5
02-23Newsfilter
Tyra Biosciences Presents Two Abstracts at ASCO GU Symposium
  • Abstract Presentation: Tyra Biosciences announced the acceptance of two abstracts for the 2026 ASCO GU Symposium, focusing on research related to FGFR3-altered metastatic urothelial cancer and low-grade non-muscle invasive bladder cancer, highlighting the company's advancements in FGFR biology.
  • Clinical Trial Details: The first abstract pertains to the SURF301 trial, which monitors ctDNA in patients treated with dabogratinib for FGFR3-altered metastatic urothelial cancer, while the second focuses on the SURF302 trial evaluating the efficacy and safety of dabogratinib in low-grade non-muscle invasive bladder cancer patients.
  • Conference Schedule: Both studies will be presented during the poster session on February 27, 2026, from 11:30 AM to 12:45 PM PST, enhancing Tyra's academic influence in the oncology field.
  • Future Development Directions: Dabogratinib, as a potential first-in-class selective FGFR3 inhibitor, is undergoing multiple clinical studies, showcasing Tyra's robust R&D capabilities and market potential in precision medicine.
Wall Street analysts forecast TYRA stock price to rise
5 Analyst Rating
Wall Street analysts forecast TYRA stock price to rise
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
30.00
Averages
33.75
High
37.00
Current: 0.000
sliders
Low
30.00
Averages
33.75
High
37.00
Piper Sandler
Piper Sandler
Overweight
upgrade
$42 -> $56
AI Analysis
2026-03-20
Reason
Piper Sandler
Piper Sandler
Price Target
$42 -> $56
AI Analysis
2026-03-20
upgrade
Overweight
Reason
Piper Sandler raised the firm's price target on Tyra Biosciences to $56 from $42 and keeps an Overweight rating on the shares heading into the stock's two key 2026 data events for dabogratinib. First up will be initial three months CR data in IR-NMIBC, followed by six months AHV data from the safety sentinel cohort in achondroplasia. The firm believes the efficacy bars are clearly defined and achievable. Piper knows from erdafitinib and infigratinib that FGFR3 inhibition works in these indications, and believes these readouts will show that dabo's selectivity for FGFR3 means it can hit the efficacy bars safely, with a clean safety profile that allows for chronic dosing.
Cantor Fitzgerald
Overweight
initiated
2026-02-24
Reason
Cantor Fitzgerald
Price Target
2026-02-24
initiated
Overweight
Reason
Cantor Fitzgerald initiated coverage of Tyra Biosciences with an Overweight rating. A constructive stance on Tyra shares is driven by three high-conviction Phase 2 clinical readouts for dabogratinib, a selective small-molecule FGFR3 inhibitor currently in development, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for Tyra Biosciences Inc (TYRA.O) is -12.07, compared to its 5-year average forward P/E of -8.72. For a more detailed relative valuation and DCF analysis to assess Tyra Biosciences Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-8.72
Current PE
-12.07
Overvalued PE
-4.26
Undervalued PE
-13.19

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.46
Current EV/EBITDA
-7.86
Overvalued EV/EBITDA
12.32
Undervalued EV/EBITDA
-19.23

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
Annual
Quarterly

Whales Holding TYRA

C
Commodore Capital LP
Holding
TYRA
+15.47%
3M Return
V
Vestal Point Capital, LP
Holding
TYRA
+4.43%
3M Return
K
Kynam Capital Management, LP
Holding
TYRA
+2.41%
3M Return
B
BVF Partners L.P.
Holding
TYRA
+1.16%
3M Return
T
TCG Crossover Management, LLC
Holding
TYRA
-0.62%
3M Return
R
RA Capital Management, L.P.
Holding
TYRA
-4.24%
3M Return

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Frequently Asked Questions

What is Tyra Biosciences Inc (TYRA) stock price today?

The current price of TYRA is 38.03 USD — it has increased 3.6

What is Tyra Biosciences Inc (TYRA)'s business?

Tyra Biosciences, Inc. is a clinical-stage biotechnology company focused on developing precision medicines that target large opportunities in FGFR biology. Its in-house precision medicine platform, SNAP, enables precise drug design through iterative molecular SNAPshots that help predict genetic alterations to cause acquired resistance to existing therapies. It has a differentiated pipeline with three product candidates in clinical development in targeted oncology and genetically defined conditions. Its lead precision medicine stemming from SNAP, TYRA-300, is a potential selective FGFR3 inhibitor that is designed to avoid the toxicities associated with inhibition of FGFR1, FGFR2 and FGFR4, while being agnostic for the FGFR3 gatekeeper mutations. It is also developing TYRA-200, an oral, investigational, FGFR1/2/3 inhibitor, in the SURF201 study for metastatic intrahepatic cholangiocarcinoma, and TYRA-430, an oral, investigational FGFR4/3-biased inhibitor for FGF19+/FGFR4-driven cancers.

What is the price predicton of TYRA Stock?

Wall Street analysts forecast TYRA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TYRA is33.75 USD with a low forecast of 30.00 USD and a high forecast of 37.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Tyra Biosciences Inc (TYRA)'s revenue for the last quarter?

Tyra Biosciences Inc revenue for the last quarter amounts to -36.52M USD, increased 22.77

What is Tyra Biosciences Inc (TYRA)'s earnings per share (EPS) for the last quarter?

Tyra Biosciences Inc. EPS for the last quarter amounts to -23681000.00 USD, increased 20.85

How many employees does Tyra Biosciences Inc (TYRA). have?

Tyra Biosciences Inc (TYRA) has 87 emplpoyees as of March 28 2026.

What is Tyra Biosciences Inc (TYRA) market cap?

Today TYRA has the market capitalization of 2.05B USD.