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PTGX Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
107.840
Open
105.510
VWAP
104.74
Vol
583.87K
Mkt Cap
6.62B
Low
102.700
Amount
61.15M
EV/EBITDA(TTM)
--
Total Shares
63.81M
EV
6.16B
EV/OCF(TTM)
106.78
P/S(TTM)
145.61
Protagonist Therapeutics, Inc. is a biopharmaceutical company focused on peptide therapeutics. The Company’s clinical programs fall into two categories of diseases: hematology and blood disorders, and inflammatory and immunomodulatory diseases. Its two peptides derived from its proprietary discovery technology platform, rusfertide and icotrokinra, are in advanced Phase III clinical development. Its rusfertide (PTG-300) is an injectable hepcidin mimetic in development for the potential treatment of polycythemia vera (PV) and other blood disorders. Icotrokinra, an orally delivered IL-23R specific antagonist for the potential treatment of psoriasis, psoriatic arthritis (PsA), ulcerative colitis and inflammatory bowel disease (IBD) indications. The Company also has a pre-clinical stage oral drug discovery program addressing clinically and commercially validated targets, including the IL-17 oral peptide antagonist PN-881, an oral hepcidin program, and an oral obesity program.
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Events Timeline

(ET)
2026-03-18
08:50:00
Protagonist Therapeutics Receives $50M Milestone Payment
select

News

Barron's
8.5
03-25Barron's
Johnson & Johnson Divests from 3 Biotech Companies While Retaining Investments in Potential Acquisition Candidates
  • Johnson & Johnson's Holdings Report: The company has restated its fourth-quarter holdings report, which was filed last week.

  • Exit from Biotechs: Johnson & Johnson has exited three biotech companies as part of its portfolio adjustments.

  • Retention of Stakes: Despite the exits, the company has retained its stakes in several rumored acquisition targets.

  • Strategic Moves: These actions indicate a strategic shift in Johnson & Johnson's investment approach within the biotech sector.

moomoo
5.0
03-24moomoo
Insider at Protagonist Therapeutics (PTGX.US) Plans to Sell $5.39 Million in Common Stock via Form 144
  • Stock Sale Announcement: Dinesh Patel plans to sell 54,700 shares of Protagonist Therapeutics (PTGX.US) on March 24, with a total market value of approximately $5.39 million.

  • Reduction in Holdings: Patel has reduced his shareholding in Protagonist Therapeutics by 48,273 shares since January 23, 2026, valued at around $4.06 million.

Yahoo Finance
8.5
03-22Yahoo Finance
RTW Investments Takes New Stake in Apellis Pharmaceuticals
  • New Investment Move: RTW Investments initiated a new position in Apellis Pharmaceuticals during Q4 2026, acquiring 7,666,764 shares valued at $192.59 million, indicating confidence in the biotech firm’s future prospects.
  • Market Performance Analysis: Currently priced at $17.21, Apellis shares have declined 29% over the past year, significantly underperforming the S&P 500, which has risen 15% in the same period, reflecting market caution regarding its growth trajectory.
  • Revenue and Growth Potential: Apellis generated approximately $689 million in product revenue last year, with its flagship therapy alone contributing about $587 million, demonstrating real demand and potential for market share expansion in the rare disease sector.
  • Portfolio Strategy: Apellis accounts for 1.93% of RTW's reportable AUM, suggesting a strategic pivot towards more stable revenue streams while still maintaining exposure to high-growth opportunities within its broader investment portfolio.
Yahoo Finance
8.5
03-22Yahoo Finance
RTW Investments Increases Stake in Cogent Biosciences by $116 Million
  • Stake Increase: RTW Investments disclosed an acquisition of 4,124,755 shares of Cogent Biosciences in its February 17, 2026 SEC filing, with an estimated transaction value of $115.95 million, indicating strong confidence in the company's future prospects.
  • Market Performance: Cogent Biosciences' stock has surged 360% over the past year, compared to a mere 15% gain for the S&P 500, highlighting significant market anticipation for its potential drug launches and positive investor sentiment.
  • Financial Position: Currently, Cogent has a market capitalization of $5.4 billion, and despite a net income of -$328.94 million, it boasts approximately $900 million in cash reserves, providing ample runway for R&D and clinical trials through 2028.
  • Strategic Implications: The increase in RTW's stake to 2.7% reflects confidence in high-risk biotech investments, particularly with upcoming FDA reviews, where successful clinical outcomes could further propel the stock price upward.
stocktwits
2.0
03-18stocktwits
Icotyde Receives FDA Approval, Protagonist Hits Milestone
  • FDA Approval Milestone: Icotyde has received FDA approval for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients aged 12 and older, based on four late-stage studies involving 2,500 patients that met all primary endpoints and demonstrated a favorable safety profile, which is expected to significantly enhance Protagonist's market position.
  • Milestone Payment Incentive: The FDA approval triggers a $50 million milestone payment to Protagonist, with eligibility for up to $580 million in additional regulatory and sales milestone payments, as well as tiered royalties ranging from 6% to 10% on global net sales, greatly improving the company's financial outlook.
  • Analyst Optimism: H.C. Wainwright analyst Douglas Tsao noted that the earlier-than-expected approval and
CNBC
9.0
03-18CNBC
Johnson & Johnson's Icotyde Receives FDA Approval
  • FDA Approval: Johnson & Johnson's oral medication Icotyde has received FDA approval, becoming the first oral option for treating moderate to severe plaque psoriasis, expected to serve as the first-line systemic treatment between topical and injectable therapies.
  • Significant Market Potential: J&J anticipates that Icotyde could exceed $5 billion in annual sales once approved for other autoimmune conditions, highlighting its substantial potential in the competitive psoriasis treatment market.
  • Increased Patient Acceptance: The oral formulation of Icotyde is likely to appeal to approximately 75% of the 8 million U.S. psoriasis patients who do not transition from topical treatments to injections due to needle phobia, potentially enhancing patient adherence to treatment.
  • Changing Competitive Landscape: Icotyde targets the same IL-23 receptor as J&J's Tremfya and AbbVie's Skyrizi, offering a relatively simple and safe treatment option that could alter the competitive dynamics in psoriasis treatment.
Wall Street analysts forecast PTGX stock price to rise
13 Analyst Rating
Wall Street analysts forecast PTGX stock price to rise
12 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
94.54
High
115.00
Current: 0.000
sliders
Low
65.00
Averages
94.54
High
115.00
Leerink
Faisal Khurshid
Outperform
maintain
$107 -> $110
AI Analysis
2026-03-19
Reason
Leerink
Faisal Khurshid
Price Target
$107 -> $110
AI Analysis
2026-03-19
maintain
Outperform
Reason
Leerink analyst Faisal Khurshid raised the firm's price target on Protagonist Therapeutics to $110 from $107 and keeps an Outperform rating on the shares. The firm is "impressed" with the strength of Icotyde's label and believes the approval will fund its pipeline well into the future.
Citizens
Citizens
Outperform
maintain
$112 -> $120
2026-03-19
Reason
Citizens
Citizens
Price Target
$112 -> $120
2026-03-19
maintain
Outperform
Reason
Citizens raised the firm's price target on Protagonist Therapeutics to $120 from $112 and keeps an Outperform rating on the shares. The firm says Icotyde's approval represents a "meaningful inflection point" for the psoriasis field and validates Protagonist 's peptide discovery platform.
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Valuation Metrics

The current forward P/E ratio for Protagonist Therapeutics Inc (PTGX.O) is 26.40, compared to its 5-year average forward P/E of -16.95. For a more detailed relative valuation and DCF analysis to assess Protagonist Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-16.95
Current PE
26.40
Overvalued PE
32.56
Undervalued PE
-66.45

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
19.45
Current EV/EBITDA
-13.54
Overvalued EV/EBITDA
155.26
Undervalued EV/EBITDA
-116.36

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
40.28
Current PS
43.26
Overvalued PS
68.18
Undervalued PS
12.38

Financials

AI Analysis
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Quarterly

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Whales Holding PTGX

C
Commodore Capital LP
Holding
PTGX
+22.87%
3M Return
P
Perceptive Advisors LLC
Holding
PTGX
+9.34%
3M Return
D
Driehaus Capital Management LLC
Holding
PTGX
+7.84%
3M Return
N
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.
Holding
PTGX
+4.04%
3M Return
P
Pentwater Capital Management LP
Holding
PTGX
-1.83%
3M Return
W
Woodline Partners LP
Holding
PTGX
-2.09%
3M Return

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Frequently Asked Questions

What is Protagonist Therapeutics Inc (PTGX) stock price today?

The current price of PTGX is 103.67 USD — it has decreased -1.64

What is Protagonist Therapeutics Inc (PTGX)'s business?

Protagonist Therapeutics, Inc. is a biopharmaceutical company focused on peptide therapeutics. The Company’s clinical programs fall into two categories of diseases: hematology and blood disorders, and inflammatory and immunomodulatory diseases. Its two peptides derived from its proprietary discovery technology platform, rusfertide and icotrokinra, are in advanced Phase III clinical development. Its rusfertide (PTG-300) is an injectable hepcidin mimetic in development for the potential treatment of polycythemia vera (PV) and other blood disorders. Icotrokinra, an orally delivered IL-23R specific antagonist for the potential treatment of psoriasis, psoriatic arthritis (PsA), ulcerative colitis and inflammatory bowel disease (IBD) indications. The Company also has a pre-clinical stage oral drug discovery program addressing clinically and commercially validated targets, including the IL-17 oral peptide antagonist PN-881, an oral hepcidin program, and an oral obesity program.

What is the price predicton of PTGX Stock?

Wall Street analysts forecast PTGX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PTGX is94.54 USD with a low forecast of 65.00 USD and a high forecast of 115.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Protagonist Therapeutics Inc (PTGX)'s revenue for the last quarter?

Protagonist Therapeutics Inc revenue for the last quarter amounts to 7.44M USD, decreased -95.64

What is Protagonist Therapeutics Inc (PTGX)'s earnings per share (EPS) for the last quarter?

Protagonist Therapeutics Inc. EPS for the last quarter amounts to -0.69 USD, decreased -134.85

How many employees does Protagonist Therapeutics Inc (PTGX). have?

Protagonist Therapeutics Inc (PTGX) has 132 emplpoyees as of April 01 2026.

What is Protagonist Therapeutics Inc (PTGX) market cap?

Today PTGX has the market capitalization of 6.62B USD.