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REPL Overview

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ET
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Intellectia

Loading chart...

High
10.440
Open
9.985
VWAP
10.18
Vol
2.57M
Mkt Cap
841.41M
Low
9.905
Amount
26.18M
EV/EBITDA(TTM)
--
Total Shares
82.57M
EV
644.90M
EV/OCF(TTM)
--
P/S(TTM)
--
Replimune Group, Inc. is a clinical-stage biotechnology company engaged in the development of novel oncolytic immunotherapies. Its proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor-derived antigens and altering of the tumor microenvironment to ignite a systemic response. Its lead product candidate, RP1, is a selectively replicating version of HSV-1 that expresses GALV-GP R(-) and human GM-CSF. Its lead indication for its lead product candidate, RP1, is the potential treatment of advanced melanoma. Its pipeline product candidates include RP2 and RP3. It has designed its RP2 product candidate to express an anti-CTLA-4 antibody-like protein intended to block the inhibition of the immune response.
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Events Timeline

(ET)
2026-06-04
14:20:00
FDA Pledges to Prevent Political Interference in Meeting with Rare Disease Nonprofits
select
link
2026-06-02 (ET)
2026-06-02
09:50:00
FDA Issues Draft Guidance for Gene Therapies
select
link
2026-06-01 (ET)
2026-06-01
09:40:00
Replimune Group Trading Halted Due to Volatility
select
2026-05-31 (ET)
2026-05-31
17:20:00
Replimune RP2 Clinical Trial Data Receives Positive Feedback
select
2026-05-31
16:40:00
Replimune Presents 3-Year Survival Data for RP1 Plus Nivolumab
select
2026-05-29 (ET)
2026-05-29
17:00:00
Dell's Strong Earnings Propel Tech Stocks Higher
select

News

CNBC
9.0
06-17CNBC
UniQure to Seek FDA Approval for Huntington's Gene Therapy
  • New FDA Guidance: UniQure learned in a recent meeting that a three-year analysis from a Phase 1/2 study would support accelerated approval for its Huntington's disease gene therapy, marking a significant turnaround after previous criticisms.
  • Clinical Data Reversal: Although the FDA previously indicated that UniQure's clinical trial data was insufficient for application support, the new guidance reflects a shift in FDA policy, potentially bringing renewed hope for rare disease drug development.
  • Strong Market Reaction: Following the announcement, UniQure's shares surged 70%, indicating investor optimism about the company's future prospects, especially with FDA backing, which could rapidly increase demand for its gene therapy.
  • Commitment to Further Research: UniQure has pledged to align with the FDA on study design before submitting its application, including comparing the treatment to current standard care, ensuring the therapy's efficacy and laying the groundwork for future market introduction.
Newsfilter
8.5
06-17Newsfilter
UniQure to Seek Approval for Huntington's Gene Therapy
  • FDA Approval Guidance: UniQure plans to submit its application for Huntington's gene therapy to the FDA in Q3, following a meeting where the FDA indicated that a three-year analysis from a Phase 1/2 study would support accelerated approval, marking a significant shift in regulatory stance.
  • Clinical Trial Data Controversy: Despite previous criticisms from former FDA leaders regarding UniQure's clinical trial data, the therapy demonstrated a 75% reduction in disease progression in a Phase 1/2 trial, suggesting its efficacy warrants further validation.
  • Stock Surge: Following the announcement of its application plans, UniQure's shares soared 70% on Wednesday, reflecting market optimism about the therapy's prospects and investor confidence in the new FDA guidance.
  • Future Research Commitment: UniQure is committed to conducting a controlled study comparing its treatment to the current standard of care, with plans to finalize the study design before submitting its application to ensure compliance with FDA requirements.
stocktwits
9.5
06-01stocktwits
Replimune's Cancer Immunotherapy Shows Promising Early Data
  • Tumor Shrinkage Observed: Replimune noted tumor shrinkage in both injected and non-injected lesions during the RP2 trial, indicating that RP2 can trigger a systemic anti-tumor immune response, thus providing new treatment hope for patients.
  • Impressive Efficacy Data: The response rate for RP2 alone was 19%, while the combination with Nivolumab achieved a 19.1% response rate, with nearly 49% of patients maintaining disease control, showcasing the therapy's potential in treating advanced tumors.
  • FDA Review Priority: The FDA has decided to prioritize the review of Replimune's application, citing a lack of treatment options for patients with advanced melanoma, reigniting market confidence after two previous rejections.
  • Earnings Forecast and Market Reaction: Although a fourth-quarter loss of $0.72 per share is expected, slightly better than last year's $0.82, Replimune's stock surged 13% in pre-market trading, reflecting investor optimism about the company's future performance.
NASDAQ.COM
8.5
06-01NASDAQ.COM
Replimune Receives FDA Support for BLA Resubmission
  • BLA Resubmission Progress: Replimune Group Inc. announced an agreement with the FDA to resubmit its Biologics License Application (BLA) for RP1 in advanced melanoma within days, which is expected to boost the company's stock price and enhance market confidence.
  • Patent Filing Success: Clearmind Medicine Inc. successfully filed a patent in Japan for its 5-Methoxy-2-aminoindan (MEAI) aimed at treating depression, strengthening its global intellectual property portfolio and potentially laying the groundwork for future market expansion.
  • Clinical Data Update: C4 Therapeutics Inc. is set to present updated clinical data on Cemsidomide on June 12, 2026, which is anticipated to positively impact its application in treating multiple myeloma, further increasing investor interest in the company.
  • Optimistic Financial Outlook: Alpha Teknova Inc. reported total revenue of $11.1 million for Q1 2026, a 13% increase year-over-year, and expects full-year revenue to range between $42 million and $44 million, indicating strong growth potential in the bioreagent market.
Newsfilter
2.0
05-31Newsfilter
Replimune Presents Final Data for RP2 Oncolytic Therapy
  • Clinical Trial Results: At the 2026 American Society of Clinical Oncology annual meeting, Replimune presented final Phase 1 data for RP2 alone and in combination with nivolumab, showing a 19.0% objective response rate in 85 heavily pretreated patients with advanced solid tumors, indicating its potential in treating late-stage cancers.
  • Combination Therapy Efficacy: The combination of RP2 with nivolumab achieved a 19.1% objective response rate and a disease control rate of 48.9%, highlighting the clinical significance of this combination in improving patient survival, particularly in uveal melanoma patients.
  • Good Tolerability: Both RP2 monotherapy and its combination with nivolumab demonstrated good tolerability with no unexpected toxicities and no Grade 4 or 5 treatment-related adverse events, indicating a safety advantage for this therapy.
  • Immune Response Mechanism: The study revealed that RP2 reprograms the tumor microenvironment from
NASDAQ.COM
9.0
05-30NASDAQ.COM
Replimune Reports Landmark Three-Year Survival Data
  • Clinical Trial Results: Replimune presented three-year survival data from its IGNYTE trial at the 2026 ASCO annual meeting, revealing that nearly half of treated patients were alive at three years, underscoring the durability and effectiveness of the treatment.
  • Survival and Response Rates: The combination therapy achieved a median overall survival of 32.9 months, with an objective response rate of 33.6% and a median duration of response of 24.8 months, indicating that almost 45% of responders maintained their response at three years, showcasing broad applicability among patients.
  • Safety Profile Analysis: The regimen demonstrated consistent survival benefits across key patient subgroups and maintained a favorable safety profile, primarily consisting of Grade 1-2 side effects with no new safety signals, further enhancing its clinical application potential.
  • Company Development Strategy: Founded in 2015, Replimune is advancing its RPx platform to develop versatile oncolytic immunotherapies that can be used alone or in combination with other treatments, marking significant innovation progress in the field of cancer therapy.
Wall Street analysts forecast REPL stock price to rise
7 Analyst Rating
Wall Street analysts forecast REPL stock price to rise
4 Buy
3 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
3.00
Averages
11.43
High
18.00
Current: 0.000
sliders
Low
3.00
Averages
11.43
High
18.00
Wedbush
Neutral
maintain
$2 -> $6
AI Analysis
2026-06-01
Reason
Wedbush
Price Target
$2 -> $6
AI Analysis
2026-06-01
maintain
Neutral
Reason
Wedbush raised the firm's price target on Replimune to $6 from $2 and keeps a Neutral rating on the shares. The firm notes the company announced resubmission and reconsideration for the Biologics License Application for RP1 plus nivolumab in advanced melanoma following discussion with the FDA. As a reminder, this is the third BLA submission for Replimune, following the original Complete Response Letter last year citing lack of confidence in the IGNYTE trial in establishing substantial evidence of efficacy, the company resubmitted the BLA, with denial once again coming in April following what Wedbush can best describe as "a clown show by the FDA." The firm continues to believe the RP1/nivo profile is fit for approval.
JPMorgan
Underweight
to
Neutral
upgrade
$8
2026-05-29
Reason
JPMorgan
Price Target
$8
2026-05-29
upgrade
Underweight
to
Neutral
Reason
JPMorgan upgraded Replimune to Neutral from Underweight with an $8 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for REPL
Unlock Now

Valuation Metrics

The current forward P/E ratio for Replimune Group Inc (REPL.O) is 0.00, compared to its 5-year average forward P/E of -5.73. For a more detailed relative valuation and DCF analysis to assess Replimune Group Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.73
Current PE
0.00
Overvalued PE
-2.18
Undervalued PE
-9.29

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.54
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.75
Undervalued EV/EBITDA
-3.83

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
12.15
Current PS
128.30
Overvalued PS
43.32
Undervalued PS
-19.03

Financials

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C
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3M Return
B
Baker Bros. Advisors LP
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Redmile Group, LLC
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Frequently Asked Questions

What is Replimune Group Inc (REPL) stock price today?

The current price of REPL is 10.19 USD — it has increased 1.9

What is Replimune Group Inc (REPL)'s business?

Replimune Group, Inc. is a clinical-stage biotechnology company engaged in the development of novel oncolytic immunotherapies. Its proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor-derived antigens and altering of the tumor microenvironment to ignite a systemic response. Its lead product candidate, RP1, is a selectively replicating version of HSV-1 that expresses GALV-GP R(-) and human GM-CSF. Its lead indication for its lead product candidate, RP1, is the potential treatment of advanced melanoma. Its pipeline product candidates include RP2 and RP3. It has designed its RP2 product candidate to express an anti-CTLA-4 antibody-like protein intended to block the inhibition of the immune response.

What is the price predicton of REPL Stock?

Wall Street analysts forecast REPL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for REPL is11.43 USD with a low forecast of 3.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Replimune Group Inc (REPL)'s revenue for the last quarter?

Replimune Group Inc revenue for the last quarter amounts to -71.87M USD, increased 8.86

What is Replimune Group Inc (REPL)'s earnings per share (EPS) for the last quarter?

Replimune Group Inc. EPS for the last quarter amounts to -66090000.00 USD, increased 25.85

How many employees does Replimune Group Inc (REPL). have?

Replimune Group Inc (REPL) has 479 emplpoyees as of June 20 2026.

What is Replimune Group Inc (REPL) market cap?

Today REPL has the market capitalization of 841.41M USD.