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REPL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
2.190
Open
2.170
VWAP
2.10
Vol
3.95M
Mkt Cap
179.18M
Low
2.030
Amount
8.29M
EV/EBITDA(TTM)
--
Total Shares
82.57M
EV
-17.34M
EV/OCF(TTM)
--
P/S(TTM)
--
Replimune Group, Inc. is a clinical-stage biotechnology company engaged in the development of novel oncolytic immunotherapies. Its proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor-derived antigens and altering of the tumor microenvironment to ignite a systemic response. Its lead product candidate, RP1, is a selectively replicating version of HSV-1 that expresses GALV-GP R(-) and human GM-CSF. Its lead indication for its lead product candidate, RP1, is the potential treatment of advanced melanoma. Its pipeline product candidates include RP2 and RP3. It has designed its RP2 product candidate to express an anti-CTLA-4 antibody-like protein intended to block the inhibition of the immune response.
Show More

Events Timeline

(ET)
2026-04-10
17:10:00
Replimune Receives Complete Response Letter from FDA
select

News

stocktwits
7.0
04-14stocktwits
REPL Faces Pressure After FDA Issues Second Complete Response Letter
  • Regulatory Pressure on REPL: REPL's stock plummeted 64% after the FDA issued a second Complete Response Letter (CRL) for its lead drug RP1 in combination with nivolumab for anti-PD-1-failed melanoma, highlighting a lack of alignment with the FDA and prompting widespread analyst downgrades across Wall Street.
  • HOTH Financing Impact: HOTH's stock declined 1% following the announcement of a $2 million stock offering priced at $0.70 per share, overshadowing positive pipeline updates for its HT-001 therapy, which showed significant efficacy in treating skin toxicities, indicating market concerns over dilution.
  • ONCO's Stock Slide: ONCO's shares fell 27% after implementing a 1-for-5 reverse stock split to comply with Nasdaq's minimum bid price requirement, despite ongoing efforts to acquire Realbotix in an all-stock deal, reflecting investor anxiety over compliance pressures.
  • Retail Investor Sentiment: Retail sentiment on Stocktwits showed REPL as 'bearish' while HOTH and ONCO were 'extremely bullish', indicating a divergence in market sentiment despite all three stocks underperforming the broader XLV ETF over the past year, with declines of 77%, 36%, and 97% respectively.
Newsfilter
9.0
04-13Newsfilter
Replimune Faces FDA CRL for RP1 Melanoma Therapy Amid Analyst Downgrades
  • FDA Rejection Impact: Replimune's RP1 melanoma therapy received a Complete Response Letter (CRL) from the FDA, indicating significant hurdles in obtaining market approval, which could lead to a decline in future revenue expectations for the company.
  • Analyst Downgrades: Following the FDA rejection, analysts have sharply cut their ratings and price targets for Replimune, reflecting a pessimistic sentiment regarding the company's future prospects, which may further undermine investor confidence.
  • Review Process Dispute: Replimune has disputed the FDA's review process, claiming unfairness, which could lead to further communications with the regulatory body and impact the company's future approval strategies.
  • Negative Market Reaction: The combination of the FDA rejection and negative analyst feedback may put pressure on Replimune's stock price, prompting investors to closely monitor how the company addresses this challenge to restore market confidence.
seekingalpha
9.5
04-13seekingalpha
Replimune Shares Hit All-Time Low After FDA Rejection
  • FDA Rejection: Replimune's melanoma drug RP1 received a Complete Response Letter from the FDA on April 10, causing shares to plummet to an all-time low of $1.50 on Monday, reflecting a negative market sentiment towards the company's future prospects.
  • Analyst Downgrades: J.P. Morgan, BMO Capital Markets, and Wedbush have all downgraded Replimune, with BMO's Evan David Seigerman setting a price target of $1, indicating a lack of confidence in RP1's potential for approval.
  • Clinical Trial Uncertainty: Analysts noted that the FDA expressed concerns regarding Replimune's BLA resubmission, particularly criticizing the single-arm trial design and efficacy assessment methods used in the RPL-001-16 trial, which raises the risk of RP1's future approval.
  • Severe Market Reaction: Following the FDA's rejection, Replimune's stock fell by 56% on Monday, demonstrating a significant loss of investor confidence that could adversely affect the company's financing and research capabilities.
Fool
8.0
04-13Fool
Trump Threatens 50% Tariff on China Amid Trade Tensions
  • Tariff Threat Escalation: President Trump threatened a staggering 50% tariff on China during a Fox News interview, which could significantly impact multinational companies like Apple that rely heavily on Chinese supply chains, further escalating trade tensions.
  • Increased Economic Risks: This tariff threat not only poses operational challenges for global retail giants like Nike but also raises investor concerns about the economic repercussions of the ongoing Middle East conflict, adding layers of uncertainty to the market.
  • Market Reaction: Although Trump labeled the underlying reports as potentially 'fake news', the market's reaction indicates a heightened sensitivity among investors regarding future trade relations, which could lead to increased volatility in stock prices.
  • Geopolitical Implications: Against the backdrop of rising tensions in the Middle East, Trump's tariff threat introduces new risks to the global economy, potentially affecting U.S.-China diplomatic relations and their competitiveness in international markets.
stocktwits
9.5
04-13stocktwits
Replimune's RP-1 Faces Second FDA Rejection, Shares Plunge
  • FDA Rejection Impact: The FDA's second rejection of Replimune's melanoma treatment RP-1 has led to a staggering 60% drop in pre-market trading, pushing the stock to a record low and highlighting significant regulatory hurdles threatening the company's future.
  • Analyst Downgrade: Jefferies downgraded Replimune from 'Buy' to 'Hold' and slashed its price target to $2 from $13, a nearly 85% reduction, indicating a pessimistic outlook on the company's path forward following the FDA's decision.
  • Job Cuts Risk: Following the FDA's rejection, Replimune warned of potential operational cutbacks and job losses, reflecting the severe financial challenges the company faces amid increasing uncertainty surrounding RP-1's development.
  • Market Sentiment Fluctuation: Despite the sharp decline in stock price, retail investor sentiment on Stocktwits remains 'extremely bullish', with message volumes surging over 2000% in the past 24 hours, indicating continued interest in Replimune despite the negative news.
seekingalpha
2.0
04-13seekingalpha
U.S. Stock Futures Drop as Oil Prices Surge Above $100 Amid Iran Tensions
  • Market Reaction to Tensions: U.S. stock futures fell Monday morning as investors reacted to the breakdown in peace talks between the U.S. and Iran, indicating heightened sensitivity to geopolitical risks in the market.
  • Oil Price Surge: President Trump’s threat of a military blockade in the Strait of Hormuz quickly pushed oil prices back above $100 a barrel, a level that could have widespread implications for the global economy.
  • Baker Hughes Stock Rise: Baker Hughes (BKR) shares rose by 2% after agreeing to sell its Waygate Technologies unit to Hexagon AB for approximately $1.45 billion in cash, a strategic move aimed at streamlining its portfolio and enhancing earnings stability.
  • Children's Place Stock Plunge: Children's Place (PLCE) shares tumbled 16% following a disappointing Q4 marked by a 19.4% year-over-year sales decline to $329 million, reflecting ongoing challenges with weak e-commerce traffic and reduced consumer demand.
Wall Street analysts forecast REPL stock price to rise
7 Analyst Rating
Wall Street analysts forecast REPL stock price to rise
4 Buy
3 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
3.00
Averages
11.43
High
18.00
Current: 0.000
sliders
Low
3.00
Averages
11.43
High
18.00
Wedbush
Outperform
to
Neutral
downgrade
$19 -> $2
AI Analysis
2026-04-13
Reason
Wedbush
Price Target
$19 -> $2
AI Analysis
2026-04-13
downgrade
Outperform
to
Neutral
Reason
Wedbush downgraded Replimune to Neutral from Outperform with a price target of $2, down from $19, after the FDA issued a second complete response letter for the company's BLA for RP1 in combination with nivolumab in PD-1 refractory melanoma. Overall, Wedbush views the additional CRL as disappointing given what it viewed as convincing treatment effect in a patient population with significant unmet need.
Leerink
Jonathan Chang
Outperform
to
Market Perform
downgrade
$11 -> $2
2026-04-13
Reason
Leerink
Jonathan Chang
Price Target
$11 -> $2
2026-04-13
downgrade
Outperform
to
Market Perform
Reason
Leerink analyst Jonathan Chang downgraded Replimune to Market Perform from Outperform with a price target of $2, down from $11. The FDA has issued a Complete Response Letter regarding the Biologics License Application resubmission for RP1 plus nivolumab in anti-PD-1-failed melanoma. The firm caught up with Replimune's management, who were deeply disappointed by the FDA's decision, and pointed out inconsistencies in regulatory feedback. Overall, Leerink views the CRL as a negative for its thesis and says it is removing the RP1 melanoma opportunity from its valuation.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for REPL
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Valuation Metrics

The current forward P/E ratio for Replimune Group Inc (REPL.O) is 0.00, compared to its 5-year average forward P/E of -6.09. For a more detailed relative valuation and DCF analysis to assess Replimune Group Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.09
Current PE
0.00
Overvalued PE
-2.15
Undervalued PE
-10.02

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.83
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.89
Undervalued EV/EBITDA
-4.54

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
8.51
Current PS
57.64
Overvalued PS
33.82
Undervalued PS
-16.80

Financials

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Frequently Asked Questions

What is Replimune Group Inc (REPL) stock price today?

The current price of REPL is 2.08 USD — it has decreased -4.15

What is Replimune Group Inc (REPL)'s business?

Replimune Group, Inc. is a clinical-stage biotechnology company engaged in the development of novel oncolytic immunotherapies. Its proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor-derived antigens and altering of the tumor microenvironment to ignite a systemic response. Its lead product candidate, RP1, is a selectively replicating version of HSV-1 that expresses GALV-GP R(-) and human GM-CSF. Its lead indication for its lead product candidate, RP1, is the potential treatment of advanced melanoma. Its pipeline product candidates include RP2 and RP3. It has designed its RP2 product candidate to express an anti-CTLA-4 antibody-like protein intended to block the inhibition of the immune response.

What is the price predicton of REPL Stock?

Wall Street analysts forecast REPL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for REPL is11.43 USD with a low forecast of 3.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Replimune Group Inc (REPL)'s revenue for the last quarter?

Replimune Group Inc revenue for the last quarter amounts to -71.87M USD, increased 8.86

What is Replimune Group Inc (REPL)'s earnings per share (EPS) for the last quarter?

Replimune Group Inc. EPS for the last quarter amounts to -66090000.00 USD, increased 25.85

How many employees does Replimune Group Inc (REPL). have?

Replimune Group Inc (REPL) has 479 emplpoyees as of April 21 2026.

What is Replimune Group Inc (REPL) market cap?

Today REPL has the market capitalization of 179.18M USD.