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ONC Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
274.550
Open
270.200
VWAP
269.91
Vol
367.88K
Mkt Cap
32.03B
Low
265.020
Amount
99.30M
EV/EBITDA(TTM)
47.71
Total Shares
118.57M
EV
202.16B
EV/OCF(TTM)
14.74
P/S(TTM)
8.51
BeOne Medicines AG, formerly BeiGene, Ltd., is a global oncology company engaged in discovering and developing treatments for cancer patients worldwide. With a portfolio spanning hematology and solid tumors, the Company is engaged in the development of its diverse pipeline of novel therapeutics. Its products include Brukinsa, Tevimbra and Pamiparib. Brukinsa is an orally available, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). Tevimbra is a humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is designed to minimize binding to Fc-gamma (Fcy) receptors on macrophages, helping the body’s immune cells detect and fight tumors. The Company’s product pipeline in development includes Sonrotoclax, Tarlatamab, Zanidatamab, Blinatumomab, BGB-26808, BGB-R046, BG-68501, BG-C9074, BGB-43395, Xaluritamig, and others.
Show More

Events Timeline

(ET)
2026-06-11
08:00:00
BeOne Medicines Presents Phase 3 Data for CLL in Elderly Patients
select
2026-05-27 (ET)
2026-05-27
17:10:00
BeOne Medicines Announces HERIZON-GEA-01 Trial Data
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2026-05-13 (ET)
2026-05-13
13:30:00
BeOne Medicines Receives FDA Accelerated Approval for Beqalzi to Treat Lymphoma
select
2026-05-06 (ET)
2026-05-06
06:30:00
BeOne Sets 2026 Total Revenue Guidance at $6.3B to $6.5B
select
2026-05-06
06:30:00
BeOne Q1 Revenue Hits $1.51B, Exceeds Expectations
select

News

Newsfilter
9.0
06-12Newsfilter
BeOne's Drug Shows Durable Efficacy in Chronic Lymphocytic Leukemia
  • Significant Efficacy: Tacabrutideg demonstrated an overall response rate of 85.1% in heavily pretreated relapsed/refractory chronic lymphocytic leukemia (CLL) patients, with early activity also observed in BTK inhibitor-naïve patients, indicating its potential for earlier lines of treatment.
  • Good Safety Profile: In a study of 67 patients, tacabrutideg was generally well tolerated with no treatment-related deaths and no new toxicities identified, leading to rapid and sustained improvements in cytopenia, significantly enhancing patients' quality of life.
  • Combination Therapy Potential: The combination of BRUKINSA and sonrotoclax showed deep and durable responses in both treatment-naïve and relapsed/refractory settings, particularly in treatment-naïve CLL where a 100% overall response rate and 59.5% complete response rate were achieved, highlighting its potential as a foundation for time-limited therapy.
  • Clinical Data Update: Updated data presented at EHA 2026 indicated a 24-month progression-free survival rate of 53.8% for heavily pretreated patients receiving tacabrutideg, providing critical evidence for future clinical applications and potentially transforming the treatment landscape for B-cell malignancies.
NASDAQ.COM
2.0
06-11NASDAQ.COM
BeOne Medicines Stock Shows Oversold Signal
  • Oversold Indicator: BeOne Medicines Ltd (Ticker: ONC) hit an RSI of 28.9 during Thursday's trading, indicating an oversold condition with a low price of $253.9475, suggesting that recent heavy selling may be exhausting.
  • Market Comparison: Compared to the S&P 500 ETF (SPY) with an RSI of 51.5, ONC's oversold status could attract bullish investors looking for buying opportunities, reflecting a divergence in market sentiment.
  • Price Fluctuation: ONC's 52-week low is $239.25 and high is $385.22, with the latest trade at $260.31, indicating potential for price rebound within its trading range.
  • Investor Focus: Investors may pay attention to ONC's oversold signal to identify potential buying opportunities, aiming to capitalize on gains when the market rebounds.
Newsfilter
9.0
06-11Newsfilter
BRUKINSA Shows Long-Term Efficacy in Patients Over 80
  • Sustained Efficacy: Nearly two-thirds of patients aged 80 and older treated with BRUKINSA remained progression-free after nearly 6.5 years, demonstrating the drug's effectiveness and tolerability in high-risk groups, reinforcing its role as the foundational BTK inhibitor.
  • Clinical Data Highlights: The SEQUOIA subgroup analysis revealed a median age of 81 years with a 100% overall response rate and a 72-month progression-free survival rate of 63.8%, indicating BRUKINSA's therapeutic potential in elderly patients, particularly those with high-risk features.
  • Safety Analysis: BRUKINSA exhibited consistent safety profiles in long-term follow-ups, particularly in older patients, with low rates of atrial fibrillation enhancing confidence in its use as a first-line treatment, supporting clinical decision-making.
  • Patient Decision Factors: Recent studies indicate that safety, disease severity, and efficacy are the primary considerations for patients choosing first-line CLL treatments, while treatment duration is less influential, highlighting the importance of aligning treatment discussions with patient priorities.
Newsfilter
8.5
06-01Newsfilter
BeOne Medicines Presents New Data at ASCO Meeting
  • Clinical Data Unveiled: BeOne showcased new data from three priority programs at the 2026 ASCO Annual Meeting, highlighting significant advancements in its oncology pipeline, which are expected to propel multiple assets into pivotal trial phases.
  • CDK4 Inhibitor Excels: BGB-43395 demonstrated a confirmed overall response rate of 68.4% in 1L HR+/HER2- metastatic breast cancer, with a favorable safety profile when combined with letrozole, supporting its application in a global randomized Phase 3 clinical trial.
  • B7-H4 ADC Shows Promise: BG-C9074 achieved a confirmed overall response rate of 45.5% in ovarian cancer and 40.0% in triple-negative breast cancer, indicating early efficacy across different tumor types and supporting further development efforts.
  • GPC3x4-1BB Bispecific Breakthrough: BGB-B2033 exhibited a confirmed overall response rate of 28.9% in heavily pre-treated hepatocellular carcinoma patients, with a favorable safety profile, positioning it for rapid clinical development aimed at establishing a new standard of care in challenging cancers.
Newsfilter
2.0
05-29Newsfilter
BeOne's Drug Shows New Breakthroughs in CLL Treatment
  • Long-Term Efficacy Data: The SEQUOIA study indicates that BRUKINSA shows a progression-free survival (PFS) of 71.8% after a median follow-up of 84.01 months, significantly outperforming the 31.0% PFS of the BR group, highlighting its long-term efficacy in first-line treatment for chronic lymphocytic leukemia (CLL).
  • Real-World Evidence: An analysis of 10,523 CLL/SLL patients treated with BTK inhibitors revealed that BRUKINSA significantly reduced the risk of death and treatment discontinuation, further solidifying its position as the best-in-class BTK inhibitor.
  • Combination Therapy Potential: The combination of BRUKINSA with the next-generation BCL2 inhibitor sonrotoclax demonstrated an unprecedented overall response rate of 100% and a complete response rate of 59.5% in high-risk CLL patients, indicating a promising direction for time-limited treatments.
  • Safety Consistency: The safety profile of BRUKINSA remains consistent with previous studies, with no new safety signals identified, ensuring its sustainability and patient confidence in clinical applications.
Newsfilter
8.5
05-27Newsfilter
TEVIMBRA and ZIIHERA Combination Therapy Significantly Improves Survival Rates
  • Significant Survival Improvement: The HERIZON-GEA-01 trial demonstrated that the combination of TEVIMBRA and ZIIHERA with chemotherapy achieved a median overall survival of 26.4 months, compared to 19.2 months in the control group, indicating the potential importance of this combination in treating HER2+ gastroesophageal adenocarcinoma.
  • Effective Regardless of PD-L1 Status: Results showed that this combination therapy provided significant survival benefits in both PD-L1 positive and negative patients, particularly in those with PD-L1 <1%, where the median survival was 29.7 months, far exceeding the control group's 15.8 months, highlighting its broad applicability.
  • Strong Durability of Response: The median duration of response for the ZIIHERA and TEVIMBRA combination was 20.7 months, significantly longer than the 14.3 months for ZIIHERA alone and 8.3 months for the control group, underscoring the clinical significance of this combination in prolonging patient survival.
  • Regulatory Progress: The U.S. FDA has accepted a supplemental Biologics License Application for TEVIMBRA with priority review, and the Chinese NMPA has also accepted applications for ZIIHERA and TEVIMBRA, indicating that this combination therapy is poised for rapid approval in multiple markets.
Wall Street analysts forecast ONC stock price to rise
11 Analyst Rating
Wall Street analysts forecast ONC stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
385.00
Averages
403.76
High
424.00
Current: 0.000
sliders
Low
385.00
Averages
403.76
High
424.00
RBC Capital
Leonid Timashev
Outperform
maintain
$425 -> $436
AI Analysis
2026-06-02
Reason
RBC Capital
Leonid Timashev
Price Target
$425 -> $436
AI Analysis
2026-06-02
maintain
Outperform
Reason
RBC Capital analyst Leonid Timashev raised the firm's price target on BeOne Medicines to $436 from $425 and keeps an Outperform rating on the shares. At ASCO, the company presented on three interesting solid tumor assets - a CDk4 inhibitor in breast cancer, a GPC3-41BB bispecific in HCC, and a B7-H4 ADC in ovarian cancer, and the firm believes that each looks to be delivering on its promised profile, with either unique safety or efficacy advantages, which can make them best-in-class, or at least competitive, in the coming years, the analyst tells investors in a research note.
Leerink
NULL
to
Outperform
maintain
$364 -> $367
2026-05-15
Reason
Leerink
Price Target
$364 -> $367
2026-05-15
maintain
NULL
to
Outperform
Reason
Leerink raised the firm's price target on BeOne Medicines to $367 from $364 and keeps an Outperform rating on the shares. The firm notes the company announced that the FDA has granted sonrotoclax accelerated approval in relapse/refractory mantle cell lymphoma. This is the first approval for sonrotoclax with additional trials ongoing in relapsed or refractory mantle cell lymphoma in combination with zanubrutinib, in R/R chronic lymphocytic leukemia / small lymphocytic lymphoma in combination with anti-CD20 antibodies, and treatment-naive chronic lymphocytic leukemia in combination with zanubrutinib.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ONC
Unlock Now

Valuation Metrics

The current forward P/E ratio for BeOne Medicines AG (ONC.O) is 42.55, compared to its 5-year average forward P/E of 70.15. For a more detailed relative valuation and DCF analysis to assess BeOne Medicines AG's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PE
70.15
Current PE
42.55
Overvalued PE
132.89
Undervalued PE
7.42

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
26.62
Current EV/EBITDA
15.22
Overvalued EV/EBITDA
61.26
Undervalued EV/EBITDA
-8.02

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
5.63
Current PS
3.67
Overvalued PS
6.67
Undervalued PS
4.59

Financials

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Whales Holding ONC

B
Bluebox Asset Management Uk Ltd.
Holding
ONC
+107.56%
3M Return
P
PRIMECAP Management Company
Holding
ONC
+37.24%
3M Return
F
Franklin Templeton Sealand Fund Management Co., Ltd.
Holding
ONC
+27.25%
3M Return
G
Guotai Asset Management Company Limited
Holding
ONC
+19.52%
3M Return
H
Hillhouse Capital Management, Ltd.
Holding
ONC
+12.68%
3M Return
B
Bosera Asset Management Co., Ltd.
Holding
ONC
+10.60%
3M Return

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Frequently Asked Questions

What is BeOne Medicines AG (ONC) stock price today?

The current price of ONC is 270.15 USD — it has increased 2.84

What is BeOne Medicines AG (ONC)'s business?

BeOne Medicines AG, formerly BeiGene, Ltd., is a global oncology company engaged in discovering and developing treatments for cancer patients worldwide. With a portfolio spanning hematology and solid tumors, the Company is engaged in the development of its diverse pipeline of novel therapeutics. Its products include Brukinsa, Tevimbra and Pamiparib. Brukinsa is an orally available, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). Tevimbra is a humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is designed to minimize binding to Fc-gamma (Fcy) receptors on macrophages, helping the body’s immune cells detect and fight tumors. The Company’s product pipeline in development includes Sonrotoclax, Tarlatamab, Zanidatamab, Blinatumomab, BGB-26808, BGB-R046, BG-68501, BG-C9074, BGB-43395, Xaluritamig, and others.

What is the price predicton of ONC Stock?

Wall Street analysts forecast ONC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ONC is403.76 USD with a low forecast of 385.00 USD and a high forecast of 424.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is BeOne Medicines AG (ONC)'s revenue for the last quarter?

BeOne Medicines AG revenue for the last quarter amounts to 1.51B USD, increased 35.46

What is BeOne Medicines AG (ONC)'s earnings per share (EPS) for the last quarter?

BeOne Medicines AG. EPS for the last quarter amounts to 0.15 USD, decreased

How many employees does BeOne Medicines AG (ONC). have?

BeOne Medicines AG (ONC) has 12000 emplpoyees as of June 19 2026.

What is BeOne Medicines AG (ONC) market cap?

Today ONC has the market capitalization of 32.03B USD.