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ALNY Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
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Intellectia

Loading chart...

High
322.380
Open
322.000
VWAP
320.23
Vol
92.98K
Mkt Cap
42.76B
Low
318.640
Amount
29.78M
EV/EBITDA(TTM)
76.35
Total Shares
132.62M
EV
42.55B
EV/OCF(TTM)
81.18
P/S(TTM)
11.59
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
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Events Timeline

(ET)
2026-03-05
08:40:00
Tenaya Therapeutics Partners with Alnylam to Develop Cardiovascular Disease Treatments
select
2026-02-12 (ET)
2026-02-12
08:10:00
Alnylam Q4 Revenue at $1.1B, Below Consensus
select
2026-02-12
08:10:00
Sees FY26 Revenue from Collaborations and Royalties at $400M-$500M
select

News

Benzinga
6.5
03-10Benzinga
BridgeBio's Promising Biotech Pipeline Highlighted by William Blair
  • Unique Market Position: Analyst John Boyle highlights BridgeBio's unique position with the accelerating launch of Attruby and near-term NDA submissions, setting the stage for late-2026/early-2027 launches in the rare genetic disease treatment market.
  • Product Competitive Edge: Market surveys indicate that prescribers view both Attruby and Amvuttra as superior to Pfizer's Tafamidis, which has approximately $6 billion in annual sales, suggesting that BridgeBio's products are gaining traction in clinical applications.
  • Sales Forecast and Risks: The analyst models U.S. sales of Attruby reaching $3.4 billion by 2035, while acknowledging potential generic entry risks in late 2028; however, Attruby's strong TTR stabilization and simple twice-daily dosing could justify premium pricing.
  • Other Market Opportunities: BridgeBio also sees significant market opportunities with other rare disease drugs, particularly infigratinib for achondroplasia and encaleret for autosomal dominant hypocalcemia type 1, with the latter achieving its primary endpoint in the CALIBRATE Phase 3 study in October 2025, indicating strong future prospects.
stocktwits
7.5
03-06stocktwits
Tenaya Partners with Alnylam for Heart Drug Development
  • Collaboration Details: Tenaya Therapeutics has entered into a partnership with Alnylam Pharmaceuticals to validate up to 15 gene targets, potentially earning up to $1.13 billion in development and commercial milestone payments, highlighting the significant potential in heart disease drug development.
  • Upfront Payment Structure: Under the agreement, Tenaya will receive up to $10 million as an upfront payment, which not only provides funding for its research but also lays the groundwork for subsequent drug development efforts.
  • Market Reaction Analysis: Following the announcement, Tenaya's stock surged 41% during regular trading but pulled back 5% in after-hours trading, reflecting a blend of initial market optimism and subsequent caution regarding the collaboration.
  • Investor Sentiment Shift: On the Stocktwits platform, retail sentiment around TNYA stock shifted from 'bearish' to 'bullish' over the past 24 hours, indicating investor optimism about Tenaya's future gene therapy TN401, especially in the absence of curative competition.
Yahoo Finance
4.5
03-05Yahoo Finance
Health Care Stocks Decline, NYSE Health Care Index Drops 2.3%
  • Overall Decline in Health Care Stocks: On Thursday afternoon, health care stocks broadly fell, with the NYSE Health Care Index dropping 2.3%, reflecting market concerns about the sector's outlook, which could impact investor confidence and lead to capital outflows.
  • Diminished Market Sentiment: The downward trend in the health care sector may be linked to overall economic uncertainty, as investors grow increasingly wary of potential policy changes and regulatory pressures, thereby affecting stock performance.
  • Investor Reactions: In light of the decline in health care stocks, investors may reassess their portfolios, seeking more defensive asset allocations to mitigate potential market volatility and risks.
  • Uncertain Industry Outlook: The short-term performance of the health care sector may be influenced by multiple factors, including policy changes and fluctuations in market demand, prompting investors to closely monitor developments to adjust their investment strategies.
Benzinga
2.0
03-05Benzinga
Tenaya Therapeutics Partners with Alnylam for Genetic Research
  • Collaboration Agreement: Tenaya Therapeutics has entered into a research collaboration with Alnylam Pharmaceuticals focused on identifying genetic targets for cardiovascular diseases, with Tenaya set to validate up to 15 gene targets and potentially receive $10 million upfront and up to $1.13 billion in milestone payments, significantly enhancing its research capabilities.
  • Technical Advantages: Tenaya employs human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for high-throughput genetic target identification, alongside engineered heart tissue and preclinical in vivo models for validation, having generated over 150 genetic targets that contribute to the development of clinical-stage candidates.
  • Clinical Trial Progress: In December 2025, Tenaya shared interim data from the RIDGE-1 Phase 1b/2 trial of TN-401 gene therapy for rare inherited heart disease, reporting safety, biopsy, and arrhythmia results from three patients, indicating the therapy's potential in treating such conditions.
  • Market Performance Analysis: Despite a 31.20% increase to 76 cents, Tenaya's stock remains 29.1% and 23.6% below its 100-day and 200-day simple moving averages, indicating a bearish trend in the medium to long term, with analysts generally rating it as a
seekingalpha
7.5
03-05seekingalpha
Tenaya Therapeutics Partners with Alnylam for Up to $1.1B Cardiovascular Drug Collaboration
  • Collaboration Agreement: Tenaya Therapeutics has signed a research collaboration with Alnylam Pharmaceuticals worth up to $1.1 billion, aimed at discovering 15 genetic targets associated with cardiovascular diseases, showcasing the company's strong potential in the biotech sector.
  • Upfront Payment and Milestone Rewards: Under the terms, Tenaya will receive up to $10 million as an upfront payment and is eligible for an additional $1.13 billion based on development and commercial milestones, significantly enhancing the company's liquidity and supporting its R&D activities.
  • Strategic Importance: CEO Faraz Ali emphasized that this multi-target collaboration underscores Tenaya's commitment to rigorous science and leverages its proprietary capabilities to drive the discovery and development of cardiovascular candidates, further solidifying its position in the biopharmaceutical industry.
  • Positive Market Reaction: Following the announcement of the collaboration, Tenaya's stock rose approximately 10% in premarket trading, reflecting investor optimism regarding the potential of this partnership, which may enhance the company's market recognition and future growth prospects.
NASDAQ.COM
7.5
03-05NASDAQ.COM
Tenaya and Alnylam Enter Research Collaboration Agreement
  • Collaboration Agreement: Tenaya Therapeutics has signed a research collaboration agreement with Alnylam Pharmaceuticals to discover potential human genetic targets for cardiovascular disease, marking a strategic partnership in gene therapy.
  • Funding Support: Tenaya will receive up to $10 million in upfront payments along with reimbursement for related costs, ensuring sufficient funding for its research activities during the two-year validation period.
  • Potential Earnings: Should all genetic targets lead to approved therapeutics, Tenaya could be eligible for up to $1.13 billion in development and commercial milestone payments, significantly enhancing its financial position and market competitiveness.
  • Stock Price Reaction: In pre-market trading on Nasdaq, Tenaya's shares rose by 11.8% to $0.6499, reflecting positive market expectations and increased investor confidence regarding the collaboration.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Canaccord
Buy
maintain
$415 -> $429
AI Analysis
2026-02-17
Reason
Canaccord
Price Target
$415 -> $429
AI Analysis
2026-02-17
maintain
Buy
Reason
Canaccord raised the firm's price target on Alnylam to $429 from $415 and keeps a Buy rating on the shares. The firm updated its model following Q4 results which was largely uneventful following its January preannouncement of a slight top and bottom line miss. But the bigger picture is that the Amvuttra launch in TTR is going really well and longer term they continue to see upside versus. the company's and Street's estimates.
Canaccord
Whitney Ijem
Buy
maintain
$415 -> $429
2026-02-17
Reason
Canaccord
Whitney Ijem
Price Target
$415 -> $429
2026-02-17
maintain
Buy
Reason
Canaccord analyst Whitney Ijem lowered the firm's price target on Alnylam to $429 from $415 and keeps a Buy rating on the shares. The firm updated its model following Q4 results which was largely uneventful following its January preannouncement of a slight top- and bottom- line miss. But the bigger picture is that the Amvuttra launch in TTR is going really well and longer term they continue to see upside versus. the company's and Street's estimates.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
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Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 60.41, compared to its 5-year average forward P/E of -44.18. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-44.18
Current PE
60.41
Overvalued PE
28.31
Undervalued PE
-116.67

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7696.91
Current EV/EBITDA
43.64
Overvalued EV/EBITDA
51858.13
Undervalued EV/EBITDA
-67251.95

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
15.12
Current PS
10.01
Overvalued PS
18.94
Undervalued PS
11.29

Financials

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Whales Holding ALNY

F
FengHe Fund Management Pte. Ltd.
Holding
ALNY
+17.35%
3M Return
T
Two Sigma Investments, LP
Holding
ALNY
+10.26%
3M Return
N
Nomura Asset Management Taiwan Ltd.
Holding
ALNY
+7.51%
3M Return
H
Himension Capital (Singapore) Pte Ltd
Holding
ALNY
+3.36%
3M Return
A
Architas Multi-Manager Europe Ltd.
Holding
ALNY
+2.99%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
+2.76%
3M Return

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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 319.67 USD — it has decreased -0.84

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.10B USD, increased 84.95

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.37 USD, decreased -310.77

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of March 11 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 42.76B USD.