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ALNY Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
300.170
Open
295.910
VWAP
296.09
Vol
926.77K
Mkt Cap
39.39B
Low
293.060
Amount
274.41M
EV/EBITDA(TTM)
48.44
Total Shares
133.51M
EV
39.09B
EV/OCF(TTM)
54.83
P/S(TTM)
9.33
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
Show More

Events Timeline

(ET)
2026-05-07
09:40:00
MBX Biosciences Appoints Mark Soued as Chief Commercial Officer
select
2026-04-30 (ET)
2026-04-30
08:10:00
Alnylam Reports Q1 Revenue of $1.167B
select
2026-04-06 (ET)
2026-04-06
07:10:00
BioCryst Appoints Sandeep Menon as Chief R&D Officer
select
2026-03-30 (ET)
2026-03-30
13:10:00
Alnylam Releases New Cardiovascular Data, Vutrisiran Significantly Improves Patient Quality of Life
select
2026-03-30
13:10:00
Alnylam Presents Phase 2 Safety Data for Zilebesiran
select
2026-03-24 (ET)
2026-03-24
07:40:00
Alnylam Announces Strategy to Improve Care for ATTR-CM Patients
select

News

Newsfilter
8.5
05-04Newsfilter
Alnylam to Present New Vutrisiran Data at Heart Failure 2026
  • New Data Presentation: Alnylam Pharmaceuticals will present new data analyses for vutrisiran at the Heart Failure 2026 congress in Barcelona from May 9-12, 2026, further supporting its efficacy as a first-line treatment for patients with cardiomyopathy.
  • Clinical Study Validation: The HELIOS-B study demonstrates vutrisiran's adaptability to patients with high disease burden, indicating its potential value in complex clinical scenarios, which may enhance treatment options for patients.
  • Global Observational Study: Alnylam will also introduce the design of the DemonsTTRate study, aimed at evaluating the real-world use of vutrisiran, emphasizing the company's commitment to long-term efficacy and potentially providing critical data for future clinical practices.
  • Safety Analysis: The congress will showcase a safety analysis of vutrisiran related to vitamin A, assessing adverse reactions in clinical trials and real-world datasets, ensuring patient safety and treatment effectiveness during administration.
Yahoo Finance
9.5
05-03Yahoo Finance
Alnylam Pharmaceuticals Q1 Results Exceed Expectations
  • Performance Beat: Alnylam Pharmaceuticals reported Q1 revenue of $1.2 billion, exceeding forecasts by 4.5%, with earnings per share (EPS) at $1.51, 67% above expectations, indicating strong financial performance that boosts investor confidence.
  • Future Growth Outlook: Analysts forecast revenues of $5.61 billion in 2026, reflecting a 31% increase from the past 12 months, with EPS expected to soar 86% to $7.51, showcasing a more bullish sentiment towards the company's earnings potential.
  • Stable Price Target: Despite the improved earnings outlook, the consensus price target remains unchanged at $449, suggesting that the market does not anticipate significant long-term value creation, prompting investors to consider diverse valuation opinions.
  • Industry Growth Comparison: Alnylam is projected to achieve an annualized growth rate of 43% by 2026, significantly outpacing the 21% growth forecast for similar companies, highlighting its competitive advantage and market potential in the biopharmaceutical sector.
seekingalpha
9.5
04-30seekingalpha
Alnylam Pharmaceuticals Q1 2026 Earnings Call Highlights
  • Significant Revenue Growth: Alnylam reported over $1 billion in global net product revenues for Q1 2026, with TTR revenue reaching $910 million, indicating strong performance in the TTR market and supporting the achievement of the annual sales guidance of $4.4 billion to $4.7 billion.
  • Strategic Collaboration Expansion: CEO Yvonne Greenstreet highlighted new partnerships aimed at enhancing TTR disease awareness and diagnosis, reflecting Alnylam's pursuit of global leadership under its 'Alnylam 2030' strategy, which focuses on sustainable innovation for business growth.
  • Increased R&D Spending: CFO Jeffrey Poulton reported non-GAAP R&D expenses of $335 million, a 39% increase, indicating ongoing investment in research and development, while maintaining profitability, showcasing confidence in future product development.
  • Market Dynamics Analysis: Management emphasized that despite challenges from German pricing adjustments and U.S. insurance reauthorizations, Q1 results were consistent with expectations, demonstrating the company's flexibility and adaptability in navigating market fluctuations.
seekingalpha
9.5
04-30seekingalpha
Alnylam Pharmaceuticals Q1 Earnings Exceed Expectations
  • Strong Earnings Report: Alnylam Pharmaceuticals reported a Q1 non-GAAP EPS of $1.99, beating expectations by $0.52, which highlights the company's improved profitability and boosts investor confidence.
  • Revenue Surge: The company achieved Q1 revenue of $1.17 billion, representing a 96.9% year-over-year increase and exceeding market expectations by $50 million, reflecting robust demand and sales performance for its products.
  • Guidance Reaffirmation: Alnylam reiterated its 2026 financial guidance, projecting combined net product revenues between $4.9 billion and $5.3 billion, and total TTR net product revenues between $4.4 billion and $4.7 billion, indicating strong confidence in future growth.
  • Market Strategy: Alnylam has made progress in transforming ATTR amyloidosis care and expanding its TTR franchise, demonstrating its strategic decision-making capabilities in innovative drug development and market expansion.
seekingalpha
9.5
04-29seekingalpha
Alnylam Pharmaceuticals Q1 Earnings Announcement Scheduled
  • Earnings Release Date: Alnylam Pharmaceuticals is set to announce its Q1 2023 earnings on April 30 before market open, with consensus EPS estimate at $0.91 and revenue expected to reach $1.12 billion, reflecting an impressive 88.5% year-over-year growth, marking a critical performance indicator for the company.
  • Performance Expectations: Over the past two years, Alnylam has beaten EPS and revenue estimates 63% of the time, indicating stability in managing market expectations, although recent revisions show 7 downward adjustments for EPS and 12 for revenue in the last three months.
  • Market Reaction: Despite the optimistic outlook, analysts caution that Alnylam's current valuation may still appear overvalued, urging investors to carefully assess the balance between long-term growth potential and short-term performance volatility.
  • Strategic Partnership Progress: Alnylam's research pact with Tenaya, valued at up to $1.1 billion, underscores the company's ongoing innovation in treating ATTR amyloidosis and its strategy to expand the TTR franchise, potentially supporting future revenue growth.
NASDAQ.COM
6.5
04-24NASDAQ.COM
ETF Analysis: FDG Implies 18.96% Upside Potential
  • FDG ETF Potential: The American Century Focused Dynamic Growth ETF (FDG) has an implied analyst target price of $152.53 per unit, while trading at $128.22, indicating an 18.96% upside potential that reflects market optimism about the ETF's future performance.
  • HubSpot Price Analysis: HubSpot Inc (HUBS) is currently priced at $214.69, with an analyst target of $336.16, suggesting a significant 56.58% upside, indicating analysts' positive outlook on its growth prospects.
  • Reddit Investment Outlook: Reddit Inc (RDDT) trades at $152.96, with a target price of $223.03, representing a 45.81% potential increase, reflecting market confidence in its business outlook.
  • Alnylam Growth Expectations: Alnylam Pharmaceuticals Inc (ALNY) is priced at $313.79, with an analyst target of $450.22, indicating a 43.48% upside, showcasing analysts' optimism regarding its future performance.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Morgan Stanley
Equal Weight
maintain
$360 -> $370
AI Analysis
2026-05-01
Reason
Morgan Stanley
Price Target
$360 -> $370
AI Analysis
2026-05-01
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Alnylam to $370 from $360 and keeps an Equal Weight rating on the shares.
Bernstein
Outperform
maintain
$448 -> $447
2026-05-01
Reason
Bernstein
Price Target
$448 -> $447
2026-05-01
maintain
Outperform
Reason
Bernstein lowered the firm's price target on Alnylam to $447 from $448 and keeps an Outperform rating on the shares. The firm notes Amvuttra beat consensus by 5%. Shares ended the day up only 3%, lower than the mid-single digit Bernstein expected, with bear feedback that the beat relied too much on outside-U.S. guide midpoint still requires large step-up in quarter-over-quarter growth. The firm thinks U.S. numbers look very strong with continued gains vs. competitors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
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Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 31.95, compared to its 5-year average forward P/E of -38.77. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-38.77
Current PE
31.95
Overvalued PE
35.79
Undervalued PE
-113.32

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7408.97
Current EV/EBITDA
22.44
Overvalued EV/EBITDA
51056.73
Undervalued EV/EBITDA
-65874.66

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
14.36
Current PS
5.39
Overvalued PS
18.70
Undervalued PS
10.03

Financials

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Whales Holding ALNY

H
Himension Capital (Singapore) Pte Ltd
Holding
ALNY
+26.97%
3M Return
C
Capula Management Ltd
Holding
ALNY
+20.27%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
+20.01%
3M Return
T
Two Sigma Investments, LP
Holding
ALNY
+15.10%
3M Return
Q
Qube Research & Technologies Ltd
Holding
ALNY
+12.03%
3M Return
F
FMR
Holding
ALNY
+10.60%
3M Return

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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 295.05 USD — it has decreased -0.29

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.17B USD, increased 96.43

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.51 USD, decreased -1178.57

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of May 11 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 39.39B USD.