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ALNY Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

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High
305.680
Open
302.430
VWAP
301.76
Vol
2.28M
Mkt Cap
40.32B
Low
297.620
Amount
687.43M
EV/EBITDA(TTM)
50.10
Total Shares
133.51M
EV
40.43B
EV/OCF(TTM)
56.71
P/S(TTM)
9.65
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
Show More

Events Timeline

(ET)
2026-05-12
05:50:00
Alnylam Releases New Analyses Supporting Vutrisiran for Cardiac Amyloidosis Treatment
select
2026-05-07 (ET)
2026-05-07
09:40:00
MBX Biosciences Appoints Mark Soued as Chief Commercial Officer
select
2026-04-30 (ET)
2026-04-30
08:10:00
Alnylam Reports Q1 Revenue of $1.167B
select
2026-04-06 (ET)
2026-04-06
07:10:00
BioCryst Appoints Sandeep Menon as Chief R&D Officer
select
2026-03-30 (ET)
2026-03-30
13:10:00
Alnylam Releases New Cardiovascular Data, Vutrisiran Significantly Improves Patient Quality of Life
select

News

Newsfilter
8.5
05-28Newsfilter
Avaí Bio Achieves Milestone in α-Klotho Cell Bank Development
  • Production Milestone: On May 20, 2026, Avaí Bio and Austrianova announced the completion of a GMP-grade Master Cell Bank for α-Klotho, marking a significant advancement in the anti-aging therapy field, which is expected to propel the clinical and preclinical research of α-Klotho cell therapy.
  • Regulatory Compliance Testing: The Master Cell Bank will undergo comprehensive third-party testing to ensure the absence of pathogenic viruses and contaminants, meeting the requirements of regulatory bodies such as the FDA, which is a prerequisite for advancing clinical trials.
  • Strategic Partnership Advantage: Klothonova, the joint venture between Avaí Bio and Austrianova, leverages the latter's cell encapsulation technology and GMP manufacturing capabilities, creating a unique integrated structure from development to clinic, enhancing competitiveness in the anti-aging biotech sector.
  • Future Outlook: Avaí Bio plans to present the latest data from the α-Klotho therapy at the Klotho Conference in September 2026, further increasing market visibility and laying the groundwork for long-term growth in its cell-based therapeutic platform.
seekingalpha
6.0
05-19seekingalpha
Citi Initiates Bullish Coverage on SMid Cap Biotechs
  • Analyst Rating Upgrade: Citi analyst Eric Joseph initiated Buy ratings on five biotech companies including Ionis (IONS), Alnylam (ALNY), and BioMarin (BMRN), reflecting a positive outlook for significant growth in the cardiovascular, metabolism, and endocrine sectors, which indicates strong confidence in the biotech industry.
  • Ionis Price Target: The analyst set a $115 price target for Ionis, emphasizing that its pipeline based on antisense oligonucleotides provides a solid foundation for durable growth, showcasing confidence in its future performance.
  • BioMarin Valuation Discount: BioMarin received a $75 price target, with analysts noting its EV/Rev ratio of 4x is significantly lower than peers' 8-9x, indicating a substantial valuation discount that may attract investor interest.
  • Alnylam Investment Opportunity: Alnylam's price target is set at $380, with analysts arguing that despite its year-to-date underperformance, the impressive market launch of its heart disease therapy Amvuttra presents an attractive buying opportunity, signaling potential for future growth.
NASDAQ.COM
4.5
05-19NASDAQ.COM
Analysis of IBB ETF Trading Dynamics
  • Price Fluctuation Analysis: IBB ETF's 52-week low is $119.78 per share, with a high of $179.64, and a current trading price of $163.87, indicating relative stability in a volatile market that may attract investor interest.
  • Technical Analysis Tool: Comparing the current share price to the 200-day moving average can provide valuable technical insights for investors, aiding in better market trend assessment and timing for investments.
  • ETF Unit Trading Mechanism: ETFs trade like stocks, where investors buy and sell 'units' that can be created or destroyed based on investor demand, impacting the liquidity and market performance of the ETF.
  • Inflows and Outflows Monitoring: Weekly monitoring of changes in ETF shares outstanding focuses on those experiencing notable inflows (new units created) or outflows (old units destroyed), as these liquidity shifts can affect the performance of individual stocks held within the ETF.
Newsfilter
8.5
05-12Newsfilter
Alnylam's New Therapy Reduces Cardiovascular Event Risks
  • Sustained Efficacy: The HELIOS-B study demonstrated that vutrisiran significantly reduced all-cause mortality and cardiovascular events in ATTR-CM patients, particularly in the 65% of patients with atrial fibrillation, highlighting its potential as a first-line treatment option.
  • Safety Analysis: A pooled analysis of over 25,000 patient-years indicated that the rates of vitamin A deficiency-related ocular adverse events were low and comparable to placebo, reinforcing confidence in the safety profile of vutrisiran for clinical use.
  • Long-Term Study Design: The DemonsTTRate study aims to enroll over 2,000 ATTR-CM patients to generate up to five years of real-world clinical outcome data, further validating the clinical effectiveness and treatment patterns of vutrisiran.
  • Global Experience Accumulation: Vutrisiran has accumulated over 13,000 patient-years of global experience in both ATTR-CM and hereditary transthyretin-mediated amyloidosis (hATTR-PN), reflecting its efficacy and safety across diverse patient populations.
Newsfilter
8.5
05-04Newsfilter
Alnylam to Present New Vutrisiran Data at Heart Failure 2026
  • New Data Presentation: Alnylam Pharmaceuticals will present new data analyses for vutrisiran at the Heart Failure 2026 congress in Barcelona from May 9-12, 2026, further supporting its efficacy as a first-line treatment for patients with cardiomyopathy.
  • Clinical Study Validation: The HELIOS-B study demonstrates vutrisiran's adaptability to patients with high disease burden, indicating its potential value in complex clinical scenarios, which may enhance treatment options for patients.
  • Global Observational Study: Alnylam will also introduce the design of the DemonsTTRate study, aimed at evaluating the real-world use of vutrisiran, emphasizing the company's commitment to long-term efficacy and potentially providing critical data for future clinical practices.
  • Safety Analysis: The congress will showcase a safety analysis of vutrisiran related to vitamin A, assessing adverse reactions in clinical trials and real-world datasets, ensuring patient safety and treatment effectiveness during administration.
Yahoo Finance
9.5
05-03Yahoo Finance
Alnylam Pharmaceuticals Q1 Results Exceed Expectations
  • Performance Beat: Alnylam Pharmaceuticals reported Q1 revenue of $1.2 billion, exceeding forecasts by 4.5%, with earnings per share (EPS) at $1.51, 67% above expectations, indicating strong financial performance that boosts investor confidence.
  • Future Growth Outlook: Analysts forecast revenues of $5.61 billion in 2026, reflecting a 31% increase from the past 12 months, with EPS expected to soar 86% to $7.51, showcasing a more bullish sentiment towards the company's earnings potential.
  • Stable Price Target: Despite the improved earnings outlook, the consensus price target remains unchanged at $449, suggesting that the market does not anticipate significant long-term value creation, prompting investors to consider diverse valuation opinions.
  • Industry Growth Comparison: Alnylam is projected to achieve an annualized growth rate of 43% by 2026, significantly outpacing the 21% growth forecast for similar companies, highlighting its competitive advantage and market potential in the biopharmaceutical sector.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Citi
NULL
to
Buy
initiated
$380
AI Analysis
2026-05-18
Reason
Citi
Price Target
$380
AI Analysis
2026-05-18
initiated
NULL
to
Buy
Reason
Citi initiated coverage of Alnylam with a Buy rating and $380 price target. The expanded launch of Amvuttra for ATTR-CM has \"no doubt been impressive,\" says the analyst, who views 28% year-to-date pullback as \"an attractive long-term entry point.\" Pressure has been led by competitor concerns, but the firm sees \"more tailwinds than headwinds for Amvuttra,\" the analyst added.
Morgan Stanley
Equal Weight
maintain
$360 -> $370
2026-05-01
Reason
Morgan Stanley
Price Target
$360 -> $370
2026-05-01
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Alnylam to $370 from $360 and keeps an Equal Weight rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
Unlock Now

Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 31.65, compared to its 5-year average forward P/E of -38.12. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-38.12
Current PE
31.65
Overvalued PE
36.81
Undervalued PE
-113.05

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7408.37
Current EV/EBITDA
22.53
Overvalued EV/EBITDA
51057.40
Undervalued EV/EBITDA
-65874.14

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
14.21
Current PS
5.42
Overvalued PS
18.64
Undervalued PS
9.79

Financials

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Whales Holding ALNY

B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
+24.26%
3M Return
T
Two Sigma Investments, LP
Holding
ALNY
+19.36%
3M Return
N
Nomura Asset Management Taiwan Ltd.
Holding
ALNY
+17.21%
3M Return
J
Jacobs Levy Equity Management Inc
Holding
ALNY
+16.53%
3M Return
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Capital Research
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ALNY
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Voleon Capital Management LP
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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 301.98 USD — it has decreased -1.01

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.17B USD, increased 96.43

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.51 USD, decreased -1178.57

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of May 31 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 40.32B USD.