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ALNY Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
312.250
Open
306.560
VWAP
309.40
Vol
966.54K
Mkt Cap
41.49B
Low
305.000
Amount
299.05M
EV/EBITDA(TTM)
73.77
Total Shares
133.43M
EV
41.11B
EV/OCF(TTM)
78.44
P/S(TTM)
11.13
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
Show More

Events Timeline

(ET)
2026-04-06
07:10:00
BioCryst Appoints Sandeep Menon as Chief R&D Officer
select
2026-03-30 (ET)
2026-03-30
13:10:00
Alnylam Releases New Cardiovascular Data, Vutrisiran Significantly Improves Patient Quality of Life
select
2026-03-30
13:10:00
Alnylam Presents Phase 2 Safety Data for Zilebesiran
select
2026-03-24 (ET)
2026-03-24
07:40:00
Alnylam Announces Strategy to Improve Care for ATTR-CM Patients
select
2026-03-05 (ET)
2026-03-05
08:40:00
Tenaya Therapeutics Partners with Alnylam to Develop Cardiovascular Disease Treatments
select

News

Globenewswire
8.5
04-20Globenewswire
Transformation of Value in Biotechnology Sector
  • Value Shift: The biotechnology sector is undergoing a profound transformation where scientific progress is increasingly viewed as a measurable financial asset rather than just research expenditure, reinforced by fair-value accounting under U.S. GAAP that allows companies to reflect clinical advancements and commercialization timing on their balance sheets.
  • Investment Opportunities in Clinical Assets: Institutional investors are increasingly recognizing the investment value of clinical-stage biotech assets, even in the absence of current revenue, as Oncotelic Therapeutics exemplifies how scientific progress can directly influence financial positioning, significantly enhancing enterprise valuation through its diversified pipeline and 45% stake in GMP Bio.
  • Clinical Development Drives Valuation: As drug candidates advance through clinical development, their value significantly increases due to rising probabilities of success and proximity to commercialization, particularly for late-stage assets nearing regulatory approval, which tend to command a disproportionate share of enterprise value, reflecting investors' focus on pipeline asset maturity.
  • AI and Manufacturing Convergence: AI-driven drug development and GMP-compliant manufacturing platforms are accelerating timelines and improving scalability across the biotech industry, with Oncotelic Therapeutics demonstrating how to integrate oncology drug development with AI platforms, thereby linking scientific advancement with financial valuation and positioning the company favorably in the rapidly evolving biotech landscape.
Newsfilter
8.5
04-20Newsfilter
Biotechnology Sector Undergoes Value Transformation
  • Value Transformation Trend: The biotechnology sector is undergoing a profound transformation where scientific progress is increasingly viewed as a measurable financial asset, particularly as drug candidates approach commercialization, significantly enhancing companies' balance sheet values.
  • Fair Value Accounting Implementation: The adoption of fair-value accounting under U.S. GAAP allows life sciences companies to incorporate clinical progress, probability of success, and commercialization timing into financial reporting, thereby increasing transparency and attracting institutional investors to clinical-stage biotech assets.
  • Clinical Progress Drives Valuation: As drug candidates advance through clinical development, their value increases significantly due to rising probabilities of success and proximity to commercialization, with late-stage assets commanding a disproportionate share of enterprise value, reflecting investors' focus on pipeline asset maturity.
  • AI and GMP Manufacturing Convergence: The integration of AI-driven drug development and GMP-compliant manufacturing accelerates timelines and enhances scalability across the biotech industry, improving clinical development efficiency and market readiness, further driving the alignment of scientific progress with financial valuation.
NASDAQ.COM
4.5
04-17NASDAQ.COM
CGGR Stock Price Analysis and ETF Dynamics
  • Price Fluctuation Analysis: CGGR's 52-week low is $31.33 per share, with a high of $45.835, and the latest trade at $44.81 indicates the stock is nearing its peak, potentially attracting investor interest.
  • Technical Analysis Tool: Comparing the latest stock price to the 200-day moving average provides investors with a useful technical analysis perspective, aiding in trend assessment and potential buying opportunities.
  • ETF Trading Mechanism: Exchange-traded funds (ETFs) trade like stocks, where investors buy and sell 'units' that can be created or destroyed based on demand, impacting liquidity and market performance.
  • Inflows and Outflows Monitoring: Weekly monitoring of changes in ETF shares outstanding focuses on those experiencing notable inflows (new units created) or outflows (old units destroyed), assessing their impact on underlying assets and market trends.
Newsfilter
9.5
03-30Newsfilter
Vutrisiran Enhances Quality of Life for ATTR-CM Patients
  • Significant Treatment Effects: Vutrisiran demonstrated substantial improvements in health-related quality of life for ATTR-CM patients in the HELIOS-B analysis, particularly in physical limitations and overall quality of life, with effects comparable to those seen in younger patients, reinforcing its efficacy and durability as a first-line treatment.
  • High Adherence Data: Real-world data indicated that 93.8% of patients remained adherent to Vutrisiran treatment after 12 months, with a mean follow-up of 613.8 days, showcasing the drug's excellent tolerability and persistence in clinical practice.
  • Reduced Risk of Disease Progression: The HELIOS-B double-blind analysis revealed that Vutrisiran significantly lowered the risk of patients progressing to advanced disease, with only 8.0% of treated patients transitioning to NYHA class III or higher, compared to 10.7% in the placebo group, indicating a clear therapeutic advantage.
  • Favorable Safety Profile: Vutrisiran exhibited a favorable safety profile in patients with advanced disease, with a similar or lower incidence of adverse events compared to the placebo group, further supporting its potential for use in high-risk patients.
Newsfilter
7.5
03-24Newsfilter
Alnylam Advances Early Diagnosis and Care for ATTR-CM
  • Early Diagnosis Strategy: Alnylam collaborates with Viz.ai and the American Heart Association to launch an AI-driven care pathway for ATTR-CM, aiming to accelerate patient identification through an FDA-approved AI algorithm, thereby enhancing diagnostic efficiency and improving patient care quality.
  • Clinical Research Initiative: The AWARE study will evaluate the integration of AI screening into clinical workflows, with the goal of generating empirical data across five pilot health systems to support broader adoption of AI technologies and improve diagnostic timelines for ATTR-CM.
  • System of Care Improvement: Alnylam supports a three-year initiative led by the American Heart Association, convening a cohort of 10 multidisciplinary health systems to identify care gaps and share best practices, optimizing the diagnosis and management processes for ATTR-CM patients.
  • Commitment to Long-Term Impact: Through these initiatives, Alnylam aims not only to enhance early recognition of ATTR-CM but also to ensure timely interventions for patients through systemic collaboration and technological innovation, ultimately improving long-term health outcomes.
NASDAQ.COM
4.5
03-20NASDAQ.COM
Analysis of IBB ETF Trading Dynamics
  • Price Fluctuation Analysis: The IBB ETF has a 52-week low of $107.43 and a high of $179.64, with the latest trade at $163.76, indicating significant volatility over the past year that could influence investor decisions and market sentiment.
  • Technical Analysis Tool: Comparing the latest share price to the 200-day moving average can provide valuable technical insights for investors, aiding in trend assessment and more informed investment choices.
  • ETF Trading Mechanism: ETFs trade similarly to stocks, where investors buy and sell 'units' that can be created or destroyed based on demand, impacting liquidity and market performance of the ETF.
  • Inflows and Outflows Monitoring: Weekly monitoring of changes in ETF shares outstanding helps identify those experiencing notable inflows (new units created) or outflows (old units destroyed), which can affect the performance of individual components within the ETF.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Truist
Buy
to
Buy
downgrade
$515 -> $505
AI Analysis
2026-04-13
Reason
Truist
Price Target
$515 -> $505
AI Analysis
2026-04-13
downgrade
Buy
to
Buy
Reason
Truist lowered the firm's price target on Alnylam to $505 from $515 and keeps a Buy rating on the shares as part of a broader research note previewing Q1 results among Biotech names. Though confident in robust y/y growth, the management cautioned for Q1 seasonal weakness in the US from typical payer dynamics and 2 less shipping weeks, the analyst tells investors in a research note.
Jefferies
Buy
to
Hold
downgrade
$522 -> $330
2026-03-16
Reason
Jefferies
Price Target
$522 -> $330
2026-03-16
downgrade
Buy
to
Hold
Reason
Jefferies downgraded Alnylam to Hold from Buy with a price target of $330, down from $522, after assuming coverage of the name. The firm is "impressed" with the company's RNAi platform but says the shares are "priced to perfection." Alnylam's longer term consensus expectations are at risk as they price in big market growth and low competition, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
Unlock Now

Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 37.74, compared to its 5-year average forward P/E of -39.40. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-39.40
Current PE
37.74
Overvalued PE
34.78
Undervalued PE
-113.57

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7409.66
Current EV/EBITDA
45.54
Overvalued EV/EBITDA
51055.94
Undervalued EV/EBITDA
-65875.27

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
14.50
Current PS
5.87
Overvalued PS
18.76
Undervalued PS
10.25

Financials

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Whales Holding ALNY

Q
Qube Research & Technologies Ltd
Holding
ALNY
+125.56%
3M Return
A
Architas Multi-Manager Europe Ltd.
Holding
ALNY
+53.95%
3M Return
F
FengHe Fund Management Pte. Ltd.
Holding
ALNY
+25.48%
3M Return
N
Nomura Asset Management Taiwan Ltd.
Holding
ALNY
+11.89%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
+9.47%
3M Return
H
Himension Capital (Singapore) Pte Ltd
Holding
ALNY
+8.76%
3M Return

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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 310.94 USD — it has increased 0.41

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.10B USD, increased 84.95

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.37 USD, decreased -310.77

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of April 21 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 41.49B USD.