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ALNY Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
332.480
Open
318.370
VWAP
327.34
Vol
601.85K
Mkt Cap
41.92B
Low
318.370
Amount
197.01M
EV/EBITDA(TTM)
74.85
Total Shares
132.62M
EV
41.71B
EV/OCF(TTM)
79.59
P/S(TTM)
11.36
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
Show More

Events Timeline

(ET)
2026-03-30
13:10:00
Alnylam Presents Phase 2 Safety Data for Zilebesiran
select
2026-03-30
13:10:00
Alnylam Releases New Cardiovascular Data, Vutrisiran Significantly Improves Patient Quality of Life
select
2026-03-24 (ET)
2026-03-24
07:40:00
Alnylam Announces Strategy to Improve Care for ATTR-CM Patients
select
2026-03-05 (ET)
2026-03-05
08:40:00
Tenaya Therapeutics Partners with Alnylam to Develop Cardiovascular Disease Treatments
select

News

Newsfilter
9.5
03-30Newsfilter
PinnedVutrisiran Enhances Quality of Life for ATTR-CM Patients
  • Significant Treatment Effects: Vutrisiran demonstrated substantial improvements in health-related quality of life for ATTR-CM patients in the HELIOS-B analysis, particularly in physical limitations and overall quality of life, with effects comparable to those seen in younger patients, reinforcing its efficacy and durability as a first-line treatment.
  • High Adherence Data: Real-world data indicated that 93.8% of patients remained adherent to Vutrisiran treatment after 12 months, with a mean follow-up of 613.8 days, showcasing the drug's excellent tolerability and persistence in clinical practice.
  • Reduced Risk of Disease Progression: The HELIOS-B double-blind analysis revealed that Vutrisiran significantly lowered the risk of patients progressing to advanced disease, with only 8.0% of treated patients transitioning to NYHA class III or higher, compared to 10.7% in the placebo group, indicating a clear therapeutic advantage.
  • Favorable Safety Profile: Vutrisiran exhibited a favorable safety profile in patients with advanced disease, with a similar or lower incidence of adverse events compared to the placebo group, further supporting its potential for use in high-risk patients.
Newsfilter
7.5
03-24Newsfilter
Alnylam Advances Early Diagnosis and Care for ATTR-CM
  • Early Diagnosis Strategy: Alnylam collaborates with Viz.ai and the American Heart Association to launch an AI-driven care pathway for ATTR-CM, aiming to accelerate patient identification through an FDA-approved AI algorithm, thereby enhancing diagnostic efficiency and improving patient care quality.
  • Clinical Research Initiative: The AWARE study will evaluate the integration of AI screening into clinical workflows, with the goal of generating empirical data across five pilot health systems to support broader adoption of AI technologies and improve diagnostic timelines for ATTR-CM.
  • System of Care Improvement: Alnylam supports a three-year initiative led by the American Heart Association, convening a cohort of 10 multidisciplinary health systems to identify care gaps and share best practices, optimizing the diagnosis and management processes for ATTR-CM patients.
  • Commitment to Long-Term Impact: Through these initiatives, Alnylam aims not only to enhance early recognition of ATTR-CM but also to ensure timely interventions for patients through systemic collaboration and technological innovation, ultimately improving long-term health outcomes.
NASDAQ.COM
4.5
03-20NASDAQ.COM
Analysis of IBB ETF Trading Dynamics
  • Price Fluctuation Analysis: The IBB ETF has a 52-week low of $107.43 and a high of $179.64, with the latest trade at $163.76, indicating significant volatility over the past year that could influence investor decisions and market sentiment.
  • Technical Analysis Tool: Comparing the latest share price to the 200-day moving average can provide valuable technical insights for investors, aiding in trend assessment and more informed investment choices.
  • ETF Trading Mechanism: ETFs trade similarly to stocks, where investors buy and sell 'units' that can be created or destroyed based on demand, impacting liquidity and market performance of the ETF.
  • Inflows and Outflows Monitoring: Weekly monitoring of changes in ETF shares outstanding helps identify those experiencing notable inflows (new units created) or outflows (old units destroyed), which can affect the performance of individual components within the ETF.
NASDAQ.COM
4.5
03-11NASDAQ.COM
Analysis of IBB ETF Trading Dynamics
  • Price Fluctuation Analysis: IBB ETF's 52-week low is $107.43 per share, with a high of $179.64, and the current trading price at $171.83 indicates volatility near its high, potentially influencing investor buying decisions.
  • Technical Analysis Tool: Comparing the current share price to the 200-day moving average provides investors with deeper technical insights, aiding in market trend assessment and potential buy or sell timing.
  • ETF Unit Trading Mechanism: ETF units can be traded like stocks and can be created or destroyed based on investor demand, providing flexibility that allows ETFs to better adapt to market fluctuations.
  • Inflows and Outflows Monitoring: Weekly monitoring of changes in shares outstanding highlights significant inflows or outflows, which not only impacts the overall performance of the ETF but may also directly affect the individual stocks held within it.
Benzinga
6.5
03-10Benzinga
BridgeBio's Promising Biotech Pipeline Highlighted by William Blair
  • Unique Market Position: Analyst John Boyle highlights BridgeBio's unique position with the accelerating launch of Attruby and near-term NDA submissions, setting the stage for late-2026/early-2027 launches in the rare genetic disease treatment market.
  • Product Competitive Edge: Market surveys indicate that prescribers view both Attruby and Amvuttra as superior to Pfizer's Tafamidis, which has approximately $6 billion in annual sales, suggesting that BridgeBio's products are gaining traction in clinical applications.
  • Sales Forecast and Risks: The analyst models U.S. sales of Attruby reaching $3.4 billion by 2035, while acknowledging potential generic entry risks in late 2028; however, Attruby's strong TTR stabilization and simple twice-daily dosing could justify premium pricing.
  • Other Market Opportunities: BridgeBio also sees significant market opportunities with other rare disease drugs, particularly infigratinib for achondroplasia and encaleret for autosomal dominant hypocalcemia type 1, with the latter achieving its primary endpoint in the CALIBRATE Phase 3 study in October 2025, indicating strong future prospects.
stocktwits
7.5
03-06stocktwits
Tenaya Partners with Alnylam for Heart Drug Development
  • Collaboration Details: Tenaya Therapeutics has entered into a partnership with Alnylam Pharmaceuticals to validate up to 15 gene targets, potentially earning up to $1.13 billion in development and commercial milestone payments, highlighting the significant potential in heart disease drug development.
  • Upfront Payment Structure: Under the agreement, Tenaya will receive up to $10 million as an upfront payment, which not only provides funding for its research but also lays the groundwork for subsequent drug development efforts.
  • Market Reaction Analysis: Following the announcement, Tenaya's stock surged 41% during regular trading but pulled back 5% in after-hours trading, reflecting a blend of initial market optimism and subsequent caution regarding the collaboration.
  • Investor Sentiment Shift: On the Stocktwits platform, retail sentiment around TNYA stock shifted from 'bearish' to 'bullish' over the past 24 hours, indicating investor optimism about Tenaya's future gene therapy TN401, especially in the absence of curative competition.
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Current: 0.000
sliders
Low
351.00
Averages
479.53
High
580.00
Jefferies
Buy
to
Hold
downgrade
$522 -> $330
AI Analysis
2026-03-16
Reason
Jefferies
Price Target
$522 -> $330
AI Analysis
2026-03-16
downgrade
Buy
to
Hold
Reason
Jefferies downgraded Alnylam to Hold from Buy with a price target of $330, down from $522, after assuming coverage of the name. The firm is "impressed" with the company's RNAi platform but says the shares are "priced to perfection." Alnylam's longer term consensus expectations are at risk as they price in big market growth and low competition, the analyst tells investors in a research note.
Canaccord
Buy
maintain
$415 -> $429
2026-02-17
Reason
Canaccord
Price Target
$415 -> $429
2026-02-17
maintain
Buy
Reason
Canaccord raised the firm's price target on Alnylam to $429 from $415 and keeps a Buy rating on the shares. The firm updated its model following Q4 results which was largely uneventful following its January preannouncement of a slight top and bottom line miss. But the bigger picture is that the Amvuttra launch in TTR is going really well and longer term they continue to see upside versus. the company's and Street's estimates.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALNY
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Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals Inc (ALNY.O) is 32.89, compared to its 5-year average forward P/E of -40.69. For a more detailed relative valuation and DCF analysis to assess Alnylam Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-40.69
Current PE
32.89
Overvalued PE
32.41
Undervalued PE
-113.78

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7416.42
Current EV/EBITDA
47.82
Overvalued EV/EBITDA
51072.14
Undervalued EV/EBITDA
-65904.98

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
14.64
Current PS
5.79
Overvalued PS
18.81
Undervalued PS
10.47

Financials

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Whales Holding ALNY

F
FengHe Fund Management Pte. Ltd.
Holding
ALNY
+14.42%
3M Return
T
Two Sigma Investments, LP
Holding
ALNY
+0.74%
3M Return
N
Nomura Asset Management Taiwan Ltd.
Holding
ALNY
-1.42%
3M Return
D
Deerfield Management Company, L.P.
Holding
ALNY
-2.62%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
ALNY
-3.78%
3M Return
E
Eagle Asset Management, Inc.
Holding
ALNY
-4.85%
3M Return

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Frequently Asked Questions

What is Alnylam Pharmaceuticals Inc (ALNY) stock price today?

The current price of ALNY is 331.18 USD — it has increased 4.77

What is Alnylam Pharmaceuticals Inc (ALNY)'s business?

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

What is the price predicton of ALNY Stock?

Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is479.53 USD with a low forecast of 351.00 USD and a high forecast of 580.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alnylam Pharmaceuticals Inc (ALNY)'s revenue for the last quarter?

Alnylam Pharmaceuticals Inc revenue for the last quarter amounts to 1.10B USD, increased 84.95

What is Alnylam Pharmaceuticals Inc (ALNY)'s earnings per share (EPS) for the last quarter?

Alnylam Pharmaceuticals Inc. EPS for the last quarter amounts to 1.37 USD, decreased -310.77

How many employees does Alnylam Pharmaceuticals Inc (ALNY). have?

Alnylam Pharmaceuticals Inc (ALNY) has 2500 emplpoyees as of March 31 2026.

What is Alnylam Pharmaceuticals Inc (ALNY) market cap?

Today ALNY has the market capitalization of 41.92B USD.