Lenz Therapeutics Short Interest Rises to 44%
Welcome to this week's installment of "The Short Interest Report" - The Fly's weekly recap of short interest trends among some of the most widely followed high-short-float stocks. Using the data from our partner, which utilizes the latest information from stock lenders to estimate short interest changes for thousands of publicly traded companies, this report will screen for some of biggest changes in short interest as a percentage of free float and days-to-cover ratios while also considering the short interest data on some of the more volatile and heavier-traded names of the week. Based on the availability of data from Ortex, the report tracks the trading period that covers prior Friday through Thursday of this week, excluding holidays. As a basis of comparison for stocks discussed below, the S&P 500 index was up 0.7%, the Nasdaq Composite was up 0.9%, the Russell 2000 index was up 0.5%, the Russell 2000 Growth ETFwas up 0.7%, and the Russell 2000 Value ETFwas up 0.3% in the five-day trading session range through February 26.SHORT INTEREST GAINERSOrtex-reported short interest on Lenz Therapeuticstroughed at a four-month low of around 34% in the final week of December but has since tracked higher, with the momentum in bearish positioning accelerating once the stock was unable to sustain its January bounce. This week, in the five-day period covered through Thursday, shorts as a percentage of free float on the name rose from just under 40% to 44%, matching a nearly-three-month high, while days-to-cover on the name jumped from 7.9 to 8.8. The stock was up 12.2% in that time-span, though shares are still down 38% from late-January peak and down 17% year-to-date.Ortex-reported short interest on Tyra Biosciencesfell from a five-month high of 36% in mid-January all the way down below 23% last week, though this week – coinciding with a 6% jump in the stock price – bears are willing to renew their bets on the downside. Shorts as a percentage of free float rose from 22.8% to 27.5% in the five-day period covered through Thursday, while days-to-cover turned higher from 8.2 to 8.5. The stock has nearly tripled from early November lows as investors reward its oncology potential while the sell-side community heaps praise on its recent topline Phase 3 infigratinib results.Ortex-reported short interest on Dave & Busterstroughed at a three-month low of 33% about two weeks ago, with investors betting that the stock's decline of over 30% in just three weeks was overdone. With sentiment in consumer space turning more frail over the balance of February and the price action coiling around these lows, bears are seemingly willing to bet that the company's upcoming Q4 results – likely in early April – will fail to produce a positive catalyst. Shorts as a percentage of free float in the gaming/entertainment chain rose from 34.3% to a two-month high of 40.2% and days-to-cover on the name increased to 9.0 from 7.3 – a sizeable rise given the stock's steady trading volume. Shares were off by just 0.6% in the five-day period covered but traded down 5% on Friday and have now lost 9% year-to-date.SHORT INTEREST DECLINERSOrtex-reported short interest in Under Armourremains in freefall, sliding lower for the fifth consecutive week from 28.0% to 22.5% in the five-day period covered through Thursday of this week. The overzealous bears had finally capitulated in mid-January, when the stock was already up 40% from November lows as its short-interest hit a peak of 35%. Shares have since added another 32% for a total 85% gain since November, prompting the furious short-covering. Under Armour was down 1.2% this week and shares are caught in Friday's broader market and consumer sector downdraft with a slide of 3%, though the stock is still a top-performing name in Footwear/Accessories and Apparel/Manufacturing groups year-to-date with a 46% year-to-date return.Ortex-reported short interest in Redwirelooked as though its retreat had stalled in the first week of February when bearish positioning as a percentage of free float fell to four-month low of 17.6%, but after resurfacing for the balance of the month, shorts have reconsidered further exposure. This week, short interest as a percentage of free float on Redwire was down from 21.8% to 18.3%, with the stock's 11% gain justifying concerns among the bears. This week's earnings from the integrated space / defense tech company was also rewarded by traders with double-digit gains, and though shares are down over 6% heading into the weekend, Friday's late-breaking report about the possibility of a richly valued $1.7 trillion SpaceX IPO as soon as March is met positively in the space technology group.
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- FDA Approval: The U.S. FDA has approved Tenpoint Therapeutics' Yuvezzi (2.75%/0.1% ophthalmic solution), marking it as the first dual-agent eye drop for presbyopia, expected to be broadly available in the U.S. by Q2 2026, addressing the needs of approximately 2 billion global presbyopia patients.
- Market Reaction: LENZ Therapeutics' stock fell about 9% following the approval of Yuvezzi, although analyst William Blair believes this reaction is an overreaction, asserting that VIZZ still possesses a best-in-class profile and has made good progress in its launch efforts.
- Product Comparison: Yuvezzi and LENZ's VIZZ exhibit significant label differences, with VIZZ demonstrating superior efficacy, faster onset, and longer durability, while Yuvezzi may introduce new risks, including those associated with vascular insufficiency.
- Marketing Strategy: LENZ is focused on promoting VIZZ, with analysts noting that the company has successfully increased awareness among eye care professionals in Q4 and launched a direct-to-consumer campaign to drive demand in the upcoming quarters.
- New Product Competition: The FDA has approved Tenpoint's Yuvezzi eye drops for the treatment of presbyopia, creating direct competition with LENZ's VIZZ, which could alter market dynamics and drive sales growth for both products.
- Market Reaction Analysis: Analysts suggest that LENZ's recent stock price drop may be an overreaction, believing that the launch of Yuvezzi will pose new market challenges for LENZ, prompting it to accelerate product innovation and market strategy adjustments.
- Potential Market Opportunity: The introduction of Yuvezzi is viewed as having blockbuster potential, likely attracting a significant number of presbyopia patients and further driving Tenpoint's market share growth in the ophthalmic sector, enhancing its competitive position.
- Industry Outlook: As the demand for presbyopia treatments increases, the successful launch of Yuvezzi may trigger more competition, prompting the entire industry to accelerate the development of new products to meet evolving consumer needs.
- Securities Fraud Investigation: Pomerantz LLP is investigating LENZ Therapeutics and its executives for potential securities fraud, which could undermine investor confidence and lead to further declines in stock price.
- FDA Adverse Event Report: On December 12, 2025, a case of retinal tear associated with LENZ's VIZZ eye drop was reported in the FDA's adverse event system, raising serious concerns about product safety in the market.
- Stock Price Plunge: Following the adverse event disclosure, LENZ's stock price fell by $6.36, or 25.96%, closing at $18.14 per share on December 12, 2025, reflecting a pessimistic outlook from investors regarding the company's future.
- Legal Action Risks: The investigation may lead to class action lawsuits, with Pomerantz LLP advising investors to stay informed, potentially impacting LENZ's financial health and market reputation in the long term.
- Product Launch: LENZ Therapeutics has introduced VIZZ (1.44% aceclidine ophthalmic solution), a once-daily eye drop that enables 93% of participants to achieve 20/40 or better near vision within 30 minutes, lasting up to 10 hours, significantly enhancing the quality of life for older adults.
- Marketing Campaign: The 'Make it VIZZable' campaign featuring actress Sarah Jessica Parker emphasizes the convenience of VIZZ in daily life, expected to attract consumer attention and drive sales growth.
- User Experience: Parker shares her personal experience of no longer needing reading glasses after using VIZZ, highlighting its convenience in daily activities, indicating that VIZZ is not just a product but a solution for improving quality of life.
- Industry Impact: The launch of VIZZ provides an innovative solution for the presbyopia issue faced by approximately 1.8 billion people globally and 128 million in the U.S., potentially transforming traditional vision correction methods and increasing demand for non-glasses solutions.
- Securities Fraud Investigation: Pomerantz LLP is investigating LENZ Therapeutics for potential securities fraud or other unlawful business practices, which could lead to significant losses for investors and damage the company's reputation and shareholder confidence.
- FDA Adverse Event Report: On December 12, 2025, a case of retinal tear associated with LENZ's VIZZ eye drops appeared in the FDA's adverse event reporting system, raising serious concerns about product safety and triggering a market reaction.
- Stock Price Plunge: Following the adverse event disclosure, LENZ's stock price fell by $6.36, or 25.96%, to close at $18.14 per share on December 12, 2025, reflecting investors' pessimism about the company's future prospects.
- Law Firm Background: Pomerantz LLP, recognized as a leading firm in securities class action litigation, has successfully recovered multimillion-dollar damages for numerous victims, highlighting its significant influence and expertise in securities fraud cases.

- Stock Plunge: LENZ's stock price fell by $6.36, or 25.96%, to close at $18.14 per share on December 12, 2025, following reports of a retinal tear associated with its VIZZ eye drop, significantly undermining investor confidence.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether LENZ and its executives engaged in securities fraud or other unlawful business practices, which could lead to a class action lawsuit and heighten market concerns regarding the company's compliance.
- Investor Alert: Affected investors are advised to contact Pomerantz LLP, highlighting the firm's expertise in securities litigation and its commitment to protecting investor rights, potentially encouraging more investors to join the class action for compensation.
- Industry Impact: This incident not only directly impacts LENZ's stock but may also trigger regulatory scrutiny across the ophthalmic drug market, affecting the market performance and investor confidence of other companies in the sector.







