Lenz Therapeutics Short Interest Rises to 44%
Welcome to this week's installment of "The Short Interest Report" - The Fly's weekly recap of short interest trends among some of the most widely followed high-short-float stocks. Using the data from our partner, which utilizes the latest information from stock lenders to estimate short interest changes for thousands of publicly traded companies, this report will screen for some of biggest changes in short interest as a percentage of free float and days-to-cover ratios while also considering the short interest data on some of the more volatile and heavier-traded names of the week. Based on the availability of data from Ortex, the report tracks the trading period that covers prior Friday through Thursday of this week, excluding holidays. As a basis of comparison for stocks discussed below, the S&P 500 index was up 0.7%, the Nasdaq Composite was up 0.9%, the Russell 2000 index was up 0.5%, the Russell 2000 Growth ETFwas up 0.7%, and the Russell 2000 Value ETFwas up 0.3% in the five-day trading session range through February 26.SHORT INTEREST GAINERSOrtex-reported short interest on Lenz Therapeuticstroughed at a four-month low of around 34% in the final week of December but has since tracked higher, with the momentum in bearish positioning accelerating once the stock was unable to sustain its January bounce. This week, in the five-day period covered through Thursday, shorts as a percentage of free float on the name rose from just under 40% to 44%, matching a nearly-three-month high, while days-to-cover on the name jumped from 7.9 to 8.8. The stock was up 12.2% in that time-span, though shares are still down 38% from late-January peak and down 17% year-to-date.Ortex-reported short interest on Tyra Biosciencesfell from a five-month high of 36% in mid-January all the way down below 23% last week, though this week – coinciding with a 6% jump in the stock price – bears are willing to renew their bets on the downside. Shorts as a percentage of free float rose from 22.8% to 27.5% in the five-day period covered through Thursday, while days-to-cover turned higher from 8.2 to 8.5. The stock has nearly tripled from early November lows as investors reward its oncology potential while the sell-side community heaps praise on its recent topline Phase 3 infigratinib results.Ortex-reported short interest on Dave & Busterstroughed at a three-month low of 33% about two weeks ago, with investors betting that the stock's decline of over 30% in just three weeks was overdone. With sentiment in consumer space turning more frail over the balance of February and the price action coiling around these lows, bears are seemingly willing to bet that the company's upcoming Q4 results – likely in early April – will fail to produce a positive catalyst. Shorts as a percentage of free float in the gaming/entertainment chain rose from 34.3% to a two-month high of 40.2% and days-to-cover on the name increased to 9.0 from 7.3 – a sizeable rise given the stock's steady trading volume. Shares were off by just 0.6% in the five-day period covered but traded down 5% on Friday and have now lost 9% year-to-date.SHORT INTEREST DECLINERSOrtex-reported short interest in Under Armourremains in freefall, sliding lower for the fifth consecutive week from 28.0% to 22.5% in the five-day period covered through Thursday of this week. The overzealous bears had finally capitulated in mid-January, when the stock was already up 40% from November lows as its short-interest hit a peak of 35%. Shares have since added another 32% for a total 85% gain since November, prompting the furious short-covering. Under Armour was down 1.2% this week and shares are caught in Friday's broader market and consumer sector downdraft with a slide of 3%, though the stock is still a top-performing name in Footwear/Accessories and Apparel/Manufacturing groups year-to-date with a 46% year-to-date return.Ortex-reported short interest in Redwirelooked as though its retreat had stalled in the first week of February when bearish positioning as a percentage of free float fell to four-month low of 17.6%, but after resurfacing for the balance of the month, shorts have reconsidered further exposure. This week, short interest as a percentage of free float on Redwire was down from 21.8% to 18.3%, with the stock's 11% gain justifying concerns among the bears. This week's earnings from the integrated space / defense tech company was also rewarded by traders with double-digit gains, and though shares are down over 6% heading into the weekend, Friday's late-breaking report about the possibility of a richly valued $1.7 trillion SpaceX IPO as soon as March is met positively in the space technology group.
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- Earnings Miss: Lenz Therapeutics reported fourth-quarter revenue of $1.59 million for fiscal 2025, significantly below analysts' expectations of $3.1 million, leading to a nearly 20% drop in stock price this week as investor sentiment soured.
- Widening Net Loss: The company's GAAP net loss deepened to $35.9 million ($1.16 per share), compared to a loss of $12.7 million in the same quarter last year, highlighting the financial strain of commercialization costs.
- Price Target Cuts: Citigroup and Bank of America both slashed their price targets for Lenz from $52 and $35 to $26 and $29 respectively, indicating growing concerns about the company's future profitability.
- Market Potential Assessment: Despite short-term challenges, analysts believe Lenz's VIZZ product has the potential to attract a large patient base, particularly for treating presbyopia, and suggest investors give the company more time to evaluate its marketing effectiveness.
- Price Reduction Announcement: Lenz Therapeutics has announced a price cut for its product, reducing the price from $35 to $29.
- Impact on Global Research: This price adjustment is part of a broader strategy to enhance accessibility and support global research initiatives.
- Product Sales Success: LENZ's VIZZ product has sold over 45,000 boxes in its early launch phase, prescribed by more than 10,000 eye care professionals, indicating strong market acceptance that exceeds recent eye care product launches.
- Strong Financial Position: As of the end of 2025, the company reported over $292.3 million in cash and cash equivalents, remaining debt-free, which supports future market expansion and product promotion efforts.
- Sales Team Expansion: The company plans to expand its sales force to 117 representatives to increase call frequency with existing prescribers and broaden the number of physicians covered, thereby driving market penetration of the product.
- Increased Market Awareness: Brand awareness among eye care professionals has reached 98%, with expectations to exceed 10,000 prescribing doctors by the end of Q1, indicating significant progress in consumer education and market promotion efforts.

- Financial Health: LENZ Therapeutics ended 2025 with approximately $292.3 million in cash and equivalents, providing substantial resources for future investments, indicating a strong financial foundation post-product launch.
- Successful Product Launch: The VIZZ treatment generated approximately $1.6 million in revenue during its first quarter, with over 45,000 boxes sold and more than 10,000 prescribing eye care professionals, reflecting a gradual increase in market acceptance.
- Marketing Strategy: The direct-to-consumer campaign featuring Sarah Jessica Parker drove website traffic up to tenfold during national activations, significantly enhancing consumer engagement and expected to accelerate market penetration of the product.
- Increased Operating Expenses: Operating expenses rose to approximately $40 million in Q4, primarily due to the establishment of the sales force and the launch of VIZZ, yet the company is actively expanding its sales force to enhance physician engagement and accelerate product adoption.
- Earnings Miss: Lenz Therapeutics reported a Q4 loss of $1.16 per share on sales of only $1.6 million, significantly below analysts' expectations of a $0.90 loss and $3.1 million in sales, resulting in an 11.2% drop in stock price during early trading.
- Product Launch: The company launched VIZZ eye drops in October 2025, aimed at providing a medical alternative to reading glasses for presbyopia, with expectations of 45,000 prescriptions by Q1 2026, but Q4 uptake fell short of market expectations.
- Rising Expenses: The company's selling, general, and administrative expenses (SG&A) quadrupled during the initial sales push, putting pressure on profitability and causing investor anxiety regarding future earnings potential.
- Lack of Guidance: Management failed to provide clear guidance for 2026, particularly regarding prescription growth, leaving investors confused about the new product's market acceptance and contributing to the stock's decline.
- Earnings Miss: LENZ Therapeutics reported a Q4 GAAP EPS of -$1.16, missing expectations by $0.26, indicating ongoing challenges in profitability that could undermine investor confidence.
- Revenue Shortfall: The company generated $1.59 million in revenue, falling short of the anticipated $3.09 million, reflecting weak market demand and insufficient sales strategies, which may lead to increased cash flow pressures in the future.
- Cash Reserves: As of December 31, 2025, LENZ held $292.3 million in cash, cash equivalents, and marketable securities, which is expected to fund operations post-launch, despite the current poor financial performance.
- Market Reaction Outlook: Given the disappointing earnings report, investors may adopt a cautious stance towards LENZ's future growth, especially as the company has yet to achieve positive operating cash flow, potentially impacting its market valuation.









