The Short List: Current Top 10 Most Shorted Stocks
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 26 2025
0mins
Should l Buy NTLA?
Source: Benzinga
Reasons for Short Selling: Traders short stocks to either bet on a decline in value or to profit from potential short squeezes, where rising prices force short sellers to buy back shares, creating a feedback loop of increasing demand.
Characteristics of Heavily Shorted Stocks: Stocks become heavily shorted when experienced traders believe they are overvalued, indicating serious risks, while retail traders may see high short interest as an opportunity for quick gains.
Top Heavily Shorted Stocks: As of November 26, 2025, the most shorted stocks include The Wendy's Co. (WEN) at 55.36% short interest, followed by Cambium Networks Corp. (CMBM) and Lucid Group, Inc. (LCID).
Risks and Volatility: While short squeezes can lead to significant gains, they come with high risks and volatility, necessitating careful monitoring and due diligence by traders.
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Analyst Views on NTLA
Wall Street analysts forecast NTLA stock price to rise
22 Analyst Rating
9 Buy
12 Hold
1 Sell
Moderate Buy
Current: 14.950
Low
4.00
Averages
16.50
High
54.00
Current: 14.950
Low
4.00
Averages
16.50
High
54.00
About NTLA
Intellia Therapeutics, Inc. is a clinical-stage gene editing company focused on developing medicine with CRISPR-based therapies and other core technologies. CRISPR/Cas9 is a gene editing technology that leverages the body’s natural processes to precisely edit DNA. The Company is developing lonvoguran ziclumeran (lonvo-z), referred to as NTLA-2002, for the treatment of hereditary angioedema (HAE) and nexiguran ziclumeran (nex-z) also referred to as NTLA-2001, for the treatment of transthyretin (ATTR) amyloidosis. It is focused on completing late-stage clinical development of its lead product candidates, lonvo-z for the treatment of patients with HAE and nex-z for the treatment of patients with ATTR amyloidosis with cardiomyopathy (ATTR-CM) and hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN). Its lead product candidates are the first in vivo genome editing product candidates into Phase III development. Its other pipeline products include REGV131-LNP1265 and AVC-201 & AVC-203.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Analysis of Investment Prospects in Healthcare Stocks
- Animal Health Leader: Zoetis has faced challenges over the past two years, including increased competition and scrutiny over drug side effects; however, its strong market position and the potential market for untreated dogs make it attractive for long-term investors, with expectations to continue launching new products to meet rising pet spending.
- New Drug Development Potential: BioNTech has underperformed in the coronavirus vaccine market, but its impressive pipeline with over 25 clinical trials in oncology, particularly the promising BNT327 developed with Bristol Myers Squibb, could set new standards of care across multiple indications, with significant clinical and regulatory progress expected over the next five years.
- Gene Editing Risks: Intellia Therapeutics' lonvo-z and nex-z are undergoing phase 3 studies but face uncertainty; despite the FDA lifting the hold on clinical trials, the high costs and complexities of gene editing treatments make steady revenue generation unlikely in the coming years, presenting substantial investment risks.
- Dividend Appeal: Zoetis has increased its dividends by 458% over the past decade, making it a top choice for income-seeking investors, reflecting its long-term investment value in the animal health market despite facing short-term challenges.
See More
Gene Drive Technology as a Solution to Invasive Species
- Global Economic Impact: According to Ben Lamm, CEO of Colossal Biosciences, invasive species result in a staggering $5.4 trillion in global economic losses, with the U.S. alone suffering over $500 billion annually, highlighting the urgent need for effective control methods.
- Humane Solution: Colossal's gene drive technology proposes using genetically modified invasive animals that produce only male offspring, eliminating the need for mass culling and poison, showcasing a more humane approach that also offers reversibility, a feature lacking in traditional methods.
- Market Potential: Companies like CRISPR Therapeutics, Beam Therapeutics, and Intellia Therapeutics are positioning their genome editing platforms as foundational infrastructure for gene drive applications, which could significantly expand their market potential beyond rare disease therapeutics if regulatory acceptance is achieved.
- Commercial Opportunity: Lamm noted that Texas has declared the screwworm a national emergency, indicating a substantial commercial opportunity in invasive species control that could yield billions for related companies, especially if gene drive technology becomes the standard.
See More
Biotech IPOs Show Strong Performance in Q1 2026
- Biotech Financing Trends: In Q1 2026, biotech companies raised a median of $287.5 million each, with nearly all possessing mid to late-stage clinical data, indicating a strong market focus on high-value science that boosts investor confidence and capital inflow.
- Industry Focus on High-Value Projects: The IQVIA report reveals that pharmaceutical R&D spending reached $159.1 billion in 2025, with companies redirecting resources toward validated late-stage programs, reflecting a market preference for credible pipelines that enhances the standing of biotech firms.
- Avaí Bio's Major Progress: Avaí Bio is set to present new data on its α-Klotho anti-aging therapy at the Second Annual Klotho Conference, being invited to speak alongside renowned researchers, which signifies an elevation in its influence within the Klotho space and may attract increased investor attention.
- Stoke Therapeutics' Breakthrough Results: Stoke Therapeutics published data on zorevunersen in The New England Journal of Medicine, demonstrating its potential disease-modifying effects in Dravet syndrome, which is expected to propel its Phase 3 EMPEROR study in 2027, further solidifying its market position.
See More
Intellia Therapeutics Overcomes Regulatory Setback
- Clinical Study Resumption: The FDA has lifted the clinical hold on Intellia Therapeutics' nex-z drug, allowing it to proceed with Phase 3 studies, a development that could drive stock recovery despite last year's price drop due to a patient death incident.
- Drug Potential Analysis: As a treatment for transthyretin amyloidosis, nex-z is expected to offer a one-time solution for hundreds of thousands of patients worldwide, and successful commercialization could significantly enhance Intellia's market position in the biotech sector.
- Risk Management Measures: The company plans to exclude patients with liver issues in late-stage studies of nex-z and will closely monitor liver inflammation, yet potential safety concerns may still hinder market acceptance.
- Market Competitive Landscape: While Intellia's partnership with Regeneron provides technical support, the high costs and complexities of gene editing drugs remain major barriers to commercialization, prompting investors to carefully assess future performance.
See More
Analysis of Intellia Therapeutics' Stock Price Recovery
- Stock Recovery: Intellia Therapeutics' stock has surged 47% over the past year, rebounding to $13.41 per share, reflecting increased market confidence in its innovative potential and future growth prospects.
- Clinical Progress: The FDA has lifted clinical holds on nex-z, allowing Intellia to advance its treatments for transthyretin amyloidosis and hereditary angioedema, marking a significant step in addressing previous setbacks.
- Risk Warning: Despite positive developments, the unclear causal relationship between nex-z and a patient's death raises concerns about potential future challenges in clinical trials, increasing investor apprehension.
- Market Potential: As a one-time treatment option, nex-z targets hundreds of thousands of patients with transthyretin amyloidosis globally, which could significantly reshape the market landscape if successfully launched, though high R&D costs and complex administration remain major hurdles.
See More
Cathie Wood's Intellia Therapeutics Surges 47%: Is It Too Late to Invest?
- Stock Performance: Intellia Therapeutics has seen a 47% increase in its stock price this year, reflecting strong market confidence in its gene-editing drugs, particularly after the FDA lifted clinical holds on nex-z, leading investors to be optimistic about its future prospects.
- Clinical Progress: The FDA's lifting of clinical holds on nex-z allows Intellia to advance its treatment for hereditary angioedema, a development that not only helps restore investor confidence but also has the potential to generate new revenue streams for the company.
- Risk Factors: Despite the positive developments, Intellia faces potential safety concerns, especially since the causal relationship between nex-z and a patient's death remains unclear, which could complicate future clinical trials and increase investment uncertainty.
- Market Competition: Intellia's partnership with Regeneron provides robust support for the development of nex-z, yet the high costs and complexities associated with gene-editing drugs remain significant barriers to market adoption, potentially limiting its acceptance among third-party payers.
See More
Analysis of Investment Prospects in Healthcare Stocks
- Animal Health Leader: Zoetis has faced challenges over the past two years, including increased competition and scrutiny over drug side effects; however, its strong market position and the potential market for untreated dogs make it attractive for long-term investors, with expectations to continue launching new products to meet rising pet spending.
- New Drug Development Potential: BioNTech has underperformed in the coronavirus vaccine market, but its impressive pipeline with over 25 clinical trials in oncology, particularly the promising BNT327 developed with Bristol Myers Squibb, could set new standards of care across multiple indications, with significant clinical and regulatory progress expected over the next five years.
- Gene Editing Risks: Intellia Therapeutics' lonvo-z and nex-z are undergoing phase 3 studies but face uncertainty; despite the FDA lifting the hold on clinical trials, the high costs and complexities of gene editing treatments make steady revenue generation unlikely in the coming years, presenting substantial investment risks.
- Dividend Appeal: Zoetis has increased its dividends by 458% over the past decade, making it a top choice for income-seeking investors, reflecting its long-term investment value in the animal health market despite facing short-term challenges.
See More
Gene Drive Technology as a Solution to Invasive Species
- Global Economic Impact: According to Ben Lamm, CEO of Colossal Biosciences, invasive species result in a staggering $5.4 trillion in global economic losses, with the U.S. alone suffering over $500 billion annually, highlighting the urgent need for effective control methods.
- Humane Solution: Colossal's gene drive technology proposes using genetically modified invasive animals that produce only male offspring, eliminating the need for mass culling and poison, showcasing a more humane approach that also offers reversibility, a feature lacking in traditional methods.
- Market Potential: Companies like CRISPR Therapeutics, Beam Therapeutics, and Intellia Therapeutics are positioning their genome editing platforms as foundational infrastructure for gene drive applications, which could significantly expand their market potential beyond rare disease therapeutics if regulatory acceptance is achieved.
- Commercial Opportunity: Lamm noted that Texas has declared the screwworm a national emergency, indicating a substantial commercial opportunity in invasive species control that could yield billions for related companies, especially if gene drive technology becomes the standard.
See More
Biotech IPOs Show Strong Performance in Q1 2026
- Biotech Financing Trends: In Q1 2026, biotech companies raised a median of $287.5 million each, with nearly all possessing mid to late-stage clinical data, indicating a strong market focus on high-value science that boosts investor confidence and capital inflow.
- Industry Focus on High-Value Projects: The IQVIA report reveals that pharmaceutical R&D spending reached $159.1 billion in 2025, with companies redirecting resources toward validated late-stage programs, reflecting a market preference for credible pipelines that enhances the standing of biotech firms.
- Avaí Bio's Major Progress: Avaí Bio is set to present new data on its α-Klotho anti-aging therapy at the Second Annual Klotho Conference, being invited to speak alongside renowned researchers, which signifies an elevation in its influence within the Klotho space and may attract increased investor attention.
- Stoke Therapeutics' Breakthrough Results: Stoke Therapeutics published data on zorevunersen in The New England Journal of Medicine, demonstrating its potential disease-modifying effects in Dravet syndrome, which is expected to propel its Phase 3 EMPEROR study in 2027, further solidifying its market position.
See More
Intellia Therapeutics Overcomes Regulatory Setback
- Clinical Study Resumption: The FDA has lifted the clinical hold on Intellia Therapeutics' nex-z drug, allowing it to proceed with Phase 3 studies, a development that could drive stock recovery despite last year's price drop due to a patient death incident.
- Drug Potential Analysis: As a treatment for transthyretin amyloidosis, nex-z is expected to offer a one-time solution for hundreds of thousands of patients worldwide, and successful commercialization could significantly enhance Intellia's market position in the biotech sector.
- Risk Management Measures: The company plans to exclude patients with liver issues in late-stage studies of nex-z and will closely monitor liver inflammation, yet potential safety concerns may still hinder market acceptance.
- Market Competitive Landscape: While Intellia's partnership with Regeneron provides technical support, the high costs and complexities of gene editing drugs remain major barriers to commercialization, prompting investors to carefully assess future performance.
See More
Analysis of Intellia Therapeutics' Stock Price Recovery
- Stock Recovery: Intellia Therapeutics' stock has surged 47% over the past year, rebounding to $13.41 per share, reflecting increased market confidence in its innovative potential and future growth prospects.
- Clinical Progress: The FDA has lifted clinical holds on nex-z, allowing Intellia to advance its treatments for transthyretin amyloidosis and hereditary angioedema, marking a significant step in addressing previous setbacks.
- Risk Warning: Despite positive developments, the unclear causal relationship between nex-z and a patient's death raises concerns about potential future challenges in clinical trials, increasing investor apprehension.
- Market Potential: As a one-time treatment option, nex-z targets hundreds of thousands of patients with transthyretin amyloidosis globally, which could significantly reshape the market landscape if successfully launched, though high R&D costs and complex administration remain major hurdles.
See More
Cathie Wood's Intellia Therapeutics Surges 47%: Is It Too Late to Invest?
- Stock Performance: Intellia Therapeutics has seen a 47% increase in its stock price this year, reflecting strong market confidence in its gene-editing drugs, particularly after the FDA lifted clinical holds on nex-z, leading investors to be optimistic about its future prospects.
- Clinical Progress: The FDA's lifting of clinical holds on nex-z allows Intellia to advance its treatment for hereditary angioedema, a development that not only helps restore investor confidence but also has the potential to generate new revenue streams for the company.
- Risk Factors: Despite the positive developments, Intellia faces potential safety concerns, especially since the causal relationship between nex-z and a patient's death remains unclear, which could complicate future clinical trials and increase investment uncertainty.
- Market Competition: Intellia's partnership with Regeneron provides robust support for the development of nex-z, yet the high costs and complexities associated with gene-editing drugs remain significant barriers to market adoption, potentially limiting its acceptance among third-party payers.
See More
