Janux Therapeutics Shares Reach 52-Week Low Following Trial Announcement
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 02 2025
0mins
Should l Buy JANX?
Source: Benzinga
Stock Performance: Janux Therapeutics Inc. (NASDAQ: JANX) experienced a significant drop in stock price, hitting a 52-week low after releasing interim data for its JANX007 Phase 1 program targeting metastatic castration-resistant prostate cancer (mCRPC).
Clinical Trial Results: The Phase 1 trials showed promising results with high prostate-specific antigen (PSA) response rates and confirmed partial responses in 30% of evaluable patients, alongside a manageable safety profile primarily involving grade 1 and 2 cytokine release syndrome (CRS).
Development Strategy: Janux is focusing on advancing JANX007 as a monotherapy and in combination with darolutamide for taxane-naïve mCRPC patients, while also considering evaluation in PARP inhibitor-refractory patients for expedited approval.
Analyst Insights: Analysts from William Blair view the stock's decline as an overreaction and see potential in JANX007, suggesting that upcoming updates from the Phase Ib trial in 2026 could restore investor confidence, with some recommending the current sell-off as a buying opportunity.
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Analyst Views on JANX
Wall Street analysts forecast JANX stock price to rise
16 Analyst Rating
15 Buy
1 Hold
0 Sell
Strong Buy
Current: 13.130
Low
25.00
Averages
55.25
High
150.00
Current: 13.130
Low
25.00
Averages
55.25
High
150.00
About JANX
Janux Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing tumor-activated immunotherapies for cancer. It has developed two bispecific platforms: Tumor Activated T Cell Engagers (TRACTr) and Tumor Activated Immunomodulators (TRACIr). The TRACTr platform produces T cell engagers (TCEs) with a tumor antigen-binding domain and a CD3 T cell binding domain, while the TRACIr platform produces bispecifics with a tumor antigen-binding domain and a costimulatory CD28 binding domain. Its clinical candidates include JANX007 and JANX008. JANX007 is a prostate-specific membrane antigen (PSMA-TRACTr) designed to target PSMA, a protein expressed in prostate cancer tumors and the vasculature of other tumors. JANX008 is an epidermal growth factor receptor (EGFR-TRACTr), being studied for the treatment of multiple solid cancers, including colorectal cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and renal cell carcinoma.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Janux Therapeutics and Bristol Myers Squibb Sign $800 Million Collaboration Agreement
- Collaboration Agreement: Janux Therapeutics has entered into an exclusive worldwide license agreement with Bristol Myers Squibb, receiving up to $50 million in upfront and near-term milestone payments, with potential total payments reaching approximately $800 million, significantly enhancing its capabilities in developing tumor immunotherapies.
- Clinical Development Support: The collaboration allows Janux to complete preclinical development up to Investigational New Drug (IND) submission, while Bristol Myers Squibb will take charge of subsequent development and commercialization, expected to accelerate the market introduction of new drugs.
- Positive Market Reaction: Following the announcement of the agreement, Janux's stock rose by 7.69% to $14.29, despite a 66.97% decline over the past 12 months, indicating that the collaboration is seen as a strong validation of its tumor-activated platform, potentially improving investor confidence.
- Optimistic Analyst Ratings: Although Clear Street downgraded its rating to Hold with a target price of $12.00, the overall analyst consensus remains a Buy with an average target price of $61.76, reflecting market confidence in Janux's future development.
See More
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for Tumor-Activated Therapy Development
- Strategic Collaboration: Janux Therapeutics has entered a partnership with Bristol Myers Squibb to focus on a yet-to-be-disclosed solid tumor target across multiple cancer types, aiming to expand treatment options for patients globally and enhance the company's market position in oncology.
- Development Management Division: Under the agreement, Janux will handle preclinical development through IND submission, while Bristol Myers Squibb will hold the IND and oversee subsequent clinical development and global commercialization, ensuring efficient resource utilization and specialized management.
- Positive Market Reaction: Following the announcement, Janux Therapeutics' stock traded over 8% higher in Thursday's premarket, reflecting market optimism regarding the collaboration's prospects, which may enhance the company's future fundraising capabilities and investor confidence.
- Global Commercialization Potential: This partnership not only strengthens Janux's R&D capabilities in oncology but also provides Bristol Myers Squibb with a new product line, expected to drive both companies' competitiveness and market share in the global market.
See More
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for $50M Collaboration on Solid Tumor Therapy
- Collaboration Agreement: Janux Therapeutics has signed an exclusive worldwide license agreement with Bristol Myers Squibb to advance a novel therapy for solid tumors, which is expected to significantly enhance both companies' market competitiveness in oncology.
- Financial Support: Under the agreement, Janux will receive up to $50 million in upfront and near-term milestone payments, along with approximately $800 million in development, regulatory, and commercial milestones, thereby strengthening the company's financial flexibility.
- Technology Integration: Janux's proprietary tumor-activated platforms (TRACTr, TRACIr, and ARM) will be combined with Bristol Myers Squibb's clinical development expertise, which is anticipated to accelerate the clinical progress of new therapies and improve treatment outcomes, further solidifying its position in the tumor immunotherapy space.
- Clinical Trial Involvement: Janux will remain actively involved in the first Phase 1 clinical study, ensuring the efficacy and safety of its technology, which not only helps enhance the company's reputation but may also pave the way for future product development.
See More
Janux Therapeutics Secures Exclusive License Agreement with Bristol Myers Squibb, Potential Earnings Up to $800 Million
- Collaboration Agreement: Janux Therapeutics has entered into an exclusive worldwide license agreement with Bristol Myers Squibb, focusing on developing a tumor antigen therapeutic for various cancer types, which is expected to significantly enhance both companies' market competitiveness in oncology.
- Financial Support: Under the agreement, Janux is eligible for up to $50 million in upfront and near-term milestone payments, along with approximately $800 million in development, regulatory, and commercial milestones, ensuring robust funding for future research and development.
- R&D Responsibility: Janux will handle preclinical development up to the submission of an Investigational New Drug (IND) application, with the successful completion of this phase laying the groundwork for Bristol Myers Squibb's clinical development and commercialization, highlighting the close collaboration between the two firms.
- Market Potential: This partnership not only provides Janux with substantial financial backing but also enhances its influence in the cancer treatment market through collaboration with Bristol Myers Squibb, potentially accelerating the market entry of new therapies.
See More
Janux Completes Phase 1a Trial for JANX008, Initiates Expansion Cohorts
- Clinical Trial Progress: Janux Therapeutics has completed the Phase 1a dose-escalation study for JANX008 across multiple solid tumor indications, marking a significant advancement in its tumor immunotherapy efforts.
- Expansion Cohorts Initiated: The program has initiated expansion cohorts to further evaluate and support dose optimization in selected solid tumor settings, demonstrating the company's confidence in the maturation of clinical data.
- Multiple Indication Development: As Janux's lead EGFR-targeted Tumor Activated T Cell Engager, JANX008 is being evaluated for various solid tumors including colorectal carcinoma and squamous cell carcinoma, indicating a broad potential market opportunity.
- Market Performance: Over the past year, JANX has traded between $13.76 and $61.59, with the latest closing price at $14.12, reflecting a positive market response to its clinical advancements.
See More
Janux Initiates Expansion Phase for JANX008 Clinical Trial Targeting EGFR
- Clinical Trial Progress: Janux Therapeutics has completed the dose-escalation phase of its ongoing Phase 1 study and initiated expansion cohorts for its EGFR-targeted TRACTr JANX008, which is designed to assess safety and clinical activity across multiple solid tumors, potentially providing critical data for future treatment options.
- Targeting Multiple Cancers: JANX008 aims to treat various solid tumors, including colorectal carcinoma, head and neck squamous cell carcinoma, and non-small cell lung cancer, demonstrating its broad applicability in cancer therapy and offering new treatment avenues for patients.
- Diverse Technology Platforms: Janux is advancing additional CD3 and CD28-based TRACTr and TRACIr programs, showcasing its innovative capabilities in immunotherapy, which may expand its product line to meet diverse patient needs in the future.
- Outlook for Progress: As clinical data matures, Janux expects to provide further updates on JANX008, which will not only enhance the company's standing in the biopharmaceutical industry but also potentially attract more investor interest in its future growth prospects.
See More
Janux Therapeutics and Bristol Myers Squibb Sign $800 Million Collaboration Agreement
- Collaboration Agreement: Janux Therapeutics has entered into an exclusive worldwide license agreement with Bristol Myers Squibb, receiving up to $50 million in upfront and near-term milestone payments, with potential total payments reaching approximately $800 million, significantly enhancing its capabilities in developing tumor immunotherapies.
- Clinical Development Support: The collaboration allows Janux to complete preclinical development up to Investigational New Drug (IND) submission, while Bristol Myers Squibb will take charge of subsequent development and commercialization, expected to accelerate the market introduction of new drugs.
- Positive Market Reaction: Following the announcement of the agreement, Janux's stock rose by 7.69% to $14.29, despite a 66.97% decline over the past 12 months, indicating that the collaboration is seen as a strong validation of its tumor-activated platform, potentially improving investor confidence.
- Optimistic Analyst Ratings: Although Clear Street downgraded its rating to Hold with a target price of $12.00, the overall analyst consensus remains a Buy with an average target price of $61.76, reflecting market confidence in Janux's future development.
See More
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for Tumor-Activated Therapy Development
- Strategic Collaboration: Janux Therapeutics has entered a partnership with Bristol Myers Squibb to focus on a yet-to-be-disclosed solid tumor target across multiple cancer types, aiming to expand treatment options for patients globally and enhance the company's market position in oncology.
- Development Management Division: Under the agreement, Janux will handle preclinical development through IND submission, while Bristol Myers Squibb will hold the IND and oversee subsequent clinical development and global commercialization, ensuring efficient resource utilization and specialized management.
- Positive Market Reaction: Following the announcement, Janux Therapeutics' stock traded over 8% higher in Thursday's premarket, reflecting market optimism regarding the collaboration's prospects, which may enhance the company's future fundraising capabilities and investor confidence.
- Global Commercialization Potential: This partnership not only strengthens Janux's R&D capabilities in oncology but also provides Bristol Myers Squibb with a new product line, expected to drive both companies' competitiveness and market share in the global market.
See More
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for $50M Collaboration on Solid Tumor Therapy
- Collaboration Agreement: Janux Therapeutics has signed an exclusive worldwide license agreement with Bristol Myers Squibb to advance a novel therapy for solid tumors, which is expected to significantly enhance both companies' market competitiveness in oncology.
- Financial Support: Under the agreement, Janux will receive up to $50 million in upfront and near-term milestone payments, along with approximately $800 million in development, regulatory, and commercial milestones, thereby strengthening the company's financial flexibility.
- Technology Integration: Janux's proprietary tumor-activated platforms (TRACTr, TRACIr, and ARM) will be combined with Bristol Myers Squibb's clinical development expertise, which is anticipated to accelerate the clinical progress of new therapies and improve treatment outcomes, further solidifying its position in the tumor immunotherapy space.
- Clinical Trial Involvement: Janux will remain actively involved in the first Phase 1 clinical study, ensuring the efficacy and safety of its technology, which not only helps enhance the company's reputation but may also pave the way for future product development.
See More
Janux Therapeutics Secures Exclusive License Agreement with Bristol Myers Squibb, Potential Earnings Up to $800 Million
- Collaboration Agreement: Janux Therapeutics has entered into an exclusive worldwide license agreement with Bristol Myers Squibb, focusing on developing a tumor antigen therapeutic for various cancer types, which is expected to significantly enhance both companies' market competitiveness in oncology.
- Financial Support: Under the agreement, Janux is eligible for up to $50 million in upfront and near-term milestone payments, along with approximately $800 million in development, regulatory, and commercial milestones, ensuring robust funding for future research and development.
- R&D Responsibility: Janux will handle preclinical development up to the submission of an Investigational New Drug (IND) application, with the successful completion of this phase laying the groundwork for Bristol Myers Squibb's clinical development and commercialization, highlighting the close collaboration between the two firms.
- Market Potential: This partnership not only provides Janux with substantial financial backing but also enhances its influence in the cancer treatment market through collaboration with Bristol Myers Squibb, potentially accelerating the market entry of new therapies.
See More
Janux Completes Phase 1a Trial for JANX008, Initiates Expansion Cohorts
- Clinical Trial Progress: Janux Therapeutics has completed the Phase 1a dose-escalation study for JANX008 across multiple solid tumor indications, marking a significant advancement in its tumor immunotherapy efforts.
- Expansion Cohorts Initiated: The program has initiated expansion cohorts to further evaluate and support dose optimization in selected solid tumor settings, demonstrating the company's confidence in the maturation of clinical data.
- Multiple Indication Development: As Janux's lead EGFR-targeted Tumor Activated T Cell Engager, JANX008 is being evaluated for various solid tumors including colorectal carcinoma and squamous cell carcinoma, indicating a broad potential market opportunity.
- Market Performance: Over the past year, JANX has traded between $13.76 and $61.59, with the latest closing price at $14.12, reflecting a positive market response to its clinical advancements.
See More
Janux Initiates Expansion Phase for JANX008 Clinical Trial Targeting EGFR
- Clinical Trial Progress: Janux Therapeutics has completed the dose-escalation phase of its ongoing Phase 1 study and initiated expansion cohorts for its EGFR-targeted TRACTr JANX008, which is designed to assess safety and clinical activity across multiple solid tumors, potentially providing critical data for future treatment options.
- Targeting Multiple Cancers: JANX008 aims to treat various solid tumors, including colorectal carcinoma, head and neck squamous cell carcinoma, and non-small cell lung cancer, demonstrating its broad applicability in cancer therapy and offering new treatment avenues for patients.
- Diverse Technology Platforms: Janux is advancing additional CD3 and CD28-based TRACTr and TRACIr programs, showcasing its innovative capabilities in immunotherapy, which may expand its product line to meet diverse patient needs in the future.
- Outlook for Progress: As clinical data matures, Janux expects to provide further updates on JANX008, which will not only enhance the company's standing in the biopharmaceutical industry but also potentially attract more investor interest in its future growth prospects.
See More
