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JANX Overview

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ET
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Intellectia

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High
16.595
Open
14.930
VWAP
15.80
Vol
2.51M
Mkt Cap
965.40M
Low
14.930
Amount
39.61M
EV/EBITDA(TTM)
--
Total Shares
60.83M
EV
-4.21M
EV/OCF(TTM)
--
P/S(TTM)
98.03
Janux Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing tumor-activated immunotherapies for cancer. It has developed three bispecific platforms: Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM). Its TRACTr platform produces T cell engagers (TCEs) with a tumor antigen-binding domain and a CD3 T cell binding domain. Its TRACIr platform produces bispecifics with a tumor antigen-binding domain and a costimulatory CD28 binding domain. Its clinical candidates include JANX007 and JANX008. JANX007 is a prostate-specific membrane antigen (PSMA-TRACTr) designed to target PSMA, a protein expressed in prostate cancer tumors and the vasculature of other tumors. JANX008 is an epidermal growth factor receptor (EGFR-TRACTr), being studied for the treatment of multiple solid cancers, including colorectal cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and others.
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Events Timeline

(ET)
2026-04-16
16:10:00
Janux Therapeutics Begins Phase 1 Trial of JANX014
select
2026-04-01 (ET)
2026-04-01
08:10:00
Janux Therapeutics Nominates Development Candidate, Receives $35 Million Milestone Payment from Bristol Myers Squibb
select
2026-02-26 (ET)
2026-02-26
16:20:00
Janux Announces Clinical Progress and Collaboration
select
2026-02-17 (ET)
2026-02-17
08:00:00
Janux Therapeutics Doses First Participant in JANX011 Clinical Trial
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News

NASDAQ.COM
4.5
04-20NASDAQ.COM
Oil Price Surge Leads to Market Decline
  • Market Decline: The S&P 500 index fell by 0.21%, the Dow Jones Industrial Average by 0.04%, and the Nasdaq 100 by 0.24%, indicating investor concerns over rising oil prices that could impact corporate earnings and overall market confidence.
  • Oil Price Surge: WTI crude oil prices increased by over 5% due to the closure of the Strait of Hormuz following the US's refusal to lift its naval blockade on Iranian vessels, which could exacerbate global oil and fuel shortages and raise operational costs for affected industries.
  • Earnings Expectations: So far, 81% of the 48 S&P 500 companies that reported earnings have exceeded estimates, with Q1 earnings projected to rise by 12% year-over-year; however, excluding the tech sector, growth is only expected to be 3%, indicating signs of an overall economic slowdown.
  • Airline and Chip Stocks Under Pressure: Airline stocks are down due to rising fuel costs, with Norwegian Cruise Line Holdings falling over 6%, while chipmakers like Intel are also down more than 2%, reflecting the negative impact of high oil prices across multiple sectors.
NASDAQ.COM
9.5
02-27NASDAQ.COM
Janux Therapeutics Reports Increased Q4 Losses
  • Earnings Overview: Janux Therapeutics reported a fourth-quarter loss of $42.40 million, translating to a loss of $0.51 per share, which is a significant increase from last year's loss of $20.22 million or $0.36 per share, indicating heightened pressure on the company's profitability.
  • Year-over-Year Comparison: The loss increased by 109% compared to the same period last year, highlighting intensified challenges in cost control and revenue growth, which may impact future financing capabilities and investor confidence.
  • Market Reaction: The larger-than-expected loss may lead investors to adopt a cautious outlook on the company's future financial performance, resulting in increased stock price volatility and affecting the company's standing in the capital markets.
  • Strategic Implications: Ongoing losses may prompt the company to reassess its R&D and operational strategies to seek more effective cost management and revenue growth pathways, thereby ensuring survival and growth in the highly competitive biopharmaceutical industry.
seekingalpha
9.5
02-26seekingalpha
Janux Therapeutics Q4 Earnings Beat Expectations
  • Earnings Surprise: Janux Therapeutics reported a Q4 GAAP EPS of -$0.51, beating expectations by $0.16, indicating some financial resilience despite ongoing losses.
  • Cash Reserves Decline: As of December 31, 2025, Janux's cash and cash equivalents totaled $966.6 million, down from $1.03 billion a year earlier, reflecting significant operational and R&D expenditures.
  • Rating Downgrade Impact: Following the latest Phase 1 JANX007 data update, Janux's stock rating was downgraded to 'Hold', which may affect investor confidence and lead to short-term stock price volatility as the market reassesses its 'best-in-class' status.
  • Partnership Progress: Bristol Myers has inked a licensing deal with Janux for cancer therapy, indicating continued market interest in Janux's technology, which could provide new revenue streams and enhance its competitive position.
Benzinga
7.5
01-22Benzinga
Janux Therapeutics and Bristol Myers Squibb Sign $800 Million Collaboration Agreement
  • Collaboration Agreement: Janux Therapeutics has entered into an exclusive worldwide license agreement with Bristol Myers Squibb, receiving up to $50 million in upfront and near-term milestone payments, with potential total payments reaching approximately $800 million, significantly enhancing its capabilities in developing tumor immunotherapies.
  • Clinical Development Support: The collaboration allows Janux to complete preclinical development up to Investigational New Drug (IND) submission, while Bristol Myers Squibb will take charge of subsequent development and commercialization, expected to accelerate the market introduction of new drugs.
  • Positive Market Reaction: Following the announcement of the agreement, Janux's stock rose by 7.69% to $14.29, despite a 66.97% decline over the past 12 months, indicating that the collaboration is seen as a strong validation of its tumor-activated platform, potentially improving investor confidence.
  • Optimistic Analyst Ratings: Although Clear Street downgraded its rating to Hold with a target price of $12.00, the overall analyst consensus remains a Buy with an average target price of $61.76, reflecting market confidence in Janux's future development.
stocktwits
7.5
01-22stocktwits
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for Tumor-Activated Therapy Development
  • Strategic Collaboration: Janux Therapeutics has entered a partnership with Bristol Myers Squibb to focus on a yet-to-be-disclosed solid tumor target across multiple cancer types, aiming to expand treatment options for patients globally and enhance the company's market position in oncology.
  • Development Management Division: Under the agreement, Janux will handle preclinical development through IND submission, while Bristol Myers Squibb will hold the IND and oversee subsequent clinical development and global commercialization, ensuring efficient resource utilization and specialized management.
  • Positive Market Reaction: Following the announcement, Janux Therapeutics' stock traded over 8% higher in Thursday's premarket, reflecting market optimism regarding the collaboration's prospects, which may enhance the company's future fundraising capabilities and investor confidence.
  • Global Commercialization Potential: This partnership not only strengthens Janux's R&D capabilities in oncology but also provides Bristol Myers Squibb with a new product line, expected to drive both companies' competitiveness and market share in the global market.
NASDAQ.COM
7.5
01-22NASDAQ.COM
Janux Therapeutics (JANX) Partners with Bristol Myers Squibb for $50M Collaboration on Solid Tumor Therapy
  • Collaboration Agreement: Janux Therapeutics has signed an exclusive worldwide license agreement with Bristol Myers Squibb to advance a novel therapy for solid tumors, which is expected to significantly enhance both companies' market competitiveness in oncology.
  • Financial Support: Under the agreement, Janux will receive up to $50 million in upfront and near-term milestone payments, along with approximately $800 million in development, regulatory, and commercial milestones, thereby strengthening the company's financial flexibility.
  • Technology Integration: Janux's proprietary tumor-activated platforms (TRACTr, TRACIr, and ARM) will be combined with Bristol Myers Squibb's clinical development expertise, which is anticipated to accelerate the clinical progress of new therapies and improve treatment outcomes, further solidifying its position in the tumor immunotherapy space.
  • Clinical Trial Involvement: Janux will remain actively involved in the first Phase 1 clinical study, ensuring the efficacy and safety of its technology, which not only helps enhance the company's reputation but may also pave the way for future product development.
Wall Street analysts forecast JANX stock price to rise
16 Analyst Rating
Wall Street analysts forecast JANX stock price to rise
15 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
55.25
High
150.00
Current: 0.000
sliders
Low
25.00
Averages
55.25
High
150.00
Barclays
Etzer Darout
Overweight -> Underweight
downgrade
$29 -> $14
AI Analysis
2026-04-20
New
Reason
Barclays
Etzer Darout
Price Target
$29 -> $14
AI Analysis
2026-04-20
New
downgrade
Overweight -> Underweight
Reason
Barclays analyst Etzer Darout double downgraded Janux Therapeutics to Underweight from Overweight with a price target of $14, down from $29. The firm continues to see long-term value in Janux's platform, but says there are better options for share upside the near and medium term. Barclays lowered the probability of success for the company's lead program JANX007, essentially removing it from the model. Janux has initiated the development of a dual-masked PSMA asset JANX014, which casts doubt over the viability of JANX007, the analyst tells investors in a research note.
UBS
Buy
to
Neutral
downgrade
$57 -> $15
2026-04-15
Reason
UBS
Price Target
$57 -> $15
2026-04-15
downgrade
Buy
to
Neutral
Reason
UBS downgraded Janux Therapeutics to Neutral from Buy with a price target of $15, down from $57. The firm cites a lack of near-term stock-moving catalysts for the downgrade. The shares have been under pressure following the "mixed" JANX007 Phase 1a data in fifth-line metastatic prostate cancer, the analyst tells investors in a research note. After speaking with to management, UBS thinks Janux's second half of 2026 data update will likely "incremental with limited impact on the stock."
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Valuation Metrics

The current forward P/E ratio for Janux Therapeutics Inc (JANX.O) is 0.00, compared to its 5-year average forward P/E of -15.38. For a more detailed relative valuation and DCF analysis to assess Janux Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-15.38
Current PE
0.00
Overvalued PE
-4.28
Undervalued PE
-26.47

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-9.02
Current EV/EBITDA
-14.75
Overvalued EV/EBITDA
0.19
Undervalued EV/EBITDA
-18.24

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
492.16
Current PS
235.21
Overvalued PS
934.97
Undervalued PS
49.36

Financials

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Whales Holding JANX

T
TCG Crossover Management, LLC
Holding
JANX
+12.38%
3M Return
L
Logos Global Management, L.P.
Holding
JANX
+11.12%
3M Return
R
RA Capital Management, L.P.
Holding
JANX
+5.88%
3M Return
C
Cormorant Asset Management, LP
Holding
JANX
+3.64%
3M Return

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Frequently Asked Questions

What is Janux Therapeutics Inc (JANX) stock price today?

The current price of JANX is 15.87 USD — it has increased 0.32

What is Janux Therapeutics Inc (JANX)'s business?

Janux Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing tumor-activated immunotherapies for cancer. It has developed three bispecific platforms: Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM). Its TRACTr platform produces T cell engagers (TCEs) with a tumor antigen-binding domain and a CD3 T cell binding domain. Its TRACIr platform produces bispecifics with a tumor antigen-binding domain and a costimulatory CD28 binding domain. Its clinical candidates include JANX007 and JANX008. JANX007 is a prostate-specific membrane antigen (PSMA-TRACTr) designed to target PSMA, a protein expressed in prostate cancer tumors and the vasculature of other tumors. JANX008 is an epidermal growth factor receptor (EGFR-TRACTr), being studied for the treatment of multiple solid cancers, including colorectal cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, and others.

What is the price predicton of JANX Stock?

Wall Street analysts forecast JANX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for JANX is55.25 USD with a low forecast of 25.00 USD and a high forecast of 150.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Janux Therapeutics Inc (JANX)'s revenue for the last quarter?

Janux Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Janux Therapeutics Inc (JANX)'s earnings per share (EPS) for the last quarter?

Janux Therapeutics Inc. EPS for the last quarter amounts to -0.51 USD, increased 41.67

How many employees does Janux Therapeutics Inc (JANX). have?

Janux Therapeutics Inc (JANX) has 109 emplpoyees as of April 21 2026.

What is Janux Therapeutics Inc (JANX) market cap?

Today JANX has the market capitalization of 965.40M USD.