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ZYME Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
28.000
Open
24.980
VWAP
26.05
Vol
1.70M
Mkt Cap
1.89B
Low
24.700
Amount
44.24M
EV/EBITDA(TTM)
--
Total Shares
74.30M
EV
1.65B
EV/OCF(TTM)
--
P/S(TTM)
18.24
Zymeworks Inc. is a global clinical-stage biotechnology company. The Company is developing a diverse pipeline of multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases such as cancer, autoimmune and inflammatory diseases (AIID). The Company engineered and developed zanidatamab, a HER2-targeted bispecific antibody using the Company’s Azymetric technology. It has entered into separate agreements with BeiGene, Ltd. and Jazz Pharmaceuticals Ireland Limited, granting each exclusive rights to develop and commercialize zanidatamab in different territories. It is advancing a pipeline of wholly-owned product candidates, leveraging its expertise in both antibody-drug conjugates and multispecific antibody therapeutics targeting novel pathways in areas of significant unmet medical need. The Company has two clinical-stage product candidates: ZW171 and ZW191. Its preclinical product candidates include ZW251, ZW220, ZW209, and ZW1528.
Show More

Events Timeline

(ET)
2026-03-02
09:00:00
Stock Futures Drop Sharply as Geopolitical Risks Escalate
select
2026-03-02
06:20:00
Zymeworks Secures $250M Funding from Royalty Pharma
select
2026-03-02
06:10:00
Zymeworks Reports Q4 Revenue of $2.5M
select
2026-01-12 (ET)
2026-01-12
06:30:00
Zymeworks Executive Changes: Mark Hollywood Promoted to COO
select
2026-01-11 (ET)
2026-01-11
19:30:00
Zymeworks Outlines Strategic Priorities and Milestones for 2026
select
2026-01-06 (ET)
2026-01-06
13:50:00
Zymeworks Reports Positive HERIZON-GEA-01 Trial Results
select
2026-01-06
13:50:00
BeOne Medicines Announces Phase 3 Results for ZIIHERA
select

News

Benzinga
9.5
03-09Benzinga
BETA Technologies Reports Disappointing Q4 Results
  • Earnings Miss: BETA Technologies reported a Q4 loss of $2.02 per share, significantly worse than the analyst consensus estimate of a loss of $0.84, indicating substantial challenges in profitability that could undermine investor confidence.
  • Sales Beat: Despite the significant losses, the company achieved quarterly sales of $11.133 million, surpassing the analyst consensus of $7.859 million, suggesting some resilience in market demand that could lay the groundwork for future growth.
  • Stock Reaction: In pre-market trading, BETA's shares fell 3.1% to $18.67, reflecting a negative investor response to the earnings report, which may lead to increased liquidity pressure in the short term.
  • Market Sentiment: The overall market sentiment is bearish, with Dow futures down over 1%, indicating investor concerns about the economic outlook, which could further impact BETA Technologies and other related stocks.
Benzinga
8.5
03-09Benzinga
Lisata Therapeutics to be Taken Private by Kuva Labs
  • Acquisition Agreement: Lisata Therapeutics Inc has agreed to be taken private by Kuva Labs, offering shareholders $5.00 per share along with a $1.00 contingent value right per share, indicating recognition of the company's future potential.
  • Significant Stock Surge: Following the acquisition announcement, Lisata Therapeutics' shares rose 20.3% in pre-market trading to $5.03, reflecting positive market reaction and increased investor confidence in the deal.
  • Impact of Privatization: The acquisition will result in Lisata Therapeutics delisting from public markets, potentially providing the company with greater flexibility to focus on long-term strategic goals while mitigating the impact of market volatility on its operations.
  • Market Dynamics Shift: The announcement of this deal has sparked interest in other related stocks, demonstrating investor enthusiasm for M&A activity in the biotech sector, which may influence future investment decisions and market trends.
moomoo
5.0
03-07moomoo
Zymeworks (ZYME.US) Insider Plans to Sell $6.13 Million Worth of Common Stock via Form 144
  • Stock Sale Announcement: Jeffery T.L.S. Smith plans to sell 247.33k shares of Zymeworks (ZYME.US) on March 6, with an estimated market value of around $6.13 million.

  • Reduction in Holdings: Since January 5, 2026, Smith has reduced his shareholding in Zymeworks by 19,848 shares, valued at approximately $475.56k.

seekingalpha
9.5
03-03seekingalpha
Zymeworks Q4 2025 Earnings Call Highlights
  • Clinical Trial Results: Zymeworks' Zanidatamab demonstrated a median progression-free survival exceeding one year and overall survival exceeding two years in the Phase III HERIZON-GEA-01 trial for HER2-positive gastric cancer patients, potentially redefining treatment standards and enhancing the company's market position in this area.
  • Improved Financial Performance: The company reported total revenue of $106 million for 2025, a significant increase from $76.3 million in 2024, primarily driven by milestone achievements in collaborations with major pharmaceutical companies, indicating strong clinical and regulatory progress.
  • Innovative Financing Strategy: Zymeworks secured a $250 million royalty-backed note financing with Royalty Pharma, preserving 70% of cash flows while utilizing this framework for share repurchases and strategic acquisitions, thereby enhancing long-term shareholder value.
  • Optimistic Future Outlook: Management expects operating expenses to decrease by 20% in 2026 compared to 2025 and plans to continue clinical studies for ZW191 and ZW251, demonstrating confidence in future growth and the ability to capitalize on market opportunities.
NASDAQ.COM
9.5
03-02NASDAQ.COM
Zymeworks Reports 2025 Financials and $250 Million Financing Agreement
  • Financial Overview: Zymeworks reported fourth-quarter revenues of $2.5 million for 2025, a significant drop from $31.0 million in the same quarter of 2024, with a net loss of $41.2 million compared to $23.5 million last year, indicating pressure on both revenue and profitability.
  • Annual Revenue Growth: For the full year 2025, revenue totaled $106.0 million, a 39% increase from $76.3 million in 2024, while net loss narrowed to $81.1 million from $122.7 million in 2024, suggesting progress in revenue growth despite ongoing losses.
  • Financing Agreement Impact: The $250 million royalty-backed financing agreement with Royalty Pharma allows Zymeworks to repay through 30% of worldwide tiered royalties, enhancing financial flexibility to support future share repurchases and strategic acquisitions.
  • Future Outlook: Zymeworks expects that, combined with the Royalty Pharma financing, its cash and cash equivalents will support operations beyond 2028, while Ziihera's potential in treating HER2-positive cancers is anticipated to further drive company growth.
NASDAQ.COM
7.5
03-02NASDAQ.COM
Zymeworks Secures $250 Million Royalty Financing from Royalty Pharma
  • Financing Agreement Details: Zymeworks has entered into a $250 million non-recourse financing agreement with Royalty Pharma, secured by future royalties, showcasing Zymeworks' flexibility and innovation in capital raising.
  • Royalty Structure: The agreement is backed by 30% of global tiered royalties from Jazz Pharmaceuticals and BeOne Medicines, ensuring stability and predictability in Zymeworks' future revenue streams.
  • Repayment Terms: Royalty Pharma will receive cumulative payments of 1.65 times the note amount by December 31, 2033, or 1.925 times thereafter, indicating a longer repayment period that alleviates short-term financial pressure on Zymeworks.
  • Milestone Payments Retention: Zymeworks retains full rights to regulatory and commercial milestone payments under agreements with Jazz and BeOne, with potential remaining milestone payments up to $1.5 billion, further enhancing the company's financial flexibility and growth prospects.
Wall Street analysts forecast ZYME stock price to rise
14 Analyst Rating
Wall Street analysts forecast ZYME stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Evercore ISI
Outperform
maintain
$33 -> $48
AI Analysis
2026-03-09
New
Reason
Evercore ISI
Price Target
$33 -> $48
AI Analysis
2026-03-09
New
maintain
Outperform
Reason
Evercore ISI raised the firm's price target on Zymeworks (ZYME) to $48 from $33 and keeps an Outperform rating on the shares. The $250M debt deal with Royalty Pharma (RPRX) is "a smart move," providing significant optionality and the terms are "favorable," allowing Zymeworks to retain upside while strengthening its balance sheet, the analyst tells investors.
H.C. Wainwright
Buy
maintain
$32 -> $46
2026-03-06
New
Reason
H.C. Wainwright
Price Target
$32 -> $46
2026-03-06
New
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Zymeworks to $46 from $32 and keeps a Buy rating on the shares post the Q4 report. The firm cites the company's shift towards a more royalty-focused strategy for the target boost.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ZYME
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Valuation Metrics

The current forward P/E ratio for Zymeworks Inc (ZYME.O) is -28.70, compared to its 5-year average forward P/E of -3.81. For a more detailed relative valuation and DCF analysis to assess Zymeworks Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.81
Current PE
-28.70
Overvalued PE
15.45
Undervalued PE
-23.07

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
6.42
Current EV/EBITDA
216.60
Overvalued EV/EBITDA
46.91
Undervalued EV/EBITDA
-34.07

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
14.36
Current PS
20.84
Overvalued PS
32.60
Undervalued PS
-3.89

Financials

AI Analysis
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Quarterly

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Whales Holding ZYME

E
EcoR1 Capital, LLC
Holding
ZYME
+7.87%
3M Return
A
Artal Group S.A.
Holding
ZYME
+7.70%
3M Return
V
Vestal Point Capital, LP
Holding
ZYME
+6.94%
3M Return
B
BVF Partners L.P.
Holding
ZYME
+6.57%
3M Return
P
Perceptive Advisors LLC
Holding
ZYME
+6.14%
3M Return
R
Rubric Capital Management LP
Holding
ZYME
+4.83%
3M Return

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Frequently Asked Questions

What is Zymeworks Inc (ZYME) stock price today?

The current price of ZYME is 25.46 USD — it has increased 4.99

What is Zymeworks Inc (ZYME)'s business?

Zymeworks Inc. is a global clinical-stage biotechnology company. The Company is developing a diverse pipeline of multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases such as cancer, autoimmune and inflammatory diseases (AIID). The Company engineered and developed zanidatamab, a HER2-targeted bispecific antibody using the Company’s Azymetric technology. It has entered into separate agreements with BeiGene, Ltd. and Jazz Pharmaceuticals Ireland Limited, granting each exclusive rights to develop and commercialize zanidatamab in different territories. It is advancing a pipeline of wholly-owned product candidates, leveraging its expertise in both antibody-drug conjugates and multispecific antibody therapeutics targeting novel pathways in areas of significant unmet medical need. The Company has two clinical-stage product candidates: ZW171 and ZW191. Its preclinical product candidates include ZW251, ZW220, ZW209, and ZW1528.

What is the price predicton of ZYME Stock?

Wall Street analysts forecast ZYME stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZYME is35.55 USD with a low forecast of 30.00 USD and a high forecast of 42.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zymeworks Inc (ZYME)'s revenue for the last quarter?

Zymeworks Inc revenue for the last quarter amounts to 27.61M USD, increased 72.59

What is Zymeworks Inc (ZYME)'s earnings per share (EPS) for the last quarter?

Zymeworks Inc. EPS for the last quarter amounts to -0.26 USD, decreased -33.33

How many employees does Zymeworks Inc (ZYME). have?

Zymeworks Inc (ZYME) has 280 emplpoyees as of March 11 2026.

What is Zymeworks Inc (ZYME) market cap?

Today ZYME has the market capitalization of 1.89B USD.