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ZYME Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
23.590
Open
23.340
VWAP
23.13
Vol
699.02K
Mkt Cap
1.70B
Low
22.650
Amount
16.17M
EV/EBITDA(TTM)
--
Total Shares
73.57M
EV
1.32B
EV/OCF(TTM)
--
P/S(TTM)
21.58
Zymeworks Inc. is a biotechnology company. The Company is engaged in managing a portfolio of healthcare assets and developing a pipeline of multifunctional biotherapeutics to improve the standard of care for conditions, including cancer, inflammation, and autoimmune disease. Its antibody-drug conjugates (ADCs) include ZW191, ZW251, and ZW220. ZW191 is a clinical-stage ADC that targets folate receptor alpha-expressing tumors including ovarian cancer, endometrial cancer, and non-small cell lung cancer (NSCLC), which is built using bystander-active, TOPO1i payload technology, ZD06519. ZW251 is a clinical-stage ADC molecule designed for the treatment of glypican 3 (GPC3)-expressing hepatocellular carcinoma (HCC). ZW220 is an ADC that targets NaPi2b-expressing NSCLC and ovarian cancer, built using bystander active TOPO1i payload technology, ZD06519. Its therapeutic platforms can be used to develop multifunctional fit-for-purpose biotherapeutics with bispecific capabilities.
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Events Timeline

(ET)
2026-06-14
19:30:00
Zymeworks Presents ZW191 Clinical Data at ESMO 2026
select
2026-05-14 (ET)
2026-05-14
17:00:00
Zymeworks Authorizes Share Repurchase of Up to $125M
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2026-05-07 (ET)
2026-05-07
16:30:00
Company Reports Q1 Revenue of $2.4M, Below Consensus
select
2026-04-21 (ET)
2026-04-21
17:40:00
Zymeworks Announces ZW191 Anti-Tumor Study Results
select
2026-04-09 (ET)
2026-04-09
06:10:00
Zymeworks Appoints Adam Schayowitz and Scott Platshon as Full-Time Executives
select
2026-04-07 (ET)
2026-04-07
13:30:00
Gilead to Acquire Tubulis for $3.15B
select
2026-04-01 (ET)
2026-04-01
06:10:00
Zymeworks Appoints Kristin Stafford as CFO
select

News

PRnewswire
7.5
06-18PRnewswire
Gandeeva and Zymeworks Partner to Enhance Antibody Drug Discovery
  • Partnership Background: Vancouver-based Gandeeva Therapeutics has partnered with Zymeworks to utilize cryo-electron microscopy (cryo-EM) for generating high-resolution structural data of antibody-antigen interfaces, thereby enhancing antibody drug discovery and development.
  • Technical Breakthrough: Gandeeva scientists successfully determined the structure of a small and flexible antigen (<20 kDa) bound to a Fab fragment of an antibody developed by Zymeworks, visualizing the nine amino acids forming the antibody-binding epitope at a resolution of 2.6 Å, significantly improving the understanding of complex biological targets.
  • Business Impact: Zymeworks' Chief Scientific Officer, Paul Moore, stated that knowledge of precise interactions at these challenging targets is crucial for selecting antibody leads and provides essential insights for optimizing biologics, potentially accelerating their drug development processes.
  • Strategic Significance: Gandeeva's founder, Sriram Subramaniam, emphasized that obtaining near-atomic resolution cryo-EM structures is a game-changer, particularly in the context of accelerating AI-driven antibody design, as it offers rapid feedback for testing and validating antibodies, thereby enhancing overall R&D efficiency.
Newsfilter
9.0
06-14Newsfilter
ZW191 Shows Significant Anti-Tumor Activity in Platinum-Resistant Ovarian Cancer Patients
  • Clinical Data Highlights: ZW191 demonstrated a confirmed objective response rate (cORR) of 78.6% in platinum-resistant ovarian cancer patients, particularly excelling in FRα-positive individuals, indicating its potential to transform treatment paradigms for difficult-to-treat cancers.
  • Survival Data: The median progression-free survival across all dose levels was reported at 7.6 months, suggesting a positive impact on extending patient survival, which further underscores the necessity for its clinical development.
  • Tolerability Analysis: While 98% of patients experienced treatment-emergent adverse events (TEAEs), most were manageable, with 55% reporting grade 3 or higher events, indicating that ZW191's safety profile aligns with its promising clinical application.
  • Dose Optimization Study Completion: The dose optimization phase of ZW191 has completed patient recruitment, with future development expected to inform dose selection between 6.4 mg/kg and 9.6 mg/kg, signaling a broad potential for clinical application.
Newsfilter
1.0
05-13Newsfilter
Zymeworks to Participate in Upcoming Investor Conferences
  • Investor Conference Schedule: Zymeworks will participate in one-on-one meetings and a fireside chat at the 2026 Stifel Virtual Targeted Oncology Forum on May 20, aiming to enhance investor interest in its multifunctional biotherapeutics pipeline.
  • Innovation Summit Participation: The management will engage in a fireside chat at the TD Cowen 7th Annual Oncology Innovation Summit on May 27, further showcasing its innovative capabilities and market potential in cancer treatment.
  • Global Healthcare Conference: Zymeworks is set to attend the 2026 Jefferies Global Healthcare Conference on June 3 in New York, conducting one-on-one meetings and a fireside chat to attract more investor attention to its drug development progress.
  • Strategic Partnerships and Product Development: Zymeworks is advancing its HER2-targeted bispecific antibody Ziihera through strategic collaborations with BeOne Medicines and Jazz Pharmaceuticals, demonstrating its strong competitive position in the biopharmaceutical sector.
NASDAQ.COM
9.0
04-22NASDAQ.COM
Zymeworks' ZW191 Shows Promising Efficacy in Phase 1 Trials
  • Clinical Trial Results: Zymeworks presented Phase 1 data for ZW191 at the AACR Annual Meeting, achieving a confirmed objective response rate of 56% in platinum-resistant ovarian cancer patients, with 68% showing tumor regression and 94% disease control, indicating its potential in treating recurrent cancers.
  • Targeting Specific Cancers: ZW191 is designed to target folate receptor alpha in ovarian and endometrial cancers, delivering a drug payload directly to tumor cells, addressing the urgent need for effective treatments in patients lacking options after standard therapies.
  • Safety Profile: ZW191 demonstrated good tolerability at doses up to 11.2 mg/kg, with 55% of patients experiencing grade 3 or higher treatment-emergent adverse events, primarily neutropenia, anemia, and thrombocytopenia, while grade 4 events were rare, indicating a manageable safety profile.
  • Next Steps in Research: The study's Part 2a has completed enrollment across North America, Europe, and Asia-Pacific, with results expected to guide the recommended dose for further registration studies, and ZW191's unique design positions it as a potential best-in-class therapy for gynecological cancers.
Newsfilter
8.5
04-17Newsfilter
Zymeworks Showcases Next-Generation ADC Programs at AACR 2026
  • Next-Gen ADC Showcase: Zymeworks presented six posters at the AACR 2026 Annual Meeting, highlighting its antibody-drug conjugate (ADC) and payload development programs, emphasizing innovative potential in treating RAS-driven cancers.
  • ZW191 Clinical Progress: ZW191, an FRα-targeting ADC, demonstrates favorable tolerability and efficacy when combined with standard therapies, supporting its further development in clinical stages.
  • Targeted Innovations: Newly developed ADCs targeting Ly6E, CLDN18.2, and PTK7 show strong anti-tumor activity across various solid tumor models, potentially offering new treatment options for difficult-to-treat cancers.
  • Future Outlook: Zymeworks plans to present updated clinical data on ZW191 during an oral presentation on April 21, 2026, further validating the efficacy and safety of its ADC platform and advancing the company's strategic development in the biotechnology sector.
Newsfilter
9.5
04-16Newsfilter
Zymeworks to Report Q1 2026 Financial Results on May 7
  • Earnings Announcement: Zymeworks will report its Q1 2026 financial results after market close on May 7, 2026, which is expected to provide investors with insights into the company's financial health and business progress.
  • Conference Call Details: Following the earnings release, management will host a conference call and webcast at 4:30 PM ET on the same day to discuss financial results and provide corporate updates, enhancing transparency and investor confidence.
  • Pipeline Development: Zymeworks is advancing its pipeline of multifunctional biotherapeutics, particularly innovative drugs targeting difficult-to-treat diseases like Ziihera®, indicating the company's ongoing innovation and competitiveness in the biotechnology sector.
  • Strategic Partnerships: The company has entered exclusive development and commercialization agreements with BeOne Medicines and Jazz Pharmaceuticals, showcasing its strategic positioning and market expansion capabilities in the global biopharmaceutical landscape.
Wall Street analysts forecast ZYME stock price to rise
14 Analyst Rating
Wall Street analysts forecast ZYME stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Current: 0.000
sliders
Low
30.00
Averages
35.55
High
42.00
Evercore ISI
Outperform
maintain
$33 -> $48
AI Analysis
2026-03-09
Reason
Evercore ISI
Price Target
$33 -> $48
AI Analysis
2026-03-09
maintain
Outperform
Reason
Evercore ISI raised the firm's price target on Zymeworks (ZYME) to $48 from $33 and keeps an Outperform rating on the shares. The $250M debt deal with Royalty Pharma (RPRX) is "a smart move," providing significant optionality and the terms are "favorable," allowing Zymeworks to retain upside while strengthening its balance sheet, the analyst tells investors.
H.C. Wainwright
Buy
maintain
$32 -> $46
2026-03-06
Reason
H.C. Wainwright
Price Target
$32 -> $46
2026-03-06
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Zymeworks to $46 from $32 and keeps a Buy rating on the shares post the Q4 report. The firm cites the company's shift towards a more royalty-focused strategy for the target boost.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ZYME
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Valuation Metrics

The current forward P/E ratio for Zymeworks Inc (ZYME.O) is 23.15, compared to its 5-year average forward P/E of -3.01. For a more detailed relative valuation and DCF analysis to assess Zymeworks Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.01
Current PE
23.15
Overvalued PE
17.02
Undervalued PE
-23.03

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
6.65
Current EV/EBITDA
-0.33
Overvalued EV/EBITDA
46.80
Undervalued EV/EBITDA
-33.50

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
11.76
Current PS
7.37
Overvalued PS
26.16
Undervalued PS
-2.64

Financials

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Whales Holding ZYME

R
Rubric Capital Management LP
Holding
ZYME
+16.33%
3M Return
B
BVF Partners L.P.
Holding
ZYME
+14.24%
3M Return
P
Perceptive Advisors LLC
Holding
ZYME
+12.49%
3M Return
R
Redmile Group, LLC
Holding
ZYME
+9.30%
3M Return
A
Artal Group S.A.
Holding
ZYME
+9.19%
3M Return
V
Vestal Point Capital, LP
Holding
ZYME
+2.78%
3M Return

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Frequently Asked Questions

What is Zymeworks Inc (ZYME) stock price today?

The current price of ZYME is 23.14 USD — it has increased 0

What is Zymeworks Inc (ZYME)'s business?

Zymeworks Inc. is a biotechnology company. The Company is engaged in managing a portfolio of healthcare assets and developing a pipeline of multifunctional biotherapeutics to improve the standard of care for conditions, including cancer, inflammation, and autoimmune disease. Its antibody-drug conjugates (ADCs) include ZW191, ZW251, and ZW220. ZW191 is a clinical-stage ADC that targets folate receptor alpha-expressing tumors including ovarian cancer, endometrial cancer, and non-small cell lung cancer (NSCLC), which is built using bystander-active, TOPO1i payload technology, ZD06519. ZW251 is a clinical-stage ADC molecule designed for the treatment of glypican 3 (GPC3)-expressing hepatocellular carcinoma (HCC). ZW220 is an ADC that targets NaPi2b-expressing NSCLC and ovarian cancer, built using bystander active TOPO1i payload technology, ZD06519. Its therapeutic platforms can be used to develop multifunctional fit-for-purpose biotherapeutics with bispecific capabilities.

What is the price predicton of ZYME Stock?

Wall Street analysts forecast ZYME stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZYME is35.55 USD with a low forecast of 30.00 USD and a high forecast of 42.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zymeworks Inc (ZYME)'s revenue for the last quarter?

Zymeworks Inc revenue for the last quarter amounts to 2.41M USD, decreased -91.12

What is Zymeworks Inc (ZYME)'s earnings per share (EPS) for the last quarter?

Zymeworks Inc. EPS for the last quarter amounts to -0.59 USD, increased 96.67

How many employees does Zymeworks Inc (ZYME). have?

Zymeworks Inc (ZYME) has 264 emplpoyees as of June 21 2026.

What is Zymeworks Inc (ZYME) market cap?

Today ZYME has the market capitalization of 1.70B USD.