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ORKA logo

ORKA Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
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Intellectia

Loading chart...

High
59.000
Open
57.980
VWAP
58.15
Vol
1.23M
Mkt Cap
3.53B
Low
56.920
Amount
71.48M
EV/EBITDA(TTM)
--
Total Shares
60.31M
EV
3.14B
EV/OCF(TTM)
--
P/S(TTM)
--
Oruka Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications. Its lead program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, psoriatic arthritis (PsA), and other conditions. ORKA-001 is an extended half-life monoclonal antibody (mAb) designed to target IL-23p19. IL-23 is a pro-inflammatory cytokine that plays a critical role in the proliferation and development of T helper 17 (Th17) cells, which are the primary drivers of several autoimmune and inflammatory disorders, including PsO. IL-23 is composed of two subunits: a p40 subunit and a p19 subunit. ORKA-002 is an extended half-life mAb designed to target IL-17A and IL-17F (IL-17A/F).
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Events Timeline

(ET)
2026-05-13
16:30:00
Oruka CEO Klein Says ORKA-001 Data Exceeds Expectations
select
2026-05-06 (ET)
2026-05-06
08:20:00
Halozyme Enters Global Exclusive Collaboration with Oruka
select
2026-04-28 (ET)
2026-04-28
19:50:00
Multiple Investment Banks Jointly Manage New Stock Offering
select
2026-04-27 (ET)
2026-04-27
16:20:00
Oruka Therapeutics Launches $500M Public Offering
select
2026-04-27
12:10:00
Oruka Therapeutics Stock Rises 19% to $82.15
select

News

Newsfilter
8.5
05-28Newsfilter
Biotech Sector Approaches Critical Phase 2 Milestones
  • Importance of Clinical Data: Phase 2 clinical data in the biotech sector is viewed as a pivotal moment where science transitions from theory to validation, with positive results attracting analyst upgrades, fostering institutional investment, and creating acquisition opportunities, thereby significantly enhancing company valuations.
  • Shifting Market Dynamics: Following a period of capital tightening, the biotech industry is entering a cycle of innovation-driven investing, with analysts and investors showing strong interest in oncology and immunology companies with robust mid-stage data, indicating potential for high valuations in the future.
  • Rise of NeOnc Technologies: NeOnc Technologies, focusing on brain cancer therapies, is garnering attention for its Phase 2 developments, where successful data could dramatically elevate its scientific credibility and acquisition potential, attracting investments from firms including Bank of America.
  • Increased Insider Confidence: NeOnc's CEO has recently purchased over $500,000 in company shares, reflecting management's confidence in future growth, and investors generally view sustained insider buying as a strong signal of management conviction, particularly for clinical-stage biotech firms.
seekingalpha
8.5
05-13seekingalpha
Oruka Therapeutics Q1 Earnings Beat Expectations
  • Earnings Performance: Oruka Therapeutics reported a Q1 GAAP EPS of -$0.48, beating expectations by $0.07, indicating improvements in financial management despite still being in a loss position.
  • Cash Reserves: As of March 31, 2026, Oruka had $496 million in cash, cash equivalents, and marketable securities, providing robust financial support for future R&D and operations.
  • Clinical Research Progress: Oruka Therapeutics discussed interim results from the EVERLAST-A study of ORKA-001 for moderate to severe plaque psoriasis, suggesting potential therapeutic efficacy that could enhance future market acceptance.
  • Public Offering Details: Oruka Therapeutics successfully priced a $700 million upsized public offering at $72.50 per share, reflecting market confidence in its drug development and providing a financial foundation for further expansion.
Fool
8.5
05-13Fool
Avidity Partners Increases Stake in Oruka Therapeutics
  • Share Acquisition: Avidity Partners Management disclosed a purchase of 100,000 shares of Oruka Therapeutics in an SEC filing dated May 13, 2026, with an estimated transaction value of $3.48 million, indicating strong conviction in the company's prospects.
  • Increased Stake: Following this acquisition, Avidity's stake in Oruka accounts for 11.77% of its 13F reportable assets, underscoring its significant commitment to the company's future growth.
  • Outstanding Market Performance: As of May 12, 2026, Oruka Therapeutics shares were priced at $64.65, reflecting a remarkable 563.1% increase over the past year, significantly outperforming the S&P 500's 26% rise, showcasing strong market confidence in its products.
  • R&D Focus: Oruka specializes in developing monoclonal antibody therapies, particularly ORKA-001 and ORKA-002 targeting psoriasis; if it continues to deliver best-in-class efficacy, it could secure a competitive edge in the crowded biopharmaceutical landscape.
Newsfilter
5.0
05-12Newsfilter
Achieve Life Sciences Appoints Three Senior Executives
  • Executive Appointments: Achieve Life Sciences has appointed Christopher Martin to its Board of Directors, Mark Zappia as Senior Vice President of Commercial, and Jim Willis as Vice President of Sales, all of whom bring successful commercial experience from Verona Pharma, which is expected to drive the company towards commercialization.
  • Financing Context: These appointments come on the heels of Achieve securing up to $354 million in financing, including $180 million upfront and up to $174 million from milestone-based warrants tied to FDA approval, demonstrating the company's commitment to advancing cytisinicline's commercialization.
  • Market Potential: Cytisinicline could become the first new smoking cessation therapy in over two decades and the first ever for vaping cessation, addressing the urgent needs of approximately 25 million smokers and 18 million e-cigarette users in the U.S., indicating significant market potential.
  • Leadership Confidence: New CEO Andrew D. Goldberg stated that the addition of these executives is one of the most consequential decisions of his tenure, reflecting Achieve's strategic positioning to tackle public health issues and enhancing confidence in the company's future growth.
Fool
9.5
05-11Fool
AbbVie's Strong Earnings Amid Competitive Threats
  • Strong Financial Performance: AbbVie reported $15 billion in revenue for Q1, exceeding its guidance of $14.7 billion and reflecting a 12.4% year-over-year growth, indicating robust market performance and a solid financial foundation.
  • Immunology Segment Dominance: AbbVie's key growth drivers, Skyrizi and Rinvoq, generated $17.6 billion and $8.3 billion in revenue last year, respectively, with Skyrizi's year-over-year growth rate reaching 49.9%, solidifying its market leadership.
  • Rising Competitive Risks: Oruka Therapeutics' ORKA-001 demonstrated a 63.5% PASI 100 achievement rate in clinical trials, posing a potential threat to Skyrizi, which typically achieves only 51%, leading to positive market reactions to Oruka's results.
  • Diversified Growth Strategy: Despite competitive pressures, AbbVie has other growth drivers like Qulipta and Botox, and is developing new products to reduce reliance on its immunology business, maintaining long-term attractiveness and a strong dividend policy.
NASDAQ.COM
9.5
05-11NASDAQ.COM
AbbVie Faces Competition from New Drug Threat
  • Strong Financial Performance: AbbVie reported $15 billion in revenue for Q1, exceeding its guidance of $14.7 billion with a year-over-year increase of 12.4%, indicating robust overall business health despite looming competitive pressures.
  • Skyrizi's Market Position: Skyrizi holds over 45% of the U.S. biologic psoriasis market, generating $17.6 billion in revenue last year with a 49.9% year-over-year growth rate, solidifying its leadership in a highly competitive landscape.
  • Emerging Competitive Threat: Oruka Therapeutics' ORKA-001 demonstrated a 63.5% PASI 100 achievement rate in clinical trials, potentially surpassing Skyrizi's 51%, leading to positive market reactions for Oruka and downward pressure on AbbVie's stock.
  • Diversified Growth Drivers: Despite competitive threats, AbbVie has other growth drivers such as Qulipta and Botox, along with a strong pipeline expected to yield new products, thereby reducing reliance on its immunology segment.
Wall Street analysts forecast ORKA stock price to rise
10 Analyst Rating
Wall Street analysts forecast ORKA stock price to rise
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
40.00
Averages
51.67
High
75.00
Current: 0.000
sliders
Low
40.00
Averages
51.67
High
75.00
Leerink
NULL
to
Outperform
maintain
$109 -> $120
AI Analysis
2026-04-30
Reason
Leerink
Price Target
$109 -> $120
AI Analysis
2026-04-30
maintain
NULL
to
Outperform
Reason
Leerink raised the firm's price target on Oruka Therapeutics to $120 from $109 and keeps an Outperform rating on the shares.
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$75 -> $120
2026-04-29
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$75 -> $120
2026-04-29
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Oruka Therapeutics to $120 from $75 and keeps a Buy rating on the shares. The EVERLAST-A "delivers in spades," positioning ORKA-001 as a best-in-disease agent with an optimized convenience profile, the analyst tells investors in a research note. The firm views the EVERLAST-A data as a "best-case scenario,: positioning ORKA-001 as a possible leading psoriasis medication that may be "preferred by the lion's share of patients due to the potential for once-yearly dosing." It increased the probability of approval for ORKA-001 to 75% from 50% in psoriasis.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ORKA
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Valuation Metrics

The current forward P/E ratio for Oruka Therapeutics Inc (ORKA.O) is 0.00, compared to its 5-year average forward P/E of -6.97. For a more detailed relative valuation and DCF analysis to assess Oruka Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.97
Current PE
0.00
Overvalued PE
-4.38
Undervalued PE
-9.56

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

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Whales Holding ORKA

C
Commodore Capital LP
Holding
ORKA
+20.40%
3M Return
F
Fairmount Funds Management LLC
Holding
ORKA
+17.03%
3M Return
A
Avoro Capital Advisors LLC
Holding
ORKA
+15.03%
3M Return
V
VR Management, LLC
Holding
ORKA
+12.64%
3M Return
P
Perceptive Advisors LLC
Holding
ORKA
+10.32%
3M Return
P
Paradigm Biocapital Advisors LP
Holding
ORKA
+8.52%
3M Return

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Frequently Asked Questions

What is Oruka Therapeutics Inc (ORKA) stock price today?

The current price of ORKA is 58.53 USD — it has increased 0.95

What is Oruka Therapeutics Inc (ORKA)'s business?

Oruka Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications. Its lead program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, psoriatic arthritis (PsA), and other conditions. ORKA-001 is an extended half-life monoclonal antibody (mAb) designed to target IL-23p19. IL-23 is a pro-inflammatory cytokine that plays a critical role in the proliferation and development of T helper 17 (Th17) cells, which are the primary drivers of several autoimmune and inflammatory disorders, including PsO. IL-23 is composed of two subunits: a p40 subunit and a p19 subunit. ORKA-002 is an extended half-life mAb designed to target IL-17A and IL-17F (IL-17A/F).

What is the price predicton of ORKA Stock?

Wall Street analysts forecast ORKA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ORKA is51.67 USD with a low forecast of 40.00 USD and a high forecast of 75.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Oruka Therapeutics Inc (ORKA)'s revenue for the last quarter?

Oruka Therapeutics Inc revenue for the last quarter amounts to -36.43M USD, increased 45.24

What is Oruka Therapeutics Inc (ORKA)'s earnings per share (EPS) for the last quarter?

Oruka Therapeutics Inc. EPS for the last quarter amounts to -23651000.00 USD, increased 13.26

How many employees does Oruka Therapeutics Inc (ORKA). have?

Oruka Therapeutics Inc (ORKA) has 68 emplpoyees as of May 31 2026.

What is Oruka Therapeutics Inc (ORKA) market cap?

Today ORKA has the market capitalization of 3.53B USD.