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ORKA Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
49.325
Open
46.570
VWAP
48.15
Vol
1.03M
Mkt Cap
2.26B
Low
46.070
Amount
49.50M
EV/EBITDA(TTM)
--
Total Shares
49.54M
EV
1.92B
EV/OCF(TTM)
--
P/S(TTM)
--
Oruka Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications. Its lead program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, psoriatic arthritis (PsA), and other conditions. ORKA-001 is an extended half-life monoclonal antibody (mAb) designed to target IL-23p19. IL-23 is a pro-inflammatory cytokine that plays a critical role in the proliferation and development of T helper 17 (Th17) cells, which are the primary drivers of several autoimmune and inflammatory disorders, including PsO. IL-23 is composed of two subunits: a p40 subunit and a p19 subunit. ORKA-002 is an extended half-life mAb designed to target IL-17A and IL-17F (IL-17A/F).
Show More

Events Timeline

(ET)
2026-03-12
17:00:00
Oruka CEO Klein Says Company Could Face Transformative Year
select
2026-01-12 (ET)
2026-01-12
07:20:00
Oruka Therapeutics Reports Positive Interim Data from ORKA-002 Phase 1 Trial
select

News

Fool
6.5
03-18Fool
VR Adviser, LLC Reduces Stake in Ocular Therapeutix
  • Share Reduction Details: On February 17, 2026, VR Adviser, LLC disclosed the sale of 5,845,915 shares of Ocular Therapeutix, with an estimated transaction value of $70.96 million, indicating a potential decline in confidence in the stock.
  • Asset Management Impact: This transaction reduced Ocular Therapeutix's share of VR Adviser's reportable assets under management to 4.39%, with a holding value of $88.81 million, reflecting a diminished significance in the fund's portfolio.
  • Market Performance Analysis: As of February 17, 2026, Ocular Therapeutix shares were priced at $6.99, down 3.98% over the past year, underperforming the S&P 500 by 15.90 percentage points, suggesting low market expectations for future growth.
  • Investor Considerations: While the reduction is a routine portfolio management action, Ocular Therapeutix's product DEXTENZA and its drug delivery technology offer differentiation in a competitive ophthalmology market, warranting investor attention on its future market expansion and revenue growth potential.
NASDAQ.COM
6.5
03-18NASDAQ.COM
VR Adviser, LLC Sells Shares of Ocular Therapeutix
  • Share Sale Overview: On February 17, 2026, VR Adviser, LLC disclosed to the SEC that it sold 5,845,915 shares of Ocular Therapeutix, with an estimated transaction value of $71.01 million, reducing its stake in the company to 4.4%.
  • Asset Management Impact: The sale resulted in a $65.05 million decrease in the value of VR Adviser's position, highlighting the direct impact of trading and stock price fluctuations on its assets under management during the fourth quarter.
  • Portfolio Adjustment: This transaction represented 3.51% of VR Adviser's reportable assets under management, indicating routine portfolio management adjustments within its strategy of concentrated investments in small-cap biotech firms.
  • Market Performance Analysis: Ocular Therapeutix's stock has declined approximately 4% over the past year and has underperformed the S&P 500 by about 16 points, reflecting uneven growth in a competitive ophthalmic pharmaceutical market, which may affect investor confidence.
NASDAQ.COM
6.5
03-16NASDAQ.COM
Experts Reveal Top Stock Picks with Doubling Potential
  • Stock Potential Recommendations: Experts have revealed five stocks with doubling potential, with one being highlighted by Director of Research Sheraz Mian as superior, indicating its unique market advantage.
  • Historical Performance Comparison: While not all recommended stocks are guaranteed winners, this stock is expected to significantly outperform earlier recommendations like Hims & Hers Health, which surged by +209%, drawing investor interest.
  • Access to Latest Recommendations: Zacks Investment Research offers the latest seven best stock picks, allowing investors to download this report for free to uncover investment opportunities for the next 30 days.
  • Market Insights: The article underscores the author's views and analyses, which may not necessarily reflect those of Nasdaq, Inc., yet provide valuable market insights for investors.
NASDAQ.COM
6.5
03-15NASDAQ.COM
VR Adviser Increases Stake in Savara by Over 1 Million Shares
  • Share Increase: VR Adviser increased its position in Savara by 1,059,332 shares during Q4, bringing its total holdings to 13,740,375 shares valued at $82.9 million, reflecting strong confidence in the company.
  • Asset Management Proportion: Savara's shares account for 4.1% of VR Adviser's over $2 billion in assets under management, indicating its significance in the firm's portfolio and potential influence on future investment decisions.
  • Market Potential: Savara focuses on developing inhaled biologics for rare respiratory diseases, and although it currently lacks approved products, its lead candidate, molgramostim, is in late-stage trials and aims to address significant unmet medical needs, suggesting long-term market potential.
  • Investment Risks: While Savara's stock surged 96.4% last year, investors should be aware of the high-risk nature of the biotech industry, as Savara has no revenue-generating products, making its future stock performance heavily reliant on regulatory approvals and potential revenue from its lead drug candidate.
Fool
6.5
03-15Fool
VR Adviser Increases Stake in Savara by Over 1 Million Shares
  • Share Increase: VR Adviser increased its position in Savara by 1,059,332 shares during Q4, bringing its total holdings to 13,740,375 shares valued at $82.9 million, reflecting confidence in Savara's future performance.
  • AUM Proportion: Savara represents 4.1% of VR Adviser's total assets under management, highlighting its strategic significance among the firm's 27 positions and indicating a strong belief in the company's potential.
  • Market Performance: Savara's stock gained 96.4% in 2022, leading investors to maintain an optimistic outlook for continued growth, particularly with expectations for 2025's performance.
  • Risk Advisory: While Savara shows promise in the biotech sector, the lack of approved products and current revenue generation necessitates caution from investors due to the inherent high-risk nature of the investment.
NASDAQ.COM
8.5
03-13NASDAQ.COM
Oruka Therapeutics Shares Hit 52-Week High Following Data Release Acceleration
  • Data Release Acceleration: Oruka Therapeutics announced an accelerated release of EVERLAST-A 16-week data due to rapid patient enrollment, now expected in Q2 2026, which is earlier than the previously anticipated second half of 2026, indicating significant progress in treating moderate-to-severe plaque psoriasis.
  • Clinical Trial Advancements: The EVERLAST-B trial commenced in December 2025 to evaluate three different doses of ORKA-001, with data expected in 2027, which will support the initiation of a phase 3 program, further advancing the company's product pipeline.
  • Strong Financial Position: As of December 31, 2025, Oruka reported $479.6 million in cash and cash equivalents, ensuring sufficient funding for future clinical trials and enhancing investor confidence in the company's growth prospects.
  • Robust Stock Performance: Since September 18, 2025, Oruka's stock price surged from $16.56 to $39.07, reflecting a 22.23% increase, showcasing market optimism regarding the company's future developments.
Wall Street analysts forecast ORKA stock price to rise
10 Analyst Rating
Wall Street analysts forecast ORKA stock price to rise
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
40.00
Averages
51.67
High
75.00
Current: 0.000
sliders
Low
40.00
Averages
51.67
High
75.00
Leerink
NULL
to
Outperform
upgrade
$58 -> $86
AI Analysis
2026-03-16
Reason
Leerink
Price Target
$58 -> $86
AI Analysis
2026-03-16
upgrade
NULL
to
Outperform
Reason
Leerink raised the firm's price target on Oruka Therapeutics to $86 from $58 and keeps an Outperform rating on the shares.
Barclays
Etzer Darout
Overweight
maintain
$48 -> $50
2026-03-13
Reason
Barclays
Etzer Darout
Price Target
$48 -> $50
2026-03-13
maintain
Overweight
Reason
Barclays analyst Etzer Darout raised the firm's price target on Oruka Therapeutics to $50 from $48 and keeps an Overweight rating on the shares post the Q4 report. The firm is positive on shares ahead of the Phase 2 data next quarter, with a "clear benchmark" from Skyrizi. ORKA-002 development continues to progress, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ORKA
Unlock Now

Valuation Metrics

The current forward P/E ratio for Oruka Therapeutics Inc (ORKA.O) is -10.68, compared to its 5-year average forward P/E of -6.99. For a more detailed relative valuation and DCF analysis to assess Oruka Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.99
Current PE
-10.68
Overvalued PE
-4.39
Undervalued PE
-9.59

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
Annual
Quarterly

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Whales Holding ORKA

C
Commodore Capital LP
Holding
ORKA
+12.42%
3M Return
P
Perceptive Advisors LLC
Holding
ORKA
+8.68%
3M Return
F
Fairmount Funds Management LLC
Holding
ORKA
+8.34%
3M Return
P
Paradigm Biocapital Advisors LP
Holding
ORKA
+6.99%
3M Return
A
Avoro Capital Advisors LLC
Holding
ORKA
+5.71%
3M Return
V
VR Management, LLC
Holding
ORKA
+5.04%
3M Return

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Frequently Asked Questions

What is Oruka Therapeutics Inc (ORKA) stock price today?

The current price of ORKA is 49.05 USD — it has increased 7.75

What is Oruka Therapeutics Inc (ORKA)'s business?

Oruka Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications. Its lead program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, psoriatic arthritis (PsA), and other conditions. ORKA-001 is an extended half-life monoclonal antibody (mAb) designed to target IL-23p19. IL-23 is a pro-inflammatory cytokine that plays a critical role in the proliferation and development of T helper 17 (Th17) cells, which are the primary drivers of several autoimmune and inflammatory disorders, including PsO. IL-23 is composed of two subunits: a p40 subunit and a p19 subunit. ORKA-002 is an extended half-life mAb designed to target IL-17A and IL-17F (IL-17A/F).

What is the price predicton of ORKA Stock?

Wall Street analysts forecast ORKA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ORKA is51.67 USD with a low forecast of 40.00 USD and a high forecast of 75.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Oruka Therapeutics Inc (ORKA)'s revenue for the last quarter?

Oruka Therapeutics Inc revenue for the last quarter amounts to -34.43M USD, increased 13.57

What is Oruka Therapeutics Inc (ORKA)'s earnings per share (EPS) for the last quarter?

Oruka Therapeutics Inc. EPS for the last quarter amounts to -22657000.00 USD, increased 20.29

How many employees does Oruka Therapeutics Inc (ORKA). have?

Oruka Therapeutics Inc (ORKA) has 68 emplpoyees as of March 31 2026.

What is Oruka Therapeutics Inc (ORKA) market cap?

Today ORKA has the market capitalization of 2.26B USD.