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ZBIO Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
24.020
Open
23.350
VWAP
22.91
Vol
600.56K
Mkt Cap
1.25B
Low
21.480
Amount
13.76M
EV/EBITDA(TTM)
--
Total Shares
53.68M
EV
1.07B
EV/OCF(TTM)
--
P/S(TTM)
52.66
Zenas BioPharma, Inc. is a clinical-stage global biopharmaceutical company focused on the development and commercialization of transformative therapies for patients with autoimmune diseases. The Company's lead product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and FcyRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. The Company is developing obexelimab as a potential immunology and inflammation (I&I) franchise for patients in several autoimmune diseases. The first three indications it is pursuing include immunoglobulin G4-related disease (IgG4-RD), relapsing multiple sclerosis (RMS) and systemic lupus erythematosus (SLE). Its other programs include ZB002 (an anti-TNFα monoclonal antibody), ZB004 (a CTLA-4-Ig fusion), and ZB001 and related programs. ZB002 is a recombinant human monoclonal antibody directed at human TNFα.
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Events Timeline

(ET)
2026-03-16
09:00:00
Stock Futures Rise as Markets Seek Recovery
select
2026-03-16
07:10:00
Zenas Reports $0 Revenue, Plans to Submit Obexelimab Marketing Applications
select
2026-03-16
07:10:00
Company Expects Cash Reserves Sufficient Until Q4 2027
select
2026-02-09 (ET)
2026-02-09
07:20:00
Zenas BioPharma Reports Obexelimab MS Trial Results
select
2026-01-05 (ET)
2026-01-05
16:30:00
Major U.S. Indices Rise Broadly, Led by Energy and Defense Stocks
select
2026-01-05
12:00:00
Major U.S. Indices Broadly Higher, Energy and Defense Stocks Lead
select
2026-01-05
07:30:00
Zenas BioPharma INDIGO Trial Results Show Obexelimab Significantly Reduces IgG4-RD Risk
select

News

seekingalpha
9.5
03-16seekingalpha
PinnedZenas BioPharma Reports Q4 EPS Miss and Cash Projections
  • Disappointing Earnings: Zenas BioPharma reported a Q4 GAAP EPS of -$4.54, missing expectations by $3.66, indicating significant challenges in profitability that may undermine investor confidence.
  • Cash Position: As of December 31, 2025, the company had $360.5 million in cash, cash equivalents, and investments, which is projected to fund operating and capital expenditures into Q2 2027, reflecting a degree of financial management capability.
  • Future Funding Outlook: Assuming receipt of $75 million from Pharmakon-managed investment funds and another $75 million from Royalty Pharma contingent on FDA approval of obexelimab, the company expects to sustain its cash position into Q4 2027, demonstrating optimism about future cash inflows.
  • Market Reaction: Despite the CEO's over $1 million stock purchase, the market's disappointment over late-stage trial data led to a significant stock price drop, indicating investor concerns about the company's future prospects.
PRnewswire
7.0
02-17PRnewswire
Purcell & Lefkowitz Investigates Zenas BioPharma for Potential Fiduciary Breaches
  • Investigation Launched: Purcell & Lefkowitz LLP has announced an investigation into Zenas BioPharma to determine whether the company's directors breached their fiduciary duties in recent corporate actions, potentially affecting shareholder rights.
  • Shareholder Rights Focus: The investigation aims to protect Zenas BioPharma shareholders, with the law firm offering free consultations to ensure shareholders are informed about their rights and options, thereby enhancing transparency in corporate governance.
  • Legal Support: Purcell & Lefkowitz LLP specializes in representing shareholders nationwide in cases of securities fraud and breaches of fiduciary duty, demonstrating their commitment to safeguarding shareholder interests.
  • Potential Impact: Should the investigation confirm misconduct by the board, Zenas BioPharma may face legal repercussions, which could undermine shareholder confidence and adversely affect the company's stock price.
PRnewswire
7.0
02-13PRnewswire
Zenas BioPharma Under Investigation for Securities Fraud
  • Securities Fraud Investigation: Pomerantz LLP is investigating claims on behalf of Zenas BioPharma investors regarding potential securities fraud or unlawful business practices by the company and its executives, highlighting serious governance concerns.
  • Disappointing Trial Results: Zenas's January 5, 2026 announcement of 'positive' results from the INDIGO trial was met with skepticism as analysts noted the drug's efficacy likely fell short of commercial viability thresholds, potentially impacting future sales prospects.
  • Stock Price Volatility: Following the trial results, Zenas's stock plummeted by 51.86% to $16.61 per share on January 5, 2026, and further declined by 8.49% to $15.20 per share the next day, reflecting a pessimistic market outlook on the company's future.
  • CEO Acknowledges Disappointment: During a conference call on January 6, 2026, Zenas's CEO expressed disappointment that the hazard ratio did not meet expectations, which may exacerbate investor concerns and lead to increased legal scrutiny.
Newsfilter
2.0
02-09Newsfilter
Obexelimab Achieves Significant Results in Multiple Sclerosis Trial
  • Clinical Trial Success: Obexelimab achieved a 95% relative reduction in new Gd-enhancing T1 lesions in the MoonStone trial for Multiple Sclerosis, demonstrating its potential to transform treatment protocols for patients.
  • Good Safety Profile: The trial indicated that Obexelimab was well tolerated with no new safety signals observed, which lays a solid foundation for future market introduction and boosts investor confidence.
  • Long-term Efficacy Confirmation: Data from the 24-week follow-up showed sustained efficacy of Obexelimab, with Gd-enhancing T1 lesions decreasing from a baseline of 0.87 to 0.04, indicating its effectiveness and tolerability in long-term treatment.
  • Broad Market Prospects: Zenas BioPharma plans to submit a Biologics License Application for Obexelimab to the FDA in 2026, which is expected to create significant market opportunities and further solidify its leadership position in the autoimmune disease sector.
seekingalpha
8.5
02-04seekingalpha
Zenas BioPharma CEO Buys $1M in Stock, Shares Rise 11%
  • Executive Purchase: Zenas BioPharma CEO Lonnie Moulder bought over $1M worth of company stock at $17.96 per share, acquiring 57,000 shares, which reflects strong confidence in the company's future prospects.
  • Increased Stake: Following this transaction, Moulder's total holdings in Zenas have risen to nearly 1.7 million shares, reinforcing his position as founder and chairman, which may enhance investor trust in the company.
  • Upcoming Catalysts: Zenas is scheduled to present at the Guggenheim Emerging Outlook: Biotech Summit 2026 on February 11, 2026, which is expected to draw investor attention to the mid-stage trial results for its lead asset targeting systemic lupus erythematosus.
  • Market Reaction: Despite earlier declines in Zenas's stock price due to disappointing late-stage trial results for its candidate against IgG4-related disease, the CEO's stock purchase may improve market sentiment and boost the share price.
PRnewswire
7.0
01-22PRnewswire
Pomerantz Investigates Zenas BioPharma After 51.86% Stock Drop
  • Stock Price Plunge: Zenas BioPharma's stock dropped $17.89, or 51.86%, to close at $16.61 on January 5, 2026, following the announcement of its IgG4-RD trial results, indicating market concerns over the drug's commercial viability.
  • Trial Results Disappointment: Although Zenas characterized the INDIGO trial results as 'positive,' analysts noted that the drug's efficacy fell short of the necessary threshold for commercial success, leading to diminished investor confidence.
  • CEO Acknowledgment of Disappointment: During a conference call on January 6, 2026, Zenas's CEO admitted that the hazard ratio did not meet expectations, causing the stock to fall another $1.41, or 8.49%, further heightening concerns about the company's future.
  • Legal Investigation Launched: Pomerantz LLP is investigating whether Zenas and its executives engaged in securities fraud or other unlawful business practices, which could significantly impact the company's future legal liabilities and financial health.
Wall Street analysts forecast ZBIO stock price to rise
5 Analyst Rating
Wall Street analysts forecast ZBIO stock price to rise
4 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
19.00
Averages
41.20
High
55.00
Current: 0.000
sliders
Low
19.00
Averages
41.20
High
55.00
Wedbush
Martin Fan
Outperform
initiated
AI Analysis
2026-02-18
Reason
Wedbush
Martin Fan
Price Target
AI Analysis
2026-02-18
initiated
Outperform
Reason
Wedbush analyst Martin Fan is adding Outperform-rated Zenas BioPharma to the Wedbush Best Ideas List as the firm sees a buying opportunity for a clinically de-risked drug likely to gain FDA approval, with potential for strong commercial uptake. Additional pipeline assets increase long-term growth prospects while providing downside protection against regulatory or commercial risk, Wedbush adds.
Citi
Buy
downgrade
$46 -> $43
2026-01-05
Reason
Citi
Price Target
$46 -> $43
2026-01-05
downgrade
Buy
Reason
Citi lowered the firm's price target on Zenas BioPharma to $43 from $46 and keeps a Buy rating on the shares after the company announced Phase 3 INDIGO results for obexelimab in IgG4-RD. A weaker hazard ratio than Uplizna's has resulted in a selloff to levels below the firm's "ultra-bear case" of $18 per share, which implies zero contribution for obex in IgG4-RD, the analyst says. The firm remains confident obexelimab will be approved and recommends investors seeking discounted opportunities at the outset of 2026 buy the stock, noting that its revised target reflects model adjustments based on increasing its view of the odds of success for obex in IgG4-RD to 80% from 60%, offset by slightly lower peak share estimates.
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Valuation Metrics

The current forward P/E ratio for Zenas Biopharma Inc (ZBIO.O) is -10.60, compared to its 5-year average forward P/E of -4.40. For a more detailed relative valuation and DCF analysis to assess Zenas Biopharma Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-4.40
Current PE
-10.60
Overvalued PE
-1.14
Undervalued PE
-7.66

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.20
Current EV/EBITDA
-7.02
Overvalued EV/EBITDA
0.69
Undervalued EV/EBITDA
-5.08

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
34.77
Current PS
38.99
Overvalued PS
75.86
Undervalued PS
-6.32

Financials

AI Analysis
Annual
Quarterly

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ZBIO logo
ZBIO
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1.40B

Whales Holding ZBIO

F
Fairmount Funds Management LLC
Holding
ZBIO
+7.55%
3M Return
E
EcoR1 Capital, LLC
Holding
ZBIO
+6.24%
3M Return
V
Vivo Capital, LLC
Holding
ZBIO
+0.00%
3M Return
N
Novo Holdings A/S
Holding
ZBIO
+0.00%
3M Return
A
ArrowMark Colorado Holdings, LLC
Holding
ZBIO
+0.00%
3M Return
R
Rock Springs Capital Management LP
Holding
ZBIO
-6.56%
3M Return

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Frequently Asked Questions

What is Zenas Biopharma Inc (ZBIO) stock price today?

The current price of ZBIO is 23.23 USD — it has decreased -3.37

What is Zenas Biopharma Inc (ZBIO)'s business?

Zenas BioPharma, Inc. is a clinical-stage global biopharmaceutical company focused on the development and commercialization of transformative therapies for patients with autoimmune diseases. The Company's lead product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and FcyRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. The Company is developing obexelimab as a potential immunology and inflammation (I&I) franchise for patients in several autoimmune diseases. The first three indications it is pursuing include immunoglobulin G4-related disease (IgG4-RD), relapsing multiple sclerosis (RMS) and systemic lupus erythematosus (SLE). Its other programs include ZB002 (an anti-TNFα monoclonal antibody), ZB004 (a CTLA-4-Ig fusion), and ZB001 and related programs. ZB002 is a recombinant human monoclonal antibody directed at human TNFα.

What is the price predicton of ZBIO Stock?

Wall Street analysts forecast ZBIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZBIO is41.20 USD with a low forecast of 19.00 USD and a high forecast of 55.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zenas Biopharma Inc (ZBIO)'s revenue for the last quarter?

Zenas Biopharma Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Zenas Biopharma Inc (ZBIO)'s earnings per share (EPS) for the last quarter?

Zenas Biopharma Inc. EPS for the last quarter amounts to -1.22 USD, increased 32.61

How many employees does Zenas Biopharma Inc (ZBIO). have?

Zenas Biopharma Inc (ZBIO) has 130 emplpoyees as of March 17 2026.

What is Zenas Biopharma Inc (ZBIO) market cap?

Today ZBIO has the market capitalization of 1.25B USD.