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SMMT Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
16.540
Open
16.180
VWAP
16.21
Vol
1.82M
Mkt Cap
12.66B
Low
16.000
Amount
29.55M
EV/EBITDA(TTM)
--
Total Shares
775.37M
EV
11.95B
EV/OCF(TTM)
--
P/S(TTM)
--
Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial.
Show More

Events Timeline

(ET)
2026-02-23
16:20:00
HARMONi-3 Clinical Trial Progress Update
select
2026-01-29 (ET)
2026-01-29
07:40:00
Summit Therapeutics Files Biologics License Application for Ivonescimab
select
2026-01-12 (ET)
2026-01-12
06:30:00
Summit Therapeutics Enters Clinical Trial Collaboration with GSK
select
2026-01-12
06:20:00
Summit Therapeutics Submits BLA for Ivonescimab
select

News

Newsfilter
8.5
02-27Newsfilter
Summit Therapeutics Announces Upcoming Investor Conference Schedule
  • Investor Conference Schedule: Summit Therapeutics will participate in three investor conferences in March 2026, including the TD Cowen Annual Health Care Conference on March 2, showcasing its ongoing developments in the biopharmaceutical sector.
  • Ivonescimab Progress: Ivonescimab (SMT112), a novel bispecific antibody, is undergoing multiple Phase III clinical trials, having treated over 4,000 patients globally, demonstrating promising safety and efficacy profiles.
  • Clinical Trial Expansion: Summit initiated the HARMONi and HARMONi-3 trials for non-small cell lung cancer (NSCLC) in 2023, with plans to enroll patients in HARMONi-7 starting in 2025, further broadening its clinical development program.
  • FDA Application Progress: The Biologics License Application (BLA) for the HARMONi trial was accepted by the FDA in January 2026, with a target approval date of November 14, 2026, marking a significant milestone for the company's market access efforts.
Businesswire
8.5
02-26Businesswire
Summit Therapeutics to Participate in Upcoming Investor Conferences
  • Investor Conference Participation: Summit Therapeutics will participate in three investor conferences in March 2026, with leadership engaging in individual meetings and fireside chats, aimed at enhancing the company's visibility and credibility among investors.
  • ivonescimab Clinical Progress: Ivonescimab (SMT112), a novel bispecific antibody, is involved in 15 Phase III clinical trials, including four globally sponsored by Summit, demonstrating its potential advantages in the tumor microenvironment.
  • FDA Application Progress: Summit submitted a Biologics License Application (BLA) for ivonescimab to the FDA in January 2026, with a target PDUFA date of November 14, 2026, which, if approved, could significantly boost the company's revenue.
  • Market Potential Assessment: Ivonescimab has been commercially applied to over 60,000 patients in China, indicating broad acceptance in the market and potential economic benefits, further solidifying Summit's position in the global biopharmaceutical sector.
seekingalpha
9.5
02-24seekingalpha
Summit Therapeutics Q4 2025 Earnings Call Highlights
  • Clinical Trial Progress: Summit Therapeutics announced the completion of screening for the squamous cohort in the HARMONi-3 study, with an interim PFS analysis planned for Q2 2026, which could accelerate discussions with regulators and potentially lead to earlier approval.
  • New Study Launch: The company initiated the ILLUMINE study focusing on PD-L1 positive frontline head and neck squamous cell carcinoma, with enrollment expected to begin next quarter, indicating strong market demand and potential commercial opportunities for new treatment options.
  • Strong Financial Position: As of year-end 2025, Summit reported a cash reserve of approximately $713.4 million with no debt, demonstrating financial robustness that supports future clinical trials and expansion plans.
  • Operational Efficiency Improvement: Fourth-quarter GAAP operating expenses were $225 million, down from $234.2 million in the third quarter, reflecting the company's effectiveness in controlling spending while providing more funding for subsequent R&D investments.
NASDAQ.COM
2.0
02-24NASDAQ.COM
Summit (SMMT) Q4 2025 Earnings Call Transcript
seekingalpha
9.5
02-23seekingalpha
Summit Therapeutics Reports Q4 Earnings Miss
  • Earnings Miss: Summit Therapeutics reported a Q4 non-GAAP EPS of -$0.14, missing expectations by $0.12, indicating ongoing challenges in achieving profitability and investor confidence.
  • Cash Position: As of December 31, 2025, the company held $713.4 million in cash and short-term investments, up from $412.3 million in 2024, reflecting improved cash management but highlighting the need for profitability focus.
  • FDA Review Progress: The lead asset of Summit is currently under FDA review, and while the market remains optimistic about its potential, the earnings miss could dampen investor sentiment, necessitating close monitoring of future developments.
  • Market Reaction: Despite the earnings miss, Summit's stock price spiked due to the FDA review of its lead asset, indicating market expectations for long-term growth potential despite short-term financial setbacks.
Yahoo Finance
8.0
02-22Yahoo Finance
US Supreme Court Strikes Down Trump's Tariff Regime
  • Market Reaction: The US Supreme Court's 6-3 ruling against Trump's tariff regime led to a swift market rebound, with the S&P 500 rising 0.7%, indicating a moderate investor optimism regarding the policy shift despite initial losses.
  • Limited Economic Impact: The ruling affects approximately 60% of tariffs under the IEEPA, and while it could lead to refund requests totaling up to $175 billion, the overall economic impact is deemed limited, resulting in a muted market response.
  • Oil Price Fluctuations: Oil prices surged about 5.5% over the past week due to escalating tensions in the Middle East, with projections suggesting a potential increase of $10 to $15 per barrel if the US engages in military action, highlighting the significant geopolitical risks to energy markets.
  • Upcoming Economic Data: The forthcoming Producer Price Index (PPI) will provide investors with crucial insights into inflation trends, which are expected to influence the Federal Reserve's monetary policy, particularly as inflation remains persistently above target levels.
Wall Street analysts forecast SMMT stock price to rise
12 Analyst Rating
Wall Street analysts forecast SMMT stock price to rise
8 Buy
3 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
18.00
Averages
42.49
High
131.90
Current: 0.000
sliders
Low
18.00
Averages
42.49
High
131.90
Citi
Yigal Nochomovitz
Buy
maintain
$40
AI Analysis
2026-02-24
Reason
Citi
Yigal Nochomovitz
Price Target
$40
AI Analysis
2026-02-24
maintain
Buy
Reason
Citi analyst Yigal Nochomovitz placed an "upside 90-day catalyst watch" on shares of Summit Therapeutics while keeping a Buy rating on the name with a $40 price target. The company's HARMONi-3 squamous cohort date in Q2 could "revitalize the stock" and bring a path to "rapid engagement" with the FDA, the analyst tells investors in a research note.
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$40 -> $30
2026-02-24
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$40 -> $30
2026-02-24
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Summit Therapeutics to $30 from $40 and keeps a Buy rating on the shares. The firm says that while the HARMONi-3 timelines remain intact, the absence of updated HARMONi-2 and HARMONi-6 overall survival analyses, which many investors expected by the end of 2025 or early 2026, "introduces near-term uncertainty that we cannot ignore."
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Valuation Metrics

The current forward P/E ratio for Summit Therapeutics Inc (SMMT.O) is -51.56, compared to its 5-year average forward P/E of -21.45. For a more detailed relative valuation and DCF analysis to assess Summit Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-21.45
Current PE
-51.56
Overvalued PE
5.25
Undervalued PE
-48.16

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-15.14
Current EV/EBITDA
-24.94
Overvalued EV/EBITDA
6.16
Undervalued EV/EBITDA
-36.44

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
360.94
Current PS
171.83
Overvalued PS
953.26
Undervalued PS
-231.38

Financials

AI Analysis
Annual
Quarterly

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Whales Holding SMMT

R
Readystate Asset Management LP
Holding
SMMT
-0.54%
3M Return
B
Baker Bros. Advisors LP
Holding
SMMT
-5.67%
3M Return
R
Rock Springs Capital Management LP
Holding
SMMT
-6.53%
3M Return

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Frequently Asked Questions

What is Summit Therapeutics Inc (SMMT) stock price today?

The current price of SMMT is 16.08 USD — it has decreased -1.53

What is Summit Therapeutics Inc (SMMT)'s business?

Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial.

What is the price predicton of SMMT Stock?

Wall Street analysts forecast SMMT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SMMT is42.49 USD with a low forecast of 18.00 USD and a high forecast of 131.90 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Summit Therapeutics Inc (SMMT)'s revenue for the last quarter?

Summit Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Summit Therapeutics Inc (SMMT)'s earnings per share (EPS) for the last quarter?

Summit Therapeutics Inc. EPS for the last quarter amounts to -0.29 USD, increased 262.50

How many employees does Summit Therapeutics Inc (SMMT). have?

Summit Therapeutics Inc (SMMT) has 265 emplpoyees as of March 11 2026.

What is Summit Therapeutics Inc (SMMT) market cap?

Today SMMT has the market capitalization of 12.66B USD.