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SMMT Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
19.415
Open
18.210
VWAP
18.74
Vol
3.89M
Mkt Cap
14.03B
Low
18.150
Amount
72.88M
EV/EBITDA(TTM)
--
Total Shares
776.16M
EV
13.43B
EV/OCF(TTM)
--
P/S(TTM)
--
Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial.
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Events Timeline

(ET)
2026-05-01
16:10:00
Apple Raises Quarterly Dividend and Announces $100B Stock Buyback
select
2026-05-01
12:10:00
Summit Therapeutics Shares Drop 23.7% to $16.38
select
2026-05-01
12:00:00
Apple Reports Strong Earnings, Raises Dividend and Announces $100B Buyback
select
2026-05-01
10:10:00
Summit Therapeutics Shares Drop 27.4% to $15.58
select
2026-04-30 (ET)
2026-04-30
16:40:00
Operational Progress Continues with ivonescimab
select

News

Globenewswire
7.0
05-04Globenewswire
Investigation into Summit Therapeutics by Johnson Fistel
  • Investigation Background: Johnson Fistel, PLLP is investigating Summit Therapeutics Inc. (NASDAQ: SMMT) to determine if its executives violated federal securities laws, potentially allowing for recovery of investor losses.
  • Financial Disclosure: On April 30, 2026, Summit reported its Q1 2026 financial results and updated on the HARMONi-3 Phase III clinical trial, revealing a significantly higher statistical significance threshold for the interim progression-free survival analysis than previously anticipated.
  • Stock Price Impact: Following this disclosure, Summit's stock price sharply declined, resulting in investor losses and prompting Johnson Fistel to investigate compliance with federal securities laws.
  • Law Firm Background: Johnson Fistel is a nationally recognized shareholder rights law firm, ranked among the Top 10 Plaintiff Law Firms in 2024, having recovered approximately $90.725 million for clients, demonstrating its effectiveness in advocating for investor rights.
stocktwits
9.5
05-01stocktwits
Summit Reports Q1 2026 Net Loss Exceeding Expectations
  • Poor Financial Performance: Summit reported a net loss of $189.4 million for Q1 2026, more than tripling the $62.9 million loss from the previous year, indicating significant pressure from increased spending on its lead asset, ivonescimab, for non-small cell lung cancer treatment.
  • Price Target Downgrade: Piper Sandler lowered its price target on Summit shares from $17 to $16 while maintaining a ‘Neutral’ rating, reflecting market concerns regarding the company's financial health and clinical trial outcomes.
  • HARMONi-3 Trial Update: Although final data from the HARMONi-3 trial is expected in the second half of 2026, the interim analysis did not meet the high statistical bar for early success, leading to investor skepticism about the trial's prospects.
  • Market Sentiment Shift: Despite a 25% drop in Summit's stock price following the report, retail sentiment on Stocktwits shifted from ‘bearish’ to ‘bullish’, indicating some investors' optimism for a potential rebound in the stock price.
seekingalpha
9.0
05-01seekingalpha
Summit Therapeutics' Clinical Trial Update
  • Trial Continuation: Summit Therapeutics announced that its HARMONi-3 trial for ivonescimab, developed with Chinese biotech Akeso, will continue as planned following an uneventful interim analysis, despite a ~22% drop in stock price on Friday.
  • Trial Design and Goals: The Phase 3 global trial aims to evaluate ivonescimab in combination with chemotherapy as a first-line treatment for metastatic non-small cell lung cancer, with early progression-free survival (PFS) analysis expected to support regulatory discussions ahead of final results scheduled for H2 2026.
  • Mixed Analyst Reactions: Barclays analyst Etzer Darout noted that the interim PFS analysis was an important catalyst investors were looking forward to, but the new guidance pressured shares, maintaining an Equal Weight rating with an $18 target on SMMT.
  • Price Target Adjustment: Jefferies analyst Faisal Khurshid trimmed his price target on Summit from $18 to $17 per share due to the interim PFS missing expectations, reflecting concerns about the trial's probability of success.
NASDAQ.COM
9.5
05-01NASDAQ.COM
Summit Therapeutics Reports Wider Q1 Loss and Clinical Progress
  • Wider Financial Loss: Summit Therapeutics reported a net loss of $189.4 million for Q1 2026, translating to a loss of $0.24 per share, which is a significant increase from the previous year's loss of $62.9 million or $0.09 per share, indicating heightened financial pressures on the company.
  • Increased Adjusted Loss: The adjusted net loss expanded to $116.6 million or $0.15 per share, compared to $51.8 million or $0.07 per share in the prior year, reflecting ongoing increases in R&D expenditures and operational costs that could impact future profitability.
  • Clinical Collaboration Progress: In January 2026, Summit announced a clinical collaboration with GSK plc to evaluate Ivonescimab in combination with GSK's novel B7-H3, with patient dosing expected to begin in mid-2026, marking a strategic expansion in its oncology treatment portfolio.
  • Ongoing Global Trials: The company's global Phase III trials, including HARMONi-3, HARMONi-7, and HARMONi-GI3, continue to enroll patients, with final Progression-Free Survival data from the HARMONi-3 trial expected in the second half of 2026, demonstrating its commitment to advancing clinical research.
seekingalpha
9.5
04-30seekingalpha
Summit Therapeutics Q1 Earnings Beat Expectations
  • Earnings Performance: Summit Therapeutics reported a Q1 GAAP EPS of -$0.24, beating expectations by $0.04, indicating some financial resilience despite still being in a loss position.
  • Cash Reserve Status: As of March 31, 2026, the company's cash and cash equivalents and short-term investments totaled $598.7 million, down from $713.4 million on December 31, 2025, reflecting urgency in fund utilization and potential future financing needs.
  • Clinical Progress Plans: Summit Therapeutics plans an interim PFS analysis for the HARMONi-3 squamous cohort in Q2 2026, indicating proactive advancements in its clinical pipeline that may lay the groundwork for future product launches.
  • Market Reaction Analysis: Despite the earnings beat, market sentiment remains cautious regarding the company's growth prospects, reflecting a complex outlook on the biopharmaceutical sector that could influence stock price volatility.
Newsfilter
9.5
04-30Newsfilter
Summit Therapeutics Reports Q1 2026 Financial Results and Clinical Updates
  • Clinical Trial Progress: Summit Therapeutics' ivonescimab has been administered to over 4,000 patients in clinical trials globally, with more than 70,000 patients treated in the commercial setting in China, indicating significant potential for the drug in the non-small cell lung cancer (NSCLC) market.
  • Financial Position: As of March 31, 2026, the company's cash and cash equivalents stood at $598.7 million, down from $713.4 million on December 31, 2025, reflecting ongoing investments in research and development and operational expenditures.
  • Increased R&D Expenses: GAAP R&D expenses for Q1 2026 reached $132.6 million, a substantial increase from $51.2 million in the same period last year, primarily driven by the expansion of clinical trials and increased stock-based compensation expenses related to ivonescimab.
  • Future Outlook: Summit plans to submit a Biologics License Application (BLA) for ivonescimab to the FDA by November 14, 2026, aiming for approval to treat patients with EGFR-mutated non-small cell lung cancer, marking a significant milestone in the company's oncology portfolio.
Wall Street analysts forecast SMMT stock price to rise
12 Analyst Rating
Wall Street analysts forecast SMMT stock price to rise
8 Buy
3 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
18.00
Averages
42.49
High
131.90
Current: 0.000
sliders
Low
18.00
Averages
42.49
High
131.90
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$30 -> $23
AI Analysis
2026-05-04
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$30 -> $23
AI Analysis
2026-05-04
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Summit Therapeutics to $23 from $30 and keeps a Buy rating on the shares. The firm says the absence of a stronger interim signal in HARMONi-3 suggests the final squamous readout in the second half of 2026 now carries more risk.
Piper Sandler
Neutral
downgrade
$17 -> $16
2026-05-01
Reason
Piper Sandler
Price Target
$17 -> $16
2026-05-01
downgrade
Neutral
Reason
Piper Sandler lowered the firm's price target on Summit Therapeutics to $16 from $17 and keeps a Neutral rating on the shares. The firm notes the company reported Q1 earnings that most notably announced the planned Q2 interim PFS analysis was performed and reviewed by the IDMC who recommended that the study continue as planned. Summit shares are "understandably weak" after-hours, Piper says, as investors question whether the impressive effect size seen in Akeso's HARMONi-6 can be replicated in Summit's global HARMONi-3 following this news, despite minimal alpha spent on this interim.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SMMT
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Valuation Metrics

The current forward P/E ratio for Summit Therapeutics Inc (SMMT.O) is 3.72, compared to its 5-year average forward P/E of -21.43. For a more detailed relative valuation and DCF analysis to assess Summit Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-21.43
Current PE
3.72
Overvalued PE
5.59
Undervalued PE
-48.45

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-15.68
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
5.81
Undervalued EV/EBITDA
-37.18

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
358.44
Current PS
220.17
Overvalued PS
939.48
Undervalued PS
-222.60

Financials

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Baker Bros. Advisors LP
Holding
SMMT
+4.26%
3M Return
R
Rock Springs Capital Management LP
Holding
SMMT
+1.39%
3M Return

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Frequently Asked Questions

What is Summit Therapeutics Inc (SMMT) stock price today?

The current price of SMMT is 18.66 USD — it has increased 3.21

What is Summit Therapeutics Inc (SMMT)'s business?

Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial.

What is the price predicton of SMMT Stock?

Wall Street analysts forecast SMMT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SMMT is42.49 USD with a low forecast of 18.00 USD and a high forecast of 131.90 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Summit Therapeutics Inc (SMMT)'s revenue for the last quarter?

Summit Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Summit Therapeutics Inc (SMMT)'s earnings per share (EPS) for the last quarter?

Summit Therapeutics Inc. EPS for the last quarter amounts to -0.24 USD, increased 166.67

How many employees does Summit Therapeutics Inc (SMMT). have?

Summit Therapeutics Inc (SMMT) has 265 emplpoyees as of May 11 2026.

What is Summit Therapeutics Inc (SMMT) market cap?

Today SMMT has the market capitalization of 14.03B USD.