Repare Therapeutics Enters $30 Million Asset Purchase Agreement with Gilead Sciences
Repare Therapeutics (RPTX) announced a definitive asset purchase agreement for Gilead Sciences (GILD) to acquire Repare's polymerase theta ATPase inhibitor, RP-3467. Under the terms of the Gilead Agreement, Repare will receive up to $30 million in total consideration, including a $25 million upfront payment, subject to customary holdbacks and adjustments, and an additional $5 million payment upon completion of specified technology transfer activities. On November 14, 2025, Repare announced that it had entered into a definitive arrangement agreement with XenoTherapeutics and Xeno Acquisition, pursuant to which Xeno will acquire all of the issued and outstanding common shares of Repare. Under the terms of the Arrangement Agreement, Repare shareholders will receive a cash payment per Common Share that will be determined based upon Repare's cash balance at closing of the Arrangement Transaction. The upfront portion of the consideration payable under the Gilead Agreement has increased Repare's cash balance and, therefore, has also increased the estimated Closing Net Cash Amount. Based on Repare's revised estimate of the Closing Net Cash Amount, it is now currently estimated that each Repare shareholder will receive a cash payment of approximately US$2.20 per Common Share at the Arrangement Closing.
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- Milestone Payments: The agreement allows Genhouse to potentially receive up to $1.45 billion in milestone payments, which not only provides financial support to Genhouse but may also accelerate the development of GH31, enhancing its market competitiveness.
- Global Development Responsibility: Gilead will be responsible for the global development, regulatory submissions, and future commercialization of GH31, reflecting Gilead's confidence in the drug and potentially facilitating its rapid market introduction worldwide.
- Clinical Approval: GH31 has received IND approval in both the US and China, laying a solid foundation for Gilead's subsequent development and market promotion, further strengthening its positioning in the global oncology treatment market.
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