RedHill Biopharma Announces Positive Results for Opaganib Combined with Venetoclax in CLL
RedHill Biopharma announced positive in vivo results, indicating that opaganib combined with venetoclax reduces Chronic Lymphocytic Leukemia, CLL, cells by half compared to controls, and further demonstrates opaganib's potential as an add-on therapy to venetoclax in venetoclax-resistant CLL. Key highlights: Studies show that sphingosine kinase 2 is overexpressed in venetoclax-resistant cancer cells and that SPHK2 inhibition may reduce T-cell-induced activation and proliferation of venetoclax-resistant CLL cancer cells and resensitize previously resistant CLL cells; New in vivo study shows adding opaganib, a potent SPHK2 inhibitor, to venetoclax reduces CLL cell counts by 50% compared to controls and lowered CD3+, CD4+ and CD8+ T cell counts compared to controls with lowered PD1 expression; Data shows opaganib's venetoclax combination potential in CLL; builds on multiple preclinical studies demonstrating opaganib's therapeutic add-on potential in oncology; further clinical evaluation ongoing in a Phase 2 study of opaganib + darolutamide in advanced prostate cancer; Opaganib has a safety and tolerability profile shown in more than 470 clinical trials / expanded access participants. It targets multiple oncology, virology, inflammation, diabetes and obesity indications, with several U.S. government partnerships, including BARDA funding, in place
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RedHill Biopharma's RHB-102 Progress Drives 36% Rally, Stock Drops 4.29%
- Stock Volatility: RedHill Biopharma's stock fell 4.29% to $1.34 on Tuesday after a 36% rally on Monday, indicating potential profit-taking that may affect investor confidence in the short term.
- Development Progress: The company announced advancements for RHB-102 (Bekinda) in multiple gastrointestinal indications, utilizing the FDA's accelerated 505(b)(2) pathway, which aims to address GI side effects associated with GLP-1/GIP receptor agonist therapies, presenting significant market potential.
- Clinical Data Support: Clinical data for RHB-102 comes from the U.S. Phase 3 GUARD gastroenteritis study and the positive Phase 2 IBS-D study, both meeting their primary endpoints, which are expected to provide strong support for FDA approval and potentially reshape the GLP-1 market landscape.
- Market Impact: With up to 50% of patients discontinuing GLP-1 receptor agonists within three months due to side effects, successful development of RedHill's therapy could mitigate the projected $35 billion reduction in GLP-1 market valuations by 2030.
Cyclerion Therapeutics Expands Collaboration with Medsteer, Shares Surge 44.2%
- Significant Stock Surge: Cyclerion Therapeutics shares rose 44.2% to $1.99 in pre-market trading, reflecting strong market confidence in the company's expanded strategic collaboration with Medsteer, indicating positive investor sentiment towards future growth prospects.
- Deepening Strategic Collaboration: The partnership with Medsteer aims to advance the closed-loop anesthetic platform CYC-126, which is expected to accelerate the product's market entry, thereby enhancing the company's competitive edge in the anesthesia sector.
- Optimistic Market Outlook: With continuous advancements in anesthetic technology, Cyclerion's new platform is poised to meet the increasing medical demand, further driving revenue growth and strengthening its position in the healthcare industry.
- Increased Investor Confidence: The substantial stock price increase not only reflects market approval of the company's strategic direction but may also attract more investor interest, thereby supporting future financing and expansion efforts.
