Projected Target Price for VONG Analysts: $139
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 04 2025
0mins
Should l Buy ALNY?
Source: NASDAQ.COM
Vanguard Russell 1000 Growth ETF Analysis: The Vanguard Russell 1000 Growth ETF (VONG) has an implied analyst target price of $138.70 per unit, indicating a potential upside of 10.53% from its current trading price of $125.49.
Notable Holdings with Upside Potential: Key underlying holdings of VONG, such as AAON, Alnylam Pharmaceuticals, and H & R Block, show significant upside potential based on analyst target prices, with expected increases of 12.25%, 11.38%, and 11.27% respectively.
Analyst Target Price Justification: The article raises questions about whether analysts' target prices are justified or overly optimistic, suggesting that high targets could lead to future downgrades if they do not align with recent developments.
Investor Research Recommendation: Investors are encouraged to conduct further research to assess the validity of analyst targets and their alignment with current company and industry trends.
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Analyst Views on ALNY
Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is 500.28 USD with a low forecast of 351.00 USD and a high forecast of 570.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
20 Analyst Rating
16 Buy
4 Hold
0 Sell
Strong Buy
Current: 322.280
Low
351.00
Averages
500.28
High
570.00
Current: 322.280
Low
351.00
Averages
500.28
High
570.00
About ALNY
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Performance Expectations: Over the past two years, Alnylam has beaten EPS and revenue estimates 75% of the time, indicating a stable market performance; however, in the last three months, EPS estimates have seen three upward revisions and five downward adjustments, while revenue estimates experienced four upward revisions and ten downward adjustments, highlighting market uncertainty regarding future performance.
- Market Dynamics: Alnylam will exit the Nasdaq 100 alongside Lululemon and Biogen, with companies like Alnylam and Seagate being added, which may affect investor attention and the company's market positioning.
- Debt Management Strategy: Alnylam announced a partial repurchase of convertible notes due in 2027, a move that not only helps optimize its capital structure but also potentially boosts investor confidence in the company's financial health, thereby positively influencing its stock price.
See More
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- Financial Overview: The total net product revenue for the company is projected to be between $4.9 billion and $5.3 billion.
- Market Expectations: This revenue forecast indicates a positive outlook for the company's performance in the pharmaceutical sector.
See More
Alnylam Pharmaceuticals Q4 Earnings Miss Expectations
- Disappointing Earnings: Alnylam Pharmaceuticals reported a Q4 non-GAAP EPS of $1.25, missing expectations by $0.25, indicating pressure on profitability that could affect investor confidence.
- Weak Revenue Growth: Despite an 83.8% year-over-year revenue increase to $1.09 billion, the figure fell short of expectations by $70 million, suggesting that market demand did not meet anticipated levels, potentially impacting future market strategies.
- 2026 Financial Guidance: The company projects total TTR net product revenues between $4.4 billion and $4.7 billion for 2026, with rare disease net product revenues expected between $500 million and $600 million, reflecting cautious optimism for future growth while remaining attentive to market dynamics.
- R&D and SG&A Expenses: Non-GAAP R&D and SG&A expenses are anticipated to be between $2.7 billion and $2.8 billion, demonstrating the company's ongoing commitment to R&D investment, although this may exert pressure on profit margins.
See More
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- Earnings Expectations: Alnylam anticipates total Q4 2025 revenue of $1.16 billion with adjusted earnings per share of $1.50, indicating sustained growth potential in the biotech sector.
- Amvuttra Sales Surge: In Q3 2025, Amvuttra's sales skyrocketed by 162% year-over-year, primarily driven by rapid adoption in the transthyretin cardiac amyloidosis (ATTR-CM) indication, which is expected to boost Q4 performance.
- Market Performance: Although Alnylam's market share remains limited in international markets, particularly in Q4, stronger growth is anticipated in Germany and Japan in 2026, reflecting the company's strategic positioning in global markets.
- Pipeline Updates: Alnylam is expected to provide updates on its pipeline progress in the upcoming earnings report, including the initiation of a Phase 3 study for hereditary ATTR with polyneuropathy and a Phase 2 trial for Alzheimer's disease, showcasing ongoing R&D advancements.
See More
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- Inclusion Candidates: According to a report by Stephens, large-cap stocks like Marvell Technology, Vertiv, Strategy, Reddit, and Alnylam Pharmaceuticals meet the eligibility criteria for S&P 500 inclusion, drawing investor attention.
- Performance Expectations: Newly added S&P 500 constituents typically perform strongly post-announcement, prompting investors to closely monitor these candidates ahead of the U.S. Index Committee's reshuffle scheduled for Friday.
- Sector Dynamics Impact: Communication services and financials are underweight in the index relative to their market size, increasing the likelihood of Reddit and SoFi Technologies' inclusion, with the latter being the most liquid financial candidate.
- M&A Activity Potential: Data center infrastructure provider Vertiv could benefit from pending M&A activity that may create vacancies in the S&P 500, further enhancing its chances of inclusion.
See More
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- Performance Breakthrough: Alnylam Pharmaceuticals achieved nearly $3 billion in sales in 2025 and projects sales of up to $5.3 billion in 2026, demonstrating strong growth potential in the rare disease sector.
- R&D Progress: Ultragenyx anticipates two gene therapy approvals in 2026 despite facing clinical trial setbacks in 2025, indicating ongoing investment and risk management in its development pipeline.
- Regulatory Support: The FDA's recent implementation of the Rare Disease Evidence Principles framework allows for therapy approvals based on single-arm studies, showcasing support for rare disease developers and potentially accelerating new therapies to market.
- Financial Outlook: PTC closed 2025 with $1.94 billion in cash reserves and plans to continue the global launch of its flagship product Sephience in 2026, aiming for break-even cash flow, reflecting robust development in the market.
See More
