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WVE Overview

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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

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High
6.645
Open
6.470
VWAP
6.55
Vol
3.55M
Mkt Cap
1.27B
Low
6.430
Amount
23.25M
EV/EBITDA(TTM)
--
Total Shares
192.40M
EV
700.25M
EV/OCF(TTM)
--
P/S(TTM)
16.04
Wave Life Sciences Ltd. is a biotechnology company focused on unlocking the broad potential of ribonucleic acid (RNA) medicines to transform human health. The Company's RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. The Company's diversified pipeline includes clinical programs in alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease, as well as several preclinical programs utilizing the Company's broad RNA therapeutics toolkit. Its programs include WVE-006, SERPINA1 (AATD); WVE-007 (GalNAc), INHBE (Obesity); WVE-N531, Exon 53 (DMD), and WVE-003, mHTT (HD).
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Events Timeline

(ET)
2026-05-18
16:40:00
Wave Life Sciences Updates WVE-006 Trial Data
select
2026-05-12 (ET)
2026-05-12
16:20:00
Major Averages Finish Mixed as Semiconductor Stocks Pull Back
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2026-05-12
10:50:00
Trump Plans to Reduce Beef Import Tariffs
select
2026-05-11 (ET)
2026-05-11
12:30:00
Trump Approves Firing of FDA Commissioner Makary
select
link
2026-05-11
10:20:00
Trump Plans to Fire FDA Commissioner, Biotech Stocks Affected
select
2026-05-08 (ET)
2026-05-08
16:30:00
Dow Jones Slightly Up, Nasdaq Surges After Jobs Report
select
2026-05-08
13:40:00
Trump Signs Plan to Fire FDA Commissioner Makary
select
link

News

Globenewswire
7.0
05-27Globenewswire
Wave Life Sciences Under Investigation for Securities Violations
  • Investigation Background: Johnson Fistel, PLLP is investigating whether Wave Life Sciences Ltd. violated federal securities laws, focusing on the potential recovery of investor losses, indicating serious concerns about the company's compliance.
  • Clinical Trial Data: On March 26, 2026, Wave Life Sciences announced positive interim data from its clinical trial of WVE-007, showing a 14.3% reduction in visceral fat at a 240 mg dose after six months, but the stock sharply declined afterward, reflecting market concerns over data interpretation.
  • Investor Losses: Following the release of clinical data, many investors faced losses due to the stock price drop, and Johnson Fistel's investigation aims to assess whether these losses can be recovered under federal securities laws, potentially impacting the company's reputation and future financing capabilities.
  • Legal Services Offered: Johnson Fistel is a nationally recognized shareholder rights law firm that has previously recovered approximately $90.725 million for investors, demonstrating its expertise and successful track record in securities fraud cases.
NASDAQ.COM
8.5
05-22NASDAQ.COM
Biotech Sector Regulatory Approvals and Collaborations
  • Kidney Cancer Treatment Breakthrough: HUTCHMED and Innovent received NMPA approval in China for the ELUNATE-TYVYT combination therapy, supported by the FRUSICA-2 study showing a 63% reduction in disease progression or death risk, with a median progression-free survival of 22.2 months, significantly improving patient outcomes and enhancing market competitiveness.
  • Antibiotic Market Expansion: Sunshine Biopharma received Canadian approval for its generic Amoxicillin, with shipments expected to begin in August 2026, aiming to increase access to high-quality antibiotics for treating common infections, which is anticipated to drive revenue growth for the company.
  • Liquid Biopsy Technology Innovation: Guardant Health gained FDA approval for Guardant360 Liquid CDx, now the largest liquid biopsy panel with a genomic footprint 100 times broader than its predecessor, enhancing tumor profiling capabilities and expected to boost the company's market share in precision medicine.
  • New Hypertension Drug Launch: AstraZeneca received FDA approval for BAXFENDY for hypertension patients, based on positive results from the BaxHTN Phase III trial, which is expected to strengthen the company's competitive position in the cardiovascular drug market and further expand its product line.
Newsfilter
7.5
05-19Newsfilter
AlphaDetect Partners with Wave Life Sciences to Enhance Detection Efforts
  • Partnership for Detection: AlphaDetect has announced a partnership with Wave Life Sciences to accelerate the detection of Alpha-1 Antitrypsin Deficiency, which is expected to significantly improve early diagnosis rates for patients, thereby enhancing their quality of life.
  • Free Genetic Testing: AlphaDetect will provide free Alpha-1 genetic testing in its proprietary laboratory, removing financial barriers for patients and insurers, which is anticipated to enable more high-risk individuals to undergo testing and facilitate early intervention.
  • Education and Support: The sponsorship from Wave Life Sciences will assist AlphaDetect in expanding provider education and detection strategies, which is expected to increase awareness and detection rates of Alpha-1 within healthcare systems, thereby reducing misdiagnosis and underdiagnosis.
  • Updated Clinical Guidelines: The latest clinical guidelines recommend testing for Alpha-1 in all COPD patients, yet real-world results fall short; AlphaDetect's efforts aim to close this gap and promote broader implementation of detection and treatment protocols.
PRnewswire
7.5
05-19PRnewswire
Wave Life Sciences Sponsors AlphaDetect to Enhance Detection Efforts
  • Detection Capability Enhancement: As the inaugural industry sponsor, Wave Life Sciences supports AlphaDetect in accelerating the routine detection of Alpha-1 Antitrypsin Deficiency in patients with liver and lung diseases, aiming to reduce the over 90% of undiagnosed individuals significantly.
  • Free Genetic Testing: AlphaDetect will provide free Alpha-1 genetic testing in its proprietary laboratory, eliminating financial burdens for insurance and patients, which is expected to significantly enhance healthcare providers' detection capabilities and early diagnosis rates.
  • Community Connection: AlphaDetect not only offers testing services but also aims to connect Alpha-1 patients with healthcare resources and ongoing research, intending to improve patients' quality of life and slow disease progression, reflecting a deep understanding of patient needs.
  • Education and Strategy Promotion: The support from Wave Life Sciences will help AlphaDetect expand provider education and detection strategies, promoting the implementation of clinical guidelines to ensure that more high-risk patients receive timely diagnosis and treatment.
stocktwits
9.0
05-18stocktwits
Wave Life Sciences Reports Positive Early Results for WVE-006 Treatment
  • Clinical Trial Progress: Wave Life Sciences' WVE-006 demonstrated significant effects in early-stage trials, aiding patients in producing normal levels of protective proteins while significantly lowering harmful misfolded proteins, indicating the drug's potential in treating alpha-1 antitrypsin deficiency.
  • FDA Accelerated Approval Plans: The company plans to discuss trial data with the U.S. Food and Drug Administration in mid-year, considering an accelerated approval pathway, which would provide faster treatment options for patients, especially given the current lack of effective therapies.
  • Positive Patient Response: WVE-006 showed good tolerance among patients, with effects lasting at least three months post-injection and only mild to moderate side effects reported, demonstrating its safety and efficacy in clinical applications.
  • Strong Market Reaction: WVE shares jumped 7% in after-hours trading following the positive clinical results, with retail investor sentiment shifting from 'bullish' to 'extremely bullish', reflecting strong market confidence in the drug's future potential.
Newsfilter
8.5
05-18Newsfilter
WVE-006 Shows Significant Potential in Treating AAT Deficiency
  • Efficacy Data Update: WVE-006 demonstrated significant efficacy in the RestorAATion-2 trial, with total AAT levels reaching 11.9 µM and 13.6 µM in the 200 mg and 400 mg cohorts respectively, indicating the therapy's ability to effectively restore healthy M-AAT while reducing harmful Z-AAT, thus offering a new treatment option for AATD patients.
  • Safety Advantages: The RNA editing technology of WVE-006 avoids the risks associated with permanent genomic modifications from DNA editing, and no liver toxicities were observed during the trial, with all adverse events being mild to moderate, showcasing its favorable safety profile and tolerability.
  • Restoration of Dynamic AAT Production: Post-treatment, the ability to dynamically produce AAT was restored, particularly following acute upper respiratory infections, where significant increases in AAT levels were noted, suggesting the therapy's potential protective role during acute pathological states.
  • FDA Feedback Anticipation: Wave expects to receive FDA feedback on a potential accelerated approval pathway by mid-2026, further advancing the clinical development of WVE-006 and potentially providing a more convenient treatment option for AATD patients.
Wall Street analysts forecast WVE stock price to rise
14 Analyst Rating
Wall Street analysts forecast WVE stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
21.00
Averages
33.00
High
50.00
Current: 0.000
sliders
Low
21.00
Averages
33.00
High
50.00
Wells Fargo
NULL
to
Overweight
maintain
$13 -> $14
AI Analysis
2026-05-20
Reason
Wells Fargo
Price Target
$13 -> $14
AI Analysis
2026-05-20
maintain
NULL
to
Overweight
Reason
Wells Fargo raised the firm's price target on Wave Life Sciences to $14 from $13 and keeps an Overweight rating on the shares. The firm notes the WVE-007 update included 600mg SAD data, which looked better than low/mid doses on M/Z-AAT and seems protective. However, the efficacy is lower than BEAM-302. Wells is moving probability of success up to 33%.
H.C. Wainwright
Buy
downgrade
$18 -> $13
2026-05-19
Reason
H.C. Wainwright
Price Target
$18 -> $13
2026-05-19
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Wave Life Sciences to $13 from $18 and keeps a Buy rating on the shares. WVE-006's readout at the American Thoracic Society Conference validated RNA editing as a modality but fell short with respect to the landscape, the analyst tells investors in a research note. The firm says Sanofi's concurrent Phase 2 data raise the commercial bar, and BEAM-302 retains a 12-18 month regulatory lead. H.C. Wainwright believes WVE-006 "delivered an underwhelming readout."
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Valuation Metrics

The current forward P/E ratio for WAVE Life Sciences Ltd (WVE.O) is 0.00, compared to its 5-year average forward P/E of -5.29. For a more detailed relative valuation and DCF analysis to assess WAVE Life Sciences Ltd's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.29
Current PE
0.00
Overvalued PE
-1.85
Undervalued PE
-8.72

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.06
Current EV/EBITDA
-20.91
Overvalued EV/EBITDA
1.37
Undervalued EV/EBITDA
-7.48

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
16.66
Current PS
24.07
Overvalued PS
29.04
Undervalued PS
4.28

Financials

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Whales Holding WVE

B
Bluebox Asset Management Uk Ltd.
Holding
WVE
+24.26%
3M Return
E
Emerald Advisers, LLC
Holding
WVE
+14.97%
3M Return
D
Driehaus Capital Management LLC
Holding
WVE
+14.26%
3M Return
A
Artal Group S.A.
Holding
WVE
+11.24%
3M Return
A
Affinity Asset Advisors, LLC
Holding
WVE
+7.94%
3M Return
M
Maverick Capital, Ltd.
Holding
WVE
+6.06%
3M Return

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Frequently Asked Questions

What is WAVE Life Sciences Ltd (WVE) stock price today?

The current price of WVE is 6.58 USD — it has increased 1.7

What is WAVE Life Sciences Ltd (WVE)'s business?

Wave Life Sciences Ltd. is a biotechnology company focused on unlocking the broad potential of ribonucleic acid (RNA) medicines to transform human health. The Company's RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. The Company's diversified pipeline includes clinical programs in alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease, as well as several preclinical programs utilizing the Company's broad RNA therapeutics toolkit. Its programs include WVE-006, SERPINA1 (AATD); WVE-007 (GalNAc), INHBE (Obesity); WVE-N531, Exon 53 (DMD), and WVE-003, mHTT (HD).

What is the price predicton of WVE Stock?

Wall Street analysts forecast WVE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for WVE is33.00 USD with a low forecast of 21.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is WAVE Life Sciences Ltd (WVE)'s revenue for the last quarter?

WAVE Life Sciences Ltd revenue for the last quarter amounts to 38.25M USD, increased 316.85

What is WAVE Life Sciences Ltd (WVE)'s earnings per share (EPS) for the last quarter?

WAVE Life Sciences Ltd. EPS for the last quarter amounts to -0.13 USD, decreased -55.17

How many employees does WAVE Life Sciences Ltd (WVE). have?

WAVE Life Sciences Ltd (WVE) has 317 emplpoyees as of May 31 2026.

What is WAVE Life Sciences Ltd (WVE) market cap?

Today WVE has the market capitalization of 1.27B USD.