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WVE Overview

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ET
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ET
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Intellectia

Loading chart...

High
13.860
Open
13.825
VWAP
13.85
Vol
49.07K
Mkt Cap
2.59B
Low
13.825
Amount
679.57K
EV/EBITDA(TTM)
--
Total Shares
188.25M
EV
1.99B
EV/OCF(TTM)
--
P/S(TTM)
54.27
Wave Life Sciences Ltd. is a biotechnology company focused on unlocking the broad potential of ribonucleic acid (RNA) medicines to transform human health. The Company’s RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. The Company’s diversified pipeline includes clinical programs in alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington’s disease, as well as several preclinical programs utilizing the Company’s broad RNA therapeutics toolkit. Its programs include WVE-006, SERPINA1 (AATD); WVE-007 (GalNAc), INHBE (Obesity); WVE-N531, Exon 53 (DMD), and WVE-003, mHTT (HD).
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Events Timeline

(ET)
2026-03-08
22:30:00
KKR Plans to Sell CoolIT Systems for Over $3B
select
2026-03-08
17:00:00
Dr. Vinay Prasad to Leave Agency at End of April
select
link
2026-02-26 (ET)
2026-02-26
07:40:00
Wave Life Sciences Q4 Revenue $17.244M Beats Expectations
select

News

CNBC
9.0
03-06CNBC
FDA Rejects Multiple Experimental Drug Applications, Raising Investor Concerns
  • FDA Drug Rejections: The U.S. FDA has denied or discouraged applications for at least eight drugs over the past year, including UniQure's gene therapy for Huntington's disease, indicating regulatory uncertainty that could impact future treatment approvals.
  • Investor Concerns Rise: Investors are increasingly wary as the FDA appears to change its standards for drug applications, particularly for treatments targeting hard-to-treat diseases, leading to diminished confidence in ongoing development efforts.
  • Changing Regulatory Standards: The FDA's request for UniQure to conduct new placebo-controlled trials contradicts previous guidance, highlighting inconsistencies in the agency's approval process that may create uncertainty for companies in their R&D efforts.
  • Uncertain Future Outlook: Analysts warn that if the FDA does not approve Denali Therapeutics' drug for Hunter syndrome, it could further undermine other companies' confidence in running open-label studies, potentially stifling innovation across the industry.
Newsfilter
7.0
03-06Newsfilter
FDA Drug Approval Uncertainty Intensifies
  • Drug Applications Denied: According to RTW Investments, the FDA has denied or discouraged applications for at least eight new drugs over the past year, including gene therapies for Huntington's and Hunter syndrome, raising investor concerns about the prospects for other drugs in the pipeline.
  • Changing Regulatory Standards: The FDA's request for UniQure to conduct new placebo-controlled studies contradicts previous guidance, leading investors to doubt the agency's consistency and fearing that this could jeopardize future treatment approvals.
  • Negative Market Reaction: Stocks of several biotech companies have declined following FDA rejections, with analysts noting a stark conflict between the FDA's recent decisions and the flexibility promised by its leadership, causing investors to lose confidence in companies relying on FDA leniency.
  • Uncertain Future Outlook: Although FDA officials assert that biomarkers can lead to accelerated approvals, investors remain confused about the agency's approval standards, particularly for drugs targeting rare diseases, making future approval pathways increasingly uncertain.
seekingalpha
9.5
02-26seekingalpha
Wave Life Sciences Q4 2025 Earnings Call Insights
  • Declining Financial Performance: Wave Life Sciences reported fourth-quarter revenue of $17.2 million, a significant drop from $83.7 million in the prior year, primarily due to the termination of the Takeda collaboration, highlighting challenges in diversifying revenue sources despite some milestone income from GSK.
  • Increased R&D Expenses: Research and development expenses rose to $52.8 million in the fourth quarter, driven by the advancement of INHBE and RNA editing programs, reflecting the company's ongoing investment in critical areas, although this has increased short-term financial pressure.
  • Clinical Trial Progress: Management confirmed that the Phase IIa multi-dose portion of the INLIGHT study is set to initiate in the first half of this year, focusing on higher BMI patients, which is expected to provide new momentum for the company's competitiveness in obesity treatment while laying the groundwork for future clinical data releases.
  • Strong Cash Position: As of the end of the fourth quarter, Wave had cash and cash equivalents of $602.1 million, which is expected to be sufficient to fund operations into the third quarter of 2028, demonstrating robust financial management and providing a buffer for future R&D and market expansion.
NASDAQ.COM
9.5
02-26NASDAQ.COM
Wave Life Sciences Reports 2025 Financial Results and Pipeline Progress
  • Financial Decline: In Q4 2025, Wave Life Sciences reported a net loss of $53.2 million, a stark contrast to a net income of $29.3 million in Q4 2024, indicating significant challenges in profitability.
  • Pipeline Progress: The WVE-007 is undergoing the INLIGHT trial, with preliminary results showing that a single 240 mg dose achieved fat loss comparable to GLP-1 over three months, with follow-up data expected this quarter, potentially paving the way for future clinical applications.
  • New Drug Application Plans: The company anticipates submitting a New Drug Application for WVE-N531, targeting Duchenne muscular dystrophy, in 2026, which could provide substantial market opportunities and revenue potential if accelerated approval is granted.
  • Strong Cash Position: Wave ended 2025 with $602.1 million in cash and cash equivalents, expected to fund operations into Q3 2028, reflecting robust capabilities in financing and milestone payments.
seekingalpha
9.5
02-26seekingalpha
Wave Life Sciences Q4 Earnings Report Analysis
  • Earnings Performance: Wave Life Sciences reported a Q4 GAAP EPS of -$0.30, missing expectations by $0.03, indicating challenges in profitability that could affect investor confidence.
  • Revenue Decline: The company's Q4 revenue of $17.24 million represents a significant year-over-year decline of 79.4%, although it beat expectations by $1.56 million, such a steep drop raises concerns about future growth potential in the market.
  • Cash Position: As of December 31, 2025, Wave Life Sciences holds $602.1 million in cash and cash equivalents, with an expected runway into Q3 2028, providing ample funding for R&D and market expansion initiatives.
  • Strategic Focus: The company is currently concentrating on the WVE-006 project, which, despite inherent risks, may offer new growth opportunities in the competitive biopharmaceutical landscape.
Newsfilter
9.0
02-26Newsfilter
Wave Life Sciences Advances Clinical Data Updates and Financial Results
  • Clinical Trial Progress: Wave Life Sciences is on track to update clinical data for WVE-007 in Q1 2026, with preliminary results showing fat loss comparable to GLP-1 at three months, indicating the drug's potential in obesity treatment as effects are expected to continue with higher doses.
  • Initiation of Multidose Trials: The company is planning to initiate the Phase 2a multidose portion of WVE-007 in the first half of 2026, targeting individuals with higher BMI and comorbidities, with assessments expected to include safety and body weight changes, further validating its clinical efficacy.
  • Accelerated Regulatory Pathway: The regulatory engagement for WVE-006 is advancing, with feedback anticipated by mid-2026, indicating the company's strategic positioning in the AATD treatment space, potentially offering new therapeutic options for 200,000 patients.
  • Strong Financial Position: As of December 31, 2025, Wave reported cash and cash equivalents of $602.1 million, expected to fund operations into Q3 2028, demonstrating the company's financial robustness for ongoing R&D and market expansion.
Wall Street analysts forecast WVE stock price to rise
14 Analyst Rating
Wall Street analysts forecast WVE stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
21.00
Averages
33.00
High
50.00
Current: 0.000
sliders
Low
21.00
Averages
33.00
High
50.00
Canaccord
Whitney Ijem
Buy
maintain
$43 -> $52
AI Analysis
2026-03-10
New
Reason
Canaccord
Whitney Ijem
Price Target
$43 -> $52
AI Analysis
2026-03-10
New
maintain
Buy
Reason
Canaccord analyst Whitney Ijem raised the firm's price target on Wave Life Sciences to $52 from $43 and keeps a Buy rating on the shares. The firm updated its model after meeting with management and getting updates on its pipeline including WVE-007 for obesity and WVE-006 in AATD.
Wedbush
Yun Zhong
Outperform
maintain
$33 -> $35
2026-03-06
New
Reason
Wedbush
Yun Zhong
Price Target
$33 -> $35
2026-03-06
New
maintain
Outperform
Reason
Wedbush analyst Yun Zhong raised the firm's price target on Wave Life Sciences to $35 from $33 and keeps an Outperform rating on the shares. After last week's Q4 update reaffirmed that all 2026 catalysts remain on track, the firm had an opportunity to discuss with management about the pathway to approval for WVE-007. According to management, statistically significant body weight reduction of equal or less than 5% vs. placebo at 12 months, based on the FDA draft guidelines on drug development for weight reduction, with improved body composition, should be sufficient to support an FDA approval. The discussion also let the firm believe that the Q1 2026 study update this month should show sustained reduction of Activin E expression and fat loss at 240mg at six months, and higher reduction in both total and visceral fat at 400mg at three months.
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Valuation Metrics

The current forward P/E ratio for WAVE Life Sciences Ltd (WVE.O) is -13.08, compared to its 5-year average forward P/E of -5.19. For a more detailed relative valuation and DCF analysis to assess WAVE Life Sciences Ltd's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.19
Current PE
-13.08
Overvalued PE
-1.80
Undervalued PE
-8.59

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.46
Current EV/EBITDA
-13.49
Overvalued EV/EBITDA
1.08
Undervalued EV/EBITDA
-6.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
15.03
Current PS
71.28
Overvalued PS
26.85
Undervalued PS
3.21

Financials

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Whales Holding WVE

D
Driehaus Capital Management LLC
Holding
WVE
+8.18%
3M Return
A
Artal Group S.A.
Holding
WVE
+7.70%
3M Return
K
Kynam Capital Management, LP
Holding
WVE
+6.22%
3M Return
S
Sofinnova Investment, Inc.
Holding
WVE
+5.81%
3M Return
R
RA Capital Management, L.P.
Holding
WVE
+4.57%
3M Return
T
Tang Capital Management, LLC
Holding
WVE
+3.59%
3M Return

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Frequently Asked Questions

What is WAVE Life Sciences Ltd (WVE) stock price today?

The current price of WVE is 13.86 USD — it has increased 0.8

What is WAVE Life Sciences Ltd (WVE)'s business?

Wave Life Sciences Ltd. is a biotechnology company focused on unlocking the broad potential of ribonucleic acid (RNA) medicines to transform human health. The Company’s RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and common disorders. Its toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing Wave with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. The Company’s diversified pipeline includes clinical programs in alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington’s disease, as well as several preclinical programs utilizing the Company’s broad RNA therapeutics toolkit. Its programs include WVE-006, SERPINA1 (AATD); WVE-007 (GalNAc), INHBE (Obesity); WVE-N531, Exon 53 (DMD), and WVE-003, mHTT (HD).

What is the price predicton of WVE Stock?

Wall Street analysts forecast WVE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for WVE is33.00 USD with a low forecast of 21.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is WAVE Life Sciences Ltd (WVE)'s revenue for the last quarter?

WAVE Life Sciences Ltd revenue for the last quarter amounts to 17.25M USD, decreased -79.41

What is WAVE Life Sciences Ltd (WVE)'s earnings per share (EPS) for the last quarter?

WAVE Life Sciences Ltd. EPS for the last quarter amounts to -0.29 USD, decreased -261.11

How many employees does WAVE Life Sciences Ltd (WVE). have?

WAVE Life Sciences Ltd (WVE) has 317 emplpoyees as of March 11 2026.

What is WAVE Life Sciences Ltd (WVE) market cap?

Today WVE has the market capitalization of 2.59B USD.