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NUVL Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
100.760
Open
99.090
VWAP
99.76
Vol
476.13K
Mkt Cap
7.37B
Low
98.255
Amount
47.50M
EV/EBITDA(TTM)
--
Total Shares
73.54M
EV
6.46B
EV/OCF(TTM)
--
P/S(TTM)
--
Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.
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Events Timeline

(ET)
2026-04-30
08:30:00
Guardant Health Enters Strategic Collaboration with Nuvalent
select
2026-04-17 (ET)
2026-04-17
16:10:00
Nuvalent Presents Zidesamtinib Clinical Data, FDA Target Date September 18, 2026
select
2026-04-07 (ET)
2026-04-07
06:40:00
Nuvalent Submits NDA for neladalkib
select
2026-02-26 (ET)
2026-02-26
06:50:00
Nuvalent Cash and Securities Reach $1.4B, Expected to Fund Operations into 2029
select
2025-12-22 (ET)
2025-12-22
08:00:00
Nuvalent Files Automatic Mixed Securities Shelf Registration
select
2025-12-16 (ET)
2025-12-16
07:31:00
Royalty Pharma Acquires Nuvalent Royalty Interest for Up to $315 Million
select

News

moomoo
7.5
04-30moomoo
Guardant Health and Nuvalent Forge Long-Term Partnership to Create Companion Diagnostics and Aid in the Commercialization of Targeted Cancer Treatments via the Guardant Infinity™ Platform
  • Strategic Collaboration Announcement: Guardant Health has announced a multi-year strategic collaboration with Nuvalent to develop companion diagnostics for targeted cancer therapies.

  • Focus on Cancer Therapies: The partnership aims to enhance the development of diagnostics that support the commercialization of specific cancer therapies.

  • Utilization of Technology: The collaboration will leverage the Guardant Infinity™ platform to facilitate advancements in cancer diagnostics.

  • Potential Impact: This initiative is expected to improve patient outcomes by providing tailored diagnostic solutions for targeted cancer treatments.

PRnewswire
8.5
04-21PRnewswire
Nuvalent Announces Clinical Trial Data Presentation
  • Clinical Trial Data Presentation: Nuvalent will present pivotal data for neladalkib in ALK-positive NSCLC patients at the 2026 ASCO Annual Meeting, which is expected to attract investor interest and potentially drive stock price appreciation.
  • NDA Progress: The FDA has accepted Nuvalent's NDA for zidesamtinib, with a target action date of September 18, 2026, which, if approved, will provide a new treatment option for patients with ROS1-positive NSCLC, enhancing the company's market competitiveness.
  • Breakthrough Therapy Designation: Both neladalkib and zidesamtinib have received breakthrough therapy designation from the FDA, indicating their potential in treating resistant tumors, which may attract further investment and enhance the company's reputation.
  • Global Clinical Trial Strategy: The global data presentation from the ARROS-1 and ALKOVE-1 trials demonstrates Nuvalent's ongoing innovation in targeted cancer therapies, potentially laying the groundwork for future market expansion.
Newsfilter
8.5
04-21Newsfilter
Nuvalent Presents Clinical Trial Data for Cancer Treatments
  • Clinical Trial Data Presentation: Nuvalent will present pivotal data for neladalkib in ALK-positive non-small cell lung cancer patients at the 2026 ASCO Annual Meeting, which is expected to enhance its market position in oncology.
  • NDA Progress: The FDA has accepted the NDA submission for zidesamtinib, with a target action date of September 18, 2026, indicating significant market opportunities for the drug in ROS1-positive non-small cell lung cancer patients.
  • Breakthrough Therapy Designation: Both neladalkib and zidesamtinib have received breakthrough therapy designation from the FDA, highlighting their potential in treating resistant tumors and likely attracting increased investor interest.
  • Global Clinical Trial Strategy: The global scope of the ARROS-1 and ALKOVE-1 clinical trials demonstrates Nuvalent's strategic depth and breadth in cancer treatment, potentially laying a strong foundation for future growth.
PRnewswire
9.0
04-17PRnewswire
Zidesamtinib Shows Promising Activity in ROS1-Positive NSCLC Patients
  • Significant Clinical Activity: In the ARROS-1 trial, zidesamtinib demonstrated a 41% objective response rate in ROS1-positive NSCLC patients previously treated with repotrectinib or taletrectinib, indicating its potential as a new treatment option for heavily pre-treated patients.
  • Enhanced Brain Penetrance: Preclinical studies show that zidesamtinib has superior brain penetrance and antitumor activity compared to existing ROS1 inhibitors, particularly in tumors with the ROS1 G2032R mutation, supporting its potential in earlier lines of therapy.
  • FDA Application Progress: The FDA has accepted the New Drug Application for zidesamtinib with a target action date of September 18, 2026, and if approved, it is expected to launch in the U.S. market in 2026, addressing urgent needs for ROS1-positive NSCLC patients.
  • Clinical Data Support: Zidesamtinib showed an 11% complete response rate in patients with CNS disease and a 67% objective response rate in those with the ROS1 G2032R mutation, highlighting its potential in treating resistant tumors.
NASDAQ.COM
8.5
04-07NASDAQ.COM
Nuvalent Submits NDA for Neladalkib in Advanced NSCLC
  • NDA Submission: Nuvalent, Inc. has submitted an NDA to the FDA for neladalkib, an ALK-selective inhibitor designed for TKI-pretreated advanced ALK-positive NSCLC patients, marking a significant milestone in oncology drug development.
  • Clinical Trial Data: The application is supported by data from the ALKOVE-1 Phase 1/2 clinical trial, demonstrating neladalkib's efficacy in TKI-pretreated patients, which enhances its market potential and attractiveness to investors.
  • Rapid Development Timeline: Chief Development Officer Darlene Noci noted that the transition from the first clinical trial initiation to NDA submission in less than four years showcases the accelerated pace of oncology drug development, potentially drawing more investor interest in the company's future.
  • Positive Market Reaction: Nuvalent's shares rose 0.38% to $104.10 in pre-market trading on Nasdaq, reflecting a positive market response to the NDA submission and confidence in the company's growth prospects.
PRnewswire
8.5
04-07PRnewswire
Nuvalent Submits NDA for ALK-Selective Inhibitor in Advanced NSCLC
  • NDA Submission: Nuvalent has submitted an NDA to the FDA for neladalkib, an ALK-selective inhibitor targeting TKI-pretreated advanced ALK-positive NSCLC patients, marking a remarkable four-year timeline from clinical trial initiation to submission, showcasing the company's rapid advancement in oncology drug development.
  • Clinical Trial Results: In the global registration-directed ALKOVE-1 trial, neladalkib demonstrated encouraging overall activity in TKI-pretreated patients, including intracranial responses, indicating its potential to address key drivers of disease progression while maintaining a favorable safety profile consistent with its ALK-selective design.
  • Breakthrough Therapy Designation: Neladalkib has received FDA breakthrough therapy designation for patients with locally advanced or metastatic ALK-positive NSCLC previously treated with two or more ALK tyrosine kinase inhibitors, highlighting its unique value and market potential in the treatment landscape.
  • Future Development Plans: Nuvalent plans to present detailed clinical results at an upcoming medical meeting, further enhancing neladalkib's market acceptance, and is committed to working closely with the FDA to expedite the drug's approval process to meet urgent patient needs.
Wall Street analysts forecast NUVL stock price to rise
16 Analyst Rating
Wall Street analysts forecast NUVL stock price to rise
16 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
Wells Fargo
Eva Fortea Verdejo
Overweight
initiated
$116
AI Analysis
2026-03-30
Reason
Wells Fargo
Eva Fortea Verdejo
Price Target
$116
AI Analysis
2026-03-30
initiated
Overweight
Reason
Wells Fargo analyst Eva Fortea Verdejo initiated coverage of Nuvalent with an Overweight rating and $116 price target. The firm believes the company's zidesamtinib has "best-in-class" potential in ROS1-positive non-small cell lung cancer. In addition, neladalkib's safety supports differentiation in ALK-positive lung cancer, the analyst tells investors in a research note. Wells is a buyer of Nuvalent shares ahead of the two potential FDA approvals in the next 12-18 months.
UBS
Buy
maintain
$132 -> $138
2026-03-02
Reason
UBS
Price Target
$132 -> $138
2026-03-02
maintain
Buy
Reason
UBS raised the firm's price target on Nuvalent to $138 from $132 and keeps a Buy rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for NUVL
Unlock Now

Valuation Metrics

The current forward P/E ratio for Nuvalent, Inc (NUVL.O) is 0.00, compared to its 5-year average forward P/E of -16.51. For a more detailed relative valuation and DCF analysis to assess Nuvalent, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-16.51
Current PE
0.00
Overvalued PE
-10.77
Undervalued PE
-22.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.02
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-7.37
Undervalued EV/EBITDA
-18.66

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
154.09
Current PS
42.76
Overvalued PS
620.08
Undervalued PS
-311.90

Financials

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NUVL logo
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Nuvalent Inc
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Whales Holding NUVL

F
Fairmount Funds Management LLC
Holding
NUVL
+26.36%
3M Return
C
Commodore Capital LP
Holding
NUVL
+25.88%
3M Return
B
Braidwell LP
Holding
NUVL
+15.02%
3M Return
P
Perceptive Advisors LLC
Holding
NUVL
+12.49%
3M Return
P
Paradigm Biocapital Advisors LP
Holding
NUVL
+12.48%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
NUVL
+11.90%
3M Return

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Frequently Asked Questions

What is Nuvalent, Inc (NUVL) stock price today?

The current price of NUVL is 100.28 USD — it has increased 1.19

What is Nuvalent, Inc (NUVL)'s business?

Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.

What is the price predicton of NUVL Stock?

Wall Street analysts forecast NUVL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NUVL is140.86 USD with a low forecast of 125.00 USD and a high forecast of 158.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Nuvalent, Inc (NUVL)'s revenue for the last quarter?

Nuvalent, Inc revenue for the last quarter amounts to -102.23M USD, increased 18.46

What is Nuvalent, Inc (NUVL)'s earnings per share (EPS) for the last quarter?

Nuvalent, Inc. EPS for the last quarter amounts to -73328000.00 USD, increased 18.27

How many employees does Nuvalent, Inc (NUVL). have?

Nuvalent, Inc (NUVL) has 228 emplpoyees as of May 01 2026.

What is Nuvalent, Inc (NUVL) market cap?

Today NUVL has the market capitalization of 7.37B USD.