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NUVL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
105.215
Open
104.890
VWAP
102.58
Vol
412.86K
Mkt Cap
8.22B
Low
99.785
Amount
42.35M
EV/EBITDA(TTM)
--
Total Shares
78.62M
EV
6.85B
EV/OCF(TTM)
--
P/S(TTM)
--
Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.
Show More

Events Timeline

(ET)
2026-04-07
06:40:00
Nuvalent Submits NDA for neladalkib
select
2026-02-26 (ET)
2026-02-26
06:50:00
Nuvalent Cash and Securities Reach $1.4B, Expected to Fund Operations into 2029
select
2025-12-22 (ET)
2025-12-22
08:00:00
Nuvalent Files Automatic Mixed Securities Shelf Registration
select
2025-12-16 (ET)
2025-12-16
07:31:00
Royalty Pharma Acquires Nuvalent Royalty Interest for Up to $315 Million
select
2025-11-19 (ET)
2025-11-19
16:22:18
FDA Accepts Nuvalent's New Drug Application for Zidesamtinib in NSCLC
select

News

NASDAQ.COM
8.5
04-07NASDAQ.COM
Nuvalent Submits NDA for Neladalkib in Advanced NSCLC
  • NDA Submission: Nuvalent, Inc. has submitted an NDA to the FDA for neladalkib, an ALK-selective inhibitor designed for TKI-pretreated advanced ALK-positive NSCLC patients, marking a significant milestone in oncology drug development.
  • Clinical Trial Data: The application is supported by data from the ALKOVE-1 Phase 1/2 clinical trial, demonstrating neladalkib's efficacy in TKI-pretreated patients, which enhances its market potential and attractiveness to investors.
  • Rapid Development Timeline: Chief Development Officer Darlene Noci noted that the transition from the first clinical trial initiation to NDA submission in less than four years showcases the accelerated pace of oncology drug development, potentially drawing more investor interest in the company's future.
  • Positive Market Reaction: Nuvalent's shares rose 0.38% to $104.10 in pre-market trading on Nasdaq, reflecting a positive market response to the NDA submission and confidence in the company's growth prospects.
PRnewswire
8.5
04-07PRnewswire
Nuvalent Submits NDA for ALK-Selective Inhibitor in Advanced NSCLC
  • NDA Submission: Nuvalent has submitted an NDA to the FDA for neladalkib, an ALK-selective inhibitor targeting TKI-pretreated advanced ALK-positive NSCLC patients, marking a remarkable four-year timeline from clinical trial initiation to submission, showcasing the company's rapid advancement in oncology drug development.
  • Clinical Trial Results: In the global registration-directed ALKOVE-1 trial, neladalkib demonstrated encouraging overall activity in TKI-pretreated patients, including intracranial responses, indicating its potential to address key drivers of disease progression while maintaining a favorable safety profile consistent with its ALK-selective design.
  • Breakthrough Therapy Designation: Neladalkib has received FDA breakthrough therapy designation for patients with locally advanced or metastatic ALK-positive NSCLC previously treated with two or more ALK tyrosine kinase inhibitors, highlighting its unique value and market potential in the treatment landscape.
  • Future Development Plans: Nuvalent plans to present detailed clinical results at an upcoming medical meeting, further enhancing neladalkib's market acceptance, and is committed to working closely with the FDA to expedite the drug's approval process to meet urgent patient needs.
Newsfilter
9.0
04-07Newsfilter
Nuvalent Submits NDA for ALK-Selective Inhibitor in Advanced NSCLC
  • NDA Submission: Nuvalent has submitted a New Drug Application (NDA) to the FDA for neladalkib, an ALK-selective inhibitor targeting advanced ALK-positive NSCLC patients previously treated with TKIs, marking a remarkable four-year progression from clinical trial initiation to NDA submission, showcasing the company's rapid advancement in oncology drug development.
  • Clinical Trial Results: In the global registration-directed ALKOVE-1 trial, neladalkib demonstrated encouraging overall activity in TKI-pretreated patients, including intracranial responses, indicating its effectiveness in addressing key drivers of disease progression, while maintaining a well-tolerated safety profile consistent with its ALK-selective design.
  • Breakthrough Therapy Designation: Neladalkib has received FDA breakthrough therapy designation for patients with locally advanced or metastatic ALK-positive NSCLC who have been previously treated with two or more ALK tyrosine kinase inhibitors, highlighting its potential significance in the treatment landscape.
  • Future Development Plans: Nuvalent plans to present detailed clinical trial results at an upcoming medical meeting, further advancing the clinical application of neladalkib, while the company is committed to working closely with the FDA to expedite the drug's approval process.
CNBC
6.0
03-30CNBC
Latest Wall Street Rating Updates
  • UBS Upgrade: UBS upgrades Adecoagro from Neutral to Buy, raising the price target from $8 to $16.2, indicating the company is poised to benefit from the ongoing Middle East conflict, which is expected to enhance its financial performance.
  • HSBC Bullish on Carnival: HSBC upgrades Carnival from Hold to Buy, asserting that the current share price undervalues the resilience of experience-led demand, which is likely to improve the company's market performance in the near future.
  • Morgan Stanley Reiterates Meta: Morgan Stanley lowers its price target for Meta from $825 to $775 but maintains it as a top investment idea, suggesting that market sentiment has bottomed out, making it an opportune time to buy.
  • Deutsche Bank Upgrades Colgate: Deutsche Bank upgrades Colgate-Palmolive from Hold to Buy, highlighting the company's core business as having long-term investment value and the ability to weather current market volatility effectively.
moomoo
4.0
03-30moomoo
Wells Fargo Begins Coverage of Nuvalent, Inc. with Overweight Rating and $116 Target Price
  • Company Overview: Nuvalent, Inc. is a company involved in the pharmaceutical sector, focusing on innovative treatments.

  • Market Activity: The company has initiated coverage with an overweight rating and a target price set at $116.

Barron's
4.5
03-26Barron's
S&P 500 Futures Decline in Pre-Market Trading; Nuvalent and Figure Tech Solutions Take the Lead
  • Market Opening: U.S. stock markets are set to open in two hours.

  • Nuvalent Inc. Performance: Nuvalent Inc. Cl A (NUVL) saw a 7.0% increase in pre-market trading.

  • Figure Technology Solutions Performance: Figure Technology Solutions Inc. (FIGR) also experienced a 7.0% rise in pre-market trading.

  • Overall Market Sentiment: The pre-market gains indicate a positive sentiment among investors for these stocks.

Wall Street analysts forecast NUVL stock price to rise
16 Analyst Rating
Wall Street analysts forecast NUVL stock price to rise
16 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
Wells Fargo
Eva Fortea Verdejo
Overweight
initiated
$116
AI Analysis
2026-03-30
Reason
Wells Fargo
Eva Fortea Verdejo
Price Target
$116
AI Analysis
2026-03-30
initiated
Overweight
Reason
Wells Fargo analyst Eva Fortea Verdejo initiated coverage of Nuvalent with an Overweight rating and $116 price target. The firm believes the company's zidesamtinib has "best-in-class" potential in ROS1-positive non-small cell lung cancer. In addition, neladalkib's safety supports differentiation in ALK-positive lung cancer, the analyst tells investors in a research note. Wells is a buyer of Nuvalent shares ahead of the two potential FDA approvals in the next 12-18 months.
UBS
Buy
maintain
$132 -> $138
2026-03-02
Reason
UBS
Price Target
$132 -> $138
2026-03-02
maintain
Buy
Reason
UBS raised the firm's price target on Nuvalent to $138 from $132 and keeps a Buy rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for NUVL
Unlock Now

Valuation Metrics

The current forward P/E ratio for Nuvalent, Inc (NUVL.O) is 0.00, compared to its 5-year average forward P/E of -16.51. For a more detailed relative valuation and DCF analysis to assess Nuvalent, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-16.51
Current PE
0.00
Overvalued PE
-10.77
Undervalued PE
-22.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.02
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-7.37
Undervalued EV/EBITDA
-18.66

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
155.21
Current PS
44.92
Overvalued PS
623.46
Undervalued PS
-313.04

Financials

AI Analysis
Annual
Quarterly

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NUVL logo
NUVL
Nuvalent Inc
7.99B

Whales Holding NUVL

C
Commodore Capital LP
Holding
NUVL
+32.03%
3M Return
F
Fairmount Funds Management LLC
Holding
NUVL
+21.62%
3M Return
P
Perceptive Advisors LLC
Holding
NUVL
+11.96%
3M Return
P
Paradigm Biocapital Advisors LP
Holding
NUVL
+8.44%
3M Return
B
Braidwell LP
Holding
NUVL
+8.23%
3M Return
R
RA Capital Management, L.P.
Holding
NUVL
+4.19%
3M Return

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Frequently Asked Questions

What is Nuvalent, Inc (NUVL) stock price today?

The current price of NUVL is 102.74 USD — it has decreased -1.77

What is Nuvalent, Inc (NUVL)'s business?

Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.

What is the price predicton of NUVL Stock?

Wall Street analysts forecast NUVL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NUVL is140.86 USD with a low forecast of 125.00 USD and a high forecast of 158.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Nuvalent, Inc (NUVL)'s revenue for the last quarter?

Nuvalent, Inc revenue for the last quarter amounts to -102.23M USD, increased 18.46

What is Nuvalent, Inc (NUVL)'s earnings per share (EPS) for the last quarter?

Nuvalent, Inc. EPS for the last quarter amounts to -73328000.00 USD, increased 18.27

How many employees does Nuvalent, Inc (NUVL). have?

Nuvalent, Inc (NUVL) has 228 emplpoyees as of April 11 2026.

What is Nuvalent, Inc (NUVL) market cap?

Today NUVL has the market capitalization of 8.22B USD.