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NUVL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
98.510
Open
97.210
VWAP
97.20
Vol
447.75K
Mkt Cap
7.63B
Low
96.030
Amount
43.52M
EV/EBITDA(TTM)
--
Total Shares
78.62M
EV
6.29B
EV/OCF(TTM)
--
P/S(TTM)
--
Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.
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Events Timeline

(ET)
2026-02-26
06:50:00
Nuvalent Cash and Securities Reach $1.4B, Expected to Fund Operations into 2029
select
2025-12-22 (ET)
2025-12-22
08:00:00
Nuvalent Files Automatic Mixed Securities Shelf Registration
select
2025-12-16 (ET)
2025-12-16
07:31:00
Royalty Pharma Acquires Nuvalent Royalty Interest for Up to $315 Million
select
2025-11-19 (ET)
2025-11-19
16:22:18
FDA Accepts Nuvalent's New Drug Application for Zidesamtinib in NSCLC
select
2025-11-19
06:13:34
Nuvalent Sets Secondary Offering of 4.95 Million Shares at $101.00 Each
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News

Newsfilter
9.0
03-17Newsfilter
PinnedNuvalent Presents New Data on Zidesamtinib at AACR 2026
  • Clinical Data Presentation: Nuvalent showcased clinical data for zidesamtinib at the 2026 AACR Annual Meeting, focusing on TKI-pretreated patients with ROS1-positive NSCLC, indicating potential efficacy that could offer new treatment options for patients.
  • FDA Application Progress: Following results from the ARROS-1 clinical trial, the FDA has accepted the NDA submission for zidesamtinib, with a target action date of September 18, 2026, which, if approved, could provide a new treatment avenue for ROS1-positive NSCLC patients, representing significant market potential.
  • Breakthrough Therapy Designation: Zidesamtinib has received breakthrough therapy designation for patients previously treated with two or more ROS1 TKIs, highlighting its unique advantages in treating refractory tumors and potentially improving patient survival rates.
  • Brain Penetrance Capability: Designed to overcome limitations of existing ROS1 inhibitors, zidesamtinib exhibits strong brain penetrance, particularly beneficial for patients with brain metastases, potentially reducing TRK-related adverse events and enhancing treatment outcomes.
PRnewswire
9.0
03-17PRnewswire
Nuvalent Presents New Data on Zidesamtinib at AACR 2026
  • Clinical Data Presentation: Nuvalent showcased clinical data for zidesamtinib at the 2026 AACR Annual Meeting, focusing on ROS1-positive NSCLC patients previously treated with TKIs, indicating potential efficacy and offering new treatment options for patients.
  • FDA Application Progress: Following results from the ARROS-1 clinical trial, the FDA has accepted the NDA submission for zidesamtinib, with a target action date of September 18, 2026, which could expedite market access and enhance Nuvalent's competitive position.
  • Breakthrough Therapy Designation: Zidesamtinib has received breakthrough therapy designation for patients previously treated with two or more ROS1 TKIs, highlighting its potential in treating refractory tumors and likely attracting increased investor interest.
  • Brain Penetrance Advantage: Designed to improve treatment options for patients with brain metastases, zidesamtinib's unique brain penetrance may avoid adverse effects associated with existing ROS1 inhibitors, thereby enhancing patients' quality of life.
Fool
6.5
03-17Fool
Vestal Point Capital Sells Nuvalent Shares Worth $103.93 Million
  • Share Sale Overview: On February 17, 2026, Vestal Point Capital disclosed to the SEC that it sold 1,054,000 shares of Nuvalent for an estimated $103.93 million, indicating a strategic shift in its biotechnology investments.
  • Portfolio Impact: This sale reduced Nuvalent's weight in Vestal Point Capital's portfolio to less than 1%, with a quarter-end position decrease of $90.50 million, suggesting a potential reassessment of confidence in the stock.
  • Market Performance Analysis: As of February 17, 2026, Nuvalent shares were priced at $102.24, reflecting a 29.11% increase over the past year, significantly outperforming the S&P 500's approximately 19% gain, highlighting its competitive position in the biopharmaceutical market.
  • Future Outlook: Nuvalent is entering a pivotal FDA decision period, with plans to submit zidesamtinib for review by September 2026, alongside neladalkib, indicating that upcoming regulatory milestones could significantly impact its future stock performance.
NASDAQ.COM
2.0
03-17NASDAQ.COM
Vestal Point Capital Sells Nuvalent Shares Worth $103.93 Million
  • Share Sale Details: Vestal Point Capital sold 1,054,000 shares of Nuvalent in Q4 2026, amounting to an estimated $103.93 million transaction, indicating a reassessment of the company's prospects in the market.
  • Decline in Position Value: The fund's quarter-end position in Nuvalent decreased by $90.50 million, reflecting the impact of trading activities and stock price fluctuations on its investment portfolio.
  • Upcoming Regulatory Milestones: Nuvalent is preparing for a potential FDA decision on zidesamtinib in September 2026, while also planning to submit another oncology candidate, neladalkib, for regulatory review, which is crucial for its future development.
  • Strong Financial Position: As of the end of 2025, Nuvalent reported approximately $1.4 billion in cash and investments, sufficient to fund operations into 2029, showcasing the company's potential and stability moving forward.
Barron's
4.5
03-03Barron's
S&P 500 Futures Decline in Pre-Market Session; MongoDB and Credo Tech Group Underperform
  • Venture Global Inc. Performance: Venture Global Inc. (VG) saw a significant increase of 16.7% in pre-market trading.
  • Best Buy Co. Inc. Performance: Best Buy Co. Inc. (BBY) experienced a rise of 12.3% in pre-market trading.
  • Market Context: The stock market is set to open in two hours, indicating potential volatility.
  • Investor Sentiment: The pre-market gains for both companies suggest positive investor sentiment ahead of the market opening.
seekingalpha
9.5
02-26seekingalpha
Nuvalent Reports Q4 Earnings Miss with EPS of -$1.58
  • Earnings Miss: Nuvalent's Q4 GAAP EPS of -$1.58 fell short of expectations by $0.09, indicating challenges in profitability that could impact investor confidence.
  • Strong Cash Reserves: As of December 31, 2025, Nuvalent reported $1.4 billion in cash, cash equivalents, and marketable securities, demonstrating solid liquidity to support operations in the near term.
  • Funding Outlook: The company believes its existing cash and equivalents will be sufficient to fund operations into 2029, reflecting management's optimistic view on financial stability over the next few years, which may attract long-term investor interest.
  • Industry Conference Participation: Nuvalent presented at the 44th Annual J.P. Morgan Healthcare Conference, enhancing its visibility in the industry and potentially paving the way for future collaborations and financing opportunities.
Wall Street analysts forecast NUVL stock price to rise
16 Analyst Rating
Wall Street analysts forecast NUVL stock price to rise
16 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
Current: 0.000
sliders
Low
125.00
Averages
140.86
High
158.00
UBS
Buy
maintain
$132 -> $138
AI Analysis
2026-03-02
Reason
UBS
Price Target
$132 -> $138
AI Analysis
2026-03-02
maintain
Buy
Reason
UBS raised the firm's price target on Nuvalent to $138 from $132 and keeps a Buy rating on the shares.
Cantor Fitzgerald
Overweight
maintain
$135 -> $140
2026-02-27
Reason
Cantor Fitzgerald
Price Target
$135 -> $140
2026-02-27
maintain
Overweight
Reason
Cantor Fitzgerald raised the firm's price target on Nuvalent to $140 from $135 and keeps an Overweight rating on the shares. With one new drug application under review and another planned for the first half of 2026, the company is rapidly transitioning to a revenue story, where the product launches' ability to drive outer-year consensus estimates will be the primary determinant of share outperformance, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for Nuvalent, Inc (NUVL.O) is -17.36, compared to its 5-year average forward P/E of -16.51. For a more detailed relative valuation and DCF analysis to assess Nuvalent, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-16.51
Current PE
-17.36
Overvalued PE
-10.78
Undervalued PE
-22.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.02
Current EV/EBITDA
-16.07
Overvalued EV/EBITDA
-7.38
Undervalued EV/EBITDA
-18.67

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
163.09
Current PS
1124.05
Overvalued PS
645.61
Undervalued PS
-319.42

Financials

AI Analysis
Annual
Quarterly

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NUVL logo
NUVL
Nuvalent Inc
7.99B

Whales Holding NUVL

P
Paradigm Biocapital Advisors LP
Holding
NUVL
+7.41%
3M Return
C
Commodore Capital LP
Holding
NUVL
+6.79%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
NUVL
+3.54%
3M Return
P
Perceptive Advisors LLC
Holding
NUVL
+2.89%
3M Return
F
Fairmount Funds Management LLC
Holding
NUVL
-0.59%
3M Return
B
Braidwell LP
Holding
NUVL
-1.16%
3M Return

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Frequently Asked Questions

What is Nuvalent, Inc (NUVL) stock price today?

The current price of NUVL is 97.06 USD — it has decreased -0.38

What is Nuvalent, Inc (NUVL)'s business?

Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer. It develops small molecules that have the potential to overcome resistance, minimize adverse events, and address brain metastases. It is advancing a robust pipeline with investigational candidates for ROS proto-oncogene 1 (ROS1)-positive, anaplastic lymphoma kinase (ALK)-positive, and human epidermal growth factor receptor 2 (HER2)-positive non-small cell lung cancer, and multiple discovery-stage research programs. Its product candidate, Zidesamtinib (NVL-520), is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC). NVL-520 is a novel ROS1-selective inhibitor. Its product candidate, Neladalkib (NVL-655), is being developed for patients with ALK-positive NSCLC. NVL-655 is a brain-penetrant ALK-selective inhibitor. Its product candidate, NVL-330, is a brain-penetrant HER2-selective inhibitor.

What is the price predicton of NUVL Stock?

Wall Street analysts forecast NUVL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NUVL is140.86 USD with a low forecast of 125.00 USD and a high forecast of 158.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Nuvalent, Inc (NUVL)'s revenue for the last quarter?

Nuvalent, Inc revenue for the last quarter amounts to -102.23M USD, increased 18.46

What is Nuvalent, Inc (NUVL)'s earnings per share (EPS) for the last quarter?

Nuvalent, Inc. EPS for the last quarter amounts to -73328000.00 USD, increased 18.27

How many employees does Nuvalent, Inc (NUVL). have?

Nuvalent, Inc (NUVL) has 228 emplpoyees as of March 20 2026.

What is Nuvalent, Inc (NUVL) market cap?

Today NUVL has the market capitalization of 7.63B USD.