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ALNY Should I Buy

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Intellectia

Should You Buy Alnylam Pharmaceuticals Inc (ALNY) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Buy
Latest Price
301.980
1 Day change
-1.01%
52 Week Range
495.550
Analysis Updated At
2026/05/29
Should I buy Analysis is updated weekly. For real time "Should I Buy" analysis, please sign up to get free answers.

ALNY is a good buy right now for a beginner long-term investor with $50,000-$100,000 to deploy. My direct view is BUY. The stock has strong long-term growth support from analyst upgrades, positive Amvuttra launch commentary, and constructive technical momentum, while options positioning is mildly bullish. The current setup looks suitable for an immediate entry rather than waiting.

Technical Analysis

ALNY is in a short-term uptrend with bullish momentum. MACD histogram is positive at 1.951 and expanding, which supports continued upside. RSI_6 at 68.921 is elevated but not yet a strong reversal signal. Moving averages are converging, suggesting the stock may be transitioning into a stronger trend phase. Price at 303.74 is just below resistance at 303.492-308.59 after testing the pivot area at 295.241, so the chart shows a constructive breakout attempt. Overall technicals favor a buy with near-term upside potential.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Options sentiment is bullish. The put-call ratios are low on both open interest and volume, showing call-heavy positioning and positive trader sentiment. Call open interest of 17,085 versus put open interest of 6,432 also supports optimism. Volume is modest at 363 contracts, but today's option activity is running above the 30-day average, reinforcing active interest. Implied volatility is moderate, with IV rank 7.94 and IV percentile 29.37, so the market is not pricing extreme fear.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
8
Buy
5

Positive Catalysts

  • ["Citi initiated coverage with a Buy rating and $380 target on 2026-05-18.", "Citi said the expanded launch of Amvuttra for ATTR-CM has been impressive and sees more tailwinds than headwinds.", "Bernstein noted Amvuttra beat consensus by 5% and said U.S. numbers look very strong.", "Truist remains Buy-rated and expects robust year-over-year growth.", "Options sentiment is bullish with low put-call ratios.", "Technical momentum is improving with positive MACD expansion."]

Neutral/Negative Catalysts

  • ["Jefferies downgraded ALNY to Hold and cut its target sharply, calling the shares priced to perfection.", "Morgan Stanley kept Equal Weight despite raising its target.", "There is still concern from some analysts that growth expectations may already be high.", "Recent price action includes a year-to-date pullback mentioned by Citi, which may reflect lingering competition concerns.", "News flow provided is unrelated to ALNY, so there is no major fresh company-specific news catalyst in the dataset."]

Financial Performance

No latest quarter financial snapshot was available in the data because the financial section returned an error. Based on the analyst commentary, however, the latest quarter appears to have been strong, especially for Amvuttra, which beat consensus by 5%. Analysts also cited continued U.S. strength and robust year-over-year growth, while noting some seasonal weakness in Q1 from payer dynamics and fewer shipping weeks. The latest quarter season referenced in the analyst comments is Q1.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analyst sentiment is net positive but mixed. Recent changes show Citi starting coverage with Buy and a $380 target, Bernstein staying Outperform and slightly trimming target, and Truist remaining Buy with a higher target at $505. Morgan Stanley is more neutral at Equal Weight with a $370 target, while Jefferies turned cautious by downgrading to Hold and cutting target to $330. Wall Street pros mostly like the long-term growth story and Amvuttra momentum, while the main con is valuation and concern that expectations may already be rich.

Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 305.060
sliders
Low
351
Averages
479.53
High
580
Current: 305.060
sliders
Low
351
Averages
479.53
High
580
Citi
NULL
to
Buy
initiated
$380
AI Analysis
2026-05-18
Reason
Citi
Price Target
$380
AI Analysis
2026-05-18
initiated
NULL
to
Buy
Reason
Citi initiated coverage of Alnylam with a Buy rating and $380 price target. The expanded launch of Amvuttra for ATTR-CM has \"no doubt been impressive,\" says the analyst, who views 28% year-to-date pullback as \"an attractive long-term entry point.\" Pressure has been led by competitor concerns, but the firm sees \"more tailwinds than headwinds for Amvuttra,\" the analyst added.
Morgan Stanley
Equal Weight
maintain
$360 -> $370
2026-05-01
Reason
Morgan Stanley
Price Target
$360 -> $370
2026-05-01
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Alnylam to $370 from $360 and keeps an Equal Weight rating on the shares.
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