CervoMed Reports New Data on Neflamapimod Clinical Trial, Significant GFAP Reduction
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 02 2025
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Source: Globenewswire
- Significant Biomarker Improvement: At the CTAD conference, CervoMed presented data showing that neflamapimod treatment led to a significant reduction in plasma GFAP levels, achieving a median of -16.0 pg/mL (p<0.0001), indicating the drug's potential in improving neurodegenerative conditions and offering new hope for DLB patients.
- Clinical Effect Correlation: The study revealed a positive correlation between neflamapimod treatment and improvement in CDR-SB scores (r=0.35, p=0.036), which not only validates GFAP as an effective biomarker for DLB disease activity but also strengthens the conclusions regarding neflamapimod's clinical effects.
- Successful Extension Phase: During the 32-week extension phase, patients receiving the new drug batch showed significant reductions in GFAP levels and a notable increase in the A42/40 ratio (p<0.001), suggesting that neflamapimod may act on the underlying disease process in DLB, enhancing the company's confidence as it moves towards the next phase of clinical trials.
- Funding and Research Scale: The RewinD-LB trial was supported by a $21.3 million grant from the NIH, covering 43 research sites across the U.S., U.K., and Netherlands, demonstrating CervoMed's extensive research foundation and future growth potential in the neurodegenerative disease field.
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Analyst Views on CRVO
Wall Street analysts forecast CRVO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRVO is 22.75 USD with a low forecast of 19.00 USD and a high forecast of 27.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 5.170
Low
19.00
Averages
22.75
High
27.00
Current: 5.170
Low
19.00
Averages
22.75
High
27.00
About CRVO
CervoMed Inc. is a clinical-stage company focused on developing treatments for age-related neurologic disorders. The Company is developing neflamapimod, an investigational, orally administered small molecule brain penetrant that inhibits p38 mitogen-activated protein kinase alpha. Neflamapimod has the potential to treat synaptic dysfunction, the reversible aspect of the underlying neurodegenerative processes that cause disease in Lewy bodies (DLB) and certain other neurological disorders. It focuses on reducing the impact of inflammation in the brain, or neuroinflammation, which is a key factor in the manifestation of degenerative diseases of the brain, including DLB. Neflamapimod is being evaluated in the Company's ongoing RewinD-LB Trial, a Phase 2b trial in patients with DLB.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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CervoMed's Neflamapimod Shows Significant Improvement in DLB Patients in Phase 2b Trial
- Clinical Trial Results: CervoMed's Phase 2b RewinD-LB trial demonstrated that neflamapimod significantly improved CDR-SB scores in DLB patients, achieving a 52% reduction compared to placebo over 16 weeks, indicating its potential as a treatment.
- Biomarker Improvement: The treatment group showed a significant reduction in GFAP levels, suggesting that neflamapimod effectively targets neurodegenerative processes, reinforcing its scientific basis as a potential DLB therapy.
- Future Trial Plans: CervoMed is set to initiate a global Phase 3 registrational trial in the second half of 2026 to further validate neflamapimod's efficacy, advancing its path to market.
- Funding Support: The RewinD-LB trial received $21.3 million in NIH funding, covering 43 research sites across the U.S., U.K., and Netherlands, highlighting the broad support and potential impact of this research.
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