Biogen Reports Strong Q4 Earnings and Positive Nusinersen Study Results
Biogen Inc's stock rose by 6.03% as it reached a 52-week high, buoyed by positive news surrounding its recent clinical findings and earnings report.
The company reported a Q4 Non-GAAP EPS of $1.99, exceeding expectations by $0.36, and highlighted the promising results from its DEVOTE study on high-dose nusinersen for spinal muscular atrophy (SMA), which demonstrated significant safety and efficacy. Additionally, the FDA is currently reviewing this treatment, with a decision expected by April 2026, potentially enhancing Biogen's position in the SMA market.
These developments reflect Biogen's resilience in a challenging market, with strong earnings performance and a positive outlook for its innovative therapies, particularly in the SMA treatment landscape.
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- Strong Financial Performance: Biogen's 2025 earnings report revealed total revenue of $2.28 billion, down 7% year-over-year, yet surpassing analyst expectations of $2.21 billion, indicating resilience amid challenges.
- Significant Net Income Decline: The company's non-GAAP net income fell sharply to $294 million ($1.99 per share) from over $502 million a year ago, reflecting increased market competition impacting profitability.
- Product Revenue Decline: Product revenue decreased by 9% to $1.67 billion, with multiple sclerosis treatment sales dropping 14% year-over-year to $917 million, highlighting the competitive pressure from generics and biosimilars.
- Positive Future Outlook: Biogen anticipates mid-single-digit revenue decline for 2026, with adjusted net income projected between $15.25 and $16.25 billion, exceeding the average analyst estimate of $14.92 billion, showcasing potential in new drug development and market expansion.
- Strong Financial Performance: Biogen's Q4 2025 report revealed total revenue of nearly $2.28 billion, down 7% year-over-year, yet surpassing analyst expectations of $2.21 billion, demonstrating the company's resilience in challenging market conditions.
- Declining Net Income: Non-GAAP net income fell to $294 million ($1.99 per share), a significant drop from over $502 million a year ago, reflecting increased competitive pressures impacting profitability.
- Product Revenue Decline: Product revenue decreased by 9% to $1.67 billion, with the largest drug category, multiple sclerosis (MS) treatments, experiencing a 14% year-over-year decline to $917 million, highlighting the impact of generics and biosimilars on sales.
- Positive 2026 Outlook: Biogen anticipates mid-single-digit revenue decline for 2026, with adjusted net income projected between $15.25 and $16.25 billion, exceeding the average analyst estimate of $14.92 billion, indicating growth potential in its new product lines.

- Performance Exceeds Expectations: Biogen reported a non-GAAP diluted EPS of $1.99 for Q4 2025 and $15.28 for the full year, both surpassing expectations, indicating strong growth from its new product portfolio and market performance, with total revenue reaching $9.9 billion, up 2% year-over-year.
- Growth Product Success: The company’s growth products generated $3.3 billion in revenue for 2025, a 19% increase, with Q4 contributing $800 million, demonstrating significant market acceptance of new products like VUMERITY and LEQEMBI, thereby enhancing the company's competitive position.
- Significant Pipeline Progress: Management highlighted the pipeline advancements as the
- Revenue Beat: Biogen reported fiscal 2025 revenues of $2.28 billion, surpassing the consensus estimate of $2.20 billion, despite a 7% year-over-year decline, demonstrating resilience amid market challenges.
- Strong Growth Products: Revenue from growth products increased by 19% year-over-year, successfully offsetting declines in multiple sclerosis product revenues, indicating effective strategies in drug development and market promotion.
- Market Performance: Leqembi collaboration revenue reached $47 million, with in-market sales of approximately $134 million, up 54%, reflecting strong demand for the Alzheimer's drug in the market.
- Optimistic Outlook: Biogen expects fiscal 2026 earnings between $15.25 and $16.25 per share, exceeding the consensus of $14.92, and while multiple sclerosis product revenues are projected to decline, increases in growth product revenues are expected to partially offset this impact.

- Stock Performance: Biogen's stock experienced an increase on Friday despite facing declining sales.
- Drug Portfolio Issues: The company's drug portfolio showed poor performance in the fourth quarter, contributing to investor concerns.
- Earnings Performance: Biogen reported a Q4 Non-GAAP EPS of $1.99, exceeding expectations by $0.36, indicating strong profitability despite revenue challenges.
- Revenue Decline: The company’s Q4 revenue of $2.28 billion represents a 7.3% year-over-year decline, yet it surpassed expectations by $80 million, showcasing resilience amid market pressures.
- 2026 Financial Guidance: Biogen anticipates a Non-GAAP diluted EPS for 2026 between $15.25 and $16.25, exceeding the consensus estimate of $14.95, reflecting confidence in future profitability.
- Revenue Outlook Adjustment: Although total revenue for 2026 is expected to decline by a mid-single digit percentage compared to 2025, this outlook is more conservative than the estimated -5.11% growth, indicating prudent financial management.









