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IONS Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
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ET
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Intellectia

Loading chart...

High
77.400
Open
76.450
VWAP
76.12
Vol
1.66M
Mkt Cap
12.51B
Low
75.240
Amount
126.07M
EV/EBITDA(TTM)
--
Total Shares
165.26M
EV
12.93B
EV/OCF(TTM)
--
P/S(TTM)
11.97
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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Events Timeline

(ET)
2026-04-29
07:20:00
Ionis Reports Q1 Revenue of $246M
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2026-04-29
07:20:00
Ionis Raises 2026 Financial Guidance to $811.3M
select
2026-04-28 (ET)
2026-04-28
05:40:00
GSK Submits NDA for Bepirovirsen, FDA Priority Review Granted
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News

moomoo
5.0
05-05moomoo
Ionis Pharmaceuticals (IONS.US) Director Plans to Sell $4.35 Million in Common Stock via Form 144
  • Stock Sale Announcement: Ionis Pharmaceuticals' director, Joseph Loscalzo, plans to sell 54,321 shares of the company's common stock on May 4, with an estimated market value of around $4.35 million.

  • Reduction in Shareholding: Loscalzo has decreased his shareholding in Ionis Pharmaceuticals by 1,032 shares since March 3, 2026, with a total value of approximately $82,833.

Newsfilter
1.0
05-01Newsfilter
Ionis Pharmaceuticals to Participate in Multiple Investor Conferences
  • Investor Conference Schedule: Ionis Pharmaceuticals announced participation in the Bank of America Securities 2026 Health Care Conference on May 12, 2026, the RBC Capital Markets Global Healthcare Conference on May 19, 2026, and the Goldman Sachs 47th Annual Global Healthcare Conference on June 10, 2026, showcasing its innovations in RNA-targeted medicines.
  • Live Webcast and Replays: Presentations will be accessible via a live webcast on the Investors & Media section of the Ionis website, with replays available within 48 hours post-event, ensuring investors stay updated on the company's latest developments.
  • Company Background: For three decades, Ionis has focused on inventing medicines that improve the futures of patients with serious diseases, currently boasting marketed medicines and a leading pipeline in neurology, cardiometabolic diseases, and areas of high patient need, reflecting its deep expertise in the biopharmaceutical sector.
  • Innovation-Driven Technology: As a pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies while advancing new approaches in gene editing, demonstrating a profound understanding of disease biology and industry-leading technology aimed at delivering life-changing treatments for patients.
seekingalpha
9.5
04-29seekingalpha
Ionis Pharmaceuticals Q1 2026 Earnings Call Highlights
  • Sales Estimate Increase: Ionis Pharmaceuticals has raised its annual peak sales estimate for Olezarsen from over $2 billion to over $3 billion, reflecting continued demand growth for severe hypertriglyceridemia, with the FDA accepting priority review and a PDUFA date set for June 30.
  • Significant Revenue Growth: Total revenue for Q1 2026 reached $246 million, an 87% increase year-over-year, including approximately $95 million in milestone payments from multiple partnerships, indicating strong performance in both product sales and collaboration revenue.
  • Improved Financial Guidance: Ionis expects total revenue in the range of $875 million to $900 million for 2026, with a slight increase in commercial revenue share, while projecting a non-GAAP operating loss between $425 million and $475 million, reflecting confidence in future financial performance.
  • Product Sales Outlook: The company anticipates full-year sales for TRYNGOLZA and DAWNZERA to be between $100 million and $110 million and $110 million and $120 million, respectively, although a significant decline in second-quarter TRYNGOLZA revenue is expected due to the price reset effective April 1, with a gradual recovery anticipated post-June 30 approval.
NASDAQ.COM
2.0
04-29NASDAQ.COM
Ionis (IONS) Q1 2026 Earnings Call Transcript
seekingalpha
9.5
04-29seekingalpha
Ionis Pharmaceuticals Q1 Earnings Beat Expectations with 86.4% Revenue Growth
  • Strong Earnings Report: Ionis Pharmaceuticals reported a Q1 GAAP EPS of -$0.56, beating expectations by $0.35, with revenue reaching $246 million, reflecting an impressive 86.4% year-over-year growth that boosts investor confidence.
  • Cash Flow Status: As of March 31, 2026, Ionis had $1.9 billion in cash and short-term investments, a decrease of $633 million from year-end 2025, primarily due to the maturity of 0% convertible notes, indicating challenges in cash management.
  • Sales Guidance Upgrade: The company raised its peak net sales guidance for olezarsen from over $2 billion to over $3 billion, driven by increased confidence in the sHTG market opportunity, signaling optimism for future growth.
  • Improved 2026 Financial Guidance: Ionis revised its 2026 total revenue guidance from $800-825 million to $875-900 million, while reducing operating loss expectations from $500-550 million to $425-475 million, reflecting strong revenue performance and ongoing commercial success.
seekingalpha
9.5
04-28seekingalpha
Ionis Pharmaceuticals Q1 Earnings Announcement Scheduled
  • Earnings Announcement: Ionis Pharmaceuticals is set to release its Q1 2023 earnings on April 29 before the market opens, with consensus EPS estimated at -$0.78 and revenue projected at $196.01 million, reflecting a 48.5% year-over-year increase.
  • Earnings Estimate Adjustments: Over the last three months, EPS estimates have seen no upward revisions and three downward adjustments, while revenue estimates have experienced one upward revision and six downward changes, indicating market caution regarding Ionis's future performance.
  • Product Review Progress: Ionis's zilganersen has received Priority Review for Alexander disease, which could support future revenue growth, although the overall market environment remains uncertain.
  • Market Environment Impact: Amid disruptions in the Middle East, Ionis Pharmaceuticals and other healthcare stocks are viewed as oversold, potentially presenting buying opportunities for investors looking for value in the sector.
Wall Street analysts forecast IONS stock price to rise
14 Analyst Rating
Wall Street analysts forecast IONS stock price to rise
13 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Stifel
Hold
maintain
$83 -> $86
AI Analysis
2026-04-30
Reason
Stifel
Price Target
$83 -> $86
AI Analysis
2026-04-30
maintain
Hold
Reason
Stifel raised the firm's price target on Ionis Pharmaceuticals to $86 from $83 and keeps a Hold rating on the shares.
RBC Capital
Outperform
maintain
$95 -> $100
2026-04-30
Reason
RBC Capital
Price Target
$95 -> $100
2026-04-30
maintain
Outperform
Reason
RBC Capital raised the firm's price target on Ionis Pharmaceuticals to $100 from $95 and keeps an Outperform rating on the shares. The firm cites the company's better-than-expected Q1 results along with raised 2026 revenue outlook given that the FDA recently granted priority review for Tryngolza, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IONS
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Valuation Metrics

The current forward P/E ratio for Ionis Pharmaceuticals Inc (IONS.O) is 96.15, compared to its 5-year average forward P/E of -11.76. For a more detailed relative valuation and DCF analysis to assess Ionis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-11.76
Current PE
96.15
Overvalued PE
19.26
Undervalued PE
-42.77

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.37
Current EV/EBITDA
-21.48
Overvalued EV/EBITDA
-7.13
Undervalued EV/EBITDA
-19.61

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
9.51
Current PS
8.52
Overvalued PS
11.71
Undervalued PS
7.30

Financials

AI Analysis
Annual
Quarterly

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Whales Holding IONS

S
Summit Partners Public Asset Management, LLC
Holding
IONS
+29.34%
3M Return
G
GW&K Investment Management, LLC
Holding
IONS
+15.80%
3M Return
T
Two Sigma Investments, LP
Holding
IONS
+15.10%
3M Return
P
Pinnacle Associates, Ltd.
Holding
IONS
+11.20%
3M Return
G
Groupama Asset Management SA
Holding
IONS
+10.45%
3M Return
D
Deerfield Management Company, L.P.
Holding
IONS
+8.87%
3M Return

Trading Trends

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Frequently Asked Questions

What is Ionis Pharmaceuticals Inc (IONS) stock price today?

The current price of IONS is 75.71 USD — it has decreased -0.41

What is Ionis Pharmaceuticals Inc (IONS)'s business?

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.

What is the price predicton of IONS Stock?

Wall Street analysts forecast IONS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IONS is92.67 USD with a low forecast of 65.00 USD and a high forecast of 110.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Ionis Pharmaceuticals Inc (IONS)'s revenue for the last quarter?

Ionis Pharmaceuticals Inc revenue for the last quarter amounts to 246.09M USD, increased 86.98

What is Ionis Pharmaceuticals Inc (IONS)'s earnings per share (EPS) for the last quarter?

Ionis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.56 USD, decreased -39.78

How many employees does Ionis Pharmaceuticals Inc (IONS). have?

Ionis Pharmaceuticals Inc (IONS) has 1402 emplpoyees as of May 10 2026.

What is Ionis Pharmaceuticals Inc (IONS) market cap?

Today IONS has the market capitalization of 12.51B USD.