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IONS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
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Intellectia

Loading chart...

High
78.100
Open
77.540
VWAP
77.00
Vol
1.68M
Mkt Cap
12.64B
Low
76.390
Amount
129.02M
EV/EBITDA(TTM)
--
Total Shares
165.26M
EV
13.20B
EV/OCF(TTM)
--
P/S(TTM)
12.23
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Show More

Events Timeline

(ET)
2026-05-28
05:20:00
GSK Announces Bepirovirsen Trial Data, 19% Functional Cure Rate Achieved
select
2026-05-14 (ET)
2026-05-14
07:10:00
Ionis and Biogen Announce Alzheimer's Study Results
select
2026-05-14
07:10:00
Biogen CELIA Study Shows Efficacy of New Therapy for Early Alzheimer's Disease
select

News

Newsfilter
8.5
05-28Newsfilter
PinnedBepirovirsen Shows Significant Efficacy in Chronic Hepatitis B Trials
  • Functional Cure Breakthrough: In the pivotal B-Well 1 and B-Well 2 trials, bepirovirsen achieved a 19% functional cure rate overall and 26% in patients with lower viral activity, significantly outperforming the 0% rate of standard care, providing new hope for chronic hepatitis B patients.
  • Significant Treatment Outcomes: Notably, 49% of bepirovirsen recipients achieved a hepatitis B surface antigen level of ≤100 IU/mL one year post-treatment, indicating enhanced immune control associated with a significant reduction in liver cancer risk, potentially improving patient outcomes.
  • Global Impact: With over 240 million people affected by chronic hepatitis B, the successful development of bepirovirsen could transform treatment paradigms for this large patient population, reducing reliance on lifelong antiviral therapy and improving quality of life.
  • Rapid Regulatory Progress: Bepirovirsen is currently under priority review by the FDA with Breakthrough and Fast Track Designations, with the first regulatory decisions anticipated in Q3 2026, highlighting its potential market value and prospects.
seekingalpha
9.0
05-28seekingalpha
GSK's Antisense Drug Shows Promise in Hepatitis B Trials
  • Clinical Trial Success: GSK's antisense drug bepirovirsen, developed with Ionis Pharma, achieved a 19% functional cure rate in two late-stage trials, significantly surpassing the current standard treatment's less than 1% cure rate, marking a new hope for chronic hepatitis B treatment.
  • Significant Treatment Effects: In the B-Well 1 and B-Well 2 Phase 3 trials, six months of bepirovirsen therapy resulted in undetectable hepatitis B virus DNA and surface antigens for at least six months post-therapy, demonstrating clinically meaningful efficacy.
  • Good Safety Profile: Conducted across 29 countries with chronic hepatitis patients, the studies indicated that bepirovirsen has an acceptable safety and tolerability profile consistent with previous trials, laying a solid foundation for its future market application.
  • Long-term Impact Potential: GSK's science chief Tony Wood emphasized that bepirovirsen not only offers the potential for significantly improved functional cure rates but also may reduce the risk of long-term liver complications, including cancer, indicating a major advancement in chronic hepatitis B treatment.
seekingalpha
6.0
05-19seekingalpha
Citi Initiates Bullish Coverage on SMid Cap Biotechs
  • Analyst Rating Upgrade: Citi analyst Eric Joseph initiated Buy ratings on five biotech companies including Ionis (IONS), Alnylam (ALNY), and BioMarin (BMRN), reflecting a positive outlook for significant growth in the cardiovascular, metabolism, and endocrine sectors, which indicates strong confidence in the biotech industry.
  • Ionis Price Target: The analyst set a $115 price target for Ionis, emphasizing that its pipeline based on antisense oligonucleotides provides a solid foundation for durable growth, showcasing confidence in its future performance.
  • BioMarin Valuation Discount: BioMarin received a $75 price target, with analysts noting its EV/Rev ratio of 4x is significantly lower than peers' 8-9x, indicating a substantial valuation discount that may attract investor interest.
  • Alnylam Investment Opportunity: Alnylam's price target is set at $380, with analysts arguing that despite its year-to-date underperformance, the impressive market launch of its heart disease therapy Amvuttra presents an attractive buying opportunity, signaling potential for future growth.
seekingalpha
9.0
05-14seekingalpha
Biogen's Alzheimer Therapy Trial Shows Promising Results
  • Clinical Trial Results: Biogen's Phase 2 CELIA study indicates that diranersen, an experimental therapy for Alzheimer's disease, slowed clinical decline across all doses in early-stage patients, highlighting the drug's potential in treating Alzheimer's.
  • Biomarker Impact: The study demonstrated significant reductions in tau pathology associated with Alzheimer's, providing the first evidence from a randomized Phase 2 trial of a tau-directed therapy showing robust biomarker impact and cognitive benefits.
  • Safety and Tolerability: In the 416-patient trial, diranersen's safety and tolerability profile was consistent with data from a Phase 1b trial, reinforcing confidence in its safety characteristics for further development.
  • Registration Development Outlook: Biogen expressed that the Phase 2 data gives them the confidence to advance diranersen into registrational development, indicating the drug's promising future in the Alzheimer's treatment landscape.
moomoo
5.0
05-05moomoo
Ionis Pharmaceuticals (IONS.US) Director Plans to Sell $4.35 Million in Common Stock via Form 144
  • Stock Sale Announcement: Ionis Pharmaceuticals' director, Joseph Loscalzo, plans to sell 54,321 shares of the company's common stock on May 4, with an estimated market value of around $4.35 million.

  • Reduction in Shareholding: Loscalzo has decreased his shareholding in Ionis Pharmaceuticals by 1,032 shares since March 3, 2026, with a total value of approximately $82,833.

Newsfilter
1.0
05-01Newsfilter
Ionis Pharmaceuticals to Participate in Multiple Investor Conferences
  • Investor Conference Schedule: Ionis Pharmaceuticals announced participation in the Bank of America Securities 2026 Health Care Conference on May 12, 2026, the RBC Capital Markets Global Healthcare Conference on May 19, 2026, and the Goldman Sachs 47th Annual Global Healthcare Conference on June 10, 2026, showcasing its innovations in RNA-targeted medicines.
  • Live Webcast and Replays: Presentations will be accessible via a live webcast on the Investors & Media section of the Ionis website, with replays available within 48 hours post-event, ensuring investors stay updated on the company's latest developments.
  • Company Background: For three decades, Ionis has focused on inventing medicines that improve the futures of patients with serious diseases, currently boasting marketed medicines and a leading pipeline in neurology, cardiometabolic diseases, and areas of high patient need, reflecting its deep expertise in the biopharmaceutical sector.
  • Innovation-Driven Technology: As a pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies while advancing new approaches in gene editing, demonstrating a profound understanding of disease biology and industry-leading technology aimed at delivering life-changing treatments for patients.
Wall Street analysts forecast IONS stock price to rise
14 Analyst Rating
Wall Street analysts forecast IONS stock price to rise
13 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Citi
NULL
to
Buy
initiated
$115
AI Analysis
2026-05-18
Reason
Citi
Price Target
$115
AI Analysis
2026-05-18
initiated
NULL
to
Buy
Reason
Citi initiated coverage of Ionis Pharmaceuticals with a Buy rating and $115 price target and named it a top pick among small-to-mid cap biotech stocks. Tryngloza for severe hypertriglyceridemia leads the higher value proprietary pipeline, with a greater than $3.5B peak sales opportunity \"underappreciated,\" the analyst tells investors. Partnered Phase 3 readouts offer opportunities for upside momentum in the second half of 2026, the analyst added.
Stifel
Hold
maintain
$83 -> $86
2026-04-30
Reason
Stifel
Price Target
$83 -> $86
2026-04-30
maintain
Hold
Reason
Stifel raised the firm's price target on Ionis Pharmaceuticals to $86 from $83 and keeps a Hold rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IONS
Unlock Now

Valuation Metrics

The current forward P/E ratio for Ionis Pharmaceuticals Inc (IONS.O) is 90.91, compared to its 5-year average forward P/E of -10.01. For a more detailed relative valuation and DCF analysis to assess Ionis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-10.01
Current PE
90.91
Overvalued PE
22.60
Undervalued PE
-42.63

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.38
Current EV/EBITDA
-21.21
Overvalued EV/EBITDA
-7.13
Undervalued EV/EBITDA
-19.62

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
9.51
Current PS
8.41
Overvalued PS
11.71
Undervalued PS
7.31

Financials

AI Analysis
Annual
Quarterly

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Whales Holding IONS

S
Summit Partners Public Asset Management, LLC
Holding
IONS
+37.54%
3M Return
E
Eventide Asset Management, LLC
Holding
IONS
+19.45%
3M Return
T
Two Sigma Investments, LP
Holding
IONS
+19.36%
3M Return
P
Pinnacle Associates, Ltd.
Holding
IONS
+17.81%
3M Return
G
Groupama Asset Management SA
Holding
IONS
+13.03%
3M Return
C
Centerbook Partners LP
Holding
IONS
+11.12%
3M Return

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Frequently Asked Questions

What is Ionis Pharmaceuticals Inc (IONS) stock price today?

The current price of IONS is 76.5 USD — it has decreased -1.07

What is Ionis Pharmaceuticals Inc (IONS)'s business?

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.

What is the price predicton of IONS Stock?

Wall Street analysts forecast IONS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IONS is92.67 USD with a low forecast of 65.00 USD and a high forecast of 110.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Ionis Pharmaceuticals Inc (IONS)'s revenue for the last quarter?

Ionis Pharmaceuticals Inc revenue for the last quarter amounts to 246.09M USD, increased 86.98

What is Ionis Pharmaceuticals Inc (IONS)'s earnings per share (EPS) for the last quarter?

Ionis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.56 USD, decreased -39.78

How many employees does Ionis Pharmaceuticals Inc (IONS). have?

Ionis Pharmaceuticals Inc (IONS) has 1402 emplpoyees as of May 31 2026.

What is Ionis Pharmaceuticals Inc (IONS) market cap?

Today IONS has the market capitalization of 12.64B USD.