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IONS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
77.030
Open
75.360
VWAP
75.73
Vol
2.79M
Mkt Cap
12.50B
Low
74.510
Amount
210.97M
EV/EBITDA(TTM)
--
Total Shares
165.19M
EV
12.15B
EV/OCF(TTM)
--
P/S(TTM)
13.29
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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Events Timeline

(ET)
2026-02-26
09:10:00
Ionis Pharmaceuticals' Olezarsen Accepted for FDA Priority Review
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2026-02-25 (ET)
2026-02-25
07:20:00
Ionis Reports Q4 Revenue of $203M, Beating Expectations
select
2026-02-25
07:20:00
Ionis Sees FY26 Operating Loss of $500M-$550M
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2026-01-21 (ET)
2026-01-21
07:10:00
Ionis and Otsuka's Dawnzera Approved by EU
select
2026-01-07 (ET)
2026-01-07
05:10:00
GSK Announces B-Well Study Results, Bepirovirsen Shows Significant Efficacy
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News

CNBC
9.0
03-05CNBC
UniQure's Gene Therapy Faces FDA Challenges
  • FDA Study Requirement: The U.S. FDA has mandated that UniQure conduct a placebo-controlled trial to validate the efficacy of its gene therapy for Huntington's disease, despite the company's claims that such a trial is unethical due to the need for prolonged general anesthesia.
  • Clinical Trial Controversy: An FDA official indicated that UniQure's clinical trial data does not meet approval criteria, suggesting that the company may be aware of its earlier trial failures and has not pursued necessary clinical studies.
  • Stock Price Fluctuation: Despite facing challenges from the FDA, UniQure's stock rose over 10% on Thursday, although it has fallen 58% this year, reflecting market concerns regarding the therapy's prospects.
  • Regulatory Tensions: The relationship between UniQure and the FDA is increasingly strained, with the agency facing criticism for recent drug application rejections, and UniQure accusing the FDA of reversing its acceptance standards for the company's clinical trial data.
Newsfilter
9.0
03-05Newsfilter
Biogen Unveils New Research Data on Spinal Muscular Atrophy
  • High-Dose Nusinersen Research: Biogen presented long-term data on high-dose nusinersen at the 2026 Muscular Dystrophy Association conference, indicating potential benefits for spinal muscular atrophy patients, which may drive further market adoption globally.
  • Salanersen Clinical Progress: New Phase 1b data illustrate the potential of salanersen in spinal muscular atrophy, and with Phase 3 studies commencing, it is expected to provide more effective treatment options, enhancing Biogen's competitiveness in this field.
  • Global Regulatory Advances: The high-dose regimen of nusinersen has been approved in Japan, the EU, and Switzerland, and is under FDA review in the U.S., with a decision anticipated by April 3, 2026, which would further solidify Biogen's leadership in the SMA treatment market.
  • Strategic Investment and Collaboration: Biogen's partnership with Ionis Pharmaceuticals for the development of salanersen demonstrates its ongoing commitment to innovative drug development, aiming to meet the growing treatment needs of spinal muscular atrophy patients.
Newsfilter
5.0
02-27Newsfilter
Ionis Pharmaceuticals Unveils New Data for DAWNZERA at AAAAI 2026
  • Clinical Data Presentation: Ionis Pharmaceuticals will present new data for DAWNZERA (donidalorsen) at the 2026 AAAAI Annual Meeting, emphasizing its clinical value for hereditary angioedema (HAE) patients, potentially leading to significant improvements in attack frequency and quality of life.
  • Research Highlights: The presentation includes analyses from the OASIS-HAE and OASISplus studies, indicating DAWNZERA's appeal in long-term prophylactic treatment, particularly for patients switching from other therapies, showcasing its competitive market potential.
  • Extensive Poster Displays: Ionis will conduct eight poster presentations at the conference, covering various aspects from patient-reported disease control to unmet treatment needs, further solidifying its leadership position in HAE treatment.
  • Broad Market Prospects: With HAE affecting over 20,000 individuals, DAWNZERA, as the first RNA-targeted medicine, is expected to become the prophylactic treatment of choice for HAE patients, addressing their urgent need for reduced attack frequency and severity.
Newsfilter
8.5
02-26Newsfilter
Ionis Pharmaceuticals Receives FDA Priority Review for Olezarsen
  • FDA Priority Review: Ionis Pharmaceuticals announced that its drug olezarsen for severe hypertriglyceridemia has received FDA Priority Review, with a PDUFA target date of June 30, 2026, which will expedite its market entry to meet urgent patient needs for new treatment options.
  • Clinical Trial Results: In the Phase 3 CORE and CORE2 studies, olezarsen demonstrated a statistically significant reduction in triglyceride levels of up to 72% and an 85% reduction in acute pancreatitis events, indicating its substantial potential to improve patient health outcomes.
  • Market Demand: Approximately 3 million people in the U.S. suffer from severe hypertriglyceridemia, with over 1 million classified as high-risk; the limited efficacy of current treatments highlights the critical need for olezarsen to provide new hope and reduce the risk of acute pancreatitis.
  • Drug Mechanism: Olezarsen works by lowering the production of apoC-III in the liver, which regulates triglyceride metabolism, and is already approved in the U.S. and EU for patients with familial chylomicronemia syndrome, showcasing its broad application prospects in treating hypertriglyceridemia.
seekingalpha
9.5
02-25seekingalpha
Ionis Pharmaceuticals Q4 2025 Earnings Call Highlights
  • Significant Revenue Growth: Ionis Pharmaceuticals reported $944 million in revenue for 2025, a 34% year-over-year increase, with commercial product sales contributing $436 million and R&D collaborations generating $508 million, showcasing the company's strong market performance and diversified revenue streams.
  • Successful Product Launches: The independent launches of TRYNGOLZA and DAWNZERA mark a significant milestone for Ionis in 2025, with TRYNGOLZA exceeding market expectations and DAWNZERA projected to exceed $500 million in sales potential, further solidifying the company's market position.
  • Positive R&D Progress: Olezarsen achieved positive Phase III results in severe hypertriglyceridemia and received FDA breakthrough therapy designation, with plans to be launch-ready by June 2026, demonstrating the company's robust capabilities in drug development.
  • Management Change: Ionis announced Holly Kordasiewicz as the new Chief Development Officer, reflecting strategic adjustments in the executive team to support future product development and market expansion.
Benzinga
9.5
02-25Benzinga
Ionis Pharmaceuticals Reports Better-Than-Expected Q4 Results
  • Financial Performance Beat: Ionis Pharmaceuticals reported an adjusted loss of $1.15 for Q4, better than Wall Street's estimate of $1.32, although the stock is under pressure, indicating market concerns about future performance.
  • Significant Sales Growth: The company achieved $203 million in sales for Q4, surpassing the consensus of $156.09 million, primarily driven by strong sales of Tryngolza (olezarsen), which contributed to a 64% year-over-year increase.
  • Product Sales Highlights: Tryngolza generated net product sales of $50 million in Q4, a 56% increase over the prior quarter, while Dawnzera (donidalorsen) recorded $7 million in its first full quarter on the market, indicating strong market acceptance of new products.
  • Cautious Future Outlook: Ionis expects fiscal 2026 sales between $800 million and $825 million, below the consensus of $909.84 million, and anticipates an adjusted operating loss of $500 million to $550 million, reflecting a cautious approach to future growth.
Wall Street analysts forecast IONS stock price to rise
14 Analyst Rating
Wall Street analysts forecast IONS stock price to rise
13 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Piper Sandler
Allison Bratzel
Overweight
maintain
$87 -> $100
AI Analysis
2026-02-27
Reason
Piper Sandler
Allison Bratzel
Price Target
$87 -> $100
AI Analysis
2026-02-27
maintain
Overweight
Reason
Piper Sandler analyst Allison Bratzel raised the firm's price target on Ionis Pharmaceuticals to $100 from $87 and keeps an Overweight rating on the shares following Q4 reporting. Total revenue guidance of $825M-$850M came in lower than consensus expectations of $931M. However, this was in part driven by conservatism on review timing for olezarsen in sHTG, and given the news that FDA accepted the filing with Priority Review and a PDUFA of June 30, Piper expects an upward revision of guidance when Ionis reports Q1 2026.
Stifel
Hold
maintain
$73 -> $77
2026-02-26
Reason
Stifel
Price Target
$73 -> $77
2026-02-26
maintain
Hold
Reason
Stifel raised the firm's price target on Ionis Pharmaceuticals to $77 from $73 and keeps a Hold rating on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IONS
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Valuation Metrics

The current forward P/E ratio for Ionis Pharmaceuticals Inc (IONS.O) is -29.54, compared to its 5-year average forward P/E of -21.33. For a more detailed relative valuation and DCF analysis to assess Ionis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-21.33
Current PE
-29.54
Overvalued PE
-6.68
Undervalued PE
-35.98

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-14.89
Current EV/EBITDA
-21.12
Overvalued EV/EBITDA
-9.95
Undervalued EV/EBITDA
-19.84

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
9.56
Current PS
16.79
Overvalued PS
11.81
Undervalued PS
7.30

Financials

AI Analysis
Annual
Quarterly

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Whales Holding IONS

T
Two Sigma Investments, LP
Holding
IONS
+10.26%
3M Return
S
Summit Partners Public Asset Management, LLC
Holding
IONS
+6.38%
3M Return
T
Tweedy, Browne Company LLC
Holding
IONS
+4.64%
3M Return
G
Groupama Asset Management SA
Holding
IONS
+3.40%
3M Return
P
Pinnacle Associates, Ltd.
Holding
IONS
+3.00%
3M Return
C
C WorldWide Asset Management Fondsmaeglerselskab A/S
Holding
IONS
+1.59%
3M Return

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Frequently Asked Questions

What is Ionis Pharmaceuticals Inc (IONS) stock price today?

The current price of IONS is 75.66 USD — it has increased 0.4

What is Ionis Pharmaceuticals Inc (IONS)'s business?

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.

What is the price predicton of IONS Stock?

Wall Street analysts forecast IONS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IONS is92.67 USD with a low forecast of 65.00 USD and a high forecast of 110.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Ionis Pharmaceuticals Inc (IONS)'s revenue for the last quarter?

Ionis Pharmaceuticals Inc revenue for the last quarter amounts to 203.33M USD, decreased -10.26

What is Ionis Pharmaceuticals Inc (IONS)'s earnings per share (EPS) for the last quarter?

Ionis Pharmaceuticals Inc. EPS for the last quarter amounts to -1.41 USD, increased 113.64

How many employees does Ionis Pharmaceuticals Inc (IONS). have?

Ionis Pharmaceuticals Inc (IONS) has 1402 emplpoyees as of March 11 2026.

What is Ionis Pharmaceuticals Inc (IONS) market cap?

Today IONS has the market capitalization of 12.50B USD.