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IONS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
75.480
Open
75.480
VWAP
75.00
Vol
343.30K
Mkt Cap
12.51B
Low
74.590
Amount
25.75M
EV/EBITDA(TTM)
--
Total Shares
165.19M
EV
12.16B
EV/OCF(TTM)
--
P/S(TTM)
13.30
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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Events Timeline

(ET)
2026-03-23
07:10:00
Ionis Pharmaceuticals' Zilganersen NDA Accepted for Priority Review by FDA
select

News

Newsfilter
1.0
04-15Newsfilter
Ionis Pharmaceuticals to Host Q1 2026 Financial Results Webcast on April 29
  • Webcast Announcement: Ionis Pharmaceuticals has announced a live webcast scheduled for April 29, 2026, at 8:30 a.m. Eastern Time, where it will discuss its first quarter financial results and key program advancements, aiming to enhance transparency for investors regarding its operations.
  • Access to Webcast: Investors can access the webcast at https://ir.ionis.com/events-and-presentations/upcoming-events, with a replay available for a limited time post-event, ensuring that those unable to attend live can still obtain relevant information.
  • Company Overview: For three decades, Ionis has focused on inventing medicines that improve the futures of patients with serious diseases, currently boasting marketed drugs and a leading pipeline in neurology and cardiometabolic diseases, reflecting its deep expertise in the biopharmaceutical sector.
  • Innovation Leadership: As a pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies while advancing new approaches in gene editing, showcasing its profound understanding of disease biology and industry-leading technological capabilities.
CNBC
2.0
04-09CNBC
A Doctor's Journey with His Son's Rare Disease
  • Family Life Restructured: Dr. Joseph D'Orazio's family life was immediately altered upon learning of his son Gabe's diagnosis of Angelman syndrome, necessitating a complete reevaluation of daily routines and future plans to accommodate the realities of a special needs family.
  • Emotional and Professional Intertwining: As a physician, facing his son's rare disease brought profound grief and a sense of loss of control, which transformed his emotional landscape and deepened his empathy and understanding for patients' suffering in his medical career.
  • Patience and Growth: Gabe's condition taught Dr. D'Orazio invaluable lessons in patience and a reevaluation of life, enhancing his focus on emotional needs in medical practice and significantly improving his empathy as a physician.
  • Community and Advocacy: By engaging with the Foundation for Angelman Syndrome Therapeutics, Dr. D'Orazio transformed feelings of isolation into connection, aiding other families and advancing research, showcasing the resilience and unity of families affected by rare diseases.
Newsfilter
8.5
03-30Newsfilter
FDA Approves High Dose SPINRAZA for SMA Treatment
  • FDA Approval: The U.S. FDA has approved the High Dose SPINRAZA (nusinersen), which includes 50 mg/5 mL and 28 mg/5 mL doses, aimed at providing a more effective treatment option for spinal muscular atrophy (SMA) patients, with availability expected in the coming weeks, marking a significant advancement in the treatment landscape.
  • Clinical Data Support: The high dose regimen is backed by clinical data from the DEVOTE study, which demonstrated statistically significant improvements in motor function for treatment-naïve infants, with a mean difference of 26.19 points on the CHOP-INTEND scale (+15.1 vs. -11.1, p<0.0001), offering new hope for SMA patients.
  • Optimized Treatment Protocol: The new regimen features an accelerated loading phase, allowing treatment-naïve patients to receive two 50 mg injections 14 days apart, followed by 28 mg maintenance doses every four months, designed to enhance treatment convenience and effectiveness to meet urgent patient needs.
  • Global Expansion: High Dose SPINRAZA has not only been approved in the U.S. but also in the European Union, Switzerland, and Japan, with Biogen collaborating with global regulatory authorities to advance this new treatment option to meet the diverse needs of SMA patients.
NASDAQ.COM
9.0
03-27NASDAQ.COM
GSK Seeks EMA Approval for Bepirovirsen in Chronic Hepatitis B Treatment
  • Regulatory Submission Accepted: GSK plc announced that the European Medicines Agency has accepted its marketing authorization application for bepirovirsen, an antiviral drug for adults with chronic hepatitis B, marking a significant milestone in the company's drug development efforts.
  • Clinical Trial Results: The application is based on positive outcomes from the B-Well 1 and B-Well 2 Phase III trials, indicating the drug's potential efficacy and safety in treating chronic hepatitis B, which could address a significant unmet medical need.
  • Collaborative Development: GSK licensed bepirovirsen from Ionis Pharmaceuticals and collaborated on its development, showcasing the company's strategic partnerships in advancing innovative therapeutics.
  • Market Potential Assessment: Although the drug is not yet approved anywhere globally, successful market entry could open new opportunities for GSK in the chronic hepatitis B treatment space, enhancing its competitive position in the biopharmaceutical industry.
Newsfilter
5.0
03-26Newsfilter
Ionis Pharmaceuticals Lowers Tryngolza Price to Enhance Competitive Positioning
  • Pricing Strategy: Ionis Pharmaceuticals has lowered the price of Tryngolza ahead of the sHTG decision, with analysts suggesting that this move will enhance sales potential and attract more patients, thereby increasing market share.
  • Sales Potential Increase: By reducing the price, Ionis aims to stand out in a competitive market, with analysts predicting that this action will significantly boost Tryngolza's sales over the coming quarters, further solidifying its position in the treatment landscape.
  • Competitive Positioning Optimization: This price adjustment is not only a response to market demand but may also prompt competitors to reassess their pricing strategies, potentially impacting the overall industry price structure, allowing Ionis to gain a larger market advantage.
  • Market Reaction Expectations: Analysts are generally optimistic about Tryngolza's market prospects, believing that the price reduction will enhance patient acceptance and drive sales growth, indicating Ionis's keen awareness of market dynamics.
Marketbeat
5.0
03-23Marketbeat
When Insider Selling Can Be Positive: 2 Stocks to Keep an Eye On
  • Insider Selling Trends: Insider selling is increasing, with executives from Waste Management and Ionis Pharmaceuticals selling shares, indicating a potential shift in stock performance outlooks despite strong growth prospects.

  • Stock Performance and Dividends: Waste Management's stock has risen significantly, driven by insider selling, while the company maintains a strong dividend yield, suggesting a solid investment opportunity for new investors.

  • Ionis Pharmaceuticals Outlook: Ionis Pharmaceuticals faces a cautious outlook due to declining sales of its key products, despite having a strong pipeline and potential for future growth.

  • Analyst Sentiment: Analysts are generally optimistic about both companies, with a consensus rating of "Moderate Buy" for Ionis and a positive sentiment towards Waste Management, indicating potential for continued stock price appreciation.

Wall Street analysts forecast IONS stock price to rise
14 Analyst Rating
Wall Street analysts forecast IONS stock price to rise
13 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Current: 0.000
sliders
Low
65.00
Averages
92.67
High
110.00
Raymond James
Tiago Fauth
resume
$104
AI Analysis
2026-04-10
Reason
Raymond James
Tiago Fauth
Price Target
$104
AI Analysis
2026-04-10
resume
Reason
Raymond James analyst Tiago Fauth resumed coverage of Ionis Pharmaceuticals with an Outperform rating and $104 price target. The firm sees further upside in the shares given the company's "fundamentally improved story." Ionis ' stronger than expected severe hypertriglyceridemia readout positions Tryngolza as a "launch to own into 2026 and beyond," the analyst tells investors in a research note.
BofA
Buy
maintain
$100 -> $111
2026-04-09
Reason
BofA
Price Target
$100 -> $111
2026-04-09
maintain
Buy
Reason
BofA raised the firm's price target on Ionis Pharmaceuticals to $111 from $100 and keeps a Buy rating on the shares. The firm adjusted several targets in conjunction with its Q1 preview for its large-cap pharma and small-to-mid cap biopharma coverage.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IONS
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Valuation Metrics

The current forward P/E ratio for Ionis Pharmaceuticals Inc (IONS.O) is 90.91, compared to its 5-year average forward P/E of -13.40. For a more detailed relative valuation and DCF analysis to assess Ionis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-13.40
Current PE
90.91
Overvalued PE
16.16
Undervalued PE
-42.95

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-13.52
Current EV/EBITDA
4.38
Overvalued EV/EBITDA
-7.35
Undervalued EV/EBITDA
-19.70

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
9.51
Current PS
8.81
Overvalued PS
11.72
Undervalued PS
7.31

Financials

AI Analysis
Annual
Quarterly

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Whales Holding IONS

S
Summit Partners Public Asset Management, LLC
Holding
IONS
+27.51%
3M Return
G
GW&K Investment Management, LLC
Holding
IONS
+14.40%
3M Return
P
Pinnacle Associates, Ltd.
Holding
IONS
+12.17%
3M Return
T
Two Sigma Investments, LP
Holding
IONS
+11.42%
3M Return
G
Groupama Asset Management SA
Holding
IONS
+8.94%
3M Return
B
Baker Bros. Advisors LP
Holding
IONS
+6.01%
3M Return

Trading Trends

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Frequently Asked Questions

What is Ionis Pharmaceuticals Inc (IONS) stock price today?

The current price of IONS is 74.93 USD — it has decreased -1.03

What is Ionis Pharmaceuticals Inc (IONS)'s business?

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.

What is the price predicton of IONS Stock?

Wall Street analysts forecast IONS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IONS is92.67 USD with a low forecast of 65.00 USD and a high forecast of 110.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Ionis Pharmaceuticals Inc (IONS)'s revenue for the last quarter?

Ionis Pharmaceuticals Inc revenue for the last quarter amounts to 203.33M USD, decreased -10.26

What is Ionis Pharmaceuticals Inc (IONS)'s earnings per share (EPS) for the last quarter?

Ionis Pharmaceuticals Inc. EPS for the last quarter amounts to -1.41 USD, increased 113.64

How many employees does Ionis Pharmaceuticals Inc (IONS). have?

Ionis Pharmaceuticals Inc (IONS) has 1402 emplpoyees as of April 20 2026.

What is Ionis Pharmaceuticals Inc (IONS) market cap?

Today IONS has the market capitalization of 12.51B USD.