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STOK Overview

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Intellectia

Loading chart...

High
40.220
Open
39.060
VWAP
38.87
Vol
1.09M
Mkt Cap
2.19B
Low
38.030
Amount
42.41M
EV/EBITDA(TTM)
66.69
Total Shares
57.12M
EV
1.94B
EV/OCF(TTM)
36.71
P/S(TTM)
10.87
Stoke Therapeutics, Inc. is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with ribonucleic acid (RNA)-based medicines. The Company, through its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach, is engaged in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its first compound, zorevunersen (STK-002), is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. TANGO aims to restore missing proteins by increasing or stoking protein output from healthy genes, thus compensating for the non-functioning copy of the gene. The Company is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The Company’s initial focus is haploinsufficiency and diseases of the central nervous system and the eye.
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Events Timeline

(ET)
2026-03-04
17:20:00
Stoke Therapeutics and Biogen Publish Zorevunersen Study Data
select
2026-03-04
07:50:00
NervGen Pharma Appoints New Executives
select
2026-02-11 (ET)
2026-02-11
07:40:00
Stoke Therapeutics Doses First Patient in STK-002 Trial
select
2026-01-11 (ET)
2026-01-11
15:00:00
Stoke Therapeutics Accelerates EMPEROR Study Enrollment Timeline to Q2 2026
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News

NASDAQ.COM
9.0
03-05NASDAQ.COM
Stoke and Biogen Release Zorevunersen Study Data
  • Study Results Released: Stoke Therapeutics and Biogen announced the publication of data on the investigational drug Zorevunersen, indicating its potential for disease modification in patients with Dravet syndrome, marking a significant advancement in treatment options.
  • Clinical Trial Data: Results from two completed Phase 1/2a trials and ongoing open-label extension studies demonstrated substantial and durable reductions in seizures, along with improvements across multiple cognitive and behavioral measures, indicating long-term efficacy.
  • Future Research Outlook: Barry Ticho, Chief Medical Officer of Stoke, stated that Zorevunersen could become the first disease-modifying medicine for Dravet syndrome, with anticipation for the Phase 3 EMPEROR study results expected in mid-2027 to further validate its efficacy.
  • Market Reaction: Stoke shares closed at $34.42 on Nasdaq, up 1.89%, reflecting positive market expectations regarding the drug's potential.
Globenewswire
9.0
03-04Globenewswire
Zorevunersen May Transform Dravet Syndrome Treatment, New Data Shows
  • Clinical Trial Results: The Phase 1/2a studies of zorevunersen in Dravet syndrome patients demonstrated substantial reductions in seizure frequency at a 70 mg dose, with effects sustained through three years in the open-label extension studies, indicating potential disease-modifying capabilities.
  • Cognitive and Behavioral Improvements: Results showed significant enhancements in cognition, behavior, and quality of life for patients treated with zorevunersen, which not only improved daily living skills but also brought hope to families, potentially altering the life trajectories of patients.
  • Safety Assessment: A total of 81 patients received zorevunersen across Phase 1/2a and open-label extension studies, with over 800 doses administered, showing overall good tolerability; although 44% experienced elevated cerebrospinal fluid protein levels, no serious adverse events were linked to the drug.
  • Future Research Outlook: Stoke Therapeutics anticipates releasing results from the Phase 3 EMPEROR study in mid-2027, which will further validate the efficacy and safety of zorevunersen in treating Dravet syndrome, potentially leading to the first disease-modifying therapy for this condition.
Newsfilter
9.0
03-04Newsfilter
Zorevunersen Shows Promise for Dravet Syndrome Treatment
  • Clinical Trial Results: The Phase 1/2a studies of zorevunersen in Dravet syndrome patients demonstrated significant reductions in seizure frequency among those treated with a 70 mg dose, with effects persisting through three years in the open-label extension, indicating its potential as the first disease-modifying therapy.
  • Cognitive and Behavioral Improvements: Results indicate that zorevunersen not only reduces seizures but also significantly improves cognition, behavior, and quality of life across multiple measures, potentially altering the life trajectory for patients and their families by enhancing daily living skills.
  • Safety Data: Among 81 patients treated with zorevunersen, over 800 doses were administered, showing overall good tolerability; while 44% of patients in the open-label studies experienced elevated cerebrospinal fluid protein levels, no related clinical manifestations were observed, indicating a favorable safety profile.
  • Future Research Directions: Stoke Therapeutics anticipates releasing results from the Phase 3 EMPEROR study in mid-2027, aiming to further validate the efficacy and safety of zorevunersen, thereby providing new treatment options for patients with Dravet syndrome.
Newsfilter
9.0
02-11Newsfilter
Stoke Therapeutics Launches ADOA Treatment Study with STK-002
  • Clinical Trial Launch: Stoke Therapeutics has announced the first patient dosing of STK-002 in its Phase 1 OSPREY study aimed at treating the common genetic optic nerve disorder ADOA, marking a significant advancement for the company in the ophthalmology field.
  • Disease Background: ADOA is a rare genetic disease that leads to progressive and irreversible vision loss, with approximately 80% of patients showing symptoms by age 10, and currently, there are no approved treatments, highlighting the market potential for STK-002.
  • Study Design: The OSPREY study will recruit patients aged 6 to 55 diagnosed with ADOA, with primary objectives to assess the safety and tolerability of STK-002 and monitor drug exposure in blood, with dose escalation expected to continue through 2027, providing data to inform future drug development.
  • Market Outlook: STK-002, as an antisense oligonucleotide, aims to improve vision by increasing OPA1 protein expression, and if successful, it could become the first disease-modifying therapy for ADOA patients, representing significant commercial value and societal impact.
NASDAQ.COM
2.0
01-30NASDAQ.COM
Analysis of Stoke Therapeutics Options Trading
  • Options Selling Risk: Selling puts on Stoke Therapeutics does not provide the same upside potential as owning shares, as the seller only acquires shares if the contract is exercised, highlighting the inherent risks of options trading.
  • Exercise Condition Analysis: The seller will only hold shares at a cost basis of $17.75 if Stoke's stock price falls by 33.7% and the contract is exercised, indicating stringent conditions for exercising the option.
  • Annualized Return: The only upside for the put seller comes from collecting a 20.2% annualized return, suggesting that under current market conditions, the seller's profit primarily relies on the premium collected from the option.
  • Volatility Consideration: With a trailing twelve-month volatility of 70% for Stoke Therapeutics, this metric, combined with fundamental analysis, can assist investors in assessing whether selling the put at a $20 strike price is a worthwhile risk-reward proposition.
PRnewswire
8.5
01-27PRnewswire
Stoke Therapeutics Secures New Headquarters in Waltham
  • New Headquarters: Stoke Therapeutics has secured a long-term lease for a 98,500 square-foot headquarters in Waltham, set to relocate by late 2026, marking a significant step in the development of its potential disease-modifying medicine, zorevunersen, for Dravet syndrome.
  • Research Expansion: The new headquarters will bolster Stoke's research efforts in RNA medicine, particularly in preparing for the commercialization of zorevunersen, which is expected to provide the first potential new treatment for Dravet syndrome patients, enhancing the company's market position in the biotech sector.
  • Market Resilience: Despite a national slowdown in the life sciences market, Waltham and its surrounding areas continue to demonstrate strong resilience, serving as a critical support for the biotech industry, reflecting the ongoing strength of the Greater Boston life sciences market.
  • Sustainability Commitment: The new property is LEED Gold and WiredScore Platinum certified, showcasing Stoke's commitment to sustainability and modern infrastructure, aligning with the strategic needs for the company's future expansion.
Wall Street analysts forecast STOK stock price to rise
9 Analyst Rating
Wall Street analysts forecast STOK stock price to rise
8 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
35.75
High
50.00
Current: 0.000
sliders
Low
25.00
Averages
35.75
High
50.00
Wolfe Research
Outperform
initiated
$40
AI Analysis
2026-02-23
Reason
Wolfe Research
Price Target
$40
AI Analysis
2026-02-23
initiated
Outperform
Reason
Wolfe Research initiated coverage of Stoke Therapeutics with an Outperform rating and $40 price target. The firm launched coverage of the neuroscience biotech sector with a "portfolio of high conviction names across multiple therapeutic areas." Wolfe says Stoke's STK-001 could be approved as the first disease-modifying therapy for Dravet syndrome.
Guggenheim
Yatin Suneja
initiated
$60
2026-02-05
Reason
Guggenheim
Yatin Suneja
Price Target
$60
2026-02-05
initiated
Reason
Guggenheim analyst Yatin Suneja initiated coverage of Stoke Therapeutics with a Buy rating and $60 price target. The firm has a positive view of the company's lead asset, zorevunersen, an antisense oligonucleotide designed to restore SCN1A haploinsufficiency, the root cause of Dravet syndrome. Zorevunersen is the first drug showing disease-modifying potential in Dravet with benefit not only on seizure frequency but also on cognition, behavior and adaptive function, the analyst tells investors in a research note. It estimates $2.5B global peak sales for zorevunersen in Dravet.
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Valuation Metrics

The current forward P/E ratio for Stoke Therapeutics Inc (STOK.O) is -9.98, compared to its 5-year average forward P/E of -6.94. For a more detailed relative valuation and DCF analysis to assess Stoke Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.94
Current PE
-9.98
Overvalued PE
-2.33
Undervalued PE
-11.56

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.22
Current EV/EBITDA
-8.27
Overvalued EV/EBITDA
-0.26
Undervalued EV/EBITDA
-8.18

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
40.91
Current PS
99.55
Overvalued PS
67.81
Undervalued PS
14.01

Financials

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Whales Holding STOK

A
Artal Group S.A.
Holding
STOK
+7.70%
3M Return
B
BVF Partners L.P.
Holding
STOK
+6.57%
3M Return
T
Tang Capital Management, LLC
Holding
STOK
+3.59%
3M Return
D
Deerfield Management Company, L.P.
Holding
STOK
+0.18%
3M Return
B
Baker Bros. Advisors LP
Holding
STOK
-3.94%
3M Return

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Frequently Asked Questions

What is Stoke Therapeutics Inc (STOK) stock price today?

The current price of STOK is 38.35 USD — it has increased 0.1

What is Stoke Therapeutics Inc (STOK)'s business?

Stoke Therapeutics, Inc. is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with ribonucleic acid (RNA)-based medicines. The Company, through its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach, is engaged in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its first compound, zorevunersen (STK-002), is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. TANGO aims to restore missing proteins by increasing or stoking protein output from healthy genes, thus compensating for the non-functioning copy of the gene. The Company is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The Company’s initial focus is haploinsufficiency and diseases of the central nervous system and the eye.

What is the price predicton of STOK Stock?

Wall Street analysts forecast STOK stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for STOK is35.75 USD with a low forecast of 25.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Stoke Therapeutics Inc (STOK)'s revenue for the last quarter?

Stoke Therapeutics Inc revenue for the last quarter amounts to 10.63M USD, increased 117.25

What is Stoke Therapeutics Inc (STOK)'s earnings per share (EPS) for the last quarter?

Stoke Therapeutics Inc. EPS for the last quarter amounts to -0.65 USD, increased 38.30

How many employees does Stoke Therapeutics Inc (STOK). have?

Stoke Therapeutics Inc (STOK) has 128 emplpoyees as of March 11 2026.

What is Stoke Therapeutics Inc (STOK) market cap?

Today STOK has the market capitalization of 2.19B USD.