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STOK Overview

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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
33.210
Open
33.000
VWAP
32.10
Vol
480.08K
Mkt Cap
1.94B
Low
31.330
Amount
15.41M
EV/EBITDA(TTM)
--
Total Shares
59.15M
EV
1.59B
EV/OCF(TTM)
34.98
P/S(TTM)
10.15
Stoke Therapeutics, Inc. is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with ribonucleic acid (RNA)-based medicines. The Company, through its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach, is engaged in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its first compound, zorevunersen (STK-002), is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. TANGO aims to restore missing proteins by increasing or stoking protein output from healthy genes, thus compensating for the non-functioning copy of the gene. The Company is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The Company’s initial focus is haploinsufficiency and diseases of the central nervous system and the eye.
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Events Timeline

(ET)
2026-03-04
17:20:00
Stoke Therapeutics and Biogen Publish Zorevunersen Study Data
select
2026-03-04
07:50:00
NervGen Pharma Appoints New Executives
select
2026-02-11 (ET)
2026-02-11
07:40:00
Stoke Therapeutics Doses First Patient in STK-002 Trial
select

News

NASDAQ.COM
5.0
03-28NASDAQ.COM
Chair of Stoke Therapeutics Sells Shares
  • Share Sale Details: Arthur Tzianabos, chair of Stoke Therapeutics, disclosed the sale of 4,355 shares on March 10, 2026, for approximately $174,000 at an average price of $40 per share, reducing his direct holdings by 12.20% to 31,339 shares, indicating a significant decrease in ownership.
  • Options Exercise Context: This sale followed the exercise of 3,955 options, with all shares sold coming from direct holdings and no indirect entities involved, although Tzianabos retains a substantial number of additional options, reflecting ongoing confidence in the company's future prospects.
  • Clinical Progress Support: Stoke recently advanced STK-002 into a Phase 1 study for autosomal dominant optic atrophy, expanding its pipeline, and data published in The New England Journal of Medicine indicated that the lead candidate, zorevunersen, shows potential disease-modifying effects for Dravet syndrome, making future clinical data performance critical for valuation.
  • Investor Considerations: While option-driven selling among executives typically reflects compensation structures rather than sentiment changes, for long-term investors, the focus should be on the reliability of future clinical data and its potential for regulatory approval, which will directly impact the company's future returns.
Fool
5.0
03-28Fool
Stoke Therapeutics Chair Sells 4,355 Shares of Stock
  • Transaction Overview: Arthur Tzianabos, chair of Stoke Therapeutics, sold 4,355 shares of common stock on March 10, 2026, for approximately $174,000, indicating a liquidity need within his equity compensation structure.
  • Ownership Change Analysis: This sale reduced Tzianabos's direct common stock holdings by 12.20% to 31,339 shares; however, he retains 118,696 stock options, suggesting significant potential future ownership remains intact.
  • Market Performance & Company Overview: Stoke Therapeutics boasts a market capitalization of $1.9 billion, with a remarkable 340% price increase over the past year, primarily driven by its development of antisense oligonucleotide medicines targeting severe genetic diseases, showcasing its competitive edge in biotechnology.
  • Clinical Progress & Investor Outlook: The company recently advanced STK-002 into a Phase 1 study for autosomal dominant optic atrophy, and data published in The New England Journal of Medicine highlighted significant efficacy for its lead candidate, indicating that future clinical data will be crucial for investor returns.
Yahoo Finance
5.0
03-28Yahoo Finance
Stoke Therapeutics Chair Sells Shares Worth $174K Amid 340% Stock Surge
  • Transaction Overview: Arthur Tzianabos, Chair of Stoke Therapeutics, sold 4,355 shares of common stock on March 10, 2026, for approximately $174,000, indicating a liquidity need amidst a 340% stock price surge.
  • Ownership Change Analysis: This sale reduced Tzianabos's direct common stock holdings by 12.20% to 31,339 shares; however, he retains 118,696 stock options, suggesting significant potential future ownership.
  • Market Reaction and Outlook: While option-driven selling among executives typically reflects compensation structures rather than sentiment shifts, Stoke Therapeutics has shown strong clinical progress, particularly with STK-002 entering Phase 1 trials, which may support future growth.
  • Investor Focus: For long-term investors, the key takeaway lies in the ongoing performance of clinical data and the likelihood of regulatory approval, rather than the isolated stock sale, as these factors will directly influence future returns.
Fool
5.0
03-24Fool
Stoke Therapeutics Executive Sells Shares Amid Strong Performance
  • Executive Stock Sale: Barry Ticho, Chief Medical Officer of Stoke Therapeutics, sold 14,311 shares of common stock for approximately $457,000 between March 17 and March 19, 2026, indicating a significant change in his holdings.
  • Ownership Change: Following the transaction, Ticho's direct ownership decreased from 55,013 shares to 40,702 shares, a 26.01% reduction, while he retains 83,035 stock options, maintaining substantial future conversion potential.
  • Transaction Context: The sale was executed following the exercise of options and is notably larger than the recent median sale size of 5,429.5 shares, reflecting an atypical disposition of his holdings compared to historical trading activity.
  • Market Outlook: Despite the insider sale, Stoke Therapeutics has seen its stock price rise approximately 300% over the past year, and the company is advancing its RNA-based platform targeting severe genetic diseases, making future clinical data performance crucial for investors.
Newsfilter
5.0
03-17Newsfilter
Stoke Therapeutics Grants Stock Options to New Employees
  • Stock Option Grant: On March 16, 2026, Stoke Therapeutics granted stock options for a total of 58,650 shares to six new employees as a material inducement for their employment, in compliance with Nasdaq Listing Rule 5635(c)(4).
  • Exercise Price Set: The granted stock options have an exercise price of $33.96 per share, which matches the closing price of Stoke's common stock on March 16, 2026, ensuring that employees are incentivized at a stable market price.
  • Vesting Schedule: Each option will vest over a four-year period, with one-quarter of the shares vesting on the one-year anniversary of the vesting commencement date and the remaining shares vesting monthly over the following 36 months, promoting employee retention.
  • Long-Term Incentive Plan: The options have a term of 10 years and are subject to the terms of the 2023 Inducement Plan and the stock option agreement, aiming to attract and retain talent through a long-term incentive mechanism.
NASDAQ.COM
9.0
03-05NASDAQ.COM
Stoke and Biogen Release Zorevunersen Study Data
  • Study Results Released: Stoke Therapeutics and Biogen announced the publication of data on the investigational drug Zorevunersen, indicating its potential for disease modification in patients with Dravet syndrome, marking a significant advancement in treatment options.
  • Clinical Trial Data: Results from two completed Phase 1/2a trials and ongoing open-label extension studies demonstrated substantial and durable reductions in seizures, along with improvements across multiple cognitive and behavioral measures, indicating long-term efficacy.
  • Future Research Outlook: Barry Ticho, Chief Medical Officer of Stoke, stated that Zorevunersen could become the first disease-modifying medicine for Dravet syndrome, with anticipation for the Phase 3 EMPEROR study results expected in mid-2027 to further validate its efficacy.
  • Market Reaction: Stoke shares closed at $34.42 on Nasdaq, up 1.89%, reflecting positive market expectations regarding the drug's potential.
Wall Street analysts forecast STOK stock price to rise
9 Analyst Rating
Wall Street analysts forecast STOK stock price to rise
8 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
35.75
High
50.00
Current: 0.000
sliders
Low
25.00
Averages
35.75
High
50.00
Canaccord
NULL -> Buy
maintain
$36 -> $60
AI Analysis
2026-03-20
Reason
Canaccord
Price Target
$36 -> $60
AI Analysis
2026-03-20
maintain
NULL -> Buy
Reason
Canaccord raised the firm's price target on Stoke Therapeutics to $60 from $36 and keeps a Buy rating on the shares. The firm believes consensus is low as the company reiterated its timeline that it expects to complete enrollment on its ongoing Phase 3 EMPEROR trial for zorevunersen for Dravet syndrome in 2Q26, with data in mid-2027. The reason for the target increase is based on the new net price of $600k/year for zorevunersen.
Wedbush
Outperform
upgrade
$36 -> $38
2026-03-18
Reason
Wedbush
Price Target
$36 -> $38
2026-03-18
upgrade
Outperform
Reason
Wedbush raised the firm's price target on Stoke Therapeutics to $38 from $36 and keeps an Outperform rating on the shares. The firm notes the company has released their 10-K filing and while no separate press release was issued, all key objectives remain on track for the company. Most important in the near term remains the enrollment completion for the Phase 3 EMPEROR study of zorevunersen in Dravet Syndrome. Additionally, the recent publication of zorevunersen clinical data in NEJM reinforces Wedbush's view that the company is assembling a compelling data package for the drug with benefits on both seizure and non-seizure manifestations of disease.
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Valuation Metrics

The current forward P/E ratio for Stoke Therapeutics Inc (STOK.O) is -9.98, compared to its 5-year average forward P/E of -6.77. For a more detailed relative valuation and DCF analysis to assess Stoke Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.77
Current PE
-9.98
Overvalued PE
-2.39
Undervalued PE
-11.15

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.06
Current EV/EBITDA
-8.27
Overvalued EV/EBITDA
-0.35
Undervalued EV/EBITDA
-7.77

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
41.43
Current PS
99.55
Overvalued PS
68.10
Undervalued PS
14.75

Financials

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Whales Holding STOK

A
Artal Group S.A.
Holding
STOK
+1.99%
3M Return
B
BVF Partners L.P.
Holding
STOK
-2.32%
3M Return
D
Deerfield Management Company, L.P.
Holding
STOK
-2.62%
3M Return
B
Baker Bros. Advisors LP
Holding
STOK
-4.07%
3M Return
T
Tang Capital Management, LLC
Holding
STOK
-5.24%
3M Return
R
RTW Investments, LP
Holding
STOK
-10.24%
3M Return

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Frequently Asked Questions

What is Stoke Therapeutics Inc (STOK) stock price today?

The current price of STOK is 31.77 USD — it has decreased -3.29

What is Stoke Therapeutics Inc (STOK)'s business?

Stoke Therapeutics, Inc. is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with ribonucleic acid (RNA)-based medicines. The Company, through its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach, is engaged in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its first compound, zorevunersen (STK-002), is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. TANGO aims to restore missing proteins by increasing or stoking protein output from healthy genes, thus compensating for the non-functioning copy of the gene. The Company is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The Company’s initial focus is haploinsufficiency and diseases of the central nervous system and the eye.

What is the price predicton of STOK Stock?

Wall Street analysts forecast STOK stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for STOK is35.75 USD with a low forecast of 25.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Stoke Therapeutics Inc (STOK)'s revenue for the last quarter?

Stoke Therapeutics Inc revenue for the last quarter amounts to 1.40M USD, decreased -93.80

What is Stoke Therapeutics Inc (STOK)'s earnings per share (EPS) for the last quarter?

Stoke Therapeutics Inc. EPS for the last quarter amounts to -0.98 USD, increased 444.44

How many employees does Stoke Therapeutics Inc (STOK). have?

Stoke Therapeutics Inc (STOK) has 170 emplpoyees as of March 31 2026.

What is Stoke Therapeutics Inc (STOK) market cap?

Today STOK has the market capitalization of 1.94B USD.