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SKYE Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
0.637
Open
0.629
VWAP
0.63
Vol
84.69K
Mkt Cap
20.86M
Low
0.622
Amount
53.12K
EV/EBITDA(TTM)
--
Total Shares
33.38M
EV
-5.70M
EV/OCF(TTM)
--
P/S(TTM)
--
Skye Bioscience, Inc. is a clinical-stage biotechnology company. The Company is focused on development of next-generation molecules that modulate G-protein coupled receptors to treat obesity, overweight, and related conditions. The Company’s lead candidate, nimacimab, is a peripherally restricted negative allosteric modulating antibody targeting cannabinoid receptor 1 (CB1). The Company is also focused on its Phase IIa clinical trial, CBeyond, for nimacimab. The CBeyond clinical trial includes approximately 136 patients, 16 clinical trial sites and a combination arm with a GLP-1 receptor agonist to assess differences in weight loss, body composition, and other attributes. The CB1 receptor is one of the receptors in the endocannabinoid system (ECS) and plays a significant role both in the central nervous system (CNS) and peripheral tissues. The Company's Phase II study in obesity for nimacimab, is a negative allosteric modulating antibody that peripherally inhibits CB1.
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Events Timeline

(ET)
2026-03-10
16:10:00
Skye Reports Cash and Short-term Investments Totaling $25.7M
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2026-02-02 (ET)
2026-02-02
07:30:00
Skye Bioscience Reports 52-Week Efficacy Data for Nimacimab
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2026-01-29 (ET)
2026-01-29
07:30:00
Skye Bioscience Presents Nimacimab Study Results at Conference
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2026-01-12 (ET)
2026-01-12
07:10:00
Skye's 2026 Clinical Program Focuses on Nimacimab
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2026-01-05 (ET)
2026-01-05
07:30:00
Halozyme and Skye Bioscience Enter Global Collaboration Agreement
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2026-01-05
07:10:00
Halozyme and Skye Bioscience Enter Global Collaboration Agreement
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2025-11-10 (ET)
2025-11-10
16:11:39
Skye Bioscience Announces Q3 EPS of 32c, Matching Consensus Estimate
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2025-11-05 (ET)
2025-11-05
07:45:13
Skye Bioscience to unveil key findings from CBeyond study on nimacimab
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News

seekingalpha
9.5
03-11seekingalpha
Skye Bioscience Q4 2025 Earnings Call Insights
  • Clinical Progress: Skye Bioscience's nimacimab demonstrated a 3% weight loss improvement at 26 weeks when combined with semaglutide, achieving a 22.3% mean weight loss after 52 weeks, indicating its potential in weight management therapies and opening new market opportunities for the company.
  • Expansion Study Plans: The company is initiating the CBeyond expansion study to evaluate higher doses of nimacimab, planning to advance subcutaneous delivery via Halozyme's ENHANZE technology in preparation for the Phase IIb trial, which could enhance the product's competitive edge in the market.
  • Financial Position: As of year-end 2025, Skye Bioscience reported $25.7 million in cash and short-term investments, with a managed operating plan extending the runway through Q4 2026, ensuring funding for critical clinical trials and operational needs.
  • Future Outlook: Management anticipates several key catalysts in 2026, including interim data from the CBeyond expansion study and FDA meeting minutes, reflecting the company's confidence in its clinical development and regulatory readiness.
seekingalpha
9.5
03-10seekingalpha
Skye Bioscience Q4 Earnings Miss Expectations
  • Earnings Performance: Skye Bioscience reported a Q4 GAAP EPS of -$0.36, missing expectations by $0.06, indicating challenges in profitability that may affect investor confidence.
  • Cash Reserves: As of December 31, 2025, the company had $25.7 million in cash, cash equivalents, and short-term investments, which, while providing some liquidity, raises concerns about its ongoing operational viability.
  • Increased Net Loss: The net loss for Q4 2025 totaled $14.4 million, significantly higher than the $9.7 million reported in the same period of 2024, reflecting pressure on the company's cost control and revenue growth.
  • Share-Based Compensation Adjustments: Non-cash share-based compensation expenses were $1.6 million, down from $2.1 million in Q4 2024, suggesting adjustments in the compensation structure to address financial pressures.
seekingalpha
9.5
03-09seekingalpha
Skye Bioscience to Announce Q4 Earnings on March 9
  • Earnings Announcement Schedule: Skye Bioscience is set to release its Q4 earnings report on March 9, after market close, drawing significant attention from market participants regarding its performance.
  • Earnings Expectations: Analysts have a consensus EPS estimate of -$0.31, representing a 29.2% year-over-year decline, indicating the financial pressures the company is currently facing.
  • Revenue Forecast: The consensus revenue estimate for Skye Bioscience stands at $0, suggesting that the company may not achieve sales growth in the current fiscal quarter.
  • Historical Financial Data: Investors can refer to Skye Bioscience's historical financial data to assess performance trends and future potential.
Benzinga
2.0
02-02Benzinga
Skye Bioscience Reports Interim Data from Nimacimab Study
  • Clinical Trial Progress: Skye Bioscience's Phase 2a CBeyond study for obesity shows significant results with nimacimab combined with GLP-1R agonist (Wegovy), achieving an average weight loss of 14.4% at 26 weeks and 22.3% at 52 weeks, indicating the therapy's potential in weight management.
  • Safety Assessment: The extension study reported no serious adverse events for the nimacimab and semaglutide combination, demonstrating good tolerability and safety, which bolsters confidence for future clinical applications.
  • Comparative Analysis: The combination therapy group lost 13.2% of weight at 26 weeks compared to 10.25% in the semaglutide-only control group, suggesting that the combination may offer more durable weight loss effects.
  • Future Outlook: Topline data from the CBeyond Phase 2a extension is expected in Q3 2026, with analyst William Blair noting that supportive data could attract investor interest, despite a current stock price decline of 5.53%.
NASDAQ.COM
2.0
02-02NASDAQ.COM
Skye Bioscience Reports Positive Clinical Data from Nimacimab Study
  • Clinical Trial Results: Skye Bioscience's CBeyond Phase 2a study shows that the combination of nimacimab and semaglutide achieved a significant 22.3% weight loss over 52 weeks, highlighting the therapy's efficacy and potential market competitiveness.
  • Durability Advantage: During the 13-week off-therapy follow-up, the nimacimab plus semaglutide cohort regained only 17.8% of lost weight compared to 37.3% for semaglutide alone, indicating a superior durability advantage of the combination therapy.
  • Safety Assessment: The combination therapy demonstrated good tolerability at tested doses during the extension study, with no serious adverse events reported, further enhancing the therapy's market appeal.
  • Future Outlook: Skye anticipates that optimized dosing of nimacimab in future clinical trials could lead to even deeper weight loss, showcasing the company's long-term growth potential in the obesity treatment sector.
Newsfilter
8.5
01-21Newsfilter
Skye Bioscience to Present Nimacimab Efficacy Study at Keystone Conference
  • Clinical Research Presentation: Skye Bioscience will present its study on the obesity-targeting antibody nimacimab at the Keystone conference on January 28, 2026, exploring its effects on weight loss at various doses, aiming to provide new insights for obesity treatment.
  • Mechanism Exploration: The research will assess whether nimacimab can serve as a maintenance therapy after discontinuation of tirzepatide and whether its weight loss effects primarily rely on caloric restriction, thus providing crucial data support for clinical applications.
  • Innovative Drug Characteristics: Nimacimab, as a peripherally-restricted monoclonal antibody, is designed to avoid central nervous system penetration, potentially reducing the neuropsychiatric side effects commonly associated with small-molecule antagonists, showcasing its unique advantages in obesity treatment.
  • Clinical Trial Progress: Skye is currently conducting a Phase 2a clinical trial for nimacimab in combination with the GLP-1R agonist Wegovy®, which will provide empirical support for its market potential in the obesity sector.
Wall Street analysts forecast SKYE stock price to rise
5 Analyst Rating
Wall Street analysts forecast SKYE stock price to rise
4 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
10.00
Averages
14.33
High
20.00
Current: 0.000
sliders
Low
10.00
Averages
14.33
High
20.00
H.C. Wainwright
Ananda Ghosh
Buy
initiated
$20
AI Analysis
2025-09-30
Reason
H.C. Wainwright
Ananda Ghosh
Price Target
$20
AI Analysis
2025-09-30
initiated
Buy
Reason
H.C. Wainwright analyst Ananda Ghosh initiated coverage of Skye Bioscience with a Buy rating and $20 price target. The firm believes the company's nimacimab can introduce a new mechanism of longstanding interest to obesity clinicians. Nimacimab is a peripherally restricted monoclonal antibody targeting the CB1 receptor, designed to deliver the metabolic benefits of CB1 blockade without the psychiatric side effects that derailed earlier small molecule antagonists, the analyst tells investors in a research note. H.C. Wainwright views Sykes shares as undervalued at current levels.
Evercore ISI
Michael DiFiore
Outperform
initiated
$10
2025-08-14
Reason
Evercore ISI
Michael DiFiore
Price Target
$10
2025-08-14
initiated
Outperform
Reason
Evercore ISI analyst Michael DiFiore initiated coverage of Skye Bioscience with an Outperform rating and $10 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SKYE
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Valuation Metrics

The current forward P/E ratio for Skye Bioscience Inc (SKYE.O) is -0.74, compared to its 5-year average forward P/E of -2.40. For a more detailed relative valuation and DCF analysis to assess Skye Bioscience Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.40
Current PE
-0.74
Overvalued PE
1.24
Undervalued PE
-6.03

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

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Frequently Asked Questions

What is Skye Bioscience Inc (SKYE) stock price today?

The current price of SKYE is 0.6223 USD — it has decreased -0.48

What is Skye Bioscience Inc (SKYE)'s business?

Skye Bioscience, Inc. is a clinical-stage biotechnology company. The Company is focused on development of next-generation molecules that modulate G-protein coupled receptors to treat obesity, overweight, and related conditions. The Company’s lead candidate, nimacimab, is a peripherally restricted negative allosteric modulating antibody targeting cannabinoid receptor 1 (CB1). The Company is also focused on its Phase IIa clinical trial, CBeyond, for nimacimab. The CBeyond clinical trial includes approximately 136 patients, 16 clinical trial sites and a combination arm with a GLP-1 receptor agonist to assess differences in weight loss, body composition, and other attributes. The CB1 receptor is one of the receptors in the endocannabinoid system (ECS) and plays a significant role both in the central nervous system (CNS) and peripheral tissues. The Company's Phase II study in obesity for nimacimab, is a negative allosteric modulating antibody that peripherally inhibits CB1.

What is the price predicton of SKYE Stock?

Wall Street analysts forecast SKYE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SKYE is14.33 USD with a low forecast of 10.00 USD and a high forecast of 20.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Skye Bioscience Inc (SKYE)'s revenue for the last quarter?

Skye Bioscience Inc revenue for the last quarter amounts to -14.90M USD, increased 20.64

What is Skye Bioscience Inc (SKYE)'s earnings per share (EPS) for the last quarter?

Skye Bioscience Inc. EPS for the last quarter amounts to -9766487.00 USD, increased 18.77

How many employees does Skye Bioscience Inc (SKYE). have?

Skye Bioscience Inc (SKYE) has 12 emplpoyees as of March 25 2026.

What is Skye Bioscience Inc (SKYE) market cap?

Today SKYE has the market capitalization of 20.86M USD.