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RYTM Overview

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ET
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Intellectia

Loading chart...

High
91.660
Open
89.560
VWAP
90.23
Vol
821.96K
Mkt Cap
6.21B
Low
88.030
Amount
74.17M
EV/EBITDA(TTM)
--
Total Shares
68.29M
EV
5.97B
EV/OCF(TTM)
--
P/S(TTM)
30.67
Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its lead asset, IMCIVREE, as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. IMCIVREE is approved by the Food and Drug Administration (FDA) for chronic weight management in adult and pediatric patients six years of age and older with monogenic or syndromic obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1) or leptin receptor (LEPR) deficiency as determined by an FDA-approved test demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of uncertain significance (VUS). In addition to setmelanotide, it has two earlier-stage investigational MC4R agonists in clinical development, RM-718, designed for weekly administration, and bivamelagon, an oral small molecule.
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Events Timeline

(ET)
2026-03-01
16:10:00
Rhythm Pharmaceuticals Releases New Data, Setmelanotide Reduces BMI by 16.4%
select
2026-02-26 (ET)
2026-02-26
17:50:00
Rhythm Pharmaceuticals Files to Sell 2.4M Shares of Common Stock
select
2026-02-26
07:20:00
Rhythm Reports Q4 Revenue of $57.253M, Exceeds Expectations
select

News

Benzinga
9.0
03-02Benzinga
Rhythm Pharmaceuticals Reports Positive Phase 3 Trial Data for Setmelanotide
  • Significant BMI Reduction: Rhythm Pharmaceuticals reported an 18.8% placebo-adjusted difference in BMI reduction at 52 weeks in the TRANSCEND trial, indicating a positive outlook for treating acquired hypothalamic obesity, which may bolster investor confidence.
  • Primary Endpoint Achieved: The trial involved 142 patients, with 94 receiving setmelanotide therapy showing a mean BMI reduction of 16.4%, while the placebo group experienced a 2.4% increase, highlighting the drug's efficacy.
  • Hunger Score Improvement: Among patients aged 12 and older, the setmelanotide group showed an average weekly reduction of 2.5 points in hunger scores compared to a 1.3-point reduction in the placebo group, demonstrating the drug's potential in appetite control.
  • FDA Application Progress: The company has submitted a supplemental New Drug Application for setmelanotide to the FDA, with a decision expected by March 20, which could position it as the first approved treatment for this condition, enhancing market appeal.
NASDAQ.COM
9.0
03-02NASDAQ.COM
Rhythm Pharmaceuticals Reports Positive Phase 3 Results for Obesity Treatment
  • Clinical Trial Results: Rhythm Pharmaceuticals' global Phase 3 TRANSCEND trial demonstrated a mean BMI reduction of 16.4% in patients treated with Setmelanotide over 52 weeks, contrasting with a 2.4% increase in the placebo group, indicating significant efficacy.
  • Patient Cohort Analysis: Among the 142 participants, including a Japanese cohort, the results highlighted Setmelanotide's superior performance in weight reduction and hunger score improvement, particularly in patients aged 12 and older.
  • Regulatory Application Progress: Rhythm has submitted a supplemental New Drug Application (sNDA) to the U.S. FDA, with a PDUFA goal date of March 20, 2026, while also pursuing regulatory reviews in Europe and Japan, with potential approvals expected later this year.
  • Market Performance: RYTM's stock has traded between $45.90 and $122.20 over the past year, closing at $92.73, down 5.45%, but showing a slight recovery of 0.08% in after-hours trading, reflecting market interest in the new therapy.
Newsfilter
8.5
03-01Newsfilter
Rhythm Pharmaceuticals Reports Positive Data on Weight Loss Therapy Setmelanotide
  • Clinical Trial Results: Rhythm Pharmaceuticals' global Phase 3 TRANSCEND trial data for 142 patients at 52 weeks shows an 18.8% placebo-adjusted difference in BMI reduction, with a mean BMI decrease of 16.4% in 94 patients on setmelanotide compared to a 2.4% increase in the placebo group, indicating significant efficacy.
  • Hunger Score Improvement: Among patients aged 12 and older, the setmelanotide group experienced an average weekly reduction of 2.5 points in hunger scores, compared to a 1.3-point reduction in the placebo group, with statistical significance at p=0.0015, highlighting the drug's potential in hunger management.
  • Regulatory Progress: Rhythm's supplemental New Drug Application (sNDA) is under review by the FDA with a PDUFA goal date of March 20, 2026, and the final data package is expected to be submitted on March 2, 2026, further advancing market access.
  • International Market Expansion: The company plans to submit a marketing authorization application for setmelanotide to Japan's PMDA and anticipates receiving marketing authorization from the European Commission in the second half of 2026, demonstrating its strategic global positioning and market potential.
NASDAQ.COM
2.0
02-27NASDAQ.COM
RYTM Stock 52-Week Highs and Lows Analysis
  • Price Fluctuation Analysis: RYTM's 52-week low is $45.905 per share, while the high is $122.20, with the last trade at $91.99, indicating significant price volatility and reflecting market interest and investor sentiment changes.
  • Technical Indicator Observation: The current price of $91.99 is close to the 52-week low, potentially prompting investors to reassess its future performance, especially as the price is below the 200-day moving average, suggesting short-term downside risks.
  • Market Sentiment Impact: The fluctuations in RYTM's stock price may be influenced by overall market sentiment, particularly amid increasing economic uncertainty, leading investors to be more cautious, which could affect trading volume and price trends.
  • Investor Focus: As RYTM's stock price approaches the 52-week low, investors may pay close attention to changes in its fundamentals and future earnings expectations to decide whether to buy or sell at the current price level.
Benzinga
9.5
02-27Benzinga
Rhythm Pharmaceuticals Reports Strong Q4 Results Exceeding Expectations
  • Earnings Beat: Rhythm Pharmaceuticals reported a Q4 loss of $0.73 per share, better than the expected loss of $0.81, indicating improvements in cost control and operational efficiency, which bolstered investor confidence.
  • Sales Growth: The company's sales reached $57.253 million, exceeding market expectations of $56.042 million, demonstrating strong global sales growth for IMCIVREE and further solidifying its market position in rare disease treatments.
  • Future Growth Strategy: CEO David Meeker stated that the company is focused on long-term growth and is well-capitalized to achieve important commercial and clinical milestones in 2026, particularly in bringing IMCIVREE to patients with acquired HO in the U.S.
  • Analyst Rating Upgrades: Analysts from Guggenheim and Citizens raised their price targets for Rhythm Pharmaceuticals from $140 and $167 to $143 and $176, respectively, reflecting optimistic market expectations regarding the company's future growth potential.
seekingalpha
9.5
02-26seekingalpha
Rhythm Pharmaceuticals Q4 2025 Earnings Call Highlights
  • Significant Revenue Growth: Rhythm Pharmaceuticals reported Q4 2025 IMCIVREE sales of $57.3 million, a 12% sequential increase, with total annual revenue reaching $194.8 million, approximately 50% higher than 2024, indicating robust market performance.
  • Clinical Progress on Track: CEO Meeker noted that the Bivamelagon HO study showed 11 out of 14 patients achieving over 10% BMI reduction at 40 weeks, with plans to present 52-week data at a mid-year medical meeting, marking a smooth transition to Phase 3 trials.
  • International Market Expansion: IMCIVREE is now available in over 25 countries, including 8 newly added markets, showcasing the company's growth potential globally, particularly among the estimated 5,000 to 8,000 HO patients in Japan.
  • Positive Future Outlook: Management anticipates 2026 non-GAAP operating expenses to range from $385 million to $415 million, reflecting ongoing investments in clinical programs and confidence in future growth, while planning to have Bivamelagon Phase 3 trial drug supply ready by year-end 2026.
Wall Street analysts forecast RYTM stock price to rise
15 Analyst Rating
Wall Street analysts forecast RYTM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
123.00
Averages
140.62
High
167.00
Current: 0.000
sliders
Low
123.00
Averages
140.62
High
167.00
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$125 -> $110
AI Analysis
2026-03-02
New
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$125 -> $110
AI Analysis
2026-03-02
New
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Rhythm Pharmaceuticals to $110 from $125 and keeps a Buy rating on the shares, reflecting adjustments to the firm's long-term sales ramp expectations after Rhythm recently announced its Q4 results and announced additional positive data from its global Phase 3 TRANSCEND trial of setmelanotide in patients with acquired hypothalamic obesity.
Canaccord
Buy
maintain
$141 -> $140
2026-03-02
New
Reason
Canaccord
Price Target
$141 -> $140
2026-03-02
New
maintain
Buy
Reason
Canaccord lowered the firm's price target on Rhythm Pharmaceuticals to $140 from $141 and keeps a Buy rating on the shares. The firm said its 4Q report was incremental following the company's preannouncement earlier this year. On the commercial front, IMCIVREE revenue increased sequentially, driven by growth in BBS points, and the firm is encouraged by the company's prep for the launch of IMCIVREE in HO ahead of the March 20 PDUFA goal date.
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Valuation Metrics

The current forward P/E ratio for Rhythm Pharmaceuticals Inc (RYTM.O) is -34.25, compared to its 5-year average forward P/E of -12.75. For a more detailed relative valuation and DCF analysis to assess Rhythm Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.75
Current PE
-34.25
Overvalued PE
-3.25
Undervalued PE
-22.25

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-11.20
Current EV/EBITDA
-36.77
Overvalued EV/EBITDA
0.38
Undervalued EV/EBITDA
-22.78

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
35.92
Current PS
27.10
Overvalued PS
89.00
Undervalued PS
-17.15

Financials

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Whales Holding RYTM

W
Westfield Capital Management Company, L.P.
Holding
RYTM
+16.14%
3M Return
A
Artal Group S.A.
Holding
RYTM
+14.33%
3M Return
D
Driehaus Capital Management LLC
Holding
RYTM
+12.84%
3M Return
R
RA Capital Management, L.P.
Holding
RYTM
+8.53%
3M Return
P
Perceptive Advisors LLC
Holding
RYTM
+6.21%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
RYTM
+4.65%
3M Return

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Frequently Asked Questions

What is Rhythm Pharmaceuticals Inc (RYTM) stock price today?

The current price of RYTM is 91 USD — it has increased 1.61

What is Rhythm Pharmaceuticals Inc (RYTM)'s business?

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its lead asset, IMCIVREE, as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. IMCIVREE is approved by the Food and Drug Administration (FDA) for chronic weight management in adult and pediatric patients six years of age and older with monogenic or syndromic obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1) or leptin receptor (LEPR) deficiency as determined by an FDA-approved test demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of uncertain significance (VUS). In addition to setmelanotide, it has two earlier-stage investigational MC4R agonists in clinical development, RM-718, designed for weekly administration, and bivamelagon, an oral small molecule.

What is the price predicton of RYTM Stock?

Wall Street analysts forecast RYTM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for RYTM is140.62 USD with a low forecast of 123.00 USD and a high forecast of 167.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Rhythm Pharmaceuticals Inc (RYTM)'s revenue for the last quarter?

Rhythm Pharmaceuticals Inc revenue for the last quarter amounts to 57.25M USD, increased 36.87

What is Rhythm Pharmaceuticals Inc (RYTM)'s earnings per share (EPS) for the last quarter?

Rhythm Pharmaceuticals Inc. EPS for the last quarter amounts to -0.73 USD, increased 1.39

How many employees does Rhythm Pharmaceuticals Inc (RYTM). have?

Rhythm Pharmaceuticals Inc (RYTM) has 414 emplpoyees as of March 05 2026.

What is Rhythm Pharmaceuticals Inc (RYTM) market cap?

Today RYTM has the market capitalization of 6.21B USD.