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RYTM Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
83.750
Open
83.070
VWAP
82.35
Vol
894.97K
Mkt Cap
5.64B
Low
80.700
Amount
73.70M
EV/EBITDA(TTM)
--
Total Shares
68.29M
EV
5.63B
EV/OCF(TTM)
--
P/S(TTM)
28.99
Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company’s lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism.
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Events Timeline

(ET)
2026-03-20
13:20:00
PANTHERx Selected by Rhythm Pharmaceuticals as Exclusive Pharmacy Partner for IMCIVREE
select
2026-03-19 (ET)
2026-03-19
18:30:00
Rhythm Pharmaceuticals Trading Halted, News Pending
select

News

PRnewswire
7.5
03-20PRnewswire
PANTHERx Selected as Exclusive U.S. Pharmacy Partner for IMCIVREE Distribution
  • Exclusive Partnership: PANTHERx Rare Pharmacy has been selected by Rhythm Pharmaceuticals as the exclusive U.S. pharmacy distribution partner for IMCIVREE®, focusing on acquired hypothalamic obesity treatment, marking a significant expansion in the rare disease sector.
  • Personalized Patient Support: PANTHERx will leverage its industry-leading RxARECARE® model to provide therapy-specific clinical expertise to patients, caregivers, and prescribers, making complex rare disease therapies more accessible through individualized case management and comprehensive financial and insurance navigation.
  • Historic Milestone: The new indication for IMCIVREE offers crucial treatment options for patients with acquired hypothalamic obesity, with CEO Bansi Nagji highlighting its significance as a scientific milestone for affected individuals and families, demonstrating the company's commitment to high-touch clinical support.
  • Industry Leadership: Since 2020, PANTHERx has served as the exclusive pharmacy partner for IMCIVREE in chronic weight management, further solidifying its position as the largest independent rare pharmacy in the U.S., showcasing its expertise and innovation in the rare disease field.
Newsfilter
7.5
03-20Newsfilter
PANTHERx Selected as Exclusive U.S. Pharmacy Partner for IMCIVREE Distribution
  • Exclusive Partnership: PANTHERx Rare Pharmacy has been selected by Rhythm Pharmaceuticals as the exclusive U.S. pharmacy distribution partner for IMCIVREE, focusing on acquired hypothalamic obesity, which marks a significant expansion in the company's rare disease portfolio and is expected to enhance its market share and brand influence.
  • Personalized Patient Support: PANTHERx will leverage its industry-leading RxARECARE® model to provide personalized clinical support and education to patients, caregivers, and prescribers, aiming to simplify the complex treatment processes associated with rare diseases and improve patient adherence and satisfaction.
  • Historic Milestone: The new indication for IMCIVREE offers crucial treatment options for patients with acquired hypothalamic obesity, with CEO Bansi Nagji highlighting that this advancement brings hope to affected individuals and families, further solidifying the company's leadership in rare disease therapies.
  • Industry Recognition: Since 2020, PANTHERx has been the exclusive pharmacy partner for IMCIVREE, focusing on obesity related to conditions like Bardet-Biedl Syndrome, and the company's successful track record and expertise will provide robust support for the promotion of this new indication.
NASDAQ.COM
4.5
03-20NASDAQ.COM
U.S. Stocks Decline Amid Rising Energy Costs and Inflation Fears
  • Market Decline: The S&P 500 Index fell by 0.88% and the Nasdaq 100 Index dropped by 1.22%, both reaching 3.75-month lows, indicating market concerns over rising energy costs potentially impacting economic growth and inflation.
  • Rising Bond Yields: The 10-year Treasury note yield rose to 4.38%, a 7.5-month high, reflecting market fears that surging energy prices from the Iran conflict will boost inflation and may force the Fed to tighten monetary policy.
  • Escalating International Tensions: The Iran war has entered its 21st day with attacks on neighboring countries, leading Kuwait to shut down refinery units and Saudi Arabia and the UAE intercepting Iranian missiles, worsening market sentiment and increasing investor anxiety.
  • Increased Market Volatility: With the quarterly triple witching event, approximately $5.7 trillion in options and derivatives are set to expire, potentially heightening market volatility and further intensifying investor unease.
NASDAQ.COM
2.0
03-20NASDAQ.COM
US Stocks Decline Amid Iran War Concerns
  • Market Pressure Intensifies: The S&P 500 index fell by 0.37%, and the Nasdaq 100 dropped to a 3.75-month low as rising bond yields raised inflation concerns, indicating a pessimistic outlook for future economic conditions.
  • Surging Energy Prices: The IEA reported that the Iran war is disrupting 7.5 million barrels per day of global oil supply, and the closure of the Strait of Hormuz has obstructed about one-fifth of the world's oil flow, potentially pushing crude prices above the 2008 record high of nearly $150 per barrel.
  • Fed Policy Expectations: The market is pricing in only a 10% chance of a 25 basis point rate hike by the Fed at the April meeting, reflecting investor concerns over slowing economic growth, which could influence future monetary policy directions.
  • Tech Stocks Decline: The
seekingalpha
9.0
03-20seekingalpha
Rhythm Pharmaceuticals Secures FDA Label Expansion for Setmelanotide
  • FDA Approval Expansion: Rhythm Pharmaceuticals' lead asset, setmelanotide, has received FDA approval for use in patients with acquired hypothalamic obesity, a rare obesity disorder, allowing treatment for patients aged 4 and older, marking a significant advancement in the rare disease space.
  • Clinical Trial Success: The Phase 3 TRANSCEND trial demonstrated that patients with acquired hypothalamic obesity achieved an average 15.8% reduction in body mass index (BMI), compared to a 2.6% increase in the placebo group, highlighting the product's efficacy and laying a solid foundation for market launch.
  • Market Exclusivity: Imcivree is now the first and only FDA-approved therapy for acquired hypothalamic obesity, expected to be rapidly available to the targeted patient population, further solidifying Rhythm's leadership position in the rare obesity market.
  • Financial Outlook: Rhythm anticipates non-GAAP operating expenses of $385 million to $415 million in 2026, as preparations for the launch of acquired hypothalamic obesity accelerate, presenting significant market opportunities and financial growth potential for the company.
NASDAQ.COM
9.0
03-20NASDAQ.COM
FDA Approves IMCIVREE for Hypothalamic Obesity Treatment
  • FDA Approval: Rhythm Pharmaceuticals announced that IMCIVREE has received FDA approval, becoming the first and only therapy cleared for the treatment of acquired hypothalamic obesity, marking a significant breakthrough in this rare and severe condition.
  • Clinical Trial Results: In the global Phase 3 TRANSCEND trial involving 142 patients, IMCIVREE achieved a placebo-adjusted BMI reduction of -18.4%, with treated patients showing a -15.8% mean BMI decrease compared to a +2.6% increase in the placebo group, demonstrating significant efficacy.
  • Market Potential: With approximately 10,000 people in the U.S. living with acquired hypothalamic obesity, IMCIVREE is now available to U.S. patients, expected to meet the urgent needs of this specific population and drive revenue growth for the company.
  • Revenue Growth: IMCIVREE generated $57.3 million in global net product revenue in Q4 2025, a 12% increase from $51.1 million in Q3, and a significant rise from $41.8 million in Q4 2024, indicating improved market acceptance.
Wall Street analysts forecast RYTM stock price to rise
15 Analyst Rating
Wall Street analysts forecast RYTM stock price to rise
14 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
123.00
Averages
140.62
High
167.00
Current: 0.000
sliders
Low
123.00
Averages
140.62
High
167.00
H.C. Wainwright
Raghuram Selvaraju
maintain
$100 -> $105
AI Analysis
2026-03-23
New
Reason
H.C. Wainwright
Raghuram Selvaraju
Price Target
$100 -> $105
AI Analysis
2026-03-23
New
maintain
Reason
H.C. Wainwright analyst Raghuram Selvaraju raised the firm's price target on Rhythm Pharmaceuticals to $105 from $100 and keeps a Buy rating on the shares after the FDA approved an expanded indication for Imcivree to treat patients living with acquired hypothalamic obesity.
BofA
Tazeen Ahmad
Buy
maintain
$139 -> $149
2026-03-20
New
Reason
BofA
Tazeen Ahmad
Price Target
$139 -> $149
2026-03-20
New
maintain
Buy
Reason
BofA analyst Tazeen Ahmad raised the firm's price target on Rhythm Pharmaceuticals to $149 from $139 and keeps a Buy rating on the shares after the company announced FDA approval of setmelanotide for acquired hypothalamic obesity, noting a broad label with "no material surprises" and no post-marketing commitments. The firm views Rhythm as "a leader in the rare obesity space with more opportunities for upside from next-gen assets and follow-on indications," the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for RYTM
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Valuation Metrics

The current forward P/E ratio for Rhythm Pharmaceuticals Inc (RYTM.O) is -34.25, compared to its 5-year average forward P/E of -12.69. For a more detailed relative valuation and DCF analysis to assess Rhythm Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.69
Current PE
-34.25
Overvalued PE
-3.15
Undervalued PE
-22.23

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-11.25
Current EV/EBITDA
-36.77
Overvalued EV/EBITDA
0.38
Undervalued EV/EBITDA
-22.89

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
31.41
Current PS
27.10
Overvalued PS
64.46
Undervalued PS
-1.64

Financials

AI Analysis
Annual
Quarterly

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Whales Holding RYTM

D
Driehaus Capital Management LLC
Holding
RYTM
+5.77%
3M Return
W
Westfield Capital Management Company, L.P.
Holding
RYTM
+2.17%
3M Return
B
Bluebox Asset Management Uk Ltd.
Holding
RYTM
+2.04%
3M Return
A
Artal Group S.A.
Holding
RYTM
+1.27%
3M Return
P
Perceptive Advisors LLC
Holding
RYTM
+0.49%
3M Return
S
Sofinnova Investment, Inc.
Holding
RYTM
-1.57%
3M Return

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Frequently Asked Questions

What is Rhythm Pharmaceuticals Inc (RYTM) stock price today?

The current price of RYTM is 82.59 USD — it has decreased -2.43

What is Rhythm Pharmaceuticals Inc (RYTM)'s business?

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company’s lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism.

What is the price predicton of RYTM Stock?

Wall Street analysts forecast RYTM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for RYTM is140.62 USD with a low forecast of 123.00 USD and a high forecast of 167.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Rhythm Pharmaceuticals Inc (RYTM)'s revenue for the last quarter?

Rhythm Pharmaceuticals Inc revenue for the last quarter amounts to 57.25M USD, increased 36.87

What is Rhythm Pharmaceuticals Inc (RYTM)'s earnings per share (EPS) for the last quarter?

Rhythm Pharmaceuticals Inc. EPS for the last quarter amounts to -0.73 USD, increased 1.39

How many employees does Rhythm Pharmaceuticals Inc (RYTM). have?

Rhythm Pharmaceuticals Inc (RYTM) has 414 emplpoyees as of March 25 2026.

What is Rhythm Pharmaceuticals Inc (RYTM) market cap?

Today RYTM has the market capitalization of 5.64B USD.