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RYTM

Rhythm Pharmaceuticals Inc
$
86.450
-0.82(-0.940%)1D
  • Overview
  • Forecast
  • Valuation
  • Earnings
Line
Line
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Candle
Candle
1D
5D
1M
3M
6M
YTD
1Y
5Y
High
87.340
Open
87.230
VWAP
86.40
Vol
402.79K
Mkt Cap
5.69B
Low
85.8101
Amount
34.80M
EV/EBITDA(TTM)
--
Total Shares
60.97M
EV
5.63B
EV/OCF(TTM)
--
P/S(TTM)
38.99
Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on advancing its melanocortin-4 receptor (MC4R) agonists, including its lead asset, IMCIVREE, as a precision medicine designed to treat hyperphagia and severe obesity caused by rare MC4R pathway diseases. IMCIVREE is approved by the Food and Drug Administration (FDA) for chronic weight management in adult and pediatric patients six years of age and older with monogenic or syndromic obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1) or leptin receptor (LEPR) deficiency as determined by an FDA-approved test demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of uncertain significance (VUS). In addition to setmelanotide, it has two earlier-stage investigational MC4R agonists in clinical development, RM-718, designed for weekly administration, and bivamelagon, an oral small molecule.
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Market Estimates

Earnings Estimates
Revenue
YoY Chg
EPS
YoYChg
FY2025Q4
FY2025Q3
FY2025Q2
51.85M
+23.96%
--
--
47.09M
+41.62%
--
--
43.64M
+50.07%
--
--
Estimates Revision
The market is revising Downward the revenue expectations for Rhythm Pharmaceuticals, Inc. (RYTM) for FY2025, with the revenue forecasts being adjusted by -0.01% over the past three months. During the same period, the stock price has changed by 34.22%.
Revenue Estimates for FY2025
Revise Downward
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-0.01%
In Past 3 Month
Stock Price
Go Up
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+34.22%
In Past 3 Month
12 Analyst Rating
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-3.50% Downside
Wall Street analysts forecast RYTM stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for RYTM is 83.42 USD with a low forecast of 72.00 USD and a high forecast of 94.00  USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Buy
0 Hold
0 Sell
Strong Buy
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-3.50% Downside
Current: 86.450
sliders
Low
72.00
Averages
83.42
High
94.00
Canaccord
Dr. Ashley Shoemaker
Buy
maintain
$92 -> $105
2025-07-18
Reason
Canaccord raised the firm's price target on Rhythm Pharmaceuticals to $105 from $92 and keeps a Buy rating on the shares. The firm attended the Endocrine Society's Annual Meeting where obesity remained the hottest topic and what's coming up next in the pipeline and how to preserve (healthy/functional) lean muscle mass. Dr. Ashley Shoemaker stressed the importance of genetic testing for pediatric patients to a packed room and shared a link to Rhythm's testing program.
Goldman Sachs
Corinne Johnson
initiated
$97
2025-07-10
Reason
Goldman Sachs analyst Corinne Johnson resumed coverage of Rhythm Pharmaceuticals with a Buy rating and $97 price target. The firm is positive on the size of the hypothalamic obesity market and estimate a peak sales opportunity for Rhythm at $1.9B.
BofA
Tazeen Ahmad
Buy
maintain
$73 -> $95
2025-07-10
Reason
BofA analyst Tazeen Ahmad raised the firm's price target on Rhythm Pharmaceuticals to $95 from $73 and keeps a Buy rating on the shares. Rhythm announced positive topline results for the phase 2 trial evaluating next-generation oral MC4R bivamelagon in hypothalamic obesity, with bivamelagon demonstrating a BMI reduction of 9.31% at Week 14 for the 600mg high dose cohort, the analyst tells investors in a research note. The firm is encouraged by the phase 2 update that suggests an efficacy profile similar to setmelanotide but with more convenient once-daily oral dosing, and looks for additional color on how the new formulation will improve tolerability.
Wells Fargo
Derek Archila
Overweight
maintain
$91 -> $129
2025-07-10
Reason
Wells Fargo analyst Derek Archila raised the firm's price target on Rhythm Pharmaceuticals to $129 from $91 and keeps an Overweight rating on the shares. The firm believes shares should trade up meaningfully on biva's positive Phase 2 results in HO, which significantly increases the probability of success that Rhythm's MC4R franchise is durable into the mid-2040s. Wells thinks shares do not reflect this and it estimates it is worth about $35/share in upside.
Oppenheimer
Leland Gershell
Outperform
maintain
$76 -> $110
2025-07-10
Reason
Oppenheimer analyst Leland Gershell raised the firm's price target on Rhythm Pharmaceuticals to $110 from $76 and keeps an Outperform rating on the shares. The firm believes bivamelagon's positive Phase 2 SIGNAL results not only provide clinical evidence that this candidate can eventually offer an attractive daily oral alternative to setmelanotide for acquired hypothalamic obesity, but also address what it thinks has been a key IP overhang for Rhythm's stock, as setmelanotide's key patents will begin to expire in 2032 while bivamelagon's patent protection should extend beyond 2040.
Guggenheim
Buy
upgrade
$94 -> $119
2025-07-10
Reason
Guggenheim raised the firm's price target on Rhythm Pharmaceuticals to $119 from $94 and keeps a Buy rating on the shares. Bivamelagon's hypothalamic obesity Phase 2 SIGNAL study reported placebo-adjusted BMI reduction of -11.49%, -9.87%, and -4.86% for the 200 mg, 400 mg, and 600 mg doses, respectively, at 14 weeks, exceeding expectations, validating biva's clear efficacy in HO patients at just 14 weeks, the analyst tells investors in a research note. The firm sees encouraging readthrough to its once-weekly subcutaneous RM-718.

Valuation Metrics

The current forward P/E ratio for Rhythm Pharmaceuticals Inc (RYTM.O) is -31.93, compared to its 5-year average forward P/E of -11.20. For a more detailed relative valuation and DCF analysis to assess Rhythm Pharmaceuticals Inc 's fair value, click here.

Forward PE

StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-11.20
Current PE
-31.93
Overvalued PE
-4.31
Undervalued PE
-18.09

Forward EV/EBITDA

StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-8.03
Current EV/EBITDA
-37.33
Overvalued EV/EBITDA
-1.08
Undervalued EV/EBITDA
-14.98

Forward PS

StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
50.55
Current PS
29.39
Overvalued PS
146.96
Undervalued PS
-45.87

Financials

Annual
Quarterly
FY2025Q1
YoY :
+25.94%
32.70M
Total Revenue
FY2025Q1
YoY :
-66.40%
-47.00M
Operating Profit
FY2025Q1
YoY :
-64.99%
-49.50M
Net Income after Tax
FY2025Q1
YoY :
-65.53%
-0.81
EPS - Diluted
FY2025Q1
YoY :
-0.96%
-40.35M
Free Cash Flow
FY2025Q1
YoY :
-0.38%
88.85
Gross Profit Margin - %
FY2025Q1
YoY :
-45.73%
-82.92
FCF Margin - %
FY2025Q1
YoY :
-72.20%
-151.35
Net Margin - %

Trading Trends

Insider
Insiders are Neutral. There are no significant trading trends over the last month.
Sold
0-3
Months
13.3M
USD
9
3-6
Months
9.5M
USD
27
6-9
Months
5.3M
USD
2
0-12
Months
8.1M
USD
9
Bought
0-3
0
0.0
USD
Months
3-6
0
0.0
USD
Months
6-9
0
0.0
USD
Months
0-12
0
0.0
USD
Months
Hedge Fund
Hedge Funds areSelling! The selling amount has increased 288.14% over the last quarter.
Sold
0-3
Months
0.0
Volume
0
3-6
Months
3.3M
Volume
5
6-9
Months
861.3K
Volume
2
0-12
Months
0.0
Volume
0
Bought
0-3
0
0.0
Volume
Months
3-6
1
49.4K
Volume
Months
6-9
3
391.0K
Volume
Months
0-12
0
0.0
Volume
Months
Congress Trading
Congress are Neutral. There are no significant trading trends over the last month.
Sold
0-3
Months
0.0
USD
0
3-6
Months
0.0
USD
0
6-9
Months
0.0
USD
0
0-12
Months
0.0
USD
0
Bought
0-3
0
0.0
USD
Months
3-6
0
0.0
USD
Months
6-9
0
0.0
USD
Months
0-12
0
0.0
USD
Months

RYTM News & Events

Events Timeline

2025-07-10 (ET)
2025-07-10
06:50:29
Rhythm Pharmaceuticals 2.059M share Spot Secondary priced at $85.00
select
2025-07-10
06:22:59
Rhythm Pharmaceuticals prices 2.06M shares at $85.00 in upsized public offering
select
2025-07-09 (ET)
2025-07-09
16:19:06
Rhythm Pharmaceuticals announces $150M common stock offering
select
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News

9.0
07-13NASDAQ.COM
Rhythm Pharmaceuticals Presents Promising Phase 3 Data on Setmelanotide for Acquired Hypothalamic Obesity at ENDO 2025, Demonstrating Significant BMI Reductions
9.0
07-12Yahoo Finance
Rhythm Pharmaceuticals Presents Data on MC4R Agonists Setmelanotide and Bivamelagon at ENDO 2025
4.0
07-11TipRanks
Top 3 Trending Stocks, According to Analysts – 7/11/2025
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FAQ

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The current price of RYTM is 86.45 USD — it has decreased -0.94 % in the last trading day.

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