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CSTL Overview

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ET
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ET
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Intellectia

Loading chart...

High
24.980
Open
24.710
VWAP
24.37
Vol
175.50K
Mkt Cap
731.26M
Low
24.020
Amount
4.28M
EV/EBITDA(TTM)
--
Total Shares
30.33M
EV
499.46M
EV/OCF(TTM)
10.35
P/S(TTM)
2.14
Castle Biosciences, Inc. is a molecular diagnostics company offering test solutions to aid clinicians in the diagnosis and treatment of dermatologic cancers, Barrett’s esophagus (BE), uveal melanoma (UM), and in the treatment of mental health conditions. The Company offers around six commercially available proprietary multi-analyte assays with algorithmic analysis (MAAA) tests for use in the fields of dermatology, gastroenterology ophthalmology and includes a test to guide systemic treatment decisions in patients with moderate-to-severe AD. It also offers a proprietary pharmacogenomic (PGx) test to guide optimal drug treatment for patients diagnosed with depression, anxiety and other mental health conditions. Its products include DecisionDx-Melanoma, DecisionDx-SCC, MyPath Melanoma, TissueCypher, IDgenetix, and DecisionDx-UM. DecisionDx-SCC is its proprietary gene expression profile (GEP) test for patients with cutaneous squamous cell carcinoma (SCC).
Show More

Events Timeline

(ET)
2026-06-16
07:30:00
Castle Biosciences' TissueCypher Test Orders Exceed 100,000
select
2026-05-06 (ET)
2026-05-06
16:30:00
Castle Biosciences Q1 Revenue $83.7M, Raises 2026 Revenue Guidance to $345M-$355M
select

News

PRnewswire
8.5
06-25PRnewswire
DecisionDx-Melanoma Test Significantly Enhances Risk Assessment
  • Enhanced Test Accuracy: A newly published prospective study demonstrates that DecisionDx-Melanoma's i31-SLNB test significantly outperforms the MIA nomogram in identifying low and high-risk patients, aiding clinicians in making informed decisions regarding sentinel lymph node biopsy (SLNB).
  • Low-Risk Patient Outcomes: The i31-SLNB test reduces the observed sentinel lymph node positivity rate for low-risk patients to 2.6%, well below the NCCN's 5% threshold, indicating its effectiveness in identifying patients who can safely avoid unnecessary surgical risks.
  • High-Risk Patient Identification: Among patients classified as low risk by the i31-SLNB but higher risk by the MIA nomogram, the observed positivity rate was only 2.8%, while the MIA model indicated 11.5%, showcasing the i31-SLNB's superiority in accurately identifying high-risk individuals.
  • Significant Clinical Implications: The study underscores the importance of integrating tumor biology with clinicopathologic features, advancing personalized management for melanoma patients and enhancing survival rates and treatment outcomes.
Newsfilter
9.0
06-25Newsfilter
DecisionDx-Melanoma Test Significantly Enhances SLN Positivity Prediction Accuracy
  • Enhanced Test Accuracy: A newly published prospective study demonstrates that DecisionDx-Melanoma's i31-SLNB test identifies low and high-risk patients with a sentinel lymph node (SLN) positivity rate of 2.6%, significantly below the 5% threshold set by the National Comprehensive Cancer Network (NCCN), indicating its critical value in clinical decision-making.
  • Clinical Application Potential: The i31-SLNB test outperforms the traditional MIA nomogram in assessing SLN positivity risk, which reported a positivity rate of 5.8%, suggesting that i31-SLNB can more effectively assist clinicians in determining which patients may safely avoid SLNB surgery, thereby reducing unnecessary surgical risks.
  • Risk Classification Consistency: The study found that the positivity rate for patients classified as low risk by the i31-SLNB was 2.8%, while the MIA model indicated a rate of 11.5% for the same group, demonstrating the consistency and accuracy of i31-SLNB in risk classification, further supporting its clinical application.
  • Study Scale and Impact: Evaluating 912 patients considering SLNB, the study revealed an AUC of 0.74 for the i31-SLNB test, significantly higher than the MIA model's 0.61, emphasizing the importance of integrating tumor biology with clinicopathologic features to improve risk assessment and management for melanoma patients.
PRnewswire
5.0
06-19PRnewswire
Castle Biosciences Grants Restricted Stock Units to Employees
  • Employee Incentive Program: On June 15, 2026, Castle Biosciences granted 204,925 restricted stock units (RSUs) to 172 employees as an inducement for their employment, highlighting the company's commitment to attracting talent.
  • Grant Details: The RSUs were awarded under the Company's 2022 Inducement Plan in accordance with Nasdaq Listing Rule 5635(c)(4), vesting over four years with 25% vesting on the first anniversary and the remainder in three equal annual installments, ensuring continued employee service.
  • Company Background: Castle Biosciences focuses on diagnostics for dermatologic and gastroenterological diseases, aiming to improve patient care through innovative tests that enhance disease management and patient outcomes, showcasing its leadership in the healthcare sector.
  • Market Impact: By implementing such incentive measures, Castle Biosciences not only boosts employee loyalty and engagement but also enhances its attractiveness and innovative capacity in a highly competitive healthcare market.
Newsfilter
5.0
06-19Newsfilter
Castle Biosciences Grants Restricted Stock Units to Employees
  • Employee Incentive Program: On June 15, 2026, Castle Biosciences granted 204,925 restricted stock units (RSUs) to 172 employees as an inducement for their employment, reflecting the company's commitment to attracting and retaining talent.
  • Grant Details: The RSUs were awarded under the company's 2022 Inducement Plan in accordance with Nasdaq Listing Rule 5635(c)(4), vesting over four years with 25% vesting on the first anniversary and the remainder in three equal annual installments.
  • Long-term Service Commitment: Employees must continue their service through each vesting date to receive the shares, which not only enhances employee retention but also fosters a long-term partnership between the company and its workforce.
  • Strategic Company Development: By implementing this incentive program, Castle Biosciences aims to boost employee motivation and loyalty, thereby driving innovation and competitiveness in the dermatologic and gastroenterological sectors.
PRnewswire
8.5
06-16PRnewswire
Castle Biosciences Surpasses 100,000 TissueCypher Test Orders
  • Order Milestone: Castle Biosciences has surpassed 100,000 clinical test orders for its TissueCypher® Barrett's Esophagus Test, indicating robust growth in the personalized medicine sector and reflecting increasing market demand for precision healthcare solutions.
  • Risk Assessment Capability: The TissueCypher test predicts a patient's five-year risk of progression from Barrett's esophagus to high-grade dysplasia or esophageal adenocarcinoma, enabling clinicians to tailor management strategies based on individual risk profiles, thereby enhancing treatment outcomes for patients.
  • Clinical Validation Support: The test has been studied in biopsies from over 8,000 patients and is backed by more than 17 peer-reviewed publications, demonstrating its unique advantages over traditional histopathological risk assessments and further solidifying Castle Biosciences' leadership in the diagnostics field.
  • Improved Patient Experience: Patient Robin Byrd Wilfong received a low-risk result from TissueCypher, indicating only a 2% chance of progression over five years, which not only alleviated her anxiety but also empowered her to manage her health more effectively, highlighting the test's significance in providing psychological support to patients.
PRnewswire
1.0
05-13PRnewswire
Castle Biosciences to Present at 2026 Jefferies Global Healthcare Conference
  • Conference Presentation: Castle Biosciences is scheduled to present a company overview at the 2026 Jefferies Global Healthcare Conference on June 3 at 1:20 p.m. Eastern time, showcasing its innovative testing solutions aimed at improving health and attracting investor interest.
  • Live Webcast Availability: The presentation will be available via live audio webcast on Castle Biosciences' website, allowing real-time access for attendees, with a replay option provided post-event to ensure that key information reaches all interested investors.
  • Company Background: Castle Biosciences focuses on diagnostics for dermatologic and gastroenterological diseases, developing personalized, clinically actionable solutions that enhance disease management and patient outcomes, highlighting its innovative capabilities and market potential in the healthcare sector.
  • Brand and Products: The company boasts a range of trademarks and products, including the DecisionDx series, underscoring its leadership in molecular testing and personalized medicine, which further solidifies its market share and influence in the diagnostics industry.
Wall Street analysts forecast CSTL stock price to rise
5 Analyst Rating
Wall Street analysts forecast CSTL stock price to rise
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
41.00
Averages
47.20
High
52.00
Current: 0.000
sliders
Low
41.00
Averages
47.20
High
52.00
Roth Capital
Buy
initiated
$40
AI Analysis
2026-06-24
Reason
Roth Capital
Price Target
$40
AI Analysis
2026-06-24
initiated
Buy
Reason
Roth Capital initiated coverage of Castle Biosciences with a Buy rating and $40 price target. The firm believes Castle should be owned for its quality revenue growth outlook over the next five-plus years, and its profit potential over the next 5-10+ years. The company's strong balance sheet and market leading gross margins support a path to sustainable profitability, the analyst tells investors in a research note.
Roth Capital
Buy
initiated
$40
2026-06-24
Reason
Roth Capital
Price Target
$40
2026-06-24
initiated
Buy
Reason
Roth Capital initiated coverage of Castle Biosciences with a Buy rating and $40 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for CSTL
Unlock Now

Valuation Metrics

The current forward P/E ratio for Castle Biosciences Inc (CSTL.O) is 0.00, compared to its 5-year average forward P/E of -14.63. For a more detailed relative valuation and DCF analysis to assess Castle Biosciences Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-14.63
Current PE
0.00
Overvalued PE
-3.53
Undervalued PE
-25.74

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.89
Current EV/EBITDA
-10.09
Overvalued EV/EBITDA
30.35
Undervalued EV/EBITDA
-40.13

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
4.28
Current PS
1.90
Overvalued PS
8.22
Undervalued PS
0.34

Financials

AI Analysis
Annual
Quarterly

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Whales Holding CSTL

S
Summit Partners Public Asset Management, LLC
Holding
CSTL
+43.34%
3M Return
P
Portolan Capital Management, LLC
Holding
CSTL
+32.07%
3M Return
R
RTW Investments, LP
Holding
CSTL
+8.92%
3M Return

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Frequently Asked Questions

What is Castle Biosciences Inc (CSTL) stock price today?

The current price of CSTL is 24.11 USD — it has decreased -2.43

What is Castle Biosciences Inc (CSTL)'s business?

Castle Biosciences, Inc. is a molecular diagnostics company offering test solutions to aid clinicians in the diagnosis and treatment of dermatologic cancers, Barrett’s esophagus (BE), uveal melanoma (UM), and in the treatment of mental health conditions. The Company offers around six commercially available proprietary multi-analyte assays with algorithmic analysis (MAAA) tests for use in the fields of dermatology, gastroenterology ophthalmology and includes a test to guide systemic treatment decisions in patients with moderate-to-severe AD. It also offers a proprietary pharmacogenomic (PGx) test to guide optimal drug treatment for patients diagnosed with depression, anxiety and other mental health conditions. Its products include DecisionDx-Melanoma, DecisionDx-SCC, MyPath Melanoma, TissueCypher, IDgenetix, and DecisionDx-UM. DecisionDx-SCC is its proprietary gene expression profile (GEP) test for patients with cutaneous squamous cell carcinoma (SCC).

What is the price predicton of CSTL Stock?

Wall Street analysts forecast CSTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CSTL is47.20 USD with a low forecast of 41.00 USD and a high forecast of 52.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Castle Biosciences Inc (CSTL)'s revenue for the last quarter?

Castle Biosciences Inc revenue for the last quarter amounts to 83.68M USD, decreased -4.90

What is Castle Biosciences Inc (CSTL)'s earnings per share (EPS) for the last quarter?

Castle Biosciences Inc. EPS for the last quarter amounts to -0.49 USD, decreased -45.56

How many employees does Castle Biosciences Inc (CSTL). have?

Castle Biosciences Inc (CSTL) has 883 emplpoyees as of July 03 2026.

What is Castle Biosciences Inc (CSTL) market cap?

Today CSTL has the market capitalization of 731.26M USD.