Wells Fargo Raises Rating on Septerna (SEPN)
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 15 2025
0mins
Source: NASDAQ.COM
Wells Fargo Upgrade: On November 14, 2025, Wells Fargo upgraded Septerna's outlook from Equal-Weight to Overweight, with an average one-year price target of $23.46/share, indicating a potential 0.69% upside from its recent closing price.
Fund Sentiment: There are currently 186 funds reporting positions in Septerna, reflecting a slight decrease in ownership, while the average portfolio weight dedicated to SEPN has increased by 3.53%.
Institutional Holdings: Key shareholders include Ra Capital Management and Trv Gp V, with no changes in their holdings, while Driehaus Capital Management increased its stake by 4.87% and BVF decreased its holdings by 9.47%.
Market Outlook: The put/call ratio for SEPN stands at 2.57, suggesting a bearish sentiment in the market regarding the stock's future performance.
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Analyst Views on SEPN
Wall Street analysts forecast SEPN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SEPN is 33.14 USD with a low forecast of 25.00 USD and a high forecast of 43.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 23.800
Low
25.00
Averages
33.14
High
43.00
Current: 23.800
Low
25.00
Averages
33.14
High
43.00
About SEPN
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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