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MPLT Overview

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ET
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0.000
0.000(0.000%)
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ET
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Intellectia

Loading chart...

High
37.265
Open
35.050
VWAP
36.21
Vol
588.35K
Mkt Cap
1.68B
Low
34.310
Amount
21.30M
EV/EBITDA(TTM)
--
Total Shares
45.35M
EV
1.28B
EV/OCF(TTM)
--
P/S(TTM)
--
MapLight Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on improving the lives of patients suffering from debilitating central nervous system disorders (CNS). Its lead product candidate, ML-007C-MA, is a fixed-dose combination of an M1/M4 muscarinic agonist, ML-007, co-formulated with a peripherally acting anticholinergic (PAC), which it is initially developing for the treatment of schizophrenia and Alzheimer’s disease psychosis (ADP). ML-007C-MA is designed to activate both M1 and M4 muscarinic receptors in the CNS to drive efficacy, while synchronizing the pharmacokinetics of the agonist and antagonist components to mitigate peripheral cholinergic side effects. Its second product candidate, ML-004, is a 5-HT1B/1D agonist that the Company is developing for the treatment of social communication deficit and/or irritability in autism spectrum disorder. It is also advancing two preclinical programs, ML-021 and ML-009.
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Events Timeline

(ET)
2026-06-22
07:30:00
MapLight Therapeutics Announces ML-004 Autism Study Results
select
2026-05-21 (ET)
2026-05-21
16:30:00
Nasdaq Rises on Nvidia Earnings Report
select
2026-05-21
12:00:00
Nasdaq Declines as Nvidia Announces $80B Buyback
select

News

NASDAQ.COM
8.5
06-26NASDAQ.COM
Biotech Sector Update: FDA and EU Approvals
  • FDA Drug Approval: Ionis Pharmaceuticals' TRYNGOLZA received FDA approval as an adjunct therapy for severe hypertriglyceridemia, with Phase 3 studies showing up to a 72% reduction in triglycerides, significantly improving patient health and expected to drive revenue growth.
  • EU Therapy Approval: Merck's Keytruda in combination with Padcev received European approval for muscle-invasive bladder cancer, with Phase 3 trial data indicating a 60% improvement in event-free survival, laying the groundwork for market expansion in Europe.
  • New Treatment Launch: Gilead Sciences' Trodelvy was approved by the FDA as a first-line treatment for metastatic triple-negative breast cancer, demonstrating a 38% reduction in the risk of disease progression or death, projected to boost sales to $1.4 billion in 2025.
  • Strategic Restructuring and Layoffs: ADC Therapeutics announced a 17% workforce reduction, expected to save $10 million annually, aimed at reallocating resources to advance the ZYNLONTA project, although facing $3 million in severance costs in the short term, it is expected to enhance long-term financial health.
seekingalpha
6.0
06-25seekingalpha
Raymond James Initiates Strong Buy Ratings for Tonix and MapLight
  • Strong Buy Ratings: Raymond James has initiated coverage on Tonix Pharmaceuticals (TNXP) and MapLight Therapeutics (MPLT), assigning price targets of $26 and $46 per share respectively, with expectations that upcoming catalysts will drive stock price increases.
  • FDA Meeting Outlook: Analyst Tiago Fauth noted that Tonix is set to meet with the FDA in Q3 2026 to discuss the Phase 2 trial design for its Lyme disease candidate TNX-4800, which could serve as an adoption-friendly seasonal prevention option for motivated risk groups, enhancing its market competitiveness.
  • Commercial Update Anticipation: Fauth expects Tonix to release its first commercial update on Tonmya in Q2 2026, which is the first FDA-approved fibromyalgia therapy in over 15 years, projecting peak sales of $400M to $500M, thereby providing a supportive floor for TNXP shares.
  • MapLight Catalyst: MapLight's ML-007C-MA, targeting schizophrenia and Alzheimer's disease psychosis, is expected to have its mid-stage trial results released in mid-August, with the analyst suggesting that this readout is skewed to the upside and could emerge as a significant value driver for the company.
Newsfilter
5.0
06-24Newsfilter
MapLight Therapeutics Appoints New Board Members
  • New Board Members: MapLight Therapeutics elected Martin Babler and Troy Cox to its Board of Directors during the Annual Meeting on June 23, 2026, succeeding Robert Malenka and Jim Trenkle, indicating ongoing governance enhancements within the company.
  • Committee Appointments: Babler joins the Audit Committee while Cox becomes Chair of the Nominating and Corporate Governance Committee, with their extensive biotechnology experience poised to support the company's strategic execution in developing therapies for CNS disorders.
  • Rich Leadership Background: Babler has served as CEO of Alumis Inc. and held key positions at Principia Biopharma and Genentech, while Cox has executive experience at Foundation Medicine and Genentech, enhancing MapLight's competitive edge in the biopharmaceutical sector.
  • Company Vision: MapLight focuses on developing innovative therapies for CNS disorders, aiming to fill existing pharmacotherapy gaps, and its discovery platform is expected to drive clinical advancements that improve patient quality of life.
NASDAQ.COM
9.0
06-22NASDAQ.COM
MapLight's Autism Drug Trial Fails to Meet Primary Endpoint
  • Trial Outcome Disappointment: MapLight Therapeutics' IRIS Phase 2 trial failed to meet its primary endpoint regarding social communication deficits in autism spectrum disorder, as the study of 161 participants did not show improvement in caregiver-reported scores over 12 weeks, indicating the need for further validation of the drug's efficacy in this area.
  • Subgroup Analysis Shows Improvement: Despite the overall disappointing results, ML-004 demonstrated clinically meaningful improvement over placebo in adolescents (ages 12-17) with moderate or greater baseline irritability, suggesting potential efficacy in specific populations.
  • Good Safety Profile: ML-004 was generally well-tolerated in the active treatment group, with no severe or serious adverse events reported, highlighting the drug's safety advantage and providing a foundation for future clinical development.
  • FDA Follow-Up Plans: The company plans to engage with the U.S. FDA for an End-of-Phase 2 meeting after a full data review, exploring future clinical development pathways, indicating that despite the trial's failure to meet its primary endpoint, there may still be opportunities for development in targeted populations.
Yahoo Finance
6.5
05-30Yahoo Finance
FCPM III Reduces Stake in Dyne Therapeutics by $14 Million
  • Stake Reduction Details: On May 15, 2026, FCPM III Services B.V. sold 818,460 shares of Dyne Therapeutics, valued at approximately $14.11 million, indicating that despite the reduction, the fund maintains a significant position of 11.8% in the company.
  • Market Performance Analysis: As of May 14, 2026, Dyne Therapeutics shares were priced at $18.28, reflecting a 56% increase over the past year, outperforming the S&P 500 by 28 percentage points, showcasing the company's robust growth potential in the biotechnology sector.
  • R&D Progress Update: Dyne recently submitted a Biologics License Application to the FDA for its lead drug z-rostudirsen, targeting a potential U.S. launch in Q1 2027 if accelerated approval is granted, marking a significant milestone in muscle disease treatment.
  • Investor Considerations: Despite the stake reduction, Dyne remains FCPM's second-largest holding, reflecting the fund's confidence in the company's future, particularly at a pivotal moment for translating clinical data into commercial success.
CNBC
6.0
05-27CNBC
Wall Street's Latest Rating Changes Overview
  • Openlane Upgrade: JPMorgan upgraded Openlane from neutral to overweight and raised its December 2026 price target to $38, indicating that the online used car marketplace is experiencing robust growth and has potential for sustainable expansion over the coming years.
  • Dollar General Downgrade: Deutsche Bank downgraded Dollar General from buy to hold, citing challenges in its customer base and the widening gap in the K-shaped economy, which may limit same-store sales upside, reflecting a cautious outlook on the company.
  • Ecolab Upgrade: UBS upgraded Ecolab from neutral to buy and raised its price target to $325, demonstrating strong demand and positive performance expectations for the chemicals company amid a favorable market environment.
  • FedEx Upgrade: JPMorgan upgraded FedEx from neutral to overweight, expressing optimism ahead of its upcoming earnings report, particularly regarding the separation of its freight business, which is seen as an attractive risk-reward opportunity.
Wall Street analysts forecast MPLT stock price to rise
4 Analyst Rating
Wall Street analysts forecast MPLT stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
28.00
Averages
31.00
High
34.00
Current: 0.000
sliders
Low
28.00
Averages
31.00
High
34.00
Raymond James
Strong Buy
initiated
$46
AI Analysis
2026-06-24
Reason
Raymond James
Price Target
$46
AI Analysis
2026-06-24
initiated
Strong Buy
Reason
Raymond James initiated coverage of MapLight Therapeutics with a Strong Buy rating and $46 price target. Cobenfy marks the first major mechanistic innovation in schizophrenia treatment in over three decades, but it "suffers from a persistence problem," says the analyst, who believes the risk/reward into ML-007C-MA's Phase 2 ZEPHYR readout by mid-August is "skewed to the upside." While adding that the "Street has a tendency to dismiss anything Alzheimer's-related," the analyst argues that MapLight's Alzheimer's disease psychosis program is "under-the-radar" and "could emerge as a real value driver."
Craig-Hallum
Buy
downgrade
$43 -> $40
2026-06-23
Reason
Craig-Hallum
Price Target
$43 -> $40
2026-06-23
downgrade
Buy
Reason
Craig-Hallum lowered the firm's price target on MapLight Therapeutics to $40 from $43 and keeps a Buy rating on the shares. MapLight's ML-004 Phase 2 IRIS results were mixed but not thesis-breaking, with the firm noting a missed primary endpoint in social communication but a meaningful benefit in a defined adolescent subgroup for irritability with better tolerability than existing antipsychotics, the analyst tells investors in a research note.
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Valuation Metrics

The current forward P/E ratio for MapLight Therapeutics Inc (MPLT.O) is 0.00, compared to its 5-year average forward P/E of -4.45. For a more detailed relative valuation and DCF analysis to assess MapLight Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-4.45
Current PE
0.00
Overvalued PE
-3.79
Undervalued PE
-5.11

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.14
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-4.52
Undervalued EV/EBITDA
-5.76

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
Annual
Quarterly

Whales Holding MPLT

N
Novo Holdings A/S
Holding
MPLT
+32.46%
3M Return

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Frequently Asked Questions

What is MapLight Therapeutics Inc (MPLT) stock price today?

The current price of MPLT is 37.06 USD — it has increased 5.76

What is MapLight Therapeutics Inc (MPLT)'s business?

MapLight Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on improving the lives of patients suffering from debilitating central nervous system disorders (CNS). Its lead product candidate, ML-007C-MA, is a fixed-dose combination of an M1/M4 muscarinic agonist, ML-007, co-formulated with a peripherally acting anticholinergic (PAC), which it is initially developing for the treatment of schizophrenia and Alzheimer’s disease psychosis (ADP). ML-007C-MA is designed to activate both M1 and M4 muscarinic receptors in the CNS to drive efficacy, while synchronizing the pharmacokinetics of the agonist and antagonist components to mitigate peripheral cholinergic side effects. Its second product candidate, ML-004, is a 5-HT1B/1D agonist that the Company is developing for the treatment of social communication deficit and/or irritability in autism spectrum disorder. It is also advancing two preclinical programs, ML-021 and ML-009.

What is the price predicton of MPLT Stock?

Wall Street analysts forecast MPLT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MPLT is31.00 USD with a low forecast of 28.00 USD and a high forecast of 34.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is MapLight Therapeutics Inc (MPLT)'s revenue for the last quarter?

MapLight Therapeutics Inc revenue for the last quarter amounts to -64.50M USD, decreased

What is MapLight Therapeutics Inc (MPLT)'s earnings per share (EPS) for the last quarter?

MapLight Therapeutics Inc. EPS for the last quarter amounts to -51202000.00 USD, decreased

How many employees does MapLight Therapeutics Inc (MPLT). have?

MapLight Therapeutics Inc (MPLT) has 133 emplpoyees as of July 08 2026.

What is MapLight Therapeutics Inc (MPLT) market cap?

Today MPLT has the market capitalization of 1.68B USD.