Loading...

Intellectia LogoIntellectia
AI Trading Bot
Features
Markets
News
Resources
Pricing
  1. Home
  2. Stock
  3. SEPN
SEPN logo

SEPN Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
an image of Intellectia Logoan image of Intellectia

Most Trusted AI Platform for Winning Trades

TwitterYoutubeQuoraDiscordLinkedinTelegram

Copyright © 2026 Intellectia.AI. All Rights Reserved.

Company

  • Home
  • Contact
  • About Us
  • Press
  • Privacy
  • Terms of Service
  • Service Terms of Use

Resources

  • Blog
  • Tutorial
  • Help Center
  • Affiliate Program

Markets

  • Market Analysis
  • Crypto
  • Featured Screeners
  • AI Earnings Calendar
  • Market Movers
  • Stock Monitor
  • Economic Calendar
  • All US Stocks
  • All Cryptos

Tools

  • Dividend Calculator
  • Dividend Yield Calculator
  • Options Profit Calculator

Features

  • QuantAI Alpha Pick
  • SwingMax Portfolio
  • Swing Trading
  • AI Stock Picker
  • Whales Auto Tracker
  • Daytrading Center
  • Patterns Detection
  • AI Screener
  • Financial AI Agent
  • Backtesting Playground
  • AI Earnings Prediction
  • Stock Monitor
  • Technical Analysis

News

  • Overview
  • Top News
  • Daily Market Brief
  • Earnings Analysis
  • Newswire
  • Stock News
  • Crypto News
  • Institution News
  • Congress News
  • Monitor News

Compare

  • TradingView
  • SeekingAlpha
Intellectia

Loading chart...

High
25.720
Open
25.150
VWAP
25.01
Vol
212.22K
Mkt Cap
1.13B
Low
24.140
Amount
5.31M
EV/EBITDA(TTM)
--
Total Shares
44.91M
EV
737.86M
EV/OCF(TTM)
6.70
P/S(TTM)
24.39
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Show More

Events Timeline

(ET)
2026-03-10
16:40:00
Septerna Files Automatic Mixed Securities Shelf
select
2026-03-09 (ET)
2026-03-09
16:40:00
Septerna Reports Q4 Revenue of $24.12M
select
2026-03-01 (ET)
2026-03-01
11:30:00
Septerna Announces Positive Results for SEP-631 Clinical Trial
select
2026-01-08 (ET)
2026-01-08
16:20:00
Septerna Appoints Mark Wilson as Chief Legal Officer
select

News

seekingalpha
9.5
03-09seekingalpha
Septerna, Inc. Q4 Earnings Exceed Expectations
  • Strong Earnings Report: Septerna, Inc. reported a Q4 GAAP EPS of -$0.24, beating expectations by $0.02, indicating an improvement in financial performance despite still being in a loss position.
  • Significant Revenue Growth: The company achieved Q4 revenue of $24.1 million, soaring 11950% year-over-year and exceeding market expectations by $8.54 million, demonstrating robust demand and rapid growth potential for its products or services.
  • Positive Future Outlook: With the Phase 1 readout of SEP-631 approaching, Septerna anticipates a key market driver in 2026, which could further boost the company's stock price and market recognition.
  • Quant Rating Improvement: Seeking Alpha's quant rating on Septerna, Inc. reflects growing market confidence in its future performance, indicating investor recognition of the company's strategic direction and growth potential.
NASDAQ.COM
9.0
03-02NASDAQ.COM
Septerna Reports Positive Phase 1 Results for SEP-631 in Mast Cell-Driven Diseases
  • Clinical Trial Success: Septerna's SEP-631 demonstrated good tolerability and pharmacokinetic characteristics in its Phase 1 clinical trial for mast cell-driven diseases, supporting once-daily oral dosing with a half-life of 24 hours, indicating its potential for treating chronic spontaneous urticaria and other conditions.
  • Efficacy Validation: At a dose of 10 mg, SEP-631 showed significant suppression of skin wheal formation, with nearly complete inhibition observed at 90 mg and 200 mg doses, demonstrating a dose-dependent response that further validates its application in mast cell-driven diseases.
  • Follow-Up Research Plans: Based on the positive Phase 1 results, Septerna plans to initiate a Phase 2b clinical trial for chronic spontaneous urticaria in the second half of 2023, aiming to evaluate the efficacy of SEP-631 in adult patients who remain symptomatic despite treatment with second-generation antihistamines.
  • Multiple Indication Exploration: In addition to chronic spontaneous urticaria, Septerna is also exploring the efficacy of SEP-631 in other mast cell-driven diseases, including atopic dermatitis, interstitial cystitis, migraine, and asthma, showcasing its broad market potential.
Newsfilter
9.0
03-01Newsfilter
Positive Phase 1 Results for SEP-631 in Chronic Urticaria
  • Successful Clinical Trial: SEP-631 demonstrated favorable tolerability in a Phase 1 trial with healthy volunteers, showing no severe adverse events and a safety profile comparable to placebo, indicating its potential as an oral treatment option.
  • Dose-Dependent Inhibition: Complete inhibition of icatibant-induced skin wheal formation was observed at a dose as low as 10 mg, with stronger suppression at higher doses, highlighting its effectiveness in treating mast cell-driven diseases.
  • Phase 2 Development Plan: The company plans to initiate a Phase 2b clinical trial for chronic spontaneous urticaria in the second half of 2026, aiming to evaluate the efficacy of SEP-631 in patients with moderate-to-severe symptoms, thereby expanding its market application.
  • Exploration of Multiple Indications: Beyond urticaria, Septerna is assessing the treatment potential of SEP-631 in other mast cell-driven diseases, including atopic dermatitis and asthma, showcasing the broad applicability of its product.
Benzinga
8.5
02-02Benzinga
Brookfield to Acquire Peakstone Realty Trust for $1.2 Billion
  • Market Surge: U.S. stocks rose significantly on Monday, with the Dow Jones index gaining over 350 points, indicating strong investor confidence and potentially attracting more capital into the market.
  • Peakstone Realty Trust Price Surge: Shares of Peakstone Realty Trust soared 32.5% to $20.70 on Friday, reflecting positive market sentiment regarding the company's future prospects and the anticipated benefits of the acquisition.
  • Acquisition Announcement: Brookfield announced plans to acquire Peakstone Realty Trust in a $1.2 billion all-cash deal, which not only enhances Brookfield's asset portfolio but also signals its strategic intent to expand further in the real estate sector.
  • Positive Market Reaction: Following the acquisition news, Peakstone Realty Trust's stock price surged, indicating strong investor confidence in the deal and potentially attracting additional investment into the company.
renaissancecapital
8.5
01-09renaissancecapital
Aktis Oncology Launches $200 Million IPO with $100 Million Investment from Eli Lilly
  • IPO Market Recovery: Aktis Oncology launched a $200 million IPO on Monday, indicating a resurgence in the biotech IPO market after a period of uneven performance, and is set to be the first significant IPO of 2026.
  • Increased Financing Size: Just two days after the IPO launch, Aktis upsized the deal by 50%, which not only reflects growing investor confidence in its prospects but also indicates a rising interest in the biotech sector.
  • Strategic Partnership Support: Aktis disclosed a $100 million investment from partner Eli Lilly, which will provide robust support for the company's R&D and market expansion, further strengthening its position in the competitive biotech landscape.
  • Optimistic Market Outlook: As the first major biotech IPO of 2026, Aktis's success could attract more investor attention to the biotech sector, potentially driving recovery and growth across the industry.
Globenewswire
5.0
01-08Globenewswire
Septerna Appoints Mark A. Wilson as Chief Legal Officer to Enhance Governance
  • Executive Appointment: Septerna has appointed Mark A. Wilson as Chief Legal Officer, leveraging his over 25 years of experience in intellectual property and corporate law to enhance the company's governance framework and maximize the value of its proprietary Native Complex Platform™.
  • Strategic Importance: Wilson's previous role at Nektar Therapeutics, where he led global development and commercialization collaborations, equips him to effectively execute Septerna's long-term drug development strategy.
  • Industry Context: As a clinical-stage biotechnology company focused on G protein-coupled receptor (GPCR) drug discovery, Wilson's expertise will further drive innovation and development in this critical area.
  • Talent Acquisition: With a Bachelor of Science in Pharmacy and a Juris Doctor degree, and being registered with the U.S. Patent and Trademark Office, Wilson's addition will enhance Septerna's legal and intellectual property management capabilities.
Wall Street analysts forecast SEPN stock price to rise
8 Analyst Rating
Wall Street analysts forecast SEPN stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
33.14
High
43.00
Current: 0.000
sliders
Low
25.00
Averages
33.14
High
43.00
Truist
Srikripa Devarakonda
Buy
maintain
$34 -> $35
AI Analysis
2026-03-11
Reason
Truist
Srikripa Devarakonda
Price Target
$34 -> $35
AI Analysis
2026-03-11
maintain
Buy
Reason
Truist analyst Srikripa Devarakonda raised the firm's price target on Septerna to $35 from $34 and keeps a Buy rating on the shares. The firm is incrementally positive on the company after its Q4 update, where clinical trial timelines remain on track, the analyst tells investors in a research note.
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$35 -> $40
2026-03-02
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$35 -> $40
2026-03-02
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Septerna to $40 from $35 and keeps a Buy rating on the shares after the company presented data from the Phase 1 trial of SEP-631 for the treatment of chronic spontaneous urticaria and other mast cell-driven diseases. The firm's raised target reflects an increase in its view of the probability of approval for SEP-631 to 35% from the prior 30% given the positive Phase 1 data.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SEPN
Unlock Now

Valuation Metrics

The current forward P/E ratio for Septerna Inc (SEPN.O) is -100.58, compared to its 5-year average forward P/E of -22.69. For a more detailed relative valuation and DCF analysis to assess Septerna Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-22.69
Current PE
-100.58
Overvalued PE
10.05
Undervalued PE
-55.42

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.28
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
2.25
Undervalued EV/EBITDA
-4.82

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
137.01
Current PS
14.99
Overvalued PS
436.97
Undervalued PS
-162.94

Financials

AI Analysis
Annual
Quarterly

Related Community Screener

best short term day trading stock
Intellectia · 3787 candidates
Price: $1.00 - $200.00List Exchange: XNYS, XNAS, XASEMonthly Average Dollar Volume: >= 100,000
Ticker
Name
Market Cap$
top bottom
ZNTL logo
ZNTL
Zentalis Pharmaceuticals Inc
210.44M
LAMR logo
LAMR
Lamar Advertising Co
13.37B
REI logo
REI
Ring Energy Inc
203.08M
SSTK logo
SSTK
Shutterstock Inc
674.53M
AHCO logo
AHCO
Adapthealth Corp
1.42B
CRH logo
CRH
CRH PLC
80.90B

Whales Holding SEPN

A
Artal Group S.A.
Holding
SEPN
+16.11%
3M Return
D
Driehaus Capital Management LLC
Holding
SEPN
+13.27%
3M Return
V
VR Management, LLC
Holding
SEPN
+11.72%
3M Return
B
BVF Partners L.P.
Holding
SEPN
+7.51%
3M Return
R
RA Capital Management, L.P.
Holding
SEPN
+3.15%
3M Return
S
Soleus Capital Management, L.P.
Holding
SEPN
-0.49%
3M Return

Trading Trends

    Insider
    Hedge Fund
    Congress Trading

People Also Watch

Frequently Asked Questions

What is Septerna Inc (SEPN) stock price today?

The current price of SEPN is 25.17 USD — it has increased 0.12

What is Septerna Inc (SEPN)'s business?

Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.

What is the price predicton of SEPN Stock?

Wall Street analysts forecast SEPN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SEPN is33.14 USD with a low forecast of 25.00 USD and a high forecast of 43.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Septerna Inc (SEPN)'s revenue for the last quarter?

Septerna Inc revenue for the last quarter amounts to 24.12M USD, increased 11276.42

What is Septerna Inc (SEPN)'s earnings per share (EPS) for the last quarter?

Septerna Inc. EPS for the last quarter amounts to -0.24 USD, decreased -61.90

How many employees does Septerna Inc (SEPN). have?

Septerna Inc (SEPN) has 130 emplpoyees as of March 18 2026.

What is Septerna Inc (SEPN) market cap?

Today SEPN has the market capitalization of 1.13B USD.