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SEPN Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
28.805
Open
27.620
VWAP
27.35
Vol
573.81K
Mkt Cap
1.21B
Low
26.280
Amount
15.69M
EV/EBITDA(TTM)
--
Total Shares
45.08M
EV
867.38M
EV/OCF(TTM)
8.04
P/S(TTM)
16.70
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Show More

Events Timeline

(ET)
2026-05-11
16:10:00
Septerna Reports Q1 Revenue of $26.52M, Exceeding Expectations
select
2026-04-13 (ET)
2026-04-13
08:10:00
Septerna Doses First Participants in SEP-479 Clinical Trial
select
2026-03-10 (ET)
2026-03-10
16:40:00
Septerna Files Automatic Mixed Securities Shelf
select
2026-03-09 (ET)
2026-03-09
16:40:00
Septerna Reports Q4 Revenue of $24.12M
select
2026-03-01 (ET)
2026-03-01
11:30:00
Septerna Announces Positive Results for SEP-631 Clinical Trial
select

News

seekingalpha
9.5
05-12seekingalpha
Septerna, Inc. Q1 Earnings Exceed Expectations
  • Strong Earnings Report: Septerna, Inc. reported a Q1 GAAP EPS of -$0.19, beating expectations by $0.25, indicating an improvement in profitability despite still being in the red.
  • Significant Revenue Growth: The company achieved Q1 revenue of $26.52M, exceeding market expectations by $11.43M, reflecting strong market demand for its products or services, which could drive future growth.
  • Robust Cash Reserves: As of March 31, 2026, Septerna reported cash, cash equivalents, and marketable securities totaling $522.1M, ensuring sufficient operational funding for the coming years, with expectations to last at least until 2029.
  • Positive Future Outlook: With the Phase 1 readout of SEP-631, Septerna anticipates a new growth catalyst in 2026, further solidifying its market position in the biopharmaceutical sector.
CNBC
6.0
05-01CNBC
Latest Wall Street Rating Updates
  • Apple's Positive Outlook: Bank of America reiterates a buy rating on Apple, forecasting that iPhone revenues will exceed expectations in 2026 due to record upgraders and strong gross margins despite commodity pressures, indicating sustained competitiveness in the smartphone market.
  • Roblox Demand Slowdown: Bank of America downgrades Roblox to neutral, citing a significant decline in platform demand; while acknowledging its ability to compress development costs, the uncertainty around the timeline for demand recovery may impact its market performance.
  • CoreWeave Growth Potential: Citi reiterates CoreWeave as a buy, raising its price target from $126 to $155, estimating a quarterly growth of 35-40% in AI infrastructure, showcasing strong performance across a diversified customer base.
  • Hershey's Positive Outlook: TD Cowen upgrades Hershey to buy, expressing confidence that the company will raise its 2026 guidance and return to volume growth in 2027, reflecting strong recovery potential in the confectionery market.
CNBC
5.0
04-22CNBC
Trump Extends Ceasefire with Iran Amid Market Volatility
  • Ceasefire Extension: President Trump announced the extension of the ceasefire with Iran, originally set to expire today, until Tehran presents a 'unified proposal,' aiming to ease tensions in the Middle East, which could impact global oil prices.
  • Boeing Earnings Beat: Boeing reported a smaller-than-expected loss per share in Q1 and exceeded revenue expectations, leading to a more than 3% rise in its stock price, indicating a gradual recovery in a challenging aviation market that may boost investor confidence.
  • Fed Nominee Scrutiny: Kevin Warsh, Trump's nominee for Federal Reserve Chair, faced tough questions during his confirmation hearing regarding his independence and financial background, despite asserting he wouldn't lower interest rates solely at Trump's request, potentially affecting market expectations for Fed policy.
  • Best Buy's New CEO: Best Buy announced that insider Jason Bonfig will succeed CEO Corie Barry on October 31, tasked with driving sales amid a lukewarm market while the company seeks to enhance its presence in the artificial intelligence product sector.
Newsfilter
8.5
04-22Newsfilter
Trump Extends Ceasefire with Iran Amid Market Volatility
  • Ceasefire Extension: Trump announced the extension of the ceasefire with Iran, originally set to expire today, now lasting until Tehran provides a 'unified proposal', aiming to alleviate market concerns over geopolitical risks, which could positively impact oil prices and stock markets.
  • Boeing Stock Surge: Boeing shares rose over 3% this morning after the company reported a smaller-than-expected loss per share and exceeded revenue expectations in Q1, demonstrating resilience during tough times, with the CEO set to discuss results on CNBC today, further boosting market confidence.
  • Fed Nominee Scrutiny: Kevin Warsh, Trump's nominee for the Federal Reserve chair, faced tough questions during his confirmation hearing, asserting he wouldn't lower interest rates at Trump's request, raising concerns about his independence and financial background, which may influence market expectations for future monetary policy.
  • Amazon Enters GLP-1 Market: Amazon's primary care arm launched a new program to ease access to weight-loss drugs, enhancing its competitiveness in the healthcare sector while potentially boosting the market performance of related stocks, reflecting the company's strategic expansion into pharmaceuticals.
CNBC
7.5
04-21CNBC
Amazon Launches GLP-1 Management Program to Transform Weight Loss Treatment
  • Market Expansion: Amazon is launching a new GLP-1 management program through its primary care arm, Amazon One Medical, aiming to integrate obesity treatment into routine care, which is expected to significantly enhance patient adherence to long-term weight management.
  • Transparent Pricing: The program offers insured pricing starting as low as $25 per month, while cash-paying patients will find oral medications starting at $149 per month and injectable treatments like Wegovy at $299, positioning Amazon competitively in the market despite similar pricing.
  • Convenient Services: Amazon Pharmacy will provide on-demand prescription renewals, starting at $29 for message consultations and $49 for video care, which is likely to attract more customers and enhance loyalty and market share.
  • Logistical Advantage: Amazon plans to expand its same-day drug delivery service to 4,500 cities by the end of 2026, leveraging its robust logistics network and consumer reach to solidify its position within the healthcare system.
Newsfilter
8.5
04-21Newsfilter
Amazon Launches GLP-1 Weight Loss Program
  • Increased Market Competition: Amazon's launch of the GLP-1 management program through One Medical integrates obesity treatment with routine care, likely pressuring shares of companies like Hims & Hers Health and Viking Therapeutics, which fell following the announcement.
  • Transparent Pricing: The pricing for GLP-1 medications will start as low as $25 per month for insured patients, aiming to attract more customers by simplifying access to medications and enhancing market share.
  • Convenient Drug Delivery: Amazon plans to expand same-day drug delivery to 4,500 cities by the end of 2026, leveraging its robust logistics network to improve customer experience and gain an edge in the competitive weight loss drug market.
  • Diverse Treatment Options: Through Amazon Pharmacy, patients can access various GLP-1 medications, including Novo Nordisk's Wegovy and Eli Lilly's Zepbound, further driving the company's expansion into the healthcare sector.
Wall Street analysts forecast SEPN stock price to rise
8 Analyst Rating
Wall Street analysts forecast SEPN stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
33.14
High
43.00
Current: 0.000
sliders
Low
25.00
Averages
33.14
High
43.00
Stifel
Alex Thompson
Buy
initiated
$43
AI Analysis
2026-04-30
Reason
Stifel
Alex Thompson
Price Target
$43
AI Analysis
2026-04-30
initiated
Buy
Reason
Stifel analyst Alex Thompson initiated coverage of Septerna with a Buy rating and $43 price target. The firm is bullish on Septerna's G protein-coupled receptors drug discovery platform. The company's lead program SEP-479 offers a potentially first-in-class oral in the hypoparathyroidism market where there is "significantly more room to grow within the large rare disease," the analyst tells investors in a research note. Stifel believes Septerna's pipeline "represents a diversified play within two of the largest therapeutics verticals."
JPMorgan
NULL -> Overweight
upgrade
$34 -> $38
2026-03-24
Reason
JPMorgan
Price Target
$34 -> $38
2026-03-24
upgrade
NULL -> Overweight
Reason
JPMorgan raised the firm's price target on Septerna to $38 from $34 and keeps an Overweight rating on the shares. The firm updated the company's model post the Q4 report.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SEPN
Unlock Now

Valuation Metrics

The current forward P/E ratio for Septerna Inc (SEPN.O) is 107.53, compared to its 5-year average forward P/E of 10.57. For a more detailed relative valuation and DCF analysis to assess Septerna Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
10.57
Current PE
107.53
Overvalued PE
75.63
Undervalued PE
-54.50

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.52
Current EV/EBITDA
-41.81
Overvalued EV/EBITDA
3.09
Undervalued EV/EBITDA
-12.12

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
108.44
Current PS
20.66
Overvalued PS
375.06
Undervalued PS
-158.19

Financials

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Whales Holding SEPN

A
Artal Group S.A.
Holding
SEPN
+17.91%
3M Return
A
Avoro Capital Advisors LLC
Holding
SEPN
+17.33%
3M Return
V
VR Management, LLC
Holding
SEPN
+17.27%
3M Return
D
Driehaus Capital Management LLC
Holding
SEPN
+13.54%
3M Return
S
Soleus Capital Management, L.P.
Holding
SEPN
+6.19%
3M Return
B
BVF Partners L.P.
Holding
SEPN
+2.83%
3M Return

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Frequently Asked Questions

What is Septerna Inc (SEPN) stock price today?

The current price of SEPN is 26.95 USD — it has decreased -4.84

What is Septerna Inc (SEPN)'s business?

Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.

What is the price predicton of SEPN Stock?

Wall Street analysts forecast SEPN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SEPN is33.14 USD with a low forecast of 25.00 USD and a high forecast of 43.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Septerna Inc (SEPN)'s revenue for the last quarter?

Septerna Inc revenue for the last quarter amounts to 26.52M USD, increased 12010.96

What is Septerna Inc (SEPN)'s earnings per share (EPS) for the last quarter?

Septerna Inc. EPS for the last quarter amounts to -0.19 USD, decreased -61.22

How many employees does Septerna Inc (SEPN). have?

Septerna Inc (SEPN) has 130 emplpoyees as of May 18 2026.

What is Septerna Inc (SEPN) market cap?

Today SEPN has the market capitalization of 1.21B USD.