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ZNTL Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
4.750
Open
4.530
VWAP
4.24
Vol
2.37M
Mkt Cap
329.12M
Low
3.935
Amount
10.04M
EV/EBITDA(TTM)
--
Total Shares
70.93M
EV
83.23M
EV/OCF(TTM)
--
P/S(TTM)
--
Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.
Show More

Events Timeline

(ET)
2026-04-17
15:30:00
Zentalis Presents Azenosertib Data at AACR Meeting
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2026-04-10 (ET)
2026-04-10
16:10:00
S&P 500 Closes Slightly Lower on Friday Amid Oil Volatility
select
2026-04-10
12:00:00
Dow Jones Falls, Nasdaq Rises as Markets Mixed
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2026-01-06 (ET)
2026-01-06
08:10:00
Zentalis Pharmaceuticals Announces 2026 Milestones for Azenosertib Development
select
2025-11-10 (ET)
2025-11-10
16:27:19
Zentalis Announces Q3 Earnings Per Share of 37 Cents, Below Consensus Estimate of 48 Cents
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2025-09-24 (ET)
2025-09-24
15:35:12
Zentalis Board Member Letai Emerges as Top Candidate for NCI Leadership, According to STAT
select
link
2025-08-26 (ET)
2025-08-26
16:09:52
Zentalis Announces Departure of CLO Andrea Paul, James Bucher to Take Over
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News

Newsfilter
8.5
04-17Newsfilter
Zentalis Unveils New Data, Paving New Directions in Cancer Treatment
  • Preclinical Data Highlights: Zentalis presented preclinical data at the AACR meeting showing that combinations of azenosertib with antibody-drug conjugates can induce complete tumor responses in models resistant to ADCs, indicating potential applications beyond ovarian cancer and opening new avenues for pipeline expansion.
  • Significant Preclinical Efficacy: In a model resistant to the approved TOPO1i ADC, the combination of azenosertib and enfortumab vedotin achieved complete responses in 87.5% of mice, effectively preventing tumor progression even after treatment cessation, showcasing its potential in treating resistant tumors.
  • Real-World Data Validation: The real-world data presented at AACR highlight that Cyclin E1-positive ovarian cancer patients face significantly worse clinical outcomes with standard therapies, underscoring the importance of azenosertib for this population and potentially supporting the upcoming DENALI and ASPENOVA studies.
  • Strong Market Demand: Cyclin E1-positive patients had an average time to next treatment of 13.2 months post-first-line therapy, significantly lower than the 19.5 months for Cyclin E1-negative patients, emphasizing the urgent need for targeted therapies in this specific population and driving the clinical development of azenosertib.
stocktwits
9.0
04-10stocktwits
Zentalis Selects 400 mg Dose for Ovarian Cancer Treatment
  • Dose Selection: Zentalis has chosen the 400 mg dose for its ovarian cancer treatment due to its significantly higher response rate compared to the 300 mg dose, enhancing its competitive edge in clinical trials.
  • Trial Progress: The company expects to complete enrollment and report topline results from the DENALI Part 2 trial by the end of 2026, paving the way for potential regulatory approval and further business development.
  • Stock Surge: Following a bullish analyst call, Zentalis's shares soared over 40% on Friday, reaching their highest level since June 2024, reflecting market confidence in the drug's success.
  • Analyst Rating Upgrade: Guggenheim raised Zentalis's price target from $6 to $10, indicating increased confidence in the drug's chances of success in platinum-resistant ovarian cancer, suggesting a potential 56% upside from the current stock price.
Newsfilter
5.0
04-01Newsfilter
Zentalis Grants Stock Options to New Employees
  • Stock Option Grant: On April 1, 2026, Zentalis Pharmaceuticals granted 36,000 non-qualified stock options to two new employees as an inducement for their employment, reflecting the company's commitment to attracting talent.
  • Incentive Plan Context: The stock options were granted under Zentalis' 2022 Employment Inducement Incentive Award Plan, designed to attract individuals who were not previously employed by the company, in accordance with Nasdaq Listing Rule 5635(c)(4).
  • Option Exercise Price: The exercise price of the stock options is set at $2.57 per share, equal to the closing price of Zentalis' common stock on the grant date, ensuring that employee incentives are aligned with market performance.
  • Vesting Arrangement: The options will vest over four years, with 25% vesting on the first anniversary and the remaining 75% vesting in equal monthly installments, ensuring that employees remain with the company to realize their incentives, thereby enhancing retention motivation.
seekingalpha
9.5
03-26seekingalpha
Zentalis Pharmaceuticals Reports FY 2025 Financial Results
  • Financial Performance: Zentalis Pharmaceuticals reported a FY 2025 GAAP EPS of -$1.91, indicating challenges in profitability that could negatively impact investor confidence and stock performance.
  • Cash Position: As of December 31, 2025, the company had $245.9 million in cash, cash equivalents, and marketable securities, which, while providing some liquidity, raises concerns about capital efficiency and future financing needs.
  • Market Reaction Outlook: Given the reported losses, the market may adopt a cautious stance regarding Zentalis's future growth potential, necessitating close monitoring of subsequent strategic adjustments and financial improvement efforts.
  • Competitive Industry Pressure: In the context of increasing competition within the pharmaceutical sector, Zentalis must accelerate its R&D and marketing efforts to enhance product acceptance and profitability.
PRnewswire
8.5
01-12PRnewswire
Oncolytics Biotech Advances Pelareorep for Anal Cancer with 29% Response Rate
  • Clinical Data Breakthrough: Oncolytics Biotech's pelareorep demonstrated a 29% objective response rate in anal cancer during the GOBLET Cohort 4, significantly exceeding the historical benchmark of 10%, indicating its crucial clinical value in a setting with no FDA-approved treatment options.
  • Duration of Response: Among 14 evaluable patients, the median duration of response for pelareorep reached approximately 17 months, far surpassing the standard treatment's 9.5 months, showcasing the drug's durable efficacy in heavily pretreated patients and addressing a critical unmet medical need.
  • FDA Accelerated Approval Plans: Oncolytics plans to hold a Type C meeting with the FDA in Q1 2026 to discuss advancing pelareorep into a registration-directed clinical study, paving the way for potential accelerated approval if the data is validated.
  • Strategic Investment and Expert Support: The company expanded its Scientific Advisory Board by adding three globally recognized experts from Memorial Sloan Kettering Cancer Center and MD Anderson Cancer Center, further strengthening its strategic positioning in the gastrointestinal oncology field.
Newsfilter
8.5
01-12Newsfilter
Oncolytics Biotech Advances Pelareorep for Anal Cancer with 29% Response Rate
  • Clinical Data Breakthrough: Oncolytics Biotech's pelareorep demonstrated a 29% objective response rate in anal cancer patients during the GOBLET Cohort 4 study, significantly surpassing the historical benchmark of 10%, indicating the therapy's substantial potential in a patient population with no FDA-approved options.
  • Duration of Response: The study also revealed a median duration of response of approximately 17 months, far exceeding the standard treatment's 9.5 months, suggesting that pelareorep offers durable efficacy in heavily pretreated patients, addressing a critical unmet medical need.
  • FDA Accelerated Approval Plans: Oncolytics plans to hold a Type C meeting with the FDA in Q1 2026 to discuss advancing pelareorep into a registration-directed clinical study, paving the way for accelerated approval if the observed data can be replicated.
  • Strategic Investment and Expansion: The company is enhancing its strategic positioning in gastrointestinal oncology by expanding its Scientific Advisory Board, further solidifying its market presence in anal cancer and other indications.
Wall Street analysts forecast ZNTL stock price to rise
6 Analyst Rating
Wall Street analysts forecast ZNTL stock price to rise
4 Buy
2 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
4.00
Averages
6.60
High
10.00
Current: 0.000
sliders
Low
4.00
Averages
6.60
High
10.00
Guggenheim
Buy
maintain
$6 -> $10
AI Analysis
2026-04-10
Reason
Guggenheim
Price Target
$6 -> $10
AI Analysis
2026-04-10
maintain
Buy
Reason
Guggenheim raised the firm's price target on Zentalis to $10 from $6 and keeps a Buy rating on the shares, citing increased probability of success assumptions in platinum-resistant ovarian cancer.
Morgan Stanley
Michael Ulz
Equal Weight
downgrade
$8 -> $4
2025-11-11
Reason
Morgan Stanley
Michael Ulz
Price Target
$8 -> $4
2025-11-11
downgrade
Equal Weight
Reason
Morgan Stanley analyst Michael Ulz lowered the firm's price target on Zentalis to $4 from $8 and keeps an Equal Weight rating on the shares after the company reported Q3 earnings and highlighted progress with enrollment ongoing in the DENALI Part 2a study for azenosertib in platinum resistant ovarian cancer. The firm has fine tuned its azenosertib revenue estimates, having increased its PROC revenue estimate, removed revenues from non-gynecological indications and decreased its peak sales estimate to $511M from $867M previously.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ZNTL
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Valuation Metrics

The current forward P/E ratio for Zentalis Pharmaceuticals Inc (ZNTL.O) is 0.00, compared to its 5-year average forward P/E of -5.11. For a more detailed relative valuation and DCF analysis to assess Zentalis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.11
Current PE
0.00
Overvalued PE
-1.00
Undervalued PE
-9.22

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.27
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.53
Undervalued EV/EBITDA
-7.08

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
233.23
Current PS
16.34
Overvalued PS
1268.46
Undervalued PS
-801.99

Financials

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Frequently Asked Questions

What is Zentalis Pharmaceuticals Inc (ZNTL) stock price today?

The current price of ZNTL is 4.03 USD — it has decreased -13.15

What is Zentalis Pharmaceuticals Inc (ZNTL)'s business?

Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.

What is the price predicton of ZNTL Stock?

Wall Street analysts forecast ZNTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZNTL is6.60 USD with a low forecast of 4.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zentalis Pharmaceuticals Inc (ZNTL)'s revenue for the last quarter?

Zentalis Pharmaceuticals Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Zentalis Pharmaceuticals Inc (ZNTL)'s earnings per share (EPS) for the last quarter?

Zentalis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.49 USD, decreased -26.87

How many employees does Zentalis Pharmaceuticals Inc (ZNTL). have?

Zentalis Pharmaceuticals Inc (ZNTL) has 106 emplpoyees as of April 21 2026.

What is Zentalis Pharmaceuticals Inc (ZNTL) market cap?

Today ZNTL has the market capitalization of 329.12M USD.