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ZNTL Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
4.100
Open
4.070
VWAP
4.01
Vol
676.52K
Mkt Cap
284.75M
Low
3.935
Amount
2.71M
EV/EBITDA(TTM)
--
Total Shares
71.19M
EV
72.99M
EV/OCF(TTM)
--
P/S(TTM)
--
Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.
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Events Timeline

(ET)
2026-05-12
16:20:00
Zentalis CEO Reports Progress on Azenosertib for Ovarian Cancer Patients
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2026-04-17 (ET)
2026-04-17
15:30:00
Zentalis Presents Azenosertib Data at AACR Meeting
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2026-04-10 (ET)
2026-04-10
16:10:00
S&P 500 Closes Slightly Lower on Friday Amid Oil Volatility
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2026-04-10
12:00:00
Dow Jones Falls, Nasdaq Rises as Markets Mixed
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2026-01-06 (ET)
2026-01-06
08:10:00
Zentalis Pharmaceuticals Announces 2026 Milestones for Azenosertib Development
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2025-11-10 (ET)
2025-11-10
16:27:19
Zentalis Announces Q3 Earnings Per Share of 37 Cents, Below Consensus Estimate of 48 Cents
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2025-09-24 (ET)
2025-09-24
15:35:12
Zentalis Board Member Letai Emerges as Top Candidate for NCI Leadership, According to STAT
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link
2025-08-26 (ET)
2025-08-26
16:09:52
Zentalis Announces Departure of CLO Andrea Paul, James Bucher to Take Over
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News

NASDAQ.COM
9.0
05-22NASDAQ.COM
Zentalis Pharmaceuticals Reports Encouraging Phase 1b Results for Azenosertib
  • Clinical Trial Results: Zentalis Pharmaceuticals announced preliminary results from the MUIR trial, indicating Azenosertib's potential in treating platinum-resistant ovarian cancer, with results to be presented at the 2026 ASCO Annual Meeting, which could further propel the company's growth in the biopharmaceutical sector.
  • Efficacy Assessment: The Overall Response Rate (ORR) for Azenosertib combined with Paclitaxel was 50.0%, significantly higher than the 39.1% across all dose cohorts, suggesting the drug's effectiveness in a specific patient population, potentially attracting more investor interest.
  • Safety Analysis: Although approximately 20% of patients experienced serious Treatment-Related Adverse Events (TRAEs), Azenosertib demonstrated a manageable safety profile with relatively low rates of high-grade adverse events, laying a foundation for its future clinical applications.
  • Market Reaction: Zentalis Pharmaceuticals' shares closed up 11.59% at $4.14 on Thursday, reflecting a positive market response to its clinical trial results, which may support the company's future financing and research efforts.
Newsfilter
9.0
05-21Newsfilter
Zentalis Drug Shows Promising Results in Ovarian Cancer Clinical Trial
  • Clinical Trial Results: In a clinical trial for ovarian cancer, Zentalis's WEE1 inhibitor azenosertib combined with paclitaxel demonstrated a 39% overall response rate (ORR) and a median progression-free survival (PFS) of 7.3 months, indicating the potential of this combination in treating resistant ovarian cancer.
  • Optimal Dose Discovery: The 250 mg intermittent dose cohort showed a 50% ORR and a median duration of response (DOR) of 9.2 months, suggesting this dose may represent the optimal therapeutic combination, further supporting the drug's application prospects in ovarian and other tumor types.
  • Safety Analysis: Among 46 patients, a low frequency of high-grade adverse events was observed, with the most common treatment-related adverse events being fatigue (60.9%) and anemia (58.7%), indicating a favorable safety profile for further clinical use.
  • Future Research Directions: The results from the MUIR trial will provide crucial data support for Zentalis's registration trials in ovarian cancer, particularly in Cyclin E1-positive patients, further advancing the clinical development and market potential of the drug.
seekingalpha
9.5
05-12seekingalpha
Zentalis Pharmaceuticals Q1 Earnings Miss Expectations
  • Earnings Report Shortfall: Zentalis Pharmaceuticals reported a Q1 GAAP EPS of -$0.50, missing expectations by $0.03, indicating challenges in profitability that may affect investor confidence.
  • Declining Cash Reserves: As of March 31, 2026, the company's cash, cash equivalents, and marketable securities totaled $211.8 million, down from $245.9 million as of December 31, 2025, reflecting pressure on financial management.
  • Sufficient Funding Assessment: Zentalis believes that its cash reserves as of March 31, 2026, will be adequate to fund its operating expenses and capital expenditures into late 2027, indicating short-term financial stability.
  • Future Outlook: Despite the current financial shortfall, Zentalis maintains an optimistic view for the future, believing that existing funds will support its R&D and operations, potentially safeguarding subsequent product development.
Newsfilter
5.0
05-01Newsfilter
Zentalis Grants Stock Options to New Employee
  • Stock Option Grant: On May 1, 2026, Zentalis granted 26,000 non-qualified stock options to a new employee, aimed at attracting talent and enhancing the company's competitive edge.
  • Incentive Plan Context: The stock options were granted under the 2022 Employment Inducement Incentive Award Plan, complying with Nasdaq Listing Rule 5635(c)(4), specifically designed to incentivize new hires to join the company.
  • Option Exercise Price: The exercise price of the stock options is set at $4.09 per share, matching the closing price of Zentalis' common stock on the grant date, ensuring employees receive fair market value.
  • Vesting Arrangement: The options will vest over four years, with 25% vesting on the first anniversary and the remaining 75% vesting in equal monthly installments, ensuring employee retention and loyalty through continued service to Zentalis.
Newsfilter
9.0
04-21Newsfilter
Zentalis' Azenosertib Accepted for ASCO Presentation
  • ASCO Recognition: Zentalis announced that its abstract on the WEE1 inhibitor azenosertib for ovarian cancer has been accepted for presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting from June 1-5, 2026, highlighting the company's ongoing innovation in clinical oncology.
  • MUIR Trial Progress: Data from Part 1 of the MUIR trial will showcase the efficacy of azenosertib in combination with paclitaxel, particularly in platinum-resistant ovarian cancer patients, expected to provide crucial evidence for the drug's potential application across various tumor types and further propel its clinical development.
  • Clinical Trial Design: The MUIR trial is a multi-part, open-label Phase 1b clinical trial primarily assessing safety and tolerability, with key secondary objectives including objective response rate and progression-free survival, demonstrating Zentalis' rigor and foresight in clinical research.
  • Market Potential: Azenosertib, as the first treatment targeting Cyclin E1-positive platinum-resistant ovarian cancer, is in late-stage development and has received Fast Track Designation from the FDA, expected to fill a significant treatment gap for this specific patient population, indicating substantial market prospects.
Newsfilter
8.5
04-17Newsfilter
Zentalis Unveils New Data, Paving New Directions in Cancer Treatment
  • Preclinical Data Highlights: Zentalis presented preclinical data at the AACR meeting showing that combinations of azenosertib with antibody-drug conjugates can induce complete tumor responses in models resistant to ADCs, indicating potential applications beyond ovarian cancer and opening new avenues for pipeline expansion.
  • Significant Preclinical Efficacy: In a model resistant to the approved TOPO1i ADC, the combination of azenosertib and enfortumab vedotin achieved complete responses in 87.5% of mice, effectively preventing tumor progression even after treatment cessation, showcasing its potential in treating resistant tumors.
  • Real-World Data Validation: The real-world data presented at AACR highlight that Cyclin E1-positive ovarian cancer patients face significantly worse clinical outcomes with standard therapies, underscoring the importance of azenosertib for this population and potentially supporting the upcoming DENALI and ASPENOVA studies.
  • Strong Market Demand: Cyclin E1-positive patients had an average time to next treatment of 13.2 months post-first-line therapy, significantly lower than the 19.5 months for Cyclin E1-negative patients, emphasizing the urgent need for targeted therapies in this specific population and driving the clinical development of azenosertib.
Wall Street analysts forecast ZNTL stock price to rise
6 Analyst Rating
Wall Street analysts forecast ZNTL stock price to rise
4 Buy
2 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
4.00
Averages
6.60
High
10.00
Current: 0.000
sliders
Low
4.00
Averages
6.60
High
10.00
Guggenheim
Buy
maintain
$6 -> $10
AI Analysis
2026-04-10
Reason
Guggenheim
Price Target
$6 -> $10
AI Analysis
2026-04-10
maintain
Buy
Reason
Guggenheim raised the firm's price target on Zentalis to $10 from $6 and keeps a Buy rating on the shares, citing increased probability of success assumptions in platinum-resistant ovarian cancer.
Morgan Stanley
Michael Ulz
Equal Weight
downgrade
$8 -> $4
2025-11-11
Reason
Morgan Stanley
Michael Ulz
Price Target
$8 -> $4
2025-11-11
downgrade
Equal Weight
Reason
Morgan Stanley analyst Michael Ulz lowered the firm's price target on Zentalis to $4 from $8 and keeps an Equal Weight rating on the shares after the company reported Q3 earnings and highlighted progress with enrollment ongoing in the DENALI Part 2a study for azenosertib in platinum resistant ovarian cancer. The firm has fine tuned its azenosertib revenue estimates, having increased its PROC revenue estimate, removed revenues from non-gynecological indications and decreased its peak sales estimate to $511M from $867M previously.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ZNTL
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Valuation Metrics

The current forward P/E ratio for Zentalis Pharmaceuticals Inc (ZNTL.O) is 0.00, compared to its 5-year average forward P/E of -4.95. For a more detailed relative valuation and DCF analysis to assess Zentalis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-4.95
Current PE
0.00
Overvalued PE
-0.92
Undervalued PE
-8.97

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.15
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.62
Undervalued EV/EBITDA
-6.93

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
233.72
Current PS
13.46
Overvalued PS
1269.27
Undervalued PS
-801.83

Financials

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Frequently Asked Questions

What is Zentalis Pharmaceuticals Inc (ZNTL) stock price today?

The current price of ZNTL is 4 USD — it has decreased -1.23

What is Zentalis Pharmaceuticals Inc (ZNTL)'s business?

Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.

What is the price predicton of ZNTL Stock?

Wall Street analysts forecast ZNTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZNTL is6.60 USD with a low forecast of 4.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Zentalis Pharmaceuticals Inc (ZNTL)'s revenue for the last quarter?

Zentalis Pharmaceuticals Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Zentalis Pharmaceuticals Inc (ZNTL)'s earnings per share (EPS) for the last quarter?

Zentalis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.50 USD, decreased -25.37

How many employees does Zentalis Pharmaceuticals Inc (ZNTL). have?

Zentalis Pharmaceuticals Inc (ZNTL) has 106 emplpoyees as of May 31 2026.

What is Zentalis Pharmaceuticals Inc (ZNTL) market cap?

Today ZNTL has the market capitalization of 284.75M USD.