Zentalis Pharmaceuticals' Azenosertib Set for Key Milestones in 2026
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2026
0mins
Source: NASDAQ.COM
- Clinical Trial Progress: Zentalis has completed enrollment in the DENALI Part 2a trial for Azenosertib in Cyclin E1-positive platinum-resistant ovarian cancer, with dose confirmation expected in 1H 2026 and topline data by year-end, potentially supporting accelerated FDA approval.
- Market Demand: Cyclin E1-positive platinum-resistant ovarian cancer accounts for about half of all PROC cases, with patients facing limited treatment options and poor outcomes, making Azenosertib's development crucial to address this significant unmet medical need.
- New Trial Initiation: Zentalis plans to initiate the ASPENOVA Phase 3 randomized confirmatory trial in 1H 2026, running concurrently with DENALI Part 2, to compare Azenosertib with standard chemotherapy, further validating its clinical value.
- Stock Performance: ZNTL shares have traded between $1.01 and $3.06 over the past year, closing yesterday at $1.78, up 29.92%, and further rising to $1.83 in after-hours trading, reflecting positive market sentiment regarding its future prospects.
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Analyst Views on ZNTL
Wall Street analysts forecast ZNTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZNTL is 6.60 USD with a low forecast of 4.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
4 Buy
2 Hold
0 Sell
Moderate Buy
Current: 2.560
Low
4.00
Averages
6.60
High
10.00
Current: 2.560
Low
4.00
Averages
6.60
High
10.00
About ZNTL
Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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