SEPN PE Ratio & Valuation,Is SEPN Overvalued

SEPN Relative Valuation

SEPN's fair value is calculated using relative valuation, based on historical P/E and P/S ranges and their premiums/discounts relative to a competitor average, adjusted by weights. If the market price exceeds this fair value range, SEPN is overvalued; if below, it's undervalued.

Historical Valuation

Septerna Inc (SEPN) is now in the Fair zone, suggesting that its current forward PS ratio of 0.00 is considered Fairly compared with the five-year average of -15.74. The fair price of Septerna Inc (SEPN) is between -- to -- according to relative valuation methord.

Relative Value

Fair Zone

-----

Current Price：27.18

Fair

-55.41

0.00

EV/EBITDA

Septerna Inc. (SEPN) has a current EV/EBITDA of 0.00. The 5-year average EV/EBITDA is -1.34. The thresholds are as follows: Strongly Undervalued below -8.54, Undervalued between -8.54 and -4.94, Fairly Valued between 2.26 and -4.94, Overvalued between 2.26 and 5.86, and Strongly Overvalued above 5.86. The current Forward EV/EBITDA of 0.00 falls within the Historic Trend Line -Fairly Valued range.

-4.81

EV/EBIT

Septerna Inc. (SEPN) has a current EV/EBIT of -4.81. The 5-year average EV/EBIT is 1.51. The thresholds are as follows: Strongly Undervalued below -19.43, Undervalued between -19.43 and -8.96, Fairly Valued between 11.98 and -8.96, Overvalued between 11.98 and 22.45, and Strongly Overvalued above 22.45. The current Forward EV/EBIT of -4.81 falls within the Historic Trend Line -Fairly Valued range.

15.82

Septerna Inc. (SEPN) has a current PS of 15.82. The 5-year average PS is 142.92. The thresholds are as follows: Strongly Undervalued below -468.37, Undervalued between -468.37 and -162.72, Fairly Valued between 448.57 and -162.72, Overvalued between 448.57 and 754.21, and Strongly Overvalued above 754.21. The current Forward PS of 15.82 falls within the Historic Trend Line -Fairly Valued range.

-12.13

P/OCF

Septerna Inc. (SEPN) has a current P/OCF of -12.13. The 5-year average P/OCF is -2.32. The thresholds are as follows: Strongly Undervalued below -17.12, Undervalued between -17.12 and -9.72, Fairly Valued between 5.08 and -9.72, Overvalued between 5.08 and 12.48, and Strongly Overvalued above 12.48. The current Forward P/OCF of -12.13 falls within the Undervalued range.

-31.64

P/FCF

Septerna Inc. (SEPN) has a current P/FCF of -31.64. The 5-year average P/FCF is -25.44. The thresholds are as follows: Strongly Undervalued below -108.14, Undervalued between -108.14 and -66.79, Fairly Valued between 15.91 and -66.79, Overvalued between 15.91 and 57.26, and Strongly Overvalued above 57.26. The current Forward P/FCF of -31.64 falls within the Historic Trend Line -Fairly Valued range.

Septerna Inc (SEPN) has a current Price-to-Book (P/B) ratio of 3.12. Compared to its 3-year average P/B ratio of 0.82 , the current P/B ratio is approximately 281.52% higher. Relative to its 5-year average P/B ratio of 0.82, the current P/B ratio is about 281.52% higher. Septerna Inc (SEPN) has a Forward Free Cash Flow (FCF) yield of approximately 0.00%. Compared to its 3-year average FCF yield of -9.92%, the current FCF yield is approximately -100.00% lower. Relative to its 5-year average FCF yield of -9.92% , the current FCF yield is about -100.00% lower.

3.12

P/B

Median3y

0.82

Median5y

0.82

9.06

FCF Yield

Median3y

-9.92

Median5y

-9.92

Competitors Valuation Multiple

The average P/S ratio for SEPN's competitors is , providing a benchmark for relative valuation. Septerna Inc Corp (SEPN) exhibits a P/S ratio of , which is NaN% above the industry average. Given its robust revenue growth of 12113.07%, this premium appears sustainable.

P/S

P/E

EV/EBITDA

EV/EBIT

Revenue Growth

Market Cap

Performance Decomposition

Market capitalization of SEPN increased by 18.69% over the past 1 year. The primary factor behind the change was an increase in Revenue Growth from 176.00K to 21.50M.

The secondary factor is the Margin Expansion, contributed -100.33%to the performance.

Overall, the performance of SEPN in the past 1 year is driven by Revenue Growth. Which is more sustainable.

12113.07%

176.00K → 21.50M

Revenue Growth

-100.33%

-11.66K → 38.02

Margin Expansion

-11994.05%

0.16 → -19.04

P/E Change

18.69%

22.90 → 27.18

Mkt Cap Growth

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Frequently Asked Questions

Is Septerna Inc (SEPN) currently overvalued or undervalued?

What is Septerna Inc (SEPN) fair value?

SEPN's fair value is calculated using relative valuation, based on historical P/E and P/S ranges and their premiums/discounts relative to a competitor average , adjusted by weights. The fair price of Septerna Inc (SEPN) is between to according to relative valuation methord.

How does SEPN's valuation metrics compare to the industry average?

What is the current P/B ratio for Septerna Inc (SEPN) as of Dec 16 2025?

As of Dec 16 2025, Septerna Inc (SEPN) has a P/B ratio of 3.12. This indicates that the market values SEPN at 3.12 times its book value.

What is the current FCF Yield for Septerna Inc (SEPN) as of Dec 16 2025?

As of Dec 16 2025, Septerna Inc (SEPN) has a FCF Yield of 0.00%. This means that for every dollar of Septerna Inc’s market capitalization, the company generates 0.00 cents in free cash flow.

What is the current Forward P/E ratio for Septerna Inc (SEPN) as of Dec 16 2025?

As of Dec 16 2025, Septerna Inc (SEPN) has a Forward P/E ratio of -55.41. This means the market is willing to pay $-55.41 for every dollar of Septerna Inc’s expected earnings over the next 12 months.

What is the current Forward P/S ratio for Septerna Inc (SEPN) as of Dec 16 2025?

As of Dec 16 2025, Septerna Inc (SEPN) has a Forward P/S ratio of 0.00. This means the market is valuing SEPN at $0.00 for every dollar of expected revenue over the next 12 months.

SEPN Valuation