Prothena Receives $50 Million Milestone Payment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 09 2026
0mins
Should l Buy PRTA?
The company states: "Prothena (PRTA) announced that the Company earned a $50 million milestone payment from Novo Nordisk (NVO) related to the achievement of a prespecified enrollment target in the ongoing Phase 3 CLEOPATTRA clinical trial evaluating coramitug, a potential first-in-class amyloid depleter antibody, for the treatment of ATTR amyloidosis with cardiomyopathy. Novo Nordisk is evaluating coramitug in the ongoing Phase 3 CLEOPATTRA clinical trial in approximately 1280 participants with ATTR-CM with primary completion expected in 2029."
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Analyst Views on PRTA
Wall Street analysts forecast PRTA stock price to rise
5 Analyst Rating
4 Buy
0 Hold
1 Sell
Moderate Buy
Current: 10.030
Low
8.00
Averages
22.20
High
36.00
Current: 10.030
Low
8.00
Averages
22.20
High
36.00
About PRTA
Prothena Corporation plc is an Ireland-based late-stage clinical biotechnology company. The Company is engaged in protein dysregulation and a pipeline of investigational therapeutics for rare peripheral amyloid diseases. The Company is advancing a pipeline of therapeutic candidates for a range of indications and targets to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins. The Company’s pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and a range of other neurodegenerative diseases. Its clinical programs include birtamimab for the potential treatment of AL amyloidosis, prasinezumab for the potential treatment of Parkinson’s disease, NNC6019/PRX004 for the potential treatment of ATTR amyloidosis, and PRX005 and PRX012 for the potential treatment of Alzheimer’s disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Parkinson's Disease Research Findings: The study indicates that prasinezumab effectively slows disease progression in early-stage Parkinson's patients, potentially providing a longer asymptomatic period when combined with effective symptomatic therapies, thereby enhancing Prothena's competitive position in the market.
- Alzheimer's Disease Clinical Trials: BMS-986446 demonstrated good safety and tolerability in healthy participants, supporting its application in ongoing clinical studies, which could offer new treatment options for Alzheimer's patients and further solidify Prothena's product pipeline.
- Technological Innovation and Market Outlook: Prothena's CYTOPE technology is expected to enhance the efficiency of intracellular drug delivery, and combined with its deep expertise in neurodegenerative diseases, it may open new market opportunities and drive future growth.
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- Share Buyback Plan: Prothena's board has authorized a share repurchase plan allowing for the buyback of up to $100 million in outstanding shares, aimed at enhancing shareholder value and boosting market confidence, which is expected to positively impact the stock price.
- Strong Cash Position: As of December 31, 2025, Prothena reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the buyback initiative.
- Future Cash Expectations: Excluding the buyback plan, Prothena anticipates ending 2026 with approximately $255 million in cash and cash equivalents, ensuring operational flexibility for future investments and initiatives.
- Clinical Milestone Potential: The company expects to earn up to $105 million in clinical milestone payments in 2026, linked to strategic partnerships with Novo Nordisk and Bristol Myers Squibb, highlighting its potential in treating ATTR amyloidosis and neurodegenerative diseases.
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- Strong Financial Position: As of December 31, 2025, the company reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the repurchase plan.
- Future Cash Projections: Excluding any purchases under the plan, Prothena expects to end 2026 with approximately $255 million in cash, providing a stable financial foundation for future R&D and operations.
- Clinical Milestone Potential: The company anticipates earning up to $105 million in aggregate clinical milestone payments in 2026, which will further enhance its financial flexibility and support collaborative projects with Novo Nordisk and Bristol Myers Squibb.
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- Earnings Performance: Prothena reported a Q4 GAAP EPS of -$0.40, beating expectations by $0.16, indicating some improvement in cost management; however, the continued losses highlight ongoing financial pressures.
- Revenue Decline: The company generated only $0.02 million in revenue, a staggering 99.1% year-over-year decline, missing market expectations by $0.65 million, which signals severe challenges in product sales and market demand that could impact future liquidity.
- Investor Conference Participation: Prothena presented at the Evercore 8th Annual Healthcare Conference, and while the financial performance was disappointing, such events can enhance visibility among investors and potentially create future financing opportunities.
- Historical Financial Data: Historical earnings data for Prothena shows significant volatility in performance over recent quarters, with ongoing losses and declining revenues likely to affect its long-term strategy and market confidence.
See More
Prothena Board Member Paula Cobb Resigns to Join Manifold Bio as COO
- Board Change: Prothena Corporation announces that Paula Cobb will step down from the board to become COO at Manifold Bio, having made significant contributions to the company's vision and strategy during her six-year tenure.
- Leadership Impact: Board Chair Daniel G. Welch expressed gratitude for Cobb's contributions, highlighting her extensive experience in global development, business strategy, and commercial expertise that provided valuable insights to the board and leadership.
- Current Board Status: With Cobb's departure, Prothena's board now consists of 8 directors, which may impact the company's future strategic decisions and governance structure.
- Company Vision: In her farewell, Cobb reaffirmed her confidence in Prothena's strategic vision, emphasizing the company's commitment to developing transformative medicines for severe diseases caused by protein dysregulation.
See More
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- Clinical Update Announcement: Prothena presented clinical updates on prasinezumab and BMS-986446 at the 2026 International Conference on Alzheimer's and Parkinson's Diseases, highlighting their potential in treating neurodegenerative diseases, which may drive further advancements in the biotech sector.
- Parkinson's Disease Research Findings: The study indicates that prasinezumab effectively slows disease progression in early-stage Parkinson's patients, potentially providing a longer asymptomatic period when combined with effective symptomatic therapies, thereby enhancing Prothena's competitive position in the market.
- Alzheimer's Disease Clinical Trials: BMS-986446 demonstrated good safety and tolerability in healthy participants, supporting its application in ongoing clinical studies, which could offer new treatment options for Alzheimer's patients and further solidify Prothena's product pipeline.
- Technological Innovation and Market Outlook: Prothena's CYTOPE technology is expected to enhance the efficiency of intracellular drug delivery, and combined with its deep expertise in neurodegenerative diseases, it may open new market opportunities and drive future growth.
See More
Prothena Authorizes $100 Million Share Buyback Plan
- Share Buyback Plan: Prothena's board has authorized a share repurchase plan allowing for the buyback of up to $100 million in outstanding shares, aimed at enhancing shareholder value and boosting market confidence, which is expected to positively impact the stock price.
- Strong Cash Position: As of December 31, 2025, Prothena reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the buyback initiative.
- Future Cash Expectations: Excluding the buyback plan, Prothena anticipates ending 2026 with approximately $255 million in cash and cash equivalents, ensuring operational flexibility for future investments and initiatives.
- Clinical Milestone Potential: The company expects to earn up to $105 million in clinical milestone payments in 2026, linked to strategic partnerships with Novo Nordisk and Bristol Myers Squibb, highlighting its potential in treating ATTR amyloidosis and neurodegenerative diseases.
See More
Prothena Board Approves $100 Million Share Repurchase Plan
- Repurchase Plan Initiated: Prothena's board has authorized a share repurchase plan of up to $100 million, aimed at enhancing shareholder value and boosting market confidence, which is expected to have a positive impact on the stock price.
- Strong Financial Position: As of December 31, 2025, the company reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the repurchase plan.
- Future Cash Projections: Excluding any purchases under the plan, Prothena expects to end 2026 with approximately $255 million in cash, providing a stable financial foundation for future R&D and operations.
- Clinical Milestone Potential: The company anticipates earning up to $105 million in aggregate clinical milestone payments in 2026, which will further enhance its financial flexibility and support collaborative projects with Novo Nordisk and Bristol Myers Squibb.
See More
Prothena Q4 Earnings Report Analysis
- Earnings Performance: Prothena reported a Q4 GAAP EPS of -$0.40, beating expectations by $0.16, indicating some improvement in cost management; however, the continued losses highlight ongoing financial pressures.
- Revenue Decline: The company generated only $0.02 million in revenue, a staggering 99.1% year-over-year decline, missing market expectations by $0.65 million, which signals severe challenges in product sales and market demand that could impact future liquidity.
- Investor Conference Participation: Prothena presented at the Evercore 8th Annual Healthcare Conference, and while the financial performance was disappointing, such events can enhance visibility among investors and potentially create future financing opportunities.
- Historical Financial Data: Historical earnings data for Prothena shows significant volatility in performance over recent quarters, with ongoing losses and declining revenues likely to affect its long-term strategy and market confidence.
See More
Prothena Board Member Paula Cobb Resigns to Join Manifold Bio as COO
- Board Change: Prothena Corporation announces that Paula Cobb will step down from the board to become COO at Manifold Bio, having made significant contributions to the company's vision and strategy during her six-year tenure.
- Leadership Impact: Board Chair Daniel G. Welch expressed gratitude for Cobb's contributions, highlighting her extensive experience in global development, business strategy, and commercial expertise that provided valuable insights to the board and leadership.
- Current Board Status: With Cobb's departure, Prothena's board now consists of 8 directors, which may impact the company's future strategic decisions and governance structure.
- Company Vision: In her farewell, Cobb reaffirmed her confidence in Prothena's strategic vision, emphasizing the company's commitment to developing transformative medicines for severe diseases caused by protein dysregulation.
See More
Amazon Set to Surge by 31%? Check Out 10 Leading Analyst Predictions for Monday
Analyst Upgrades and Downgrades: JP Morgan downgraded Argan Inc while raising its price target, Oppenheimer maintained an Outperform rating for Amazon with a price target increase, and RBC Capital downgraded PTC Therapeutics despite raising its price target.
Price Target Adjustments: Barclays lowered Crown Castle's price target and downgraded its rating, while Benchmark raised Light & Wonder's target and maintained a Buy rating.
Significant Increases: Mizuho raised Insmed's price target significantly and maintained an Outperform rating, while HSBC upgraded Thermo Fisher Scientific from Hold to Buy with a notable price target increase.
Mixed Ratings: Argus Research cut Target's price target but kept a Buy rating, and BMO Capital reduced Old Dominion's target while upgrading its rating to Outperform.
See More
