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PRTA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
10.080
Open
9.750
VWAP
9.82
Vol
849.12K
Mkt Cap
530.79M
Low
9.510
Amount
8.34M
EV/EBITDA(TTM)
--
Total Shares
53.83M
EV
223.26M
EV/OCF(TTM)
--
P/S(TTM)
54.81
Prothena Corporation plc is an Ireland-based late-stage clinical biotechnology company. The Company is engaged in protein dysregulation and a pipeline of investigational therapeutics for rare peripheral amyloid diseases. The Company is advancing a pipeline of therapeutic candidates for a range of indications and targets to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins. The Company’s pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and a range of other neurodegenerative diseases. Its clinical programs include birtamimab for the potential treatment of AL amyloidosis, prasinezumab for the potential treatment of Parkinson’s disease, NNC6019/PRX004 for the potential treatment of ATTR amyloidosis, and PRX005 and PRX012 for the potential treatment of Alzheimer’s disease.
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Events Timeline

(ET)
2026-03-09
16:10:00
Prothena Receives $50 Million Milestone Payment
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2026-02-27 (ET)
2026-02-27
16:20:00
Prothena Expects $255M Cash by Year-End 2025
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2026-02-27
16:20:00
Prothena Authorizes $100M Share Repurchase Plan
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2026-02-19 (ET)
2026-02-19
16:10:00
Prothena Expects $72 Million Net Cash Use in 2026
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2025-12-01 (ET)
2025-12-01
06:22:00
Citizens JMP Raises Prothena Price Target to $19, Potential Milestone Payments Up to $105M
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2025-11-19 (ET)
2025-11-19
16:07:09
Prothena Reveals Poster Presentation for TDP-43 CYTOPE Initiative
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2025-11-11 (ET)
2025-11-11
09:14:28
Prothena Showcases Encouraging Phase 2 Coramitug Results Featured in AHA Journal
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2025-11-06 (ET)
2025-11-06
16:09:22
Prothena Announces Q3 Earnings Per Share of 68 Cents, Exceeding Consensus Estimate of 54 Cents
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News

Newsfilter
8.5
03-21Newsfilter
Prothena Announces Clinical Updates on Parkinson's and Alzheimer's Treatments
  • Clinical Update Announcement: Prothena presented clinical updates on prasinezumab and BMS-986446 at the 2026 International Conference on Alzheimer's and Parkinson's Diseases, highlighting their potential in treating neurodegenerative diseases, which may drive further advancements in the biotech sector.
  • Parkinson's Disease Research Findings: The study indicates that prasinezumab effectively slows disease progression in early-stage Parkinson's patients, potentially providing a longer asymptomatic period when combined with effective symptomatic therapies, thereby enhancing Prothena's competitive position in the market.
  • Alzheimer's Disease Clinical Trials: BMS-986446 demonstrated good safety and tolerability in healthy participants, supporting its application in ongoing clinical studies, which could offer new treatment options for Alzheimer's patients and further solidify Prothena's product pipeline.
  • Technological Innovation and Market Outlook: Prothena's CYTOPE technology is expected to enhance the efficiency of intracellular drug delivery, and combined with its deep expertise in neurodegenerative diseases, it may open new market opportunities and drive future growth.
NASDAQ.COM
8.0
02-28NASDAQ.COM
Prothena Authorizes $100 Million Share Buyback Plan
  • Share Buyback Plan: Prothena's board has authorized a share repurchase plan allowing for the buyback of up to $100 million in outstanding shares, aimed at enhancing shareholder value and boosting market confidence, which is expected to positively impact the stock price.
  • Strong Cash Position: As of December 31, 2025, Prothena reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the buyback initiative.
  • Future Cash Expectations: Excluding the buyback plan, Prothena anticipates ending 2026 with approximately $255 million in cash and cash equivalents, ensuring operational flexibility for future investments and initiatives.
  • Clinical Milestone Potential: The company expects to earn up to $105 million in clinical milestone payments in 2026, linked to strategic partnerships with Novo Nordisk and Bristol Myers Squibb, highlighting its potential in treating ATTR amyloidosis and neurodegenerative diseases.
seekingalpha
8.0
02-27seekingalpha
Prothena Board Approves $100 Million Share Repurchase Plan
  • Repurchase Plan Initiated: Prothena's board has authorized a share repurchase plan of up to $100 million, aimed at enhancing shareholder value and boosting market confidence, which is expected to have a positive impact on the stock price.
  • Strong Financial Position: As of December 31, 2025, the company reported $308.4 million in cash and cash equivalents with no debt, indicating robust financial health that supports the repurchase plan.
  • Future Cash Projections: Excluding any purchases under the plan, Prothena expects to end 2026 with approximately $255 million in cash, providing a stable financial foundation for future R&D and operations.
  • Clinical Milestone Potential: The company anticipates earning up to $105 million in aggregate clinical milestone payments in 2026, which will further enhance its financial flexibility and support collaborative projects with Novo Nordisk and Bristol Myers Squibb.
seekingalpha
9.5
02-19seekingalpha
Prothena Q4 Earnings Report Analysis
  • Earnings Performance: Prothena reported a Q4 GAAP EPS of -$0.40, beating expectations by $0.16, indicating some improvement in cost management; however, the continued losses highlight ongoing financial pressures.
  • Revenue Decline: The company generated only $0.02 million in revenue, a staggering 99.1% year-over-year decline, missing market expectations by $0.65 million, which signals severe challenges in product sales and market demand that could impact future liquidity.
  • Investor Conference Participation: Prothena presented at the Evercore 8th Annual Healthcare Conference, and while the financial performance was disappointing, such events can enhance visibility among investors and potentially create future financing opportunities.
  • Historical Financial Data: Historical earnings data for Prothena shows significant volatility in performance over recent quarters, with ongoing losses and declining revenues likely to affect its long-term strategy and market confidence.
Newsfilter
5.0
2025-12-12Newsfilter
Prothena Board Member Paula Cobb Resigns to Join Manifold Bio as COO
  • Board Change: Prothena Corporation announces that Paula Cobb will step down from the board to become COO at Manifold Bio, having made significant contributions to the company's vision and strategy during her six-year tenure.
  • Leadership Impact: Board Chair Daniel G. Welch expressed gratitude for Cobb's contributions, highlighting her extensive experience in global development, business strategy, and commercial expertise that provided valuable insights to the board and leadership.
  • Current Board Status: With Cobb's departure, Prothena's board now consists of 8 directors, which may impact the company's future strategic decisions and governance structure.
  • Company Vision: In her farewell, Cobb reaffirmed her confidence in Prothena's strategic vision, emphasizing the company's commitment to developing transformative medicines for severe diseases caused by protein dysregulation.
Benzinga
6.0
2025-12-01Benzinga
Amazon Set to Surge by 31%? Check Out 10 Leading Analyst Predictions for Monday
  • Analyst Upgrades and Downgrades: JP Morgan downgraded Argan Inc while raising its price target, Oppenheimer maintained an Outperform rating for Amazon with a price target increase, and RBC Capital downgraded PTC Therapeutics despite raising its price target.

  • Price Target Adjustments: Barclays lowered Crown Castle's price target and downgraded its rating, while Benchmark raised Light & Wonder's target and maintained a Buy rating.

  • Significant Increases: Mizuho raised Insmed's price target significantly and maintained an Outperform rating, while HSBC upgraded Thermo Fisher Scientific from Hold to Buy with a notable price target increase.

  • Mixed Ratings: Argus Research cut Target's price target but kept a Buy rating, and BMO Capital reduced Old Dominion's target while upgrading its rating to Outperform.

Wall Street analysts forecast PRTA stock price to rise
5 Analyst Rating
Wall Street analysts forecast PRTA stock price to rise
4 Buy
0 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
8.00
Averages
22.20
High
36.00
Current: 0.000
sliders
Low
8.00
Averages
22.20
High
36.00
BofA
Tazeen Ahmad
Underperform
maintain
$4 -> $8
AI Analysis
2025-11-24
Reason
BofA
Tazeen Ahmad
Price Target
$4 -> $8
AI Analysis
2025-11-24
maintain
Underperform
Reason
BofA analyst Tazeen Ahmad raised the firm's price target on Prothena (PRTA) to $8 from $4 and keeps an Underperform rating on the shares. Prothena no longer plans to disclose further data for its Alzheimer's drug PRX012, notes the firm, which removed value for the program from its model and is shifting focus on valuation to two Phase 3 assets under development by partners Novo (NVO) and Roche (RHHBY) - Coramitug for ATTR-cardiomyopathy and prasinezumab for early-stage Parkinson's disease. While both programs will have begun Phase 3 studies by year-end, which the firm views favorably for Prothena, the firm adds that each drug will need several years to reach the market and their competitive positioning in the case of Coramitug and clinical efficacy in the case of prasinezumab are "uncertain."
H.C. Wainwright
Buy
maintain
$20 -> $30
2025-11-07
Reason
H.C. Wainwright
Price Target
$20 -> $30
2025-11-07
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Prothena to $30 from $20 and keeps a Buy rating on the shares. The firm believes the market is overlooking the company's two partnered Phase 3 programs and a partnered Phase 2 asset with blockbuster potential.
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Valuation Metrics

The current forward P/E ratio for Prothena Corporation PLC (PRTA.O) is 11.01, compared to its 5-year average forward P/E of 1.43. For a more detailed relative valuation and DCF analysis to assess Prothena Corporation PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
1.43
Current PE
11.01
Overvalued PE
34.38
Undervalued PE
-31.52

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-6.04
Current EV/EBITDA
-0.01
Overvalued EV/EBITDA
16.77
Undervalued EV/EBITDA
-28.84

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
82.67
Current PS
21.23
Overvalued PS
248.98
Undervalued PS
-83.63

Financials

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Whales Holding PRTA

A
Armistice Capital LLC
Holding
PRTA
-4.56%
3M Return

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Frequently Asked Questions

What is Prothena Corporation PLC (PRTA) stock price today?

The current price of PRTA is 9.86 USD — it has decreased -1.69

What is Prothena Corporation PLC (PRTA)'s business?

Prothena Corporation plc is an Ireland-based late-stage clinical biotechnology company. The Company is engaged in protein dysregulation and a pipeline of investigational therapeutics for rare peripheral amyloid diseases. The Company is advancing a pipeline of therapeutic candidates for a range of indications and targets to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins. The Company’s pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and a range of other neurodegenerative diseases. Its clinical programs include birtamimab for the potential treatment of AL amyloidosis, prasinezumab for the potential treatment of Parkinson’s disease, NNC6019/PRX004 for the potential treatment of ATTR amyloidosis, and PRX005 and PRX012 for the potential treatment of Alzheimer’s disease.

What is the price predicton of PRTA Stock?

Wall Street analysts forecast PRTA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PRTA is22.20 USD with a low forecast of 8.00 USD and a high forecast of 36.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Prothena Corporation PLC (PRTA)'s revenue for the last quarter?

Prothena Corporation PLC revenue for the last quarter amounts to 21.00K USD, decreased -99.01

What is Prothena Corporation PLC (PRTA)'s earnings per share (EPS) for the last quarter?

Prothena Corporation PLC. EPS for the last quarter amounts to -0.40 USD, decreased -62.96

How many employees does Prothena Corporation PLC (PRTA). have?

Prothena Corporation PLC (PRTA) has 67 emplpoyees as of April 04 2026.

What is Prothena Corporation PLC (PRTA) market cap?

Today PRTA has the market capitalization of 530.79M USD.