Pfizer Announces Positive Results for Trispecific Antibody Study
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 13 hours ago
0mins
Should l Buy PFE?
Pfizer announced positive topline results from a Phase 2 study investigating tilrekimig in adults with moderate to severe atopic dermatitis. The study met its primary efficacy endpoint, demonstrating a statistically significant increase in the percentage of participants achieving EASI-75 at Week 16, compared to placebo. In Stage 2 of the study, which evaluated monthly dosing regimens, tilrekimig showed competitive efficacy. The placebo-adjusted percentage of participants achieving EASI-75 at Week 16 was: 38.7% for the low tested dose; 51.9% for the middle tested dose; and 49.4% for the high tested dose. The two highest dose levels tested with tilrekimig strongly suggest potentially meaningful improvements to approved standard of care biologics. Tilrekimig is an investigational trispecific antibody that simultaneously targets interleukin-4, interleukin-13, and thymic stromal lymphopoietin, with the potential to be a once-monthly treatment option for multiple chronic inflammatory conditions driven by an overactive Type 2 immune response, without affecting receptors on healthy cells. "We are encouraged by the topline Phase 2 results for tilrekimig, which show that combining the potent inhibition of IL-4/13 and TSLP pathways has the potential to deliver improved efficacy over the standard of care for atopic dermatitis," said Mike Vincent, Chief Inflammation & Immunology Officer at Pfizer. "We plan to advance a broad clinical development program for tilrekimig, a potential first-in-class trispecific antibody discovered at Pfizer, in atopic dermatitis and other Th2-mediated inflammatory diseases including asthma and COPD."
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Analyst Views on PFE
Wall Street analysts forecast PFE stock price to rise
16 Analyst Rating
5 Buy
11 Hold
0 Sell
Moderate Buy
Current: 27.050
Low
24.00
Averages
28.56
High
35.00
Current: 27.050
Low
24.00
Averages
28.56
High
35.00
About PFE
Pfizer Inc. is a research-based, global biopharmaceutical company. The Company is engaged in the discovery, development, manufacture, marketing, sale and distribution of biopharmaceutical products worldwide. Its Biopharma segment includes the Pfizer U.S. Commercial Division, and the Pfizer International Commercial Division. Its product categories include oncology, primary care and specialty care. Its oncology products include Ibrance, Xtandi, Padcev, Adcetris, Inlyta, Lorbrena, Bosulif, Tukysa, Braftovi, Mektovi, Orgovyx, Elrexfio, Tivdak and Talzenna. Its primary care products include Eliquis, Nurtec ODT/Vydura, Zavzpret, the Prevnar family, Comirnaty, Abrysvo, FSME/IMMUN-TicoVac, Nimenrix, Trumenba, and Paxlovid. Its specialty care products include Xeljanz, Enbrel (outside the United States and Canada), Inflectra, Abrilada, Cibinqo, Litfulo, Eucrisa, Velsipity, the Vyndaqel family, Genotropin, BeneFIX, Xyntha, Somavert, Ngenla, Hympavzi, Sulperazon, Zavicefta, Octagam and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Advancements: Pfizer is advancing several clinical candidates into phase 3 studies, including MET-097i for weight loss and an investigational cancer drug PF'4404; while a rapid business rebound may be unlikely, long-term improvements in R&D could yield positive outcomes.
- Eli Lilly's Supercomputer: Eli Lilly has built the most powerful supercomputer in the pharmaceutical industry with Nvidia's assistance, aimed at enhancing its drug development capabilities, and has established an AI innovation lab to optimize drug discovery and development processes, further solidifying its leadership in the fast-growing weight loss market.
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- Accelerated Phase 3 Development: Pfizer plans to expedite tilrekimig to Phase 3, with a pivotal study in atopic dermatitis set to begin in 2026, aiming to provide more effective treatment options and further solidify Pfizer's leadership in immunotherapy.
- Multiple Indication Potential: As a potentially first-in-class drug, tilrekimig targets various chronic Type 2 inflammatory conditions, including atopic dermatitis, asthma, and COPD, showcasing broad clinical development prospects that could redefine existing treatment standards.
- Clinical Development Strategy: Pfizer is conducting a two-stage Phase 2 study, targeting participants who have previously received biologic treatments and those receiving ompekimig, demonstrating the company's ongoing commitment to innovation and research in the inflammation and immunology space.
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