NeOnc Technologies' NEO100 Therapy Shows Significant Antitumor Enhancement with Ultrasound
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 01 2025
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Source: Newsfilter
- Research Collaboration Findings: A study from the University of Southern California demonstrates that ultrasound significantly enhances NEO100's therapeutic potency, driving strong antitumor effects across various brain tumor types, indicating its potential for clinical application.
- Technological Innovation: Utilizing an AI-driven, 3D bioprinting New Approach Methodology, researchers rapidly generate physiologically relevant patient-derived tumor organoids within hours, significantly accelerating biomedical research and aligning with NIH objectives to reduce animal testing.
- Clinical Trial Prospects: Validation studies reveal that NEO100 exhibits markedly enhanced tumor-killing activity when combined with focused ultrasound, supporting its advancement into future clinical trials for a wide range of brain tumors, thereby broadening its commercial and clinical opportunities.
- Market Potential: The breakthrough provides strong external validation for NEO100's potential as a first-in-class, noninvasive sonodynamic therapy, significantly expanding its market opportunities beyond current indications through the integration of AI, 3D bioprinting, and ultrasound technology.
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About NTHI
NeOnc Technologies Holdings, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on establishing treatments for intracranial malignancies, such as aggressive cancers located in the brain. It is the developer of a novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. It is developing novel drug delivery methods to be used in combination with novel drug candidates. The Company has two lead products in development: NEO100 and NEO212. NEO100 is a purified form of perillyl acid (POH) which is administered to brain cancer patients via intranasal delivery. NEO212 is a covalently conjugated molecule combining the chemotherapeutic drug temozolomide with perillyl alcohol. NEO212 is undergoing development towards intranasal application specifically for patients with uncontrolled brain metastases derived from peripheral tumors (lung, breast, skin, and others).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
