Lexaria Bioscience Updates on GLP-1 Oral Market Developments
Lexaria Bioscience provides an update of additional recent developments in the fast-moving glucagon-like peptide-1 oral market. The company said, " The GLP-1 oral pill sector is growing much faster in 2026 than expected, and faster than the pre-existing GLP-1 injectable sector. The industry's first-ever GLP-1 pill for weight loss, Wegovy, was approved by the US Food and Drug Administration on December 22, 2025 and launched in the US in January 2026. Prior to that, Rybelsus was the only FDA approved GLP-1 drug available in pill form, but it was approved for diabetes control and only used secondarily for weight loss. Within less than the first two months of its launch, Novo Nordisk had disclosed that over 600,000 prescriptions for the Wegovy pill had been written, and will report on its first-quarter sales including the Wegovy pill in May. Both the Wegovy injectable and the Wegovy pill contain the same active drug: semaglutide, with which Lexaria has conducted extensive testing to determine compatibility with Lexaria's DehydraTECH technology. According to Global Data Healthcare, 51% of the growth in Wegovy revenue between 2026 and 2031 is expected to come from the pill format, with injectable semaglutide expected to reach peak revenue in 2030, when Novo Nordisk's Wegovy semaglutide franchise is expected to reach $15.9 billion in annual revenue. This will be quite an achievement since 2025 semaglutide revenue derived from Wegovy was 100% in the injectable category, whereas 2031 revenue from Wegovy products is expected to be 17% from pills. As Lexaria's press release of March 24 noted, TD Cowen raised their previous 2030 sales forecast of the overall GLP-1 sector from $101 billion to $139 billion, Roots Analysis is forecasting sales of $180 billion by 2035, while UBS Investment Bank expects 2029 GLP-1 sales to reach $126 billion. It is not possible to know in advance, what overall portion of the GLP-1 market will be captured by the oral pill format vs. the traditional injectable format; but, if the Wegovy based semaglutide revenue projections are any indication, it could certainly be 17% or higher within a few short years of product launch. In fact, according to a Novo Nordisk executive, oral GLP-1 drugs may account for as much as 33% of the broader GLP-1 market by that time. Based on the various GLP-1 revenue forecasts ranging from $101 billion to $180 billion, this could imply an oral pill sector ranging in size from $17 billion to $60 billion by the mid 2030's."
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- Significant Study Results: Lexaria achieved the primary endpoint in the GLP-1-H24-4 study, with all four DehydraTECH test arms demonstrating good safety, as DHT-semaglutide showed a 47.9% reduction in adverse events compared to Rybelsus, laying a solid foundation for future clinical applications.
- Adverse Event Reduction: The DHT-semaglutide formulation exhibited a 54.9% reduction in gastrointestinal adverse events, highlighting its safety advantages, which may attract more pharmaceutical companies to consider its product development.
- Funding Support: Lexaria secured approximately $7.5 million through two transactions since August 31, providing a financial runway for prospective new development opportunities in 2026, thereby enhancing its viability in a competitive market.
- Future Plans: Lexaria intends to pursue follow-on clinical testing to explore the potential of a DehydraTECH + SNAC + semaglutide composition, aiming to further validate its application prospects in diabetes treatment.

- Significant Study Results: Lexaria's completed GLP-1-H24-4 study in Australia demonstrated that DHT-semaglutide achieved approximately 47.9% fewer adverse events compared to Novo Nordisk's Rybelsus, indicating its potential in safety and tolerability.
- Reduction in Side Effects: The gastrointestinal adverse events from DHT-semaglutide were reduced by 54.9%, which not only enhances patient experience but also may bolster Lexaria's competitive position in the GLP-1 market.
- Future Research Plans: Lexaria intends to further develop DHT-semaglutide and is considering incorporating salcaprozate sodium in future clinical tests to potentially enhance efficacy and compare it against Rybelsus.
- Data Sharing Agreement: Lexaria will provide the complete dataset from GLP-1-H24-4 to its pharmaceutical partner under a Material Transfer Agreement, which has been extended to April 30, 2026, to ensure adequate time for data review.








